Digital Commons Network^™

Nucleic Acid Delivery With Α-Tocopherol-Polyethyleneimine-Polyethylene Glycol Nanocarrier System., A K M Nawshad Hossian, Seetharama D Jois, Subash C. Jonnalagadda, George Mattheolabakis

College of Science & Mathematics Departmental Research

Purpose: Nucleic acid-based therapies are a promising therapeutic tool. The major obstacle in their clinical translation is their efficient delivery to the desired tissue. We developed a novel nanosized delivery system composed of conjugates of α-tocopherol, polyethyleneimine, and polyethylene glycol (TPP) to deliver nucleic acids.

Methods: We synthesized a panel of TPP molecules using different molecular weights of PEG and PEI and analyzed with various analytical approaches. The optimized version of TPP (TPP

Results: Through a panel of synthesized molecules, TPP

Conclusion: These results indicate that we successfully synthesized the TPP

Usa V. Yasmil Minaya

2020 Decisions

USDC for the District of New Jersey

Board Of Directors Quarterly Meeting - Open Packet 09/11/2020, Uc Hastings Board Of Directors

2020 Board of Directors Agenda and Materials

No abstract provided.

Comparing Profitability And Management Factors Across Operation Type: Independent Vs. Contract Growing, Elliott James Dennis

Extension Farm and Ranch Management News

First paragraph:

There is strong local and national interest in adding hog barns to existing row crop operations. Declining on farm income over the past several years has accelerated this interest. Grain operations cite diversifying farm income, adding another family to the farm operation, and/or replacing commercial fertilizer expense as the primary reasons for adding a hog barn.

A Historical Perspective On The Holcomb Fire: Differences And Similarities To The Covid-19 Situation And Other Significant Market Events, Elliott James Dennis

Extension Farm and Ranch Management News

Copyright 2020, the author. Used by permission.

2020-09-11 Minutes & Appendices, Longwood University

Board of Visitors Meeting Minutes 1964-

No abstract provided.

Call Of The Wild: A Qualitative Analysis Of Goal-Setting Among Biology Undergraduates At A Regional Zoo, Ashley Barbara Heim, Emily A. Holt

Teaching & Assessment Symposium Recordings

Free-choice learning at informal settings among undergraduates is relatively understudied. The purpose of the current study was to qualitatively describe what goals biology students set for themselves during an intervention at a regional zoo, and to describe what types of goals students were able to fulfill during this learning opportunity. Based on student responses on this assessment administered in Fall 2018, we aimed to refine the Goal-Setting Assessment, and give context to our initial findings. Specifically, we intended to refine this assessment so that the items are broad enough to be used both in formal classrooms and out-of-school environments.

We Studied What Happens When Guys Add Their Cats To Their Dating App Profiles, Lori Kogan, Shelly Volsche

Anthropology Faculty Publications and Presentations

If you’ve used a dating app, you’ll know the importance of choosing good profile pics.

These photos don’t just relay attractiveness; a recent study suggested that 43% of people think they can get a sense of someone’s personality by their picture. You might guess that someone who has included a photo of themselves hiking is an outdoorsy type of person.

But as scientists who study human-animal interactions, we wanted to know what this meant for pet owners – in particular, male cat owners.

If you’re a guy who owns a cat, what kind of effect does it have on suitors …

2019-20 Survey Of Applied Legal Education, Robert R. Kuehn, Margaret Reuter, David A. Santacroce

Faculty Works

This report presents the results of the 2019-20 Center for the Study of Applied Legal Education (CSALE) Survey of Applied Legal Education. The survey was composed of two parts – a Master Survey directed to ABA accredited U.S. law schools and a Sub-Survey distributed to each person teaching in a law clinic or field placement course. Ninety-five percent of law schools and over 1,300 clinical teachers participated in the survey. The results provide valuable insight into clinical programs and law clinic and field placement courses in areas such as design, capacity, administration, funding, and pedagogy, and into the role and …

Smoke From Wildfires Can Worsen Covid-19 Risk, Putting Firefighters In Even More Danger, Luke Montrose

Public and Population Health Faculty Publications and Presentations

Two forces of nature are colliding in the western United States, and wildland firefighters are caught in the middle.

