Digital Commons Network^™

Immune-Engineered H7n9 Influenza Hemagglutinin Improves Protection Against Viral Influenza Virus Challenge, Hyesun Jang, Lauren M. Meyers, Christine Boyle, Anne S. De Groot, Leonard Moise, Ted M. Ross

Cell and Molecular Biology Faculty Publications

The influenza hemagglutinin (HA) isolated from avian H7N9 influenza virus strains elicit weak immune responses. This low immunogenicity may be due to a regulatory T cell (T_reg)–stimulating epitopes in HA from the H7N9 isolate A/Anhui/1/2013 (Anh/13). In this report, this T_reg stimulating sequence was removed from the wild-type (WT) H7 HA amino acid sequence and replaced with a conserved CD4 + T cell stimulating sequences from human seasonal H3N2 strains and designed OPT1 H7 HA. The effectiveness of this optimized H7 HA protein was determined using a humanized mouse (HLA-DR3) expressing the human leukocyte antigen (HLA) DR3 …

Roles For A Lipid Phosphatase In The Activation Of Its Opposing Lipid Kinase, Bethany S. Strunk, N. Steinfeld, S. Lee, N. Jin, Cecilia Munõz-Rivera, Garrison Meeks, Asha Mary Thomas, C. Akemann, A. K. Mapp, J. A. Macgurn, L. S. Weisman

Biology Faculty Research

Fig4 is a phosphoinositide phosphatase that converts PI3,5P2 to PI3P. Paradoxically, mutation of Fig4 results in lower PI3,5P2, indicating that Fig4 is also required for PI3,5P2 production. Fig4 promotes elevation of PI3,5P2, in part, through stabilization of a protein complex that includes its opposing lipid kinase, Fab1, and the scaffold protein Vac14. Here we show that multiple regions of Fig4 contribute to its roles in the elevation of PI3,5P2: Its catalytic site, an N-terminal disease-related surface, and a C-terminal region. We show that mutation of the Fig4 catalytic site enhances the formation of the Fab1-Vac14-Fig4 complex, and reduces the ability …

Chimera-Like Behavior In A Heterogeneous Kuramoto Model: The Interplay Between Attractive And Repulsive Coupling, Nikita Frolov, Vladimir Maksimenko, Soumen Majhi, Sarbendu Rakshit, Dibakar Ghosh, Alexander Hramov

Journal Articles

Interaction within an ensemble of coupled nonlinear oscillators induces a variety of collective behaviors. One of the most fascinating is a chimera state that manifests the coexistence of spatially distinct populations of coherent and incoherent elements. Understanding of the emergent chimera behavior in controlled experiments or real systems requires a focus on the consideration of heterogeneous network models. In this study, we explore the transitions in a heterogeneous Kuramoto model under the monotonical increase of the coupling strength and specifically find that this system exhibits a frequency-modulated chimera-like pattern during the explosive transition to synchronization. We demonstrate that this specific …

Evaluation Of A Novel Shallow Aggregate Ebb-And-Flood Culture System And Transplant Size Effects On Hydroponic Basil Yield, Samuel Doty, Ryan W. Dickson, Michael Evans

Horticulture Faculty Publications and Presentations

Ornamental bedding plant operations transitioning to leafy greens and herb production must decide whether to invest in new hydroponic equipment or modify existing culture systems for edible crops. In addition, common practices used to increase space-use and production efficiencies during bedding plant production may be modified for hydroponic leafy greens and herbs, such as purchasing large seedlings for transplant. The objective of the first experiment was to evaluate plant growth in a modified and novel shallow aggregate ebb-and-flood (SAEF) system intended for bedding plant growers with an emphasis on comparing yield across four basil (Ocimum basilicum) cultivars grown …

Source Data: Evaluation Of Batch Fraction, Corn Silage Inclusion Level, And Mixing Duration On Long Particle Distribution Of Finishing Diets For Beef Cattle, Elizabeth Buckhaus, Dathan Smerchek, Zachary K. Smith

