Digital Commons Network^™

Perforin-Deficient Car T Cells Recapitulate Late-Onset Inflammatory Toxicities Observed In Patients, Kazusa Ishii, Marie Pouzolles, Christopher D. Chien, Rebecca A. Erwin-Cohen, M. Eric Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, Amanda K. Ombrello, Alina Dulau-Florea, Michael A. Eckhaus, Haneen Shalabi, Bonnie Yates, Daniel A. Lichtenstein, Valérie S. Zimmermann, Taisuke Kondo, Jack F. Shern, Howard A. Young, Naomi Taylor, Nirali N. Shah, Terry J. Fry

United States Public Health Resources

Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established link between perforin deficiency and primary HLH, we investigated the role of perforin in anti-CD19 CAR T cell efficacy and HLH-like toxicities in a syngeneic murine model. Perforin contributed to both CD8+ and CD4+ CAR T cell cytotoxicity but was not required for in vitro or in vivo leukemia clearance. Upon CAR-mediated in vitro activation, perforin-deficient CAR T cells produced higher amounts of proinflammatory cytokines compared with WT CAR …

Glitched Metaphors: Dysfunction In Hand-Woven Digital Jacquard, Gabe Duggan

Textile Society of America: Symposium Proceedings

This presentation demonstrates various ways in which the TC1 has supported my work’s exploration of tension, balance, and precarity. By embracing and pushing expectations of traditional fiber work, these weavings question inequalities within contemporary performances of gender and exhibitions of power. My work on the TC1/TC2 digital jacquard loom has been primarily tethered to one specific machine with which I have shared a personal past and future for just over a decade. Through this technology I have built and negated tension, challenging a broad range of power dynamics. My work with this TC1 seeks to exploit and balance this technology …

A Tale Of Two Sisters: Invisibility, Marginalization And Renown In A 20th Century Textile Arts Revitalization Movement In New Mexico, Suzanne P. Macaulay

Textile Society of America: Symposium Proceedings

While this presentation does not address oppression in the global textile industry and injustices to leagues of anonymous enslaved women workers, it does raise questions about the vicissitudes of fame and obscurity of two women relative to artistic creation and textile arts revitalization efforts. This is the story of two Varos sisters, who married two Graves brothers, and lived in Carson, New Mexico. In the early 1930s Frances and Sophie Graves with their extended families repaired Spanish colonial textiles for the Santa Fe market. At some point they began to recreate traditional Spanish colonial-type colcha embroideries from recycled materials salvaged …

Shared Provenance: Investigating Safavid-Mughal Cultural Exchange Through Luxury Silks In The Sixteenth And Seventeenth Centuries, Nazanin Hedayat Munroe

Textile Society of America: Symposium Proceedings

When examining silk textiles attributed to the early modern Persianate world, there is always some uncertainty as to whether they were produced in Safavid Iran or Mughal India. The confusion is warranted: the two courts share many of the same ideas, images, and even family connections, creating a broad cultural overlap. This becomes apparent in the arts from the mid-sixteenth century onwards, as politics and patronage prompted the migration of key Safavid artists, including weavers, from Iran to Mughal India. As Persian painting was developed in the royal atelier, luxury silks were also produced with Safavid techniques.

Examining these imported …

Colcha Circle: A Stitch In Northern New Mexico Culture, Olimpia Newman, Rebecca Abrams

Textile Society of America: Symposium Proceedings

Colcha embroidery is folk art, characteristic of northern New Mexico history, traditions, and a form of cultural expression that has not been researched and documented sufficiently. It has been practiced in private homes and small circles as a result of commissions or economic development programs, as has also been the case in the San Luis Valley, Colorado. Despite the exposure offered by local markets and demonstrations during events in New Mexico, the embroidery is in many ways an unknown technique, even to the next generation.

This video captures a candid discussion among eleven colcha artists, some of whom are entering …

The Dynamic Trophic Niche Of An Island Bird Of Prey, Ulises Balza, Nicolas A. Lois, Michael J. Polito, Klemens Puetz, Amira Saalom, Andrea Raya Rey

Faculty Publications

Optimal foraging theory predicts an inverse relationship between the availability of preferred prey and niche width in animals. Moreover, when individuals within a population have identical prey preferences and preferred prey is scarce, a nested pattern of trophic niche is expected if opportunistic and selective individuals can be identified. Here, we examined intraspecific variation in the trophic niche of a resident population of striated caracara (Phalcoboenus australis) on Isla de los Estados (Staten Island), Argentina, using pellet and stable isotope analyses. While this raptor specializes on seabird prey, we assessed this population's potential to forage on terrestrial prey, especially invasive …

