Digital Commons Network^™

Prevalence And Characterization Of Some Colibactin Genes In Clinical Enterobacteriaceae Isolates From Iraqi Patients, Mohammed T. Hussein, Safaa A. S. Al-Qaysi, Munther H. Rathi, Qasim I. Hussein, Tarek A.A. Moussa

Baghdad Science Journal

The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand DNA breaks, leading to promote human colorectal cancer (CRC). Eleven out of the eighty eight isolates (12.5%) were pks+, distributed as 7 (8%) isolates of E. coli, 2 (2.25%) of K. pneumoniae and 2 (2.25%) of E. aerogenes. The cytotoxic effects of selected pks+ isolates (E. coli and E. aerogenes) on HeLa cells were represented by decreasing cell numbers and enlarged cell …

Brain-Wide Structural And Functional Disruption In Mice With Oligodendrocyte-Specific Nf1 Deletion Is Rescued By Inhibition Of Nitric Oxide Synthase, Jad Asleh, Ben Shofty, Nadav Cohen, Alexandra Kavushansky, Alejandro Lopez-Juarez, Shlomi Constantini, Nancy Ratner, Itamar Kahn

Health & Biomedical Sciences Faculty Publications

Neurofibromin gene (NF1) mutation causes neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocytes causes myelin decompaction and increases oligodendrocyte nitric oxide (NO) levels. Nitric oxide synthase (NOS) inhibitors rescue this pathology. Whether oligodendrocyte pathology is sufficient to affect brain-wide structure and account for NF1 imaging findings is unknown. Here we show that Nf1 gene inactivation in adult oligodendrocytes (Plp-Nf1fl/+ mice) results in a motor coordination deficit. Magnetic resonance imaging in awake mice showed that fractional …

Β-Catenin And Associated Proteins Regulate Lineage Differentiation In Ground State Mouse Embryonic Stem Cells., Fang Tao, Jelly Soffers, Deqing Hu, Shiyuan Chen, Xin Gao, Ying Zhang, Chongbei Zhao, Sarah E. Smith, Jay R. Unruh, Da Zhang, Dai Tsuchiya, Aparna Venkatraman, Meng Zhao, Zhenrui Li, Pengxu Qian, Tari Parmely, Xi C. He, Michael Washburn, Laurence Florens, John M. Perry, Julia Zeitlinger, Jerry Workman, Linheng Li

Manuscripts, Articles, Book Chapters and Other Papers

Mouse embryonic stem cells (ESCs) cultured in defined medium resemble the pre-implantation epiblast in the ground state, with full developmental capacity including the germline. β-Catenin is required to maintain ground state pluripotency in mouse ESCs, but its exact role is controversial. Here, we reveal a Tcf3-independent role of β-catenin in restraining germline and somatic lineage differentiation genes. We show that β-catenin binds target genes with E2F6 and forms a complex with E2F6 and HMGA2 or E2F6 and HP1γ. Our data indicate that these complexes help β-catenin restrain and fine-tune germ cell and neural developmental potential. Overall, our data reveal a …

Impact Of Grazing Intensity On Feed Intake, Herbage Mass, And Animal Productivity In The Steppe Of Inner Mongolia, China, K. Müller, L. Lin, T. Glindemann, C. Wang, Anne Schiborra, P. Schönbach, H. W. Wan, B. M. Tas, M. Gierus, Friedhelm Taube, A. Susenbeth

IGC Proceedings (1977-2023)

No abstract provided.

Optimal Sward Height For Production In Twin And Triplet Ewes, Stephen T. Morris, Paul R. Kenyon, R. A. Corner

IGC Proceedings (1977-2023)

No abstract provided.

'Alpine Meadows' Of The Tibet Plateau Are A Synanthropic Pseudoclimax, G. Miehe, S. Miehe, K. Kaiser, K. Wesche, Xinquan Zhao, Jianquan Liu

IGC Proceedings (1977-2023)

No abstract provided.

Comparison Of Vegetation Composition Under Different Grazing Intensities In Golestan National Park And Vicinities, Iran, Mansour Mesdaghi, Masoume Amirkhani, E. Bagheri Rad

IGC Proceedings (1977-2023)

No abstract provided.

Broad Spectrum Of Plant Species Grazed And Browsed By Cattle In Bolivian Subtropical Mountain Forests, Svenja Marquardt, H. Alzérreca, S. Beck, Michael Kreuzer, Andrea C. Mayer

IGC Proceedings (1977-2023)

No abstract provided.

Evaluation Of A Beef Cattle Finishing Simulation Model For Intake And Live Weight Gain Prediction Under Different Herbage And Maize Grain Allowances, Claudio F. Machado, Stephen T. Morris, J. Hodgson, H. Berger

IGC Proceedings (1977-2023)

No abstract provided.

Recalling The (Afro)Future: Collective Memory And The Construction Of Subversive Meanings In Janelle Monáe’S Metropolis-Suites, Anders Liljedahl

Third Stone

Focusing on the intersection of collective memory, technology, and African American popular music, this paper use aspects of the sonic narratives in Janelle Monáe’s Metropolis-Suites I–V to introduce core concepts of Afrofuturism. The paper challenges the positioning of collective memory as being exterior to the sphere of individual cognitive memory. By inhabiting past, present, and future at once, Afrofuturism is able to critically revisit collective memory not only as a social framework but also as actual individual memory. Afrofuturist discourse questions the status of the human being by examining African Americans as always already robotic, and posits African American …

Knowledge Sharing Through Mobile Phone To Develop A Knowledge Base: A Study On Rural Women Of Bangladesh, Md. Mahbubul Islam, A.K.M Eamin Ali Akanda, Md. Nazmul Hasan, Dr. Partha Biplob Roy, Farzana Islam Any, Mst. Tahera Khatun, Md. Armanul Haque, Xiaojuan Zhang, Dr.

Library Philosophy and Practice (e-journal)

Abstract

The study has an aim to figure out the role of mobile communication in developing Knowledge base among rural women through knowledge sharing. Using a structured questionnaire quantitative data have been collected by survey method and qualitative data through FGDs. Data has been collected on the way of sharing knowledge, areas of expertise, sharing knowledge types, with whom sharing knowledge etc. Rural women are being interested in knowledge sharing through mobile phone because mobile phones are cheap, easier, and available medium for communication to them. Among the rural women who have completed at least secondary education, are sharing both …

Fencing Effects On Biodiversity Changes In Desertified Grassland In Hulunbeir, China, Shihai Lu, Jixi Gao, Changsong Feng, Xinshi Lu

IGC Proceedings (1977-2023)

No abstract provided.

Influence Of Dietary Forages On The Fatty Acid Profile Of Rumen Digesta, Milk And Meat, Marta Lourenço, B. Vlaeminck, S. De Smet, Veerle Fievez

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Four Fertiliser Regimes On The Persistence Of Perennial Native Grasses, Michael J. Keys, B. W. Clements

IGC Proceedings (1977-2023)

No abstract provided.

Altering Myc Phosphorylation In The Epidermis Increases The Stem Cell Population And Contributes To The Development, Progression, And Metastasis Of Squamous Cell Carcinoma, Xiaoyan Wang, Ellen M. Langer, Colin J. Daniel, Mahnaz Janghorban, Vivian Wu, Xiao-Jing Wang, Rosalie C. Sears

Otolaryngology Articles

cMYC (MYC) is a potent oncoprotein that is subject to post-translational modifications that affect its stability and activity. Here, we show that Serine 62 phosphorylation, which increases MYC stability and oncogenic activity, is elevated while Threonine 58 phosphorylation, which targets MYC for degradation, is decreased in squamous cell carcinoma (SCC). The oncogenic role of MYC in the development of SCC is unclear since studies have shown in normal skin that wild-type MYC overexpression can drive loss of stem cells and epidermal differentiation. To investigate whether and how altered MYC phosphorylation might affect SCC development, progression, and metastasis, we generated mice …

Heat Stored In The Earth System: Where Does The Energy Go?, Karina Von Schuckmann, Lijing Cheng, Matthew D. Palmer, James Hansen, Caterina Tassone, Valentin Aich, Susheel Adusumilli, Hugo Beltrami, Tim Boyer, Francisco José Cuesta-Valero, Damien Desbruyères, Catia Domingues, Almudena García-García, Pierre Gentine, John Gilson, Maximillian Gorfer, Leopold Haimberger, Masayoshi Ishii, Gregory C. Johnson, Rachel Killick, Brian A. King, Gottfried Kirchengast, Nicolas Kolodziejczyk, John Lyman, Ben Marzeion, Michael Mayer, Maeva Monier, Didier Paolo Monselesan, Sarah Purkey, Dean Roemmich, Axel Schweiger, Sonia I. Seneviratne, Andrew Shepherd, Donald A. Slater, Andrea K. Steiner, Fiammetta Straneo, Mary-Louise Timmermans, Susan E. Wijffels

United States Department of Commerce: Staff Publications

Human-induced atmospheric composition changes cause a radiative imbalance at the top of the atmosphere which is driving global warming. This Earth energy imbalance (EEI) is the most critical number defining the prospects for continued global warming and climate change. Understanding the heat gain of the Earth system—and particularly how much and where the heat is distributed—is fundamental to understanding how this affects warming ocean, atmosphere and land; rising surface temperature; sea level; and loss of grounded and floating ice, which are fundamental concerns for society. This study is a Global Climate Observing System (GCOS) concerted international effort to update the …

Hog Barn Density And Location In U.S. And Nebraska, Elliott James Dennis

Extension Farm and Ranch Management News

There is strong local and national interest in adding hog barns to existing row crop operations. Declining on farm income over the past several years has accelerated this interest. Grain operations cite diversifying farm income, adding another family to the farm operation, and/or replace commercial fertilizer expense as the primary reasons for adding a hog barn.

While there is industry demand to increase hog contract growing, these agreements can possess significant benefits and risks to producers. This is the first of a four part series which will discuss some financial and legal implications of adding a hog barn to an …

Anti-Human Trem2 Induces Microglia Proliferation And Reduces Pathology In An Alzheimer's Disease Model, Shoutang Wang, Carla M. Yuede, Susan Gilfillan, Marco Colonna, Et Al

Open Access Publications

TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of amyloid β (Aβ) accumulation, defective TREM2 function affects microglial response to Aβ plaques, exacerbating tissue damage, whereas TREM2 overexpression attenuates pathology. Thus, AD may benefit from TREM2 activation. Here, we examined the impact of an anti-human TREM2 agonistic mAb, AL002c, in a mouse AD model expressing either the common variant (CV) or the R47H variant of TREM2. Single-cell RNA-seq of microglia after acute systemic administration of AL002c showed induction of proliferation in …

September 7, 2020

The Gavel Gazette

No abstract provided.

Acinar Transformed Ductal Cells Exhibit Differential Mucin Expression In A Tamoxifen-Induced Pancreatic Ductal Adenocarcinoma Mouse Model, Kavita Mallya, Dhanya Haridas, Parthasarathy Seshacharyulu, Ramesh Pothuraju, Wade M. Junker, Shiv Ram Krishn, Sakthivel Muniyan, Raghupathy Vengoji, Surinder K. Batra, Satyanarayana Rachagani

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is acquired postnatally; to mimic this scenario, we developed an inducible Kras^G12D; Ptf1a-CreER™ (iKC) mouse model, in which Kras is activated postnatally at week 16 upon tamoxifen (TAM) administration. Upon TAM treatment, iKC mice develop pancreatic intraepithelial neoplasia (PanIN) lesions and PC with metastasis at the fourth and fortieth weeks, respectively, and exhibited acinar-to-ductal metaplasia (ADM) and transdifferentiation. Kras activation upregulated the transcription factors Ncoa3, p-cJun and FoxM1, which in turn upregulated expression of transmembrane mucins (Muc1, Muc4 and Muc16) and secretory mucin (Muc5Ac). Interestingly, knockdown of Kras^G12D in multiple PC cell lines resulted …

Legacy And Novel Per- And Polyfluoroalkyl Substances In Juvenile Seabirds From The U.S. Atlantic Coast, Anna R. Robuck, Mark G. Cantwell, James P. Mccord, Lindsay M. Addison, Marisa Pfohl, Mark J. Strynar, Richard Mckinney, David R. Katz, David N. Wiley, Rainer Lohmann

Graduate School of Oceanography Faculty Publications

Per- and polyfluoroalkyl substances (PFAS) are anthropogenic, globally distributed chemicals. Legacy PFAS, including perfluorooctane sulfonate (PFOS), have been regularly detected in marine fauna but little is known about their current levels or the presence of novel PFAS in seabirds. We measured 36 emerging and legacy PFAS in livers from 31 juvenile seabirds from Massachusetts Bay, Narragansett Bay, and the Cape Fear River Estuary (CFRE), United States. PFOS was the major legacy perfluoroalkyl acid present, making up 58% of concentrations observed across all habitats (range: 11–280 ng/g). Novel PFAS were confirmed in chicks hatched downstream of a fluoropolymer production site in …

The Rider (2020-09-07), Jacqueline Peraza

The Rider Archives

Vol.6 No.3

Higher Csf Strem2 And Microglia Activation Are Associated With Slower Rates Of Beta-Amyloid Accumulation, Michael Ewers, Laura Piccio, Carlos Cruchaga, Et Al

Open Access Publications

Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia PET are increased in AD; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (Aβ) accumulation remains unclear. To address this question, we pursued a two-pronged translational approach. Firstly, in non-demented and demented individuals, we tested CSF sTREM2 at baseline to predict (i) amyloid PET changes over ∼2 years and (ii) tau PET cross-sectionally assessed in a subset of patients. We found higher CSF sTREM2 associated …

Amygdalin Promotes Fracture Healing Through Tgf- Β/Smad Signaling In Mesenchymal Stem Cells, Jun Ying, Jie Shen, Et Al

Open Access Publications

No abstract provided.

Effect Of Chicory And Plantain On Cadmium Levels In Lambs, L. T. Parker, Peter D. Kemp, P. Loganathan, D. M. West, C. W. N. Anderson, Paul R. Kenyon, Stephen T. Morris

IGC Proceedings (1977-2023)

No abstract provided.

The Effect Of Legumes On Stability And Quality Of Yield In Long‐Term Grazing Use, Žydrė Kadžiulienė, Leonas Kadžiulis, Lina Šarūnaitė

IGC Proceedings (1977-2023)

No abstract provided.

Growing Grass For Greener Grazers: Herbage Management For Improved N Utilisation Of Grazing Cows, Nyncke J. Hoekstra, R. P. O. Schulte, E. A. Lantinga, P. C. Struik

IGC Proceedings (1977-2023)

No abstract provided.

Mapping And Clustering Analysis On Coronavirus Literature In China: A Bibliometric Analysis During 2011-2020, Mohd Akhter

Library Philosophy and Practice (e-journal)

The present study is first of its kind as it attempts to ascertain publications output on coronavirus as reflected in Scopus database from the Chinese perspective. The most productive contributors, institutions, journals and core subjects in coronavirus publications are identified in this study. The highly cited articles on coronavirus are also identified. The VOS-viewer software is used to identify the collaborative network of authors, countries and occurrence of keywords. During 2011-2020 a total of 1331 publications were published in this field. The highest number 190 publications were published in 2018. The most prolific contributor was Jiang, S. who contributed 63 …

The Potential Cost Of Discrimination In Diet Selection By Grazing Herbivores, Cécile Ginane, Bertrand Dumont, Anne Farruggia, Laurent Lanore, Pascal Carrère

IGC Proceedings (1977-2023)

No abstract provided.

Palatable Grasses Have Higher Relative Growth Rate And Competitive Ability Than Unpalatable Grasses In The Patagonian Steppe, Guillermo C. García Martínez, R. A. Golluscio

IGC Proceedings (1977-2023)

No abstract provided.