Emerging research suggests that the smoke firefighters breathe on the front lines of wildfires is putting them at greater risk from the new coronavirus, with potentially lethal effects.

At the same time, firefighting conditions make precautions such as social distancing and hand-washing difficult, increasing the chance that, once the virus enters a fire camp, it could quickly spread.

As an environmental toxicologist, I have spent the last decade expanding our understanding of how wood smoke exposure impacts human health. Much of …

Feasibility Of An Animated Video Combined With Standard Education: Breast Radiotherapy Video Education (Brave), Michelle F. Pembroke, Lynne S. Nemeth, Martina Mueller, Michelle Mollica, Julie A. Bradley

International Nursing Research Congress (INRC)

This interventional study explored the feasibility and preliminary impact of combining an animated educational video with standard of care education for patients with breast cancer referred for radiation therapy. Feasibility was determined and preliminary data showed a change in scores for patient reported anxiety, distress, and radiotherapy treatment concerns.

Mechanism And Chemoselectivity For Hocl-Mediated Oxidation Of Zinc-Bound Thiolates, Lindsay Zumwalt, Arden Perkins, O. Maduka Ogba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Quantum mechanical calculations reveal the preferred mechanism and origins of chemoselectivity for HOCl‐mediated oxidation of zinc‐bound thiolates implicated in bacterial redox sensing. Distortion/interaction models show that minimizing geometric distortion at the zinc complex during the rate‐limiting nucleophilic substitution step controls the mechanistic preference for OH over Cl transfer with HOCl and the chemoselectivity for HOCl over H₂O₂.

Synthetic Alkaloid Treatment Influences The Intestinal Epithelium And Mesenteric Adipose Transcriptome In Holstein Steers, Kyle J. Mclean, Ransom L. Baldwin Vi, Congjun Li, James L. Klotz, J. Lannett Edwards, Kyle R. Mcleod

Animal and Food Sciences Faculty Publications

Holstein steers (n = 16) were used to determine if a synthetic alkaloid, bromocriptine, would alter the transcriptome of the small intestine and adjacent mesenteric adipose. On d 0, steers were assigned to one of two treatments: control (CON; saline only) or bromocriptine (BROMO; 0.1 mg/kg BW bromocriptine mesylate injected intramuscularly every 3 d for 30 d). Steers were slaughtered and midpoint sections of jejunal epithelium and associated mesenteric fat were collected for RNA isolation. Transcriptome analysis was completed via RNA-Seq to determine if BROMO differed compared with CON within intestinal epithelium or mesenteric adipose mRNA isolates. Differential expression …

Rethinking Fda Regulation Of Complex Products, Philip E. Alford

Minnesota Journal of Law, Science & Technology

No abstract provided.

A Seasonal Study Of Ecoroof Metal And Nutrient Dynamics And Associated Drivers In An Ecoroof On A Commercial Building In North Portland Oregon, Alex Vijay Bans

Dissertations and Theses

Green stormwater infrastructure (GSI), specifically ecoroofs, is increasingly seen as an effective stormwater management tool in urban planning strategies. However, the literature suggests that ecoroofs can be sources of certain metals and nutrients. The goal of our study was to address two research questions: 1) How does ecoroof runoff compare to conventional roof runoff chemically: do ecoroofs retain certain chemicals and leach others? and 2) what are the roof characteristics and environmental variables that affect runoff quality? For 10 months, runoff events from an ecoroof were compared to those of a conventional roof; water samples were collected with autosamplers, and …

Public Health Vs. Public Health: Balancing Environmental Concerns With The Need For Sterile Medical Devices, Jack Brooksbank

Minnesota Journal of Law, Science & Technology

No abstract provided.