Report From Oakland: The Art Of Insurrection, Pedro Lange-Churión, John Zarobell

Global Studies Faculty Publications

At the end of May, the third month of a shelter-in-place order in the counties of the San Francisco Bay Area, protests erupted daily in Oakland (California) following the killing of George Floyd in Minneapolis. After a spree of early looting, the businesses along Oakland’s main corridors—many still closed to the public today, in November—had boarded up their windows leaving a ready canvas for a host of street artists and muralists to make their mark. The protest works that emerged are both beautiful and politically fraught, exposing some of the most sensitive social and economic divisions in the US. With …

"An Hundred Stories In Ten Days": Covid-19 Lessons For Culture, Learning And Copyright Law, Carys J. Craig, Bob Tarantino

Joint PIJIP/TLS Research Paper Series

In the face of a pandemic, copyright law may seem a frivolous concern; but its importance lies in the ever-expanding role that it plays in either enabling or constraining the kinds of communicative activities that are critical to a flourishing life. In this article, we reflect on how the cultural and educative practices that have burgeoned under quarantine conditions shed new light on a longstanding problem: the need to recalibrate the copyright system to better serve its purposes in the face of changing social and technological circumstances. We begin by discussing how copyright restrictions have manifested in a variety of …

Oct2020, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Newsletter, Npml [Bull]Etin, Volume 3, No. 7, October 2020, University Of South Florida St. Petersburg. Nelson Poynter Memorial Library

NPML [Bull]etin

The October 2020 issue of a newsletter for the University of South Florida St. Petersburg's Nelson Poynter Memorial Library.

Growing Collaborative Outreach Efforts To Support The Well-Being Of Communities, Jessica Kohout-Tailor, Lili Klar

Publications

Libraries of all types provide outreach efforts for their patrons to reduce stress and promote well-being. Public, school, and academic libraries often partner with external entities to provide yoga, therapy dogs, and other creative activities for their patrons. Although collaboration is expected in public, school, and academic libraries, how to collaborate and/or grow collaborative efforts is lacking in the library literature. A former public library employee and a former school librarian came together to pilot a de-stressing program for students at their academic library and each semester have continued to grow their collaborative efforts with partners on and off-campus. Strategies …

T&C Magazine Issue 22 - Fall 2020, T&C Media

T&C Magazine

Articles Include: Letter From the Editor, Westerville on a Budget, 10 of T&C's Favorite Black-Owned Businesses, Student Voting in 2020, Pandemic Style, Greek Life 1920s-2020s, Finding New Ways to Escape During Lockdown, Next Generation Warriors: Training Otterbein Nursing Students, What is Your Quarantine Personality?, Streaming Service Stats: What Were We Watching, Cardinal Course Catalog Guide: Hidden Gems, Students' Favorite Conspiracy Theories

Cimagazine - Fall 2020, Dmacc

ciMagazine

Our annual ciLive! (Celebrate! Innovation Live) gives students and the community opportunities to interact with people (some famous, all inspired) who have dreamed, created, and accomplished. During this thought-provoking and interactive event, students listen, absorb, and engage without the stress of the regular class routine. Generous sponsors make the event free and open to the public. Celebrate! Innovation Magazine is published biannually by Des Moines Area Community College West Campus

2003 Severe Acute Respiratory Syndrome (Sars) Epidemic: A One Health Perspective, Pratishtha Panigrahi

Virginia Journal of Public Health

Background: The 2003 Severe Acute Respiratory Syndrome (SARS) outbreak was a global epidemic that affected 8,098 individuals and resulted in 774 deaths by March 2003. Originating in Guangdong, China in late November 2002, this virus quickly crossed international borders to nearby countries like Hong Kong and Singapore and traveled as far as the United States. Patients infected with SARS suffered from severe respiratory symptoms that ranged from dry coughs to severe forms of pneumonia. Initial medical teams and community members in Guangdong had little to no information on the new strain of coronavirus. This gap in information and lack of …

Evaluation Of Hepatoprotective Effect Of A Polyherbal Megakutki Against Paracetamol-Induced Hepatotoxicity, Asha Elizabeth Giri, Vanishree Rao, Sandeep Singhal, Karthik Gourishetti

