Digital Commons Network^™

Railspace: A Geocritical Study Of The Railroad Through American Literature And Culture, Michael A. Smith

Electronic Theses and Dissertations

This dissertation uses geocriticism to argue that the American railroad is best understood as a set of discursively constructed railspaces formed through a variety of viewpoints, a polysensorial awareness of space, and stratified social relationships and power struggles. This study takes up four railspaces, the constituent texts of which demonstrate how intertextual discourse shapes and is shaped by the railroad. The observation car, charted through California Zephyr advertisements and Muriel Rukeyser’s “Campaign,” is an apparatus that produces perpetual spectacle. Three novels—Sister Carrie by Theodore Dreiser, Double Indemnity by James M. Cain, and Strangers on a Train by Patricia Highsmith—and …

A Catholic Ethic For Smartphones In Tanzania, Faustine Tarimo

Electronic Theses and Dissertations

This project is a synthesis of Church documents and papal encyclicals to form a Catholic ethic for the smartphone use in Tanzania. The research question for this project is how a Catholic communication ethic shapes the use of smartphones for human communication in Tanzania. The problem I want to address is the perceived danger of losing connectivity or ‘real’ face-to-face encounters between people in “let’s talk culture” in Tanzania. The goal of this project is to appreciate the use of smartphones, at the same time to attend to a Catholic ethic to integrate into a “let’s talk culture” some digital …

Towards A Bioeconomy In The Southern Cone?:Analysis Of Official Bioeconomic Approaches In Argentina, Brazil, Paraguay And Uruguay, Marisa Mathó

Undergraduate Honors Theses

Every aspect of our world is impacted by climate change – our food, water, infrastructure and security systems. Bioeconomy and the biobased economy have emerged as two types of models with the potential to transform industries away from extractive practices without losing economic activity. By pivoting decisively to embrace sustainable bioeconomic and biobased economic strategies nations can contribute to their long term development, and make a real difference in the fight against climate change. This study seeks to analyze national bioeconomic policy documents to better understand the orientation, status and level of bioeconomic policy discourse in the founding MERCOSUR countries …

Primer Registro Del Pequeño Escarabajo De La Colmena Aethina Tumida Murray (Coleoptera: Nitidulidae) En Colmenas De Abejas Africanizadas En Guatemala, José Francisco García Ochaeta

Insecta Mundi

Se registra por primera vez la presencia del pequeño escarabajo de la colmena (PEC), Aethina tumida Murray (Coleoptera: Nitidulidae), en colmenas de abejas africanizadas en el departamento de Petén, Guatemala, alimentándose de miel y polen. Se presenta información básica sobre la especie, su distribución conocida actual e ilustraciones para ayudar en su identificación.

The presence of the small hive beetle (SHB), Aethina tumida Murray (Coleoptera: Nitidulidae), is recorded for the first time in Africanized beehives from Petén department, Guatemala, feeding on honey and pollen. Basic information about the species, including its currently known distribution, and illustrations, are presented to aid …

Not Clamming Up, Beth Potier

UNH Today Archive

No abstract provided.

Impact Of Professional Sports’ Twitter Content On Their Fans, Gianna Sarkis

Theses

Professional sports organizations have begun to utilize social media to create an online community for fans. These organizations have partnered with companies to create monetary value for the team and the companies, which has led sponsorship from traditional advertising in the arena or venue of the professional sports organization to their team’s Twitter account. I investigated how fans of the professional sports organization recognized sponsored content on the organizations' Twitter pages concerning the Communication Theory of Identity (CTI). I then compared the sponsored and organic contents' interaction rates to see if there were similarities or differences between those rates. The …

A Crisis Of Kelp, Rachel L. Sherman

Capstones

Along with insects and lab-grown meat, for years seaweed has been lauded as a sustainable “food of the future” by the U.N. Food and Agricultural Organization. As the world increasingly turns to alternative foods in pursuit of a healthier Earth, seaweed has all the makings of an ecological savior. It’s plentiful — seaweeds and ocean algae make up roughly nine tenths of all the plant life on Earth — it’s cheap to harvest and get to market, packed with nutrition, and keeps oceans clean, absorbing more carbon dioxide and releasing more oxygen than the world’s rainforests.