Animal Science Data Sets

This data set was used for the project titled “Evaluation of batch fraction, corn silage inclusion level, and mixing duration on long particle distribution of finishing diets for beef cattle”

Corresponding author: Zachary K. Smith ([email protected])

File type: .xlsx
File size: 265 KB

Comparative Spatial And Behavioral Ecology Of The Prairie Lizard Sceloporus Consobrinus In The Arkansas River Valley, E. A. Free Kashon

Theses and Dissertations from 2020

Habitat-driven differences in reptile life-histories have been observed in many species. Prairie lizards, Sceloporus consobrinus, in the Arkansas River Valley inhabit rocky, forested, and intermediate habitat types that exhibit different thermal resource availabilities and habitat structures. I studied prairie lizard space usage and antipredator responses to examine whether lizards exhibit habitat-driven differences in ecology, and whether these differences are influenced, in part, by individual personality. I utilized radio telemetry to track lizards in each of these habitat types and established estimates of space usage and daily linear movements. I used behavioral approaches to quantify lizard antipredator responses to a simulated …

Effects Of Management Efforts On Fledging Success Of Endangered Interior Least Terns (Sternula Antillarum Athalassos) On The Mcclellan-Kerr Arkansas River Navigation System In Arkansas, Trevor N. Jensen

Theses and Dissertations from 2020

The Interior Least Tern (Sternula antillarum athalassos) is an endangered shorebird that primarily nests in colonies on barren riverine sandbars on many major river systems throughout the central United States. Water resource development projects such as damming and channelization have altered the natural flow regimes of these systems leading to a decrease in sandbar quality and quantity, and as a result this species is dependent on management to ensure their recovery. Managers within Arkansas have been applying a variety of management approaches to improve sandbar nesting habitat and success of this population intermittently since 2002, with increased intensity since 2015. …

Kentucky Warbler (Vol. 96, No. 3), Kentucky Library Research Collections

The Kentucky Warbler

No abstract provided.

Effect Of S100b Deletion On Membrane Properties And Localization Of Ncald And Hpca, Natasha Hesketh

Graduate School of Biomedical Sciences Theses and Dissertations

Calcium signaling is particularly important for neuronal function. Neurons utilize a wide range of calcium-binding proteins. Dysregulation of such proteins is linked to neurodegeneration. Neurocalcin delta (NCALD), hippocalcin (HPCA), and S100B are calcium sensors that are expressed in the hippocampus, a brain region essential to memory and severely damaged in Alzheimer’s disease (AD). Despite the potential importance of these proteins, we do not fully understand the physiological significance of their relationship. Because NCALD and HPCA are known to interact with S100B, we hypothesized that the loss of S100B affects NCALD and HPCA localization, and therefore electrical properties, of hippocampal neurons. …

Clemson Commencement Program, August 2020, Clemson University

Clemson Commencement Programs

No abstract provided.

Volume 104, Number 2 (Summer 2020)

Judicature

No abstract provided.

The Use Of Low-Cost Sensors And A Convolutional Neural Network To Detect And Classify Mini-Drones, Austin Florio

Master's Theses

The increasing commercial availability of mini-drones and quadrotors has led to their greater usage, highlighting the need for detection and classification systems to ensure safe operation. Instances of drones causing serious complications since 2019 alone include shutting down airports [1-2], spying on individuals [3-4], and smuggling drugs and prohibited items across borders and into prisons [5-6]. Some regulatory measures have been taken, such as registration of drones above a specific size and the establishment of no-fly zones in sensitive areas such as airports, military bases, and national parks. While commercial systems exist to detect drones [7-8], they are expensive, unreliable, …

Antología De La Clase: Creative Writing In Spanish, 2020, Britton W. Newman

Student Scholarship

Creative Writing in Spanish
Spanish 441

Ensayos

Nefi Aguilar “¿Qué hago aquí?”

