Digital Commons Network^™

Market To Me: A Case Study On The Marketing Efforts Of Salesforce Software Company, Marissa Adrianna Spiess Espinola

Experience Industry Management

Social media platforms constitute outstanding channels for fostering relationships with consumers. Recently, there has been a drastic shift towards social media marketing and away from traditional marketing. Marketers are beginning to understand the importance of social media opportunity and are implementing social media marketing strategies and initiatives into companywide marketing practices. Companies cannot afford to lack presence on social media, as competitors could outpace them with marketing efforts of products and services to the public. Social media has become a necessary tool when marketing and advertising. The purpose of this study was to examine social media marketing practices of Salesforce …

Countenancing Employment Discrimination: Facial Recognition In Background Checks, Kerri A. Thompson

Texas A&M Law Review

Employing facial recognition technology implicates anti-discrimination law under Title VII of the Civil Rights Act when used as a factor in employment decisions. The very technological breakthroughs that made facial recognition technology commercially viable—data compression and artificial intelligence— also contribute to making facial recognition technology discriminatory in its effect on members of classes protected by Title VII. This Article first explains how facial recognition technology works and its application in employee background checks. Then, it analyzes whether the use of facial recognition technology in background checks violates Title VII under the disparate impact theory of liability due to the known …

Therapeutic Plasma Exchange And Intravenous Immune Globulin In The Treatment Of Heparin-Induced Thrombocytopenia: A Systematic Review, Chinonso Onuoha, Karen D. Barton, Edward C C Wong, Jay S. Raval, Marian A. Rollins-Raval, Tina A. Ipe, Joseph E. Kiss, Leonard I. Boral, Jill Adamksi, Nicole D. Zantek, Oluwatoyosi A. Onwuemene

Pathology Research and Scholarship

BACKGROUND: Immunomodulatory strategies in heparin-induced thrombocytopenia (HIT) include the use of intravenous immune globulin (IVIG) and therapeutic plasma exchange (TPE). The optimal application of these therapies is unknown and outcomes data are limited. We investigated treatment categories and laboratory and clinical outcomes of IVIG and/or TPE in HIT with a systematic literature review.

STUDY DESIGN AND METHODS: We searched MEDLINE, Embase, and Web of Science through December 2019 for studies combining controlled vocabulary and keywords related to thrombocytopenia, heparin, TPE, and IVIG. The primary outcome was treatment indication. Secondary outcomes were platelet recovery, HIT laboratory parameters, heparin re-exposure, and post-treatment …

Stop The Bleed: A Call To Action In Louisiana, Emily Nichols, Shayna Goldfine, Jonathan Fourcade, William Salmeron

Journal of the Louisiana Public Health Association

Background: In 2018, Louisiana ranked 2nd for the highest death rates due to homicide in the US (13.3 deaths per 100,000 total population). Falling just behind Mississippi, which had 13.4 deaths per 100,000 total population, this LA statistic was an improvement from the prime position held for over five years. While the approach to improving survivability requires the collaboration of many sectors, the Stop the Bleed (STB) education campaign is one example of initiatives taken to address this public health crisis. Methods: Developed by the Joint Committee to Create a National Policy to Enhance Survivability from Mass Casualty Shooting Events, …

Sustainable Tourism For Destinations: Insights From The Gstc Destination Criteria 2.0 For Sustainable Tourism, Jonathon Day, Jennifer Lenore Romanchek

Tourism Insights

This analysis of the Global Sustainable Tourism Council’s Destination Criteria 2.0 organizes criteria into five categories of activity: Planning, Policy, Programs, Performance Management, and destination team development and management.

T. Hanks For Everything, Anissa Johnson

All NMU Master's Theses

This thesis is an excerpt of an in-progress, full-length memoir. T. Hanks for Everything celebrates the myriad of ways art molds and shapes who we become and interrogates the nature in which mere appreciation transforms into fandom. The writer reflects on the impact actor Tom Hanks has had on her life through narratives that blend the personal with the biographical, developing both the writer’s and Hanks’ characters side-by-side. The writer uses humor as a mechanism to navigate the world, to deflect pain, and to find healing in the midst of it. This thesis hopes to be a safe place for …

Resurgence In Dogs, Monica Jones

All NMU Master's Theses

After a long tradition of using aversive training techniques, animal trainers have now widely adopted science-based methods using positive reinforcement. The field of applied behavior analysis routinely employs procedures to preempt problem behaviors by establishing and maintaining more acceptable alternative behaviors. Previous studies have shown that some of these procedures can nevertheless result in recurrence of original problematic behavior once training is completed and reinforcement of the alternative behavior is discontinued, a phenomenon called “resurgence.” Although observed in many species (e.g., rats, fish, and humans), resurgence has not been demonstrated with dogs, one of the most commonly trained animals in …

The Illuminated Empty Spaces, Jane Wagar

All NMU Master's Theses

This collection of poetry and flash non-fiction is a full-length hybrid collection that focuses on themes of grief, inheritance, memory, and sexuality. Genetic inheritance, inherited trauma, and the tangible inheritance of physical objects are all explored throughout the work. The project was inspired by the loss of my mother, and my subsequent diagnosis with a BRCA2 mutation. The fractured form was inspired by the gaps in memory that are created as a result of grief. The Illuminated Empty Spaces aims to define the space that grief leaves behind, and ultimately define what that space creates room for.