But outside of Japanese …

The Cellular Origin And Molecular Drivers Of Claudin-Low Mammary Cancer, Patrick D. Raedler

Theses & Dissertations

Breast cancers of the claudin-low subtype make up a substantial portion of triple-negative breast cancers and have stem cell-like and mesenchymal features. Although it has been recognized for some time that this breast cancer subtype is highly aggressive and difficult to treat, the molecular drivers and cellular origin of claudin-low breast cancer have been poorly defined. The lack of suitable in vivo models has prohibited the study of tumor initiation and progression of this subtype. In this work, we report two novel mouse models that, upon expression of oncogenic RAS in the mammary epithelium, develop highly metastatic triple-negative mammary tumors …

Multistrain Hiv-1 Elimination: A Crispr-Cas9 And Theranostics-Based Approach, Jonathan Herskovitz

Theses & Dissertations

A critical barrier to achieving a functional cure for infection by human immunodeficiency virus type one (HIV-1) rests in the presence of latent proviral DNA integrated in the nuclei of host CD4+ T cells and mononuclear phagocytes. Accordingly, HIV-1-infected patients must adhere to lifelong regimens of antiretroviral therapy (ART) to prevent viral rebound, CD4+ T cell decline, and progression to acquired immunodeficiency syndrome (AIDS). Gene editing using clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 technology stands as one means to inactivate integrated proviral DNA. We devised a mosaic gRNA CRISPR-Cas9 system- TatDE- that targets viral transcriptional regulator genes tat / …

Antiparasitic Peptide From The Ocean: Discovery, Synthesis And Structure-Activity Relationship Study, Kh Tanvir Ahmed

Electronic Theses and Dissertations

Millions of people die every year because of infectious diseases, and malaria is among the top five of the deadliest infectious disease. In 2018, malaria took more than four hundred thousand lives, and more than half of them are children under five years of age. Most malaria-affected parts of the world are also the home of the most underprivileged people. Seemingly, antimalarial drug discovery never achieved the attraction that it requires. Like malaria, another infectious disease that is not extensively explored by drug discovery campaigns is American trypanosomiasis or Chagas disease. More than a hundred years have passed since discovering …

Stakeholders' Perceptions Of Inherent Barriers To The Potential Implementation Of Ultrasound In The Prehospital Setting Between The Saudi Red Crescent Authority And The National Guard Hospital, Maher Alsulami

Electronic Theses and Dissertations

This exploratory study was designed to illuminate both the obstacles and the opportunities inherent in the current medical emergency systems within the kingdom of Saudi Arabia in relation to the possible inclusion of ultrasound machines to assist both Saudi Red Crescent Authority professionals and emergency physicians in the hospital. The research explored the issue of implementing the ultrasound from the perspective of multiple institutions: The Saudi Red Crescent Authority and the National Guard Hospital. The research explored multiple healthcare professionals within both organizations including paramedics, EMTs, emergency doctors, and Saudi Red Crescent station administrators.

The purpose of this qualitative method …

Effectiveness Of An Interdependent Group Contingency With Randomization Using The Ipad, Chelsea Gyke

Electronic Theses and Dissertations

Classroom management, although considered one of the essentials of the optimal learning experience, is often a challenge for teachers. Certain classroom management strategies, such as group contingency interventions and token economies, are evidence-based strategies to aid teachers in gaining successful management of the classroom. The utilization of Class Dojo, a popular classroom management website, as a mechanism to implement an interdependent group contingency (IGC) intervention with randomized components may increase both the effectiveness of the intervention and the social validity of the intervention when compared to a manual implementation.