Bali Channa “Las etapas”

“Las cosas que necesitan tiempo”

Alex Collie “Agradecido por las ampollas”

“Confía en el viaje”

Samantha Dorward “El poder de las palabras”

“La primera vez, pero seguramente no la última”

“El miedo que nunca más regirá mi vida”

Olivia Groce “¿Qué vas a hacer tú?”

Aryk Hennings “Cuando crees en ti mismo”

Emily Knetsche “El hombre extraño”

“Los momentos preciosos”

Mayra Lomeli García “El pez que escapó”

Sami Lyons “Perdida”

Abbi Pagano “Latte caffè”

Emily Rea “La pulsera ‘gratis’”

Leila Shearer “No pasa nada” …

Water Quality Study Of The Muchea Livestock Truck Wash, Simon Clarendon, David Weaver, Justin L.M Hardy, Claire Coffey, Robert Summers, David Rogers, Peta Richards

Resource management technical reports

Across Australia there is a lack of information on the quality of the water discharged from facilities that are used to wash livestock trucks. This water quality scoping study partially fills that information gap and provides a starting point for future planning, design and construction of livestock truck washes.

The study was undertaken in 2011–12 at the Western Australian Muchea Livestock Centre, and aimed to gain insights into water quality associated with the truck wash facility at that site. These insights can help to inform the planning for further construction of truck wash facilities throughout the state, and whether disposing …

Ofc And Its Connectivity With Amygdala As Predictors For Future Social Anxiety In Adolescents, Yu Mao, Xi-Nian Zuo, Cody Ding, Jiang Qiu

Education Sciences and Professional Programs Faculty Works

Social anxiety is a common problem that usually emerges at puberty, during which great developmental changes occur both in the brain and mental state. However, little is known about the influence of social anxiety on adolescents’ brain and behavior. The present study investigated the neural basis of social anxiety using voxel-based morphometry (VBM) and functional connectivity analysis. Then we investigated whether social anxiety is associated with attention bias. Furthermore, we investigated the neural basis of this association. Finally, longitudinal data was used to test if these biomarkers could predict social anxiety. The results indicated that social anxiety is positively associated …

Ofc And Its Connectivity With Amygdala As Predictors For Future Social Anxiety In Adolescents, Yu Mao, Xinian Zuo, Cody Ding, Jiang Qiu

Education Sciences and Professional Programs Faculty Works

Social anxiety is a common problem that usually emerges at puberty, during which great developmental changes occur both in the brain and mental state. However, little is known about the influence of social anxiety on adolescents’ brain and behavior. The present study investigated the neural basis of social anxiety using voxel-based morphometry (VBM) and functional connectivity analysis. Then we investigated whether social anxiety is associated with attention bias. Furthermore, we investigated the neural basis of this association. Finally, longitudinal data was used to test if these biomarkers could predict social anxiety. The results indicated that social anxiety is positively associated …

Covid-19, 5g Conspiracies And Infrastructural Futures, James Meese, Jordan Frith, Rowan Wilken

Publications

This article examines the emergence of conspiracy theories linking COVID-19 with 5G, with a focus on Australia, the United States and United Kingdom. The article is in two parts. The first details long-standing concerns around mobile technologies and infrastructures before showing how they translate to specific worries about 5G technology. The second shows how these fears have fuelled specific conspiracies connecting 5G with COVID-19, how they have animated protests and acts of vandalism that have occurred during the pandemic, and the ongoing engagement of conspiracists with official inquiries into 5G. Finally, we argue that a productive way to understand what …

Comparing Apples And Oranges (And Blueberries And Grapes): Fruit Type Affects Development And Cold-Susceptibility Of Immature Drosophila Suzukii, Yanira Jiménez Padilla, Laura V. Ferguson, Brent J. Sinclair