Open Access archive

Background: Megakutki® (MK) is a polyherbal preparation of 11 standardized extracts that are individually proven for hepatoprotection scientifically. Aim: Study evaluated MK’s hepatoprotective potential against paracetamol (PCM) in in-vitro on Hep G2 cells using cell viability, cell cycle analysis and apoptotic studies and in in-vivo in Wistar rats using liver function tests, histological and DNA fragmentation study. Materials and Methods: In in-vitro studies, IC50 (50% inhibition in viability) values of silymarin, MK and PCM were found out by MTT assay. In-vitro hepatoprotection was found out by pretreating the cells with below-IC50 concentrations of MK and silymarin for 24h followed by …

Psychological Impact Of Mass Quarantine On Population During Pandemics-The Covid-19 Lock-Down (Cold) Study, Deeksha Pandey, Suvrati Bansal, Shubham Goyal, Akanksha Garg

Open Access archive

Background Quarantine often is an unpleasant experience. The aim of this study is to explore the degree of psychological distress in terms of-Depression, Anxiety and Stress among the adult population in India during the strict 21 days mandatory lockdown. We hypothesize that quantification of psychological impact of current situation will help us to modify the policies and implementation strategies. This assessment might also help in future to keep targeted services in place, to cope up with the psychological distress of the quarantined population. Method A cross sectional survey design was adopted to assess the psychological state of general population in …

Cosmic City - Cosmic Teleology: A Reading Of Metaphysics Λ 10 And Politics I 2, Brandon Henrigillis

Dissertations (1934 -)

The goal of my project is to provide a reading of Metaphysics Λ 10. Λ 10 states that there is an order in the cosmos, or a cosmic nature. The problem for the interpreter of Aristotle is how to make sense of this claim given Aristotle’s arguments elsewhere regarding nature/substance and the priority of substances over the parts of a substance. To explain what Aristotle means when he states that there is a cosmic nature and arrangement, I first examine the army and household analogies offered by Aristotle in Λ 10. I contend that the household analogy in particular provides …

Kenyon Alumni Magazine - Fall/Winter 2020

Kenyon College Alumni Bulletin

No abstract provided.

Identifying The Universals Of Death: An Interpretive Analysis Of Mortuary Ritual In Ancient Egypt And Modern America, Sarah Snare

Senior Theses

This project compares mortuary practices in ancient Egypt and modern America in an effort to identify cross-cultural consistencies in the treatment of the dead. An analysis of the meaning and motivations behind these rituals reveals that they serve similar functions in both societies. Death provokes intense emotions of grief and long periods of mourning, which can debilitate the people who knew the deceased and even the society itself. Therefore, to promote survival of individuals and the community, mortuary rituals must address these disturbances. Focusing on ancient Egypt and modern America, this study finds that mortuary practices function to restabilize society …

“It’S Like They Don’T Recognize What I Bring To The Classroom”: African Immigrant Youths’ Multilingual And Multicultural Navigation In United States Schools, Lydiah Kananu Kiramba, Alex Kumi-Yeboah, Anthony Mawuli Sallar

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Discourses of African immigrant children are rare in educational research. As such, African immigrant educational experiences are often obscured (in part, owing to the model minority myth about Africans based on higher education degrees received by African immigrants), as well as the actual experiences and realities for African immigrant K-12 students. This qualitative study examines cross-cultural educational experiences of 30 Black African immigrant youth in U.S. schools. The findings reveal multiple participants’ struggles with cultural and linguistic differences, stereotypes and marginalization in the school environment, low expectations from teachers, and adjusting to new schooling practices. The African youths’ voices exhibited …

Itihas Vol. 20 Issue No. 4, Sastra Univ

ITIHAS

NEWSLETTER FROM SASTRA DEEMED UNIVERSITY

Katz And Covid-19 How A Pandemic Changed The Reasonable Expectation Of Privacy, Wayne Unger

UC Law Science and Technology Journal

COVID-19 spread to 189 countries and infected tens of millions of people in the matter of months. Organizations, including governments and employers, turned to health surveillance technologies to slow the spread and combat the disease. Protected health information and personal information are required for the proper and effective functioning of the health surveillance technologies. The collection, use, and dissemination of protected health and personal information raised data privacy and security concerns. But under the current data privacy and security regime—based on the reasonable expectation of privacy standard—protected health and personal information is not protected to the extent that it needs …

Giant Gastric Ulcers: An Unusual Culprit, Aamer Abbass, Sameen Khalid, Vaishnavi Boppana, Joshua Hanson, Henry Lin, Denis Mccarthy