Participants included students in an elementary school self-contained special education classroom …

“That Those Hearing Or Reading Might Strive To Imitate”: Donative Intent, Positive Triangular Mimetic Desire, And The Portrayal Of The Mediator-Divine (Non)Object Relationship In Richard Rolle, Julian Of Norwich, And Richard Crashaw, Steven Geitgey

Electronic Theses and Dissertations

Mystical texts often present themselves as possessing a “donative” intent, in which the writer aims to share the significance of their own experience. This dissertation will show how a consideration of donative intent and its textual results can enrich the study of medieval and early-modern mystical writings, approaching them from the broad concept of triangular mimetic desire in conjunction with other theoretical insights in order to examine the methods through which writers seek to portray their mediator-object relationship with God and inspire reading subjects’ mimetic desire.

I will elucidate Richard Rolle’s portrayal of his mediatorial purpose and unique experiences, and …

Fluoride Removal With Augmented Bentonite In Drinking Water And Community Perceptions In Arusha, Tanzania, Kara Okular

Electronic Theses and Dissertations

High fluoride concentrations in drinking water affect millions of people around the world. The World Health Organization recommended a fluoride concentration in drinking water of ≤ 1.5 mg/L; fluoride above this concentration can cause long-term dental and skeletal fluorosis. Fluoride imparts no taste to water; therefore, people do not realize that they are ingesting high fluoridated water. Researchers sought to develop a material to remove fluoride from drinking water through sorption. Aluminum was used to form a double ionic layer on the bentonite clay surface. Once mixed in contaminated water, a coagulant, ferric sulfate, was used to separate the bentonite …

Examining The Intersectionality Of Religious Faith, Spirituality, And Healthcare Communication, Felix Okeke

Electronic Theses and Dissertations

This dissertation is my own contribution in responding to the concern raised by certain communication scholars. Their concern was that little research and few publications have been done in the communication field by communication scholars that trace the relationship among religious faith, spirituality, and healthcare communication. While Parrott (2004) describes this apparent neglect as “collective amnesia,” others label it “religion blindness.” Thus, in trying to trace this relationship, this project uses Christian, biblical, and bioethics backgrounds to establish the value, sacredness, and dignity of human life, since these concepts make healthcare and healthcare communication necessary in the first place. These …

Child Protection Services: An Evaluation Of The Current System And Recommendations For Preventing Instances Of Abuse, Sarah Varian

Graduate Teacher Education

Millions of children are reported to Child Protective Services every year, and the services those children receive differ greatly between each state depending on the laws and regulations set in place and what community programs may or may not exist to support them. Research about what factors influence child abuse occurrences and which services best meet the needs of at-risk families is vital to determine the best ways to provide support for families reported for cases of abuse or neglect (Palmer, Maiter, & Manji, 2006; Solomon & Asber, 2012). A review of literature on this topic concluded that currently, Child …

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, And Increase Plasma Β-Hydroxybutyrate, Terry D. Hinds Jr., Justin F. Creeden, Darren M. Gordon, Donald F. Stec, Matthew C. Donald, David E. Stec

Pharmacology and Nutritional Sciences Faculty Publications

The inverse relationship of plasma bilirubin levels with liver fat accumulation has prompted the possibility of bilirubin as a therapeutic for non-alcoholic fatty liver disease. Here, we used diet-induced obese mice with non-alcoholic fatty liver disease treated with pegylated bilirubin (bilirubin nanoparticles) or vehicle control to determine the impact on hepatic lipid accumulation. The bilirubin nanoparticles significantly reduced hepatic fat, triglyceride accumulation, de novo lipogenesis, and serum levels of liver dysfunction marker aspartate transaminase and ApoB100 containing very-low-density lipoprotein. The bilirubin nanoparticles improved liver function and activated the hepatic β-oxidation pathway by increasing PPARα and acyl-coenzyme A oxidase 1. …

Diagnostic Accuracy Of Mcmurry’S Test In The Diagnosis Of Meniscal Tears, Jessica Smyth, Hartwell Rainey

Physician Assistant Capstones, 2020-current

No abstract provided.

