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2020

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Exosomes Secreted Under Hypoxia Enhance Stemness In Ewing’S Sarcoma And Transform Microenvironment Cells, Matthew J. Kling Aug 2020

Exosomes Secreted Under Hypoxia Enhance Stemness In Ewing’S Sarcoma And Transform Microenvironment Cells, Matthew J. Kling

Theses & Dissertations

Intercellular communication between tumor cells and stroma within the hypoxic microenvironment promote aggressiveness and poor patient prognoses in ways that remain unclear. Here we show that hypoxic Ewing’s sarcoma (EWS) cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival and a cancer-associated phenotype in fibroblasts (CAFs). Given that hypoxia enriches for stem-like cells, we exposed EWS cells to hypoxia and hypoxic EWS-derived exosomes and assessed the stem cell phenotype. Hypoxia and hypoxic EWS-derived exosomewere found to enhance TIC formation in vitro and in vivo by reprogramming EWS cells. Analysis of the hypoxic exosomal …

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Understanding Covid-19: From Origin To Potential Therapeutics, Muhammad Moazzam, Muhammad Imran Sajid, Hamza Shahid, Jahanzaib Butt, Irfan Bashir, Muhammad Jamshaid, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari Aug 2020

Understanding Covid-19: From Origin To Potential Therapeutics, Muhammad Moazzam, Muhammad Imran Sajid, Hamza Shahid, Jahanzaib Butt, Irfan Bashir, Muhammad Jamshaid, Amir Nasrolahi Shirazi, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Currently, a global pandemic era of public health concerns is going on with the Coronavirus Disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The first case of COVID-19 was reported from Wuhan’s Huanan seafood market in China late December 2019. Bats, pangolins, and snakes have been nominated as salient carriers of the virus. Thanks to its high pathogenicity, it can cause severe respiratory infections. Fever, dry cough, sore throat, pneumonia, septic shock, and ground-glass opacities are the foremost clinical manifestations of COVID-19. Immunocompromised patients are at high risk for COVID-19 infection and may lead to …

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Personal Hand Safety Monitoring System, Anonymous Aug 2020

Personal Hand Safety Monitoring System, Anonymous

Defensive Publications Series

Techniques for monitoring user hand health and safety, estimating risks associated with user hand activity, and generation of suitable user alerts based on the estimated risk are described. With user permission, wearable devices such as AR headsets are utilized to determine a state of health of a user’s hands based on user activities and the user’s interactions with their environment. Actions such as hand washing, disinfecting, cleansing, etc. are identified. Machine learning models are utilized to identify the user practices based on observed user behavior. Protective hand wear use is identified, and surfaces, objects, and/or people touched by a user …

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Mount Banahaw’S Enigma Of Power: A Personal Reflection On Signs And Symbols At The Santa Lucia Complex, Katherine B. Arceta Aug 2020

Mount Banahaw’S Enigma Of Power: A Personal Reflection On Signs And Symbols At The Santa Lucia Complex, Katherine B. Arceta

International Journal of Religious Tourism and Pilgrimage

In the Philippines, Mount Banahaw in Quezon province is a pilgrimage site for locals and believers alike. Considered a holy mountain or even a ‘new’ Jerusalem in a mystical sense, people flock to its forested sacred sites or puwestos. The objectives of this study are (1) to identify signs and symbols within the sacred space of Mount Banahaw; (2) to explain how signs and symbols within the mountain are able to convey various religious meanings to the worshippers and; (3) to understand how pilgrims derive and interpret the meanings associated with these signs and symbols. The author retraces a pilgrim’s …

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Representing And Performing Pilgrimage In A Comic Book: On The Camino, Lucrezia Lopez Aug 2020

Representing And Performing Pilgrimage In A Comic Book: On The Camino, Lucrezia Lopez

International Journal of Religious Tourism and Pilgrimage

Over the last few decades, comic books and graphic novels have become valid literary sources within the humanities and social sciences. This paper addresses a new creative and performative artistic expression of the European pilgrimage route the Camino de Santiago in Spain through examining the autobiographical graphic novel On the Camino, written by the Norwegian cartoonist Jason (2017), which introduces a new way of sharing pilgrimage experiences through combining pictorial and literary devices. Here, the focus is on the dynamic paradigm that arises beyond the ‘fixed sequential images’ in the graphic novel and the role of readers in the spatial …