Biology Publications

Drosophila suzukii is a cosmopolitan polyphagous pest on unripe soft-skinned fruits. We sought to determine 1) temperature treatments that could be used to kill immature D. suzukii in fruit or packaging, and 2) whether development on different fruits led to differences in cold tolerance of immature D. suzukii. We reared animals from egg on a banana-based laboratory diet and diets made of apple, blueberry, cherry, grape, orange, raspberry, or strawberry homogenate in agar, and measured development time, adult body size, and cold tolerance. Diet type had complex effects on development time; in particular, flies reared on apple- or blueberry-based …

Spatial Diffusion, Richard Morrill, Gary L. Gaile, Grant Ian Thrall

Web Book of Regional Science

This volume is about how we come to have the culture and ideas we have. Most social and economic change is a direct consequence of the diffusion of some idea or phenomenon. Ideas become diffused through society in a regular manner, and because of this regularity their diffusion can often be analyzed and even predicted. The same analytical framework applied to describe and predict the spread of some cultural or human phenomenon, such as political turmoil, can also be applied to an analysis of the spread of disease. The authors chronicle the evolution of ideas for analyzing, simulating, and forecasting …

Lindenwood University Student Handbook, 2020-2021, Lindenwood University

Student Handbooks

Information and guidelines for Lindenwood University students.

Sex-Specific Modulation Of Blood Pressure And The Renin-Angiotensin System By Ace (Angiotensin-Converting Enzyme) 2, Hong Ji, Aline M. De Souza, Bilkish Bajaj, Wei Zheng, Xie Wu, Robert C. Speth, Kathryn Sandberg

HPD Articles

We showed ACE (angiotensin-converting enzyme) 2 is higher in the kidney of male compared with female mice. To further investigate this sex difference, we examined the role of ACE2 in Ang-[1-8] (angiotensin [1-8])-induced hypertension and regulation of the renin-angiotensin system in the kidney of WT (wild type) and Ace2 KO (knockout) mice. Mean arterial pressure rose faster in WT male than WT female mice after Ang-[1-8] infusion. This sex difference was attenuated in ACE2 KO mice. Ang-[1-8] infusion reduced glomerular AT1R (angiotensin type 1 receptor) binding in WT female mice by 30%, and deletion of abolished this effect. In contrast, …

Endothelial Cell Hspa12b And Yes-Associated Protein Cooperatively Regulate Angiogenesis Following Myocardial Infarction, Min Fan, Kun Yang, Xiaohui Wang, Yana Wang, Fei Tu, Tuanzhu Ha, Li Liu, David L. Williams, Chuanfu Li

ETSU Faculty Works

This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. Angiogenesis is essential for cardiac functional recovery after myocardial infarction (MI). HSPA12B is predominately expressed in endothelial cells and required for angiogenesis. Yes-associated protein (YAP) plays an important role in tumor angiogenesis. This study investigated the cooperative role of HSPA12B and YAP in angiogenesis after MI. Silencing of either HSPA12B or YAP impaired hypoxia-promoted endothelial cell proliferation and angiogenesis. Deficiency of HSPA12B suppressed YAP expression and nuclear translocation after hypoxia. Knockdown of YAP attenuated hypoxia-stimulated HSPA12B nuclear translocation and abrogated HSPA12B-promoted endothelial …

Marketing Experience: Analysis Of Competitors, Kaylee Zhou '22

2020 Intern Reports

Hespr is a start-up that focuses on promoting mental health by providing an app for the community. While the app is still in its early access program, Hespr's development team has been working diligently to improve various aspects and features. Throughout my internship, many tasks and projects were completed, such as user outreach, graphic design, written reports, and research. The objectives of this business project involved gathering information on how to analyze competitors and their marketing strategies efficiently and how to identify competitors' strengths and weaknesses effectively. My internship has provided me with valuable findings, leading me to conclude that …

Marketing & Website Visual Development To Enhance Communication For Iagc, Makayla Zheng '22

2020 Intern Reports

In the Business Context portion, the general description of the industry and organization are detailed. I interned for the Illinois Association for Gifted Children (IAGC), a nonprofit organization that works in the field of education, helping to promote the development of gifted and talented children across Illinois.