Angiotensin Ii In The Treatment Of Distributive Shock, An Old Theory Revitalized, Jennifer D. Leach, Daniel P. Curran

Physician Assistant Capstones, 2020-current

Objective: To assess whether or not angiotensin II in combination with current treatment has a favorable outcome in the treatment of distributive shock in terms of decreasing duration of vasopressor usage, increasing mean arterial pressure (MAP) above 65 mmHg, and improving mortality.

Design: Systematic Literature Review

Methods:Searches were conducted in PubMed, Google Scholar, and the James Madison University Library Database for the key terms angiotensin II, shock, septic shock, vasodilatory shock, distributive shock, blood pressure, double-blind, humans, and vasoconstrictor agents. Search results were filtered by year, for animal trials, irrelevant therapies, meta-analysis, retrospective studies, and case studies. Only original …

Beyond The Eye: The Neural Signature Of Cerebral Visual Processing In Children With Cerebral Palsy, Jacy R. Hannan

Theses & Dissertations

Cerebral palsy (CP) is a permanent, non-progressive neuromuscular disorder diagnosed early in childhood. Frequently the lesion that causes the motor impairments in individuals with CP concurrently disrupts the visual networks, placing them at a high risk of cerebral visual dysfunctions. Cerebral visual impairment (CVI) often remains unrecognized or misdiagnosed in people with CP. Despite the crucial role of visual function in the development of movement and cognition, the neurophysiological basis of the cerebral visual dysfunctions is almost entirely unknown. This investigation aimed to examine the neurophysiological mechanisms underlying cerebral visual dysfunction in children with CP. Specifically, this research used magnetoencephalographic …

Rilpivirine-Associated Aggregation-Induced Emission Enables Cell-Based Nanoparticle Tracking, Insiya Mukadam

Theses & Dissertations

Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, limitations in drug efficacy, the emergence of viral mutations and the paucity of cell-tissue targeting remain. We posit that to maximize ART potency and therapeutic outcomes newer drug formulations that reach HIV cellular reservoirs need to be created. In a step towards achieving this goal we discovered the aggregation-induced emission (AIE) property of the non-nucleoside reverse transcriptase inhibitor Rilpivirine (RPV) and used it as a platform for drug cell and subcellular tracking. RPV nanocrystals were created with endogenous AIE …

Ypfs Lessons Learned Oral History Project: An Interview With Sohail Khan, Sohail Khan, Steven H. Kasoff, Matthew A. Lieber

Documents

Suggested Citation Form: Khan, Sohail, 2020. “Lessons Learned Interview."Interview by Steven H. Kasoff and Matt A. Lieber. Yale Program on Financial Stability Lessons Learned Oral History Project. December 18, 2020. Transcript. https://ypfs.som.yale.edu/library/ypfs-lesson-learned-oral-history-project-interview-sohail-khan

The Language Of Empire, Carmin Wong

LSU New Orleans Theses and Dissertations

This manuscript focuses on Caribbean and American culture, in addition to, Guyanese Creolized English and American Standard English. The poems in this collection infuse oral and written poetic techniques to write back to the hierarchies of language and literature set by the British empire. Upon defense, this collection was distinguished as an affirming love letter to Black women.