Pathology Research and Scholarship

Mycophenolate Mofetil (MMF) is routinely used immunosuppressant in solid organ transplantation is commonly associated with several gastrointestinal (GI) side effects. Here we present a case of giant gastric ulcer of 5 cm from MMF use post cardiac transplant. CASE DESCRIPTION: A 56-year-old male with history of severe ischemic cardiomyopathy post heart transplant was on immunosuppression with MMF, tacrolimus and prednisone for 5 months. He presented with severe epigastric pain and intermittent episodes of melena for 1 month. His pain radiated to back that is worsened with eating. Associated with loss of appetite, vomiting and 16-pound weight loss in 3 months. …

The Impact Of Volunteering: A Multi-State Study Of 4-H Youth Development Volunteers, Samantha Grant, Sarah Maass, Rachelle Vettern, Rebecca Harrington

Journal of Youth Development

Volunteers are vital to youth development programming as a key piece of the workforce. This evaluation measured the impact of volunteers in the 4-H youth development program and demonstrated the value volunteers bring to youth development environments. The North Central region 4-H volunteer impact study was conducted with volunteers in the 4-H Youth Development program across 12 states. The purpose of the study was to better understand the value of being a volunteer. Results showed that volunteers personally benefited from their involvement by becoming more experienced at working with youth and by learning skills that transferred to other settings. Volunteers …

Examining Parental Perceptions And Decisions To Uptake Child Influenza Immunizations: Assessing Pandemic And Policy Impacts On Vaccination Rates Following The H1n1 Pandemic, And The Acip Laiv Preferential Recommendation Revocation, Amir H. Mehrabi

Theses and Dissertations

Introduction

2009 H1N1 Pandemic: The historical 2009 H1N1 Influenza pandemic, which had a CDC estimated accrued disease burden of 100.5 million illnesses, 936,000 hospitalizations, and 75,000 deaths from 2009 to 2018, resulted in a declared state of emergency nationally, with ensuing diminished vaccine confidence and amplified fears of infection, prompting some to pursue flu vaccination, and others to forego. Although the Centers for Disease Control and Prevention (CDC), and its Advisory Committee on Immunization Practices (ACIP) recommend an annual flu vaccine for individuals 6 months of age and older as the “first and best” defense against influenza, a low percentage …

The Roles Of Language, Communication, And Discourse In Power: A Series Of Critical (Reaction) Essays, Alessia Barbici-Wagner

The Nebraska Educator: A Student-Led Journal

The following is a conceptual paper consisting of a series of short, critical essays written for the “Language and Power” course taught by Professor Loukia K. Sarroub at the University of Nebraska-Lincoln during Fall 2019. The purpose of these essays is to understand the power of language, communication, and discourse in society and in education. Each essay is itself unique and connected to the others and explores the role of language in community and institutional settings. Language is intrinsically connected to culture, and most societies show their hierarchal power through it. For example, the short essay “‘Ketchup’ with Social Norms” …

Admissions Magazine Fall 2020, Embry-Riddle Aeronautical University

Admissions Magazine

A Cyber Warrior: Fighting cybercrime in the real world.

• Who We Are
• Houston, We've Got a Space Junk Problem
• Hands-On Experiences
• Hit the Ground Running
• From Paper Planes to Payloads
• Next Level NASA
• Spaceflight on the Brain
• Bracing for Change
• Passion Becomes Profession
• Now Trending: What's life like when you join the Embry-Riddle family? It's rewarding, challenging - and fun. Have a look for yourself.
• Dual Enrollment Student Completes Aviation Trifecta for 16th Birthday
• Connect Anytime, Anywhere with Worldwide's eUnion Virtual Community.
• Meteorology: Driven to be First
• Success On Ice
• Breaking Barriers
• My "Dream Job" is Now Reality
• Par For …

Analysis Of Semi-Arid Riparian Environments Using Satellite Imagery, Kira Overin

Graduate Theses & Non-Theses

Semi-arid riparian environments are at risk of being over-exploited or degraded due to increased water usage associated with growing housing demands. Trends surrounding these developments can be monitored using freely available Landsat satellite imagery in conjunction with seasonal stream discharge rates. This project focuses on a stream system located southwest of Ennis, Montana, where population is growing rapidly. It aims to characterize the connection between variable discharge rates in small-scale riparian environments and adjoining vegetation health, while considering possible implications of continued urbanization. Methods for preventing riparian ecosystem degradation and promoting resilience are also discussed.

Letting Go Of The Unnecessary, Isabel Arnout

Intro to Creative Writing (ENG 185) Chapbook Project

No abstract provided.

Where Do They Learn It All?, Duncan Brown

Intro to Creative Writing (ENG 185) Chapbook Project

No abstract provided.