In the Business Project Description section, the work I contributed to IAGC is exhibited.During this internship, I largely partook in the marketing aspects for IAGC. I mainly worked with improving the IAGC website to increase organization and visual enhancement allowing for easier accessibility for users. The Exhibits portion consists of visuals from my …

How To Increase A Company's Social Media Presence, Eunice Kim '22

2020 Intern Reports

The project pursued in this report is called “How to Increase a Company’s Social Media Presence.” In this context, “social media presence” will refer to how frequently Hespr posts and is active on Instagram, the levels of engagement on posts, and types of content uploaded. As the title suggests, this project will focus on factors that facilitate the growth of Hespr’s social media presence, as well as factors that may hinder progress.

Multiomic Immune Clockworks Of Pregnancy, Laura S. Peterson, Ina A. Stelzer, Amy S. Tsai, Mohammad S. Ghaemi, Xiaoyuan Han, Kazuo Ando, Virginia D. Winn, Nadine R. Martinez, Kevin Contrepois, Mira N. Moufarrej, Stephen Quake, David A. Relman, Michael P. Snyder, Gary M. Shaw, David K. Stevenson, Ronald J. Wong, Petra Arck, Martin S. Angst, Nima Aghaeepour, Brice Gaudilliere

All Dugoni School of Dentistry Faculty Articles

Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, …

Relative Size Underlies Alternative Morph Development In A Salamander, Michael P. Moore, Joseph H. K. Pechmann, Howard H. Whiteman

Faculty & Staff Research and Creative Activity

Size thresholds commonly underlie the induction of alternative morphological states. However, the respective importance of absolute and relative size to such thresholds remains uncertain. If absolute size governs expression, morph frequency should differ among environments that influence absolute sizes (e.g. resources, competition), and individuals of the same morph should have similar average sizes across environments. If relative size determines expression, the frequency of each morph may not differ among environments, but morphs within each environment should differ in size relative to one another. We tested these predictions in a salamander (Ambystoma talpoideum) that develops into either a terrestrial …

An Examination Of Reported Flirtation Behaviors, Michael Garza

Doctoral Dissertations

A great deal of sexual interest and communication occurs at the nonverbal level in the form of gestures and signs. Nonverbal behaviors like smiles, winks, body postures, physical space, eye contact, clothing, among other cues and gestures, add subtle communiqués of romantic attention because the verbal expression of sexual interest can lead to embarrassment, confusion, and ambiguity. These nonverbal courtship behaviors are important and have been used to examine the dynamics of sexual initiation and interaction both in and outside of marriage (Gecas & Libby, 1976). A primary aim of the present study is to create a flirtation questionnaire that …

The Influence Of Sleep And Physical Performance On Food Choice And Body Mass Index Of College Students, Nathalie Cahill

Doctoral Dissertations

The purpose of the present study was to investigate the role dietary choice plays between two relationships for college students: sleep and body mass index and sleep and physical performance. Previous research has continuously indicated that college students are receiving poor sleep, both in terms of length and quality (Buboltz et al., 2009; Lund et al., 2010). Poor sleep length and sleep quality has been found to impact diet (Grandner et al., 2010; Hicks et al., 1986; Wells & Cruess, 2006), weight and body mass index (Kathrotia et al., 2010; Roane et al., 2015; Vargas et al., 2014), mental health …

Impact Of Gamma Irradiation On Post-Harvest Disorders In 'Bartlett' Pears, Michelle Tu

Food Science (MS) Theses

The goal of this research was to determine the effect of irradiation on post-harvest disorders and ripening quality of ‘Bartlett’ pears stored for 3 months in air. ‘Bartlett’ pears were treated at 470 and 940 Gy and held at -1 - 0 ˚C at 95 % humidity. At 0, 45, and 90 days following treatment, the pears were brought to room temperature and allowed to ripen. The pears were then monitored for changes in respiration rate and ethylene production. After reaching the climacteric peak, pears were evaluated for incidence of post-harvest disorders, ACS and ACO enzyme activities, and quality factors …