Get Rich Or Die Tryin’: Media And Black Male Academic Identity Development, Kevin S. Mcclain

LSU New Orleans Theses and Dissertations

Black males encounter many difficulties in their educational journeys. Often these disadvantages can be linked to socioeconomic and environmental factors, which have consistently plagued the Black community. However, a relatively unexplored area of interest in higher education is the influence media representation has on the academic identity of Black males. Routinely shown in media outlets as athletes, entertainers, and criminals, Black males rarely view positive representations of themselves across media, thus limiting their academic pursuits. From this study, the researcher hoped to develop a fuller understanding on the influence between multimedia and Black male identity and academic success in higher …

Wetland To Wasteland, Plantation To Plant: The Visual Legacy Of Plantations In The South Louisiana Landscape Of Environmental Justice, Ella Mcintire

LSU New Orleans Theses and Dissertations

The Southeast Louisiana landscape sits at the intersection of a number of environmental and humanitarian crises. Violence against man and land endemic to the Plantation Era development of the Lower Mississippi laid the foundation for modern issues of coastal land loss, habitat destruction, pollution, environmental racism, and displacement. Land-use patterns of the Plantation economy made the region optimal for petrochemical processing, turning wetland to wasteland, and plantation to plant. The exhibit Climates of Inequality: Standing Up On River Road uses photography, cinematography, 360-video, and soundscapes to explore the dialogic relationship between fragile natural spaces in southern Louisiana and the historically …

Becoming A Constellation, Meredith P. Contreras

LSU New Orleans Theses and Dissertations

In the following thesis, titled “Becoming a Constellation,” nine short stories navigate themes of womanhood and illustrate the ways in which life experiences shape a person. Each piece occurs in the fictional Louisiana town of St. Denis and explores setting as an integral piece of character development. The narratives offer a glimpse into the lives of several young women as they grapple with inevitable change and difficult relationships while becoming the women they choose to be.

Cola Grows Design Studies Program, Dave Moore

UNH Today Archive

No abstract provided.

Dna Polymerase Ε: Replication Error Prevention And Consequences Of A Cancer-Associated Mutation, Chelsea R. Bulock

Theses & Dissertations

Genome integrity is necessary to prevent mutations and disease. During eukaryotic DNA replication, DNA polymerases ε (Polε) and δ (Polδ) synthesize the leading and lagging strand, respectively. Polε and Polδ also have exonuclease activity that acts in series with post-replicative mismatch repair (MMR) to remove replication errors. Defects in proofreading and MMR lead to an increase in mutations and cause cancer in humans. This dissertation focuses on several unresolved issues involving the relationship between Polε and Polδ in replication error avoidance. First, despite an abundance of data supporting the one-strand-one-polymerase replication fork model, defects in the fidelity of Polε have …

Anti-Muc4Β Antibodies As A Novel Therapeutic Modality For The Treatment Of Pancreatic Cancer, Catherine Orzechowski

Theses & Dissertations

The deregulation of cell surface glycoproteins, such as mucins, is a hallmark of many tumors of epithelial origin. The transmembrane mucin MUC4, is differentially overexpressed in several malignancies, including pancreatic, breast, ovarian, lung, cervical, and head and neck cancers. Of all the aforementioned cancers, the role of MUC4 has been the most thoroughly in pancreatic cancer (PC), which is the 4th leading cause of cancer-related deaths in the United States. While MUC4 is undetectable in the normal or inflamed pancreas (pancreatitis), its expression progressively increases during PC progression and its higher expression correlates with poor survival. The role of MUC4 …

Cardioprotective Roles Of Hydrogen Sulfide Donor Treatment In Diabetic Cardiomyopathy, Sumit Kar

Theses & Dissertations

Diabetes mellitus (DM) increases the risk of heart failure 2-4-fold. Intensive glycemic control does not abate this risk in DM patients, suggesting that DM-induced heart failure is beyond hyperglycemia. DM silently induces cardiac muscle disorder termed diabetic cardiomyopathy (DMCM), which progresses to heart failure. The objective of this dissertation is to understand the mechanistic underpinnings of DMCM to develop new solutions to diagnose and treat heart failure in DM.

The heart pumps blood due to the contraction and relaxation of terminally differentiated cardiomyocytes with limited regenerative capacity. The DM environment of hyperglycemia, hyperlipidemia, and inflammation causes cardiomyocyte death and leads …