Spotted Owls And Forest Fire: Comment, Gavin M. Jones, R. J. Gutiérrez, William M. Block, Peter C. Carlson, Emily J. Comfort, Samuel A. Cushman, Raymond J. Davis, Stephanie A. Eyes, Alan B. Franklin, Joseph L. Ganey, Shaula Hedwall, John J. Keane, Rodd Kelsey, Damon B, Lesmeister, Malcolm P. North, Susan L. Roberts, Jeremy T. Rockweit, Jamie S. Sanderlin, Sarah C. Sawyer, Ben Solvesky, Douglas J. Tempel, Ho Yi Wan, A. Leroy Westerling, Gary C. White, M. Zachariah Peery

United States Department of Agriculture Wildlife Services: Staff Publications

Western North American forest ecosystems are experiencing rapid changes in disturbance regimes because of climate change and land use legacies (Littell et al. 2018). In many of these forests, the accumulation of surface and ladder fuels from a century of fire suppression, coupled with a warming and drying climate, has led to increases in the number of large fires (Westerling 2016) and the proportion of areas burning at higher severity (Safford and Stevens 2017, Singleton et al. 2018). While the annual area burned by fire is still below historical levels (Taylor et al. 2016), some forest types in the west …

Mass Spectrometric Determination Of Retinol In Emirati Population, Israa Samir Mohamed Shawky El-Konaissi

Theses

This thesis is concerned with analyzing vitamin A deficiency. Vitamin A is crucial for several functions, including vision, growth, and cell differentiation. the main aim is to develop and validate an LC-MS/MS method for the determination of vitamin A in plasma matrix and use the new method for the determination of vitamin A levels in the obese Emirati population. Methods: A positive ion electrospray ionisation (ESI) LC-MS/MS method was used in the Multiple Reaction Monitoring (MRM) mode for quantification. It involved i) LC-MS/MS, ii) a guard column together with C18 Ascentis Express F5 column iii) Internal standard, 25-Hydroxyvitamin D3 (6, …

Tennessee Farm Bureau News - November 2020, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

On The Significance Of Students’ Appraisals Of Their Language Learning Experiences At University: A Phenomenological Approach, Amir Kaviani

All Works

© 2020 Amir Kaviani. This study focusses on students’ appraisals of their language learning experiences at university. Forty students in the third and final academic English course at a university in the UAE participated in the study. The participants completed a written survey which was developed based on Scherer’s (1987, 2001, 2011, 2013) framework of appraisals, i.e. pleasantness, novelty, goal-conduciveness, coping potential and self-compatibility checks. The analysis of the qualitative data indicates that almost all of the participants evaluate their language learning experiences positively and consider the programme to be of great value in enabling them to achieve their academic …

Effects Of Vitamin D Supplementation On Lipid Profile In Adults With The Metabolic Syndrome: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Fatme Alanouti, Myriam Abboud, Dimitrios Papandreou, Nadine Mahboub, Suzan Haidar, Rana Rizk

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, with atherogenic dyslipidemia being a major contributing factor. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement to assess whether vitamin D supplementation (VDS) alleviates dyslipidemia in adults with MetS. Scientific databases (PUBMED, MEDLINE, CINAHL, EMBASE, Cochrane Library, ClinicalTrials.gov, International Clinical Trials Registry Platform) and the gray literature were searched for randomized controlled trials of VDS, reporting on blood lipids. A narrative review, meta-analyses, sensitivity analyses, and appraisal of the risk of …

Skeletal Muscle And The Maintenance Of Vitamin D Status, Mark S. Rybchyn, Myriam Abboud, David A. Puglisi, Clare Gordon-Thomson, Tara C. Brennan-Speranza, Rebecca S. Mason, David R. Fraser

All Works

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the …

Spatially Clustered Resources Increase Male Aggregation And Mating Duration In Drosophila Melanogaster, Er Churchill, Jr Bridle, Mdf Thom

School of Psychology

In environments where females mate multiply, males should adjust their behaviour and physiology in response to the perceived level of sperm competition to maximize their fitness. Evidence of such plasticity has been found in several laboratory and field studies, but little is known about the cues stimulating these responses in natural populations. One way in which males appear to assess sperm competition risk is through encounter rates with conspecific males. Such encounter rates may be driven by the spatial distribution of resources required by males (i.e. food patches or potential mates), which in turn affects local density. However, explicit links …

Return To Play After Isolated Meniscal Repairs In Athletes: A Systematic Review., Erica R Blanchard, Christopher J Hadley, Eric D Wicks, William Emper, Stephen B. Cohen

Rothman Institute Papers

Background: Meniscal tears are a common knee injury. Isolated meniscal tears are less common; however, unaddressed tears can be troublesome, particularly for athletes. There is currently a lack of data in the literature on athletes returning to play after isolated meniscal repair.

Purpose: To evaluate the return to play rate and time to return to play for athletes with isolated meniscal injuries.

Study Design: Systematic review; Level of evidence, 4.

Methods: A search of the PubMed, EMBASE, and Cochrane electronic databases was conducted to identify studies that reported the time and the rate of return to play in athletes after …

Multimedia Technologies Utilisation As Correlate Of Lecturers’ Teaching Effectiveness In Colleges Of Education In South West, Nigeria., Adesanya Olusegun Oyeleye, Adeyemi Rem I Oluwafemi

Library Philosophy and Practice (e-journal)

The study investigated multimedia technologies utilisation as a correlate of lecturers’ teaching effectiveness in colleges of education in south west, Nigeria. . This is for the purpose of ascertaining the relationship and contribution of multimedia technologies to lecturers’ teaching effectiveness in Nigerian colleges of education. The descriptive research design was adopted, while a multi-stage sampling procedure was used in the study. Stratified sampling technique was used to select colleges of education and simple random sampling method was employed to select lecturers from the selected colleges of education. A total of 862 lecturers (627 males and 235 females) participated in the …

Ucc Minutes, November 17, 2020, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

Vitamin D Levels Affect Survival In A Bcr-Abl Acute Lymphoblastic Leukemia Mouse Model But Do Not Cause Vitamin-Drug Interactions, Kavya Annu

Theses and Dissertations (