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“This Trip Is Very Meaningful To Me, So I Want To Remember It Forever”: Pilgrim Tattoos In Santiago De Compostela, Christian Kurrat, Patrick Heiser Aug 2020

“This Trip Is Very Meaningful To Me, So I Want To Remember It Forever”: Pilgrim Tattoos In Santiago De Compostela, Christian Kurrat, Patrick Heiser

International Journal of Religious Tourism and Pilgrimage

Pilgrim tattoos have come into fashion: in Santiago de Compostela, the destination of all Ways of St. James, tattoo studios are springing up and in social networks, corresponding photographs can be found more and more often. In this paper we present the results of a survey of pilgrims who have been tattooed after their pilgrimage (N=256). It turns out that certain symbols and body parts are particularly popular among pilgrim tattoos. The tattooing practice of pilgrims also depends strongly on age, nationality and previous tattoos. The central features of the pilgrimage itself, on the other hand, have only a weak …

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The Imprint Of The Pilgrimage An Ethnography Of A Tattoo Studio In Jerusalem, Mustafa Diktaş Aug 2020

The Imprint Of The Pilgrimage An Ethnography Of A Tattoo Studio In Jerusalem, Mustafa Diktaş

International Journal of Religious Tourism and Pilgrimage

Several major religions exhibit complex attitudes towards self-mutilation and adornment. Judaism, Islam, and Christianity forbid marking the body and associate it with sin. Still, many people apparently have continued to feel a need for confirmation of their religion and their religious journeys by marking their bodies. This ethnographic study focuses on the recent situation in pilgrimage tattooing, utilising the local and daily processes of a tattoo shop called Razzouk Tattoo located in the Christian quarter of the old city of Jerusalem. The aim of this paper is not only to give a panoptic view of the tattoo studio but also …

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Full Issue Aug 2020

Full Issue

Studia Antiqua

No abstract provided.

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Symbolism Of Temple Gates In Ancient Israel, Talitha Hart Aug 2020

Symbolism Of Temple Gates In Ancient Israel, Talitha Hart

Studia Antiqua

The gates of the city and the temple establish boundaries between inner and outer space, while also allowing access to an area that is clearly separated from its surroundings. Throughout ancient Israel, the city gate was seen as representing economic activity, belonging, justice, and strength. I would argue that the gate of the temple represented many of the same things and was seen in a similar way. I have decided to include the tabernacle, as well as both Solomon’s and Herod’s temples, in this analysis, as they seem to have been seen in a similar light even if they were …

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Covenant Peoples, Covenant Journeys: Archetypal Similarities Between The Noah, Abraham, And Moses Narratives, Jeremy Madsen Aug 2020

Covenant Peoples, Covenant Journeys: Archetypal Similarities Between The Noah, Abraham, And Moses Narratives, Jeremy Madsen

Studia Antiqua

The stories of Noah, Abraham, and Moses display remarkable similarities. All three follow a narrative pattern where God appears in theophany to a prophet-patriarch figure, God forms a covenant with this prophet-patriarch and his people to bring them to a new land, and God guides them on a divinely-assisted journey until they reach that land. Rather than being the result of typological shaping or historical resemblance, the narrative similarities between these three stories are most likely indicative of a common narrative archetype, which this paper titles the covenant journey archetype. The thrice-fold repetition of this archetype within the Pentateuch attests …

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Method For Crowd Trampling And Crushing Simulation Based On Psychological Model, Tingting Liu, Liu Zhen, Yanjie Chai, Cuijuan Liu, Jiaxin Chen Aug 2020

Method For Crowd Trampling And Crushing Simulation Based On Psychological Model, Tingting Liu, Liu Zhen, Yanjie Chai, Cuijuan Liu, Jiaxin Chen

Journal of System Simulation

Abstract: With the accelerated development of urbanization, the number and the scale of cultural events have increased rapidly. In such crowded places, the risk of crowd trampling and crushing will be greatly increased. However, the current studies on crowd trampling and crushing simulation are relatively rare. In order to deduce the crowd trampling and crushing scene, a crowd trampling and crushing simulation model based on the psychological principles was proposed. The model considered emotional factors for the trampling and crushing in the dense crowd; simulated crowd trampling and crushing process and introduced the judgment criterions for the crowd trampling and …

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Real Time Fluid Simulation Framework Based On Directcompute, Liu Lu, Liu Zhen, Gaoqi He, Chen Tian, Tingting Liu, Cuijuan Liu Aug 2020

Real Time Fluid Simulation Framework Based On Directcompute, Liu Lu, Liu Zhen, Gaoqi He, Chen Tian, Tingting Liu, Cuijuan Liu

Journal of System Simulation

Abstract: A real time fluid simulation framework based on DirectCompute acceleration was proposed to solve problems of low simulation efficiency that caused by the increasing fluid particle size and long processing time that caused by the complex solid-liquid boundary. In the simulation, a grid local collision detection method was adopted to speed up the search for the solid-liquid boundary. Fluid calculation, collision detection and surface reconstruction were computed parallel in the GPU with DirectCompute technology to accelerate the SPH fluid simulation. It could optimize the storage structure of fluid simulation, and save the storage space. Experimental results show that the …

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Gpu-Accelerated Cloth Animation Based On Module Division, Kun Zhou, Liu Zhen, Gaoqi He, Chen Tian, Tingting Liu, Cuijuan Liu Aug 2020

Gpu-Accelerated Cloth Animation Based On Module Division, Kun Zhou, Liu Zhen, Gaoqi He, Chen Tian, Tingting Liu, Cuijuan Liu

Journal of System Simulation

Abstract: In order to improve the simulation speed of cloth animation, a module division parallel computing method was proposed by studying two kinds of cloth simulation models with dynamics and position based dynamics (PBD). A computing task was divided into a plurality of independent blocks by the way of data block. GPU parallel computing was used within the data block to improve the real-time performance and robustness of the cloth simulation. The applicability and effectiveness of the algorithm were verified under different scenarios and stochastic wind field. Experimental results show that under the same conditions, the proposed method can effectively …

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Dynamic Water Surface Simulation Based On Secondary Reflection Mapping, Li Hua, Huamin Yang, Feng Xin Aug 2020

Dynamic Water Surface Simulation Based On Secondary Reflection Mapping, Li Hua, Huamin Yang, Feng Xin

Journal of System Simulation

Abstract: In order to improve the effects of dynamic water surface simulation, a method was proposed which utilized 3D mesh modeling water surface and was optimized by projective grid method; A mirror image of the subject above the water was generated which was called the first reflection map; then the simplified Navier-Stokes equation was enforced onto the first texture mapping. The reflection and refraction was calculated to form a secondary reflection map with respect to the perspective mapping coordiante; Perspective texture mapping was enforced to water surface to achieve fast simulated water surface. Experimental test shows that the approach can …

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Subject-Specific Body Segment Parameter Optimization, Lv Xiaolei, Shihong Xia Aug 2020

Subject-Specific Body Segment Parameter Optimization, Lv Xiaolei, Shihong Xia

Journal of System Simulation

Abstract: In conventional methods of physics based character animation, human model are approximated by the rigid body models. However, the human body parts are not as easily described as rigid bodies with defined joints and inflexible geometry, daily varying mass, etc. A body segment parameter optimization method based on the force plate data and motion capture data was proposed. This method optimized the body segment parameter iteratively using the Lagrange constraints based on the contact information and motion capture data. Different subjects took part in the motion capture process with various kinds of motions. A comprehensive evaluation was done for …

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Real-Time Virtual Simulation Of Tidal Bore, Guisheng Fang Aug 2020

Real-Time Virtual Simulation Of Tidal Bore, Guisheng Fang

Journal of System Simulation

Abstract: Tidal bore is a kind of unique natural landscape and tourism resource in the world. Research on characteristic of tidal bore is very useful to help people realize surge prevention and disaster reduction and discover new resources of tidal bore. The traditional research method based on numerical simulation has great deficiencies in the aspect of interaction and real-time and visualization. The virtual simulation method was introduced to simulate the tidal bore. The Navier-Stokes equations were solved by the Smoothed Particle Hydrodynamics method to simulate dynamically the formation, evolution and dissipation of the tidal bore. The phenomena of the intersecting, …

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Interactive Illustration Technologies For Energy Stations Using Unity3d, Gaoqi He, Kailin Yang, Jin Yi, Chen Qi, Haijie Li, Zhigeng Pan Aug 2020

Interactive Illustration Technologies For Energy Stations Using Unity3d, Gaoqi He, Kailin Yang, Jin Yi, Chen Qi, Haijie Li, Zhigeng Pan

Journal of System Simulation

Abstract: This paper presents one web-based interactive illustration system for energy stations using Unity3D as render engine. Interaction, scene rendering and data-driven visual analysis are the key technologies for this study. One low-coupling logical framework of virtual illustration is designed for five view layers using state pattern. From the viewpoint of event response and trigger on-demand, one concise human-computer-interaction interface is carried out. High-quality visualization of energy station is realized using Unity3D, which includes dynamic texture, water animation in water pipe, modeling and bake. Json database is used as transfer hub for external data access. Thus the dynamic …

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Research On Motion Capture In Substation Virtual Environment, Yuping Huo, Xiu’E Zhang, Li Bing, Weiqing Li Aug 2020

Research On Motion Capture In Substation Virtual Environment, Yuping Huo, Xiu’E Zhang, Li Bing, Weiqing Li

Journal of System Simulation

Abstract: In the immersive transformer training simulator, using MEMS inertial motion capture system, the operator’s motion data was captured and analyzed. According to the typical operation in the substation virtual environment, the semantics of interaction were studied. SVM classification algorithm based on grid search and cross validation was used to recognize operator’s gestures. The identified gestures were used to actuate the virtual human’s action in the substation virtual environment. A priority classified character animation method with deformation weight control was proposed to render different priority level actions at the same time. Two modes of virtual operation performance, character animation sequences …

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Multimedia Annotation Refinement Based On Contextual Information Diffusion, Tian Feng, Fuhua Shang Aug 2020

Multimedia Annotation Refinement Based On Contextual Information Diffusion, Tian Feng, Fuhua Shang

Journal of System Simulation

Abstract: A data driven multimedia annotation refinement method based on dataset contextual information diffusion was proposed. The label contextual graph was constructed, and the label correlation can be diffused on textual label space; Multimedia object content relevant graph was constructed. Label contextual graph and multimedia object content relevant graph were mutually reinforced and formulated into a regularized framework. The proposed method incorporated both multimedia content correlation and label contextual information, and the optimization process was solved by approximate solution algorithm. The experimental results on real world dataset show that the proposed method can obviously improve the annotation performance.

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Effects Of Mind–Body Exercises On Schizophrenia: A Systematic Review With Meta-Analysis, Gao Xia Wei, Lin Yang, Kellie Imm, Paul D. Loprinzi, Lee Smith, Xiangyang Zhang, Qian Yu Aug 2020

Effects Of Mind–Body Exercises On Schizophrenia: A Systematic Review With Meta-Analysis, Gao Xia Wei, Lin Yang, Kellie Imm, Paul D. Loprinzi, Lee Smith, Xiangyang Zhang, Qian Yu

Faculty and Student Publications

© Copyright © 2020 Wei, Yang, Imm, Loprinzi, Smith, Zhang and Yu. Background: Mind–body exercises (MBEs) have been widely accepted as a complementary therapy for the patients with low exercise tolerance. Currently, the number of experimental studies investigating the effect of MBEs for improving symptoms in people with schizophrenia is increasing. However, results are inconsistent. Methods: We systematically reviewed and meta-analyzed the effects of mind–body exercises on schizophrenia. Seven electronic databases (Pubmed, Web of Science, PsycINFO, Embase, Cochrane Central Register of Controlled Trials [CENTRAL], CNKI and Wangfang) were screened through October 2019 and risks of bias of included studies were …

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Therapeutic Efficacy Of Antioxidants In Ameliorating Obesity Phenotype And Associated Comorbidities, Steven Tun, Caleb James Spainhower, Cameron Lee Cottrill, Hari Vishal Lakhani, Sneha S. Pillai, Anum Dilip, Hibba Chaudhry, Joseph I. Shapiro, Komal Sodhi Aug 2020

Therapeutic Efficacy Of Antioxidants In Ameliorating Obesity Phenotype And Associated Comorbidities, Steven Tun, Caleb James Spainhower, Cameron Lee Cottrill, Hari Vishal Lakhani, Sneha S. Pillai, Anum Dilip, Hibba Chaudhry, Joseph I. Shapiro, Komal Sodhi

Pharmacology, Physiology and Toxicology

Obesity has been a worldwide epidemic for decades. Despite the abundant increase in knowledge regarding the etiology and pathogenesis of obesity, the prevalence continues to rise with estimates predicting considerably higher numbers by the year 2030. Obesity is characterized by an abnormal lipid accumulation, however, the physiological consequences of obesity are far more concerning. The development of the obesity phenotype constitutes dramatic alterations in adipocytes, along with several other cellular mechanisms which causes substantial increase in systemic oxidative stress mediated by reactive oxygen species (ROS). These alterations promote a chronic state of inflammation in the body caused by the redox …

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Just What The Doctor Ordered: Produce Prescriptions Are More Important—And Popular—Than Ever, Andy Hirschfeld Aug 2020

Just What The Doctor Ordered: Produce Prescriptions Are More Important—And Popular—Than Ever, Andy Hirschfeld

CREW News Archive

Nationwide, programs providing chronically ill people free and discounted produce are seeing a surge of demand during the pandemic.

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The Indiana Statesman, Isu 101 Fall 2020, Indiana State University Aug 2020

The Indiana Statesman, Isu 101 Fall 2020, Indiana State University

Student Newspaper

ISU 101 Fall 2020; Library offers services to help students succeed; Sycamorisms: A vocabularly guide to all things Indiana State

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Testing The Combined Module Swapping And Repair By Modification Strategies: A Step Toward Universal Toolbox, Catherine A. Martini Aug 2020

Testing The Combined Module Swapping And Repair By Modification Strategies: A Step Toward Universal Toolbox, Catherine A. Martini

Biology Theses

The crux of synthetic biology is the engineering of biological components to modulate the activity of specific DNA-based promoter(s) to drive gene expression; thus, providing a means to modulate pathways between signal detection and cellular response. However, the longstanding frustration of synthetic biologists has been the inability to transfer those engineered components between cellular systems — this lack of “modular universality” or “universal toolbox” impedes research by forcing a metaphorical reinvention of the wheel in new systems. The modular swapping strategy expanded the available “toolbox” with customizable hybrid repressors formed from “swapping” the DNA-recognition modules (DRMs) and environmental-sensing modules (ESMs) …

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Oceanographic Determinants Of The Abundance Of Common Dolphins (Delphinus Delphis) In The South Of Portugal., J. Castro, A. Couto, F. O. Borges, M. I. Laborde, H. C. Pearson, R. Rosa, A. Cid, Heidi C. Pearson Aug 2020

Oceanographic Determinants Of The Abundance Of Common Dolphins (Delphinus Delphis) In The South Of Portugal., J. Castro, A. Couto, F. O. Borges, M. I. Laborde, H. C. Pearson, R. Rosa, A. Cid, Heidi C. Pearson

Faculty, Staff, and Students

Off mainland Portugal, the common dolphin (Delphinus delphis) is the most sighted cetacean, although information on this species is limited. The Atlantic coast of Southern Portugal is characterized by an intense wind-driven upwelling, creating ideal conditions for common dolphins. Using data collected aboard whale-watching boats (1929 sightings and 4548 h effort during 2010–2014), this study aims to understand the relationships between abundance rates (AR) of dolphins of different age classes (adults, juveniles, calves and newborns) and oceanographic [chlorophyll a (Chl-a) and sea surface temperature (SST)] variables. Over 70% of the groups contained immature animals. The AR of adults was negatively …

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Seeking Shelter, Wendy Gilbert Gronbeck Aug 2020

Seeking Shelter, Wendy Gilbert Gronbeck

Erma Bombeck Writers' Workshop Blog

I once met a nun who ran an orphanage in Saigon during the Vietnam War. She told me that near the end of the war, they routinely and without hesitation lied about the children waiting for adoption. They’d say anything to get the kids adopted and away from the bombs and the guns. You know who’s better at padding resumes to promote adoption? Those people who write for animal shelters.

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Massage Therapy For Agitation In Dementia Benchmark, Ashley Salyer Aug 2020

Massage Therapy For Agitation In Dementia Benchmark, Ashley Salyer

MSN Capstone Projects

Dementia is a progressive disease that eventually results in cognitive and functional decline as well as behavioral and psychological symptoms. Age is a significant risk factor for dementia and due to an increase in longevity, the number of people with dementia is rising. Expanding research on dementia and management interventions should be a priority due to the nature of the disease, its impact on healthcare, and its emotional effect on both the individual and family. Over prescription of medication for behavioral and psychological symptoms in dementia has been identified as problem in long-term care facilities. The current practice at many …

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Searching For New Analgesics Without Addiction Risks, Mohammad Atiqur Rahman Aug 2020

Searching For New Analgesics Without Addiction Risks, Mohammad Atiqur Rahman

Theses and Dissertations

Opioids are widely used to treat acute and chronic pain. But opioid addiction to these compounds can cause social and life-threatening health problems, including the risk of overdose. In this thesis, I evaluated IBNtxA (3-iodobenzoyl naltrexamine), a novel mu opioid receptor (MOR) agonist structurally related to the classical MOR antagonist naltrexone, in drug discrimination studies in order to better understand its subjective effects and more thoroughly its abuse liability. IBNtxA represents an intriguing lead compound for preclinical drug development specifically targeting MOR splice variants, potentially creating effective analgesics with reduced side effects. These results indicate that IBNtxA produces potent antinociception …

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Complement Activation By C-Reactive Protein Is Critical For Protection Of Mice Against Pneumococcal Infection, Sanjay K. Singh, Donald N. Ngwa, Alok Agrawal Aug 2020

Complement Activation By C-Reactive Protein Is Critical For Protection Of Mice Against Pneumococcal Infection, Sanjay K. Singh, Donald N. Ngwa, Alok Agrawal

ETSU Faculty Works

C-reactive protein (CRP), a component of the innate immune system, is an antipneumococcal plasma protein. Human CRP has been shown to protect mice against infection with lethal doses of Streptococcus pneumoniae by decreasing bacteremia. in vitro, CRP binds to phosphocholine-containing substances, such as pneumococcal C-polysaccharide, in a Ca2+-dependent manner. Phosphocholine-complexed human CRP activates the complement system in both human and murine sera. The mechanism of antipneumococcal action of CRP in vivo, however, has not been defined yet. In this study, we tested a decades-old hypothesis that the complement-activating property of phosphocholine-complexed CRP contributes to protection of mice against pneumococcal infection. …

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A Perturbed System: How Tenured Faculty Responded To The Covid-19 Shift To Remote Instruction, Rachel L. Rupnow, Nicole D. Ladue, Nicole M. James, Heather E. Bergan-Roller Aug 2020

A Perturbed System: How Tenured Faculty Responded To The Covid-19 Shift To Remote Instruction, Rachel L. Rupnow, Nicole D. Ladue, Nicole M. James, Heather E. Bergan-Roller

Faculty Articles, Papers, and Other Scholarship

This study investigates six university professors' reflections on the shift to remote instruction during the Spring 2020 semester in response to the COVID-19 global pandemic. The rapid shift in instructional platform presents an opportunity to learn from unresolved challenges that persisted through the semester. Here we present a qualitative study of how experienced (i.e., associate or full) chemistry professors report their teaching practices in light of the COVID-19 disruptions. We observed four major themes: personal factors, contextual factors of the structure and culture, teacher thinking, and teachers' practice. These themes revealed that the professors in this study adapted quickly using …

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