The Diamond, September 11, 2020, Dordt University

Dordt Diamond

• Front Page: Student Enrollment Spikes for 2020-2021 School Year; History Repeating Itself: Outdoor Classes Mirror 1918 Pandemic; Dordt Students Quarantined at Hotels to Attend School
• News: Masking Up: Protecting Ourselves and Each Other; Changes in Chapel Bring New Opportunities; Dordt Alumni Returns as Professor; Dordt Receives NSF Grant; Dordt University Plans for a Test-Optional Application
• Arts & Entertainment: Tenet: A Satisfying Must-See; Dr. Groenewold Recital; The Movie that Mutated
• Feature: Swing Dance Nixed. Fall Sports and Outside Intramurals a Go; The Hope Fund Supports Students
• Opinion: Critique, Tweets, and Institutional Insecurity in the New Age of Anxiety; Priorities for Dordt; …

Covid-19: The Humanities And Social Sciences Have Much To Contribute To Beating This Pandemic And The Next, L Cladi, S Green

School of Law, Humanities and Social Sciences

Letter

Chimes: September 11, 2020, Calvin University

Chimes

Academic calendar changes announced, effective next school year by Harm Venhuizen

Local CRC appoints deacon who is in same-sex marriage by Juliana Knot

Three months after George Floyd, Calvin continues to respond to BLM by Katherine Benedict

Students recount their isolation experiences after report symptoms by Abigail Ham

Calvin mourns the loss of rising senior Iris Jones by Harm Venhuizen

Graduation for class of 2020 postponed until April 17, 2021 by Juliana Knot

COVID-19 dashboard help keep Calvin community informed by Lauren Vanden Bosch

SAO to launch "Toknight Show", other tentative events by Susanaah Epp

Celebration Cinema offers "drive-in" alternative …

The Well-Stocked Bookshelf: Reviews Of Young Adult Literature, Ed Spicer

Michigan Reading Journal

No abstract provided.

Of Cabbages And Kings: Welcoming New Reviewers, Leah Van Belle, Lynette Autrey, Tara Mulvany, Melanie Zamborowski

Michigan Reading Journal

No abstract provided.

Alternative To Round Robin Reading, Jillian Grifhorst, Jennifer Lessway, Melanie Zamborowski

Michigan Reading Journal

No abstract provided.

Great Lakes, Great Books, Lynette Marten Suckow

Michigan Reading Journal

No abstract provided.

A Closer Look: Children's And Young Adult Literature, Noor Charara, Stephanie Fazekas-Hardy, Brandon Gleaton, Melissa Isaac

Michigan Reading Journal

No abstract provided.

Cultivating Middle School Students' Literacy Learning Of Story Structure Through Video Production, Chrystine C. Mitchell, Nicole Hessler

Michigan Reading Journal

No abstract provided.

Sward Allowance At Early Lactation Of Primiparous Dairy Cows: Ii‐Ingestive Behaviour, P. Chilibroste, C. Carballo, D. A. Mattiauda, Pablo Soca

IGC Proceedings (1977-2023)

No abstract provided.

Sward Allowance At Early Lactation Of Primiparous Dairy Cows: I‐Milk Yield And Composition, P. Chilibroste, D. A. Mattiauda, Pablo Soca, A. Meikle

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Management On The Productivity Of Chloris Gayana In The Rangelands Of Uganda, B. G. Bwengye, E. N. Sabiiti, P. Grimaud

IGC Proceedings (1977-2023)

No abstract provided.

Different Grazing Manner Effects On Ecological Indicators Of The Typical Steppe Vegetation In Mongolia Plateau, Xiuxia Bao, Jin Yi, Qimuge Wuren, Yong Lian, Buda Su

IGC Proceedings (1977-2023)

No abstract provided.

Efficient Cocaine Degradation By Cocaine Esterase-Loaded Red Blood Cells, Luigia Rossi, Francesca Pierigè, Marco Agostini, Noemi Bigini, Veronica Termopoli, Yingting Cai, Fang Zheng, Chang-Guo Zhan, Donald W. Landry, Mauro Magnani

Molecular Modeling and Biopharmaceutical Center Faculty Publications

Recombinant bacterial cocaine esterase (CocE) represents a potential protein therapeutic for cocaine use disorder treatment. Unfortunately, the native enzyme was highly unstable and the corresponding mutagenized derivatives, RBP-8000 and E196-301, although improving in vitro thermo-stability and in vivo half-life, were a partial solution to the problem. For cocaine use disorder treatment, an efficient cocaine-metabolizing enzyme with a longer residence time in circulation would be needed. We investigated in vitro the possibility of developing red blood cells (RBCs) loaded with RBP-8000 and E196-301 as a biocompatible system to metabolize cocaine for a longer period of time. RBP 8000 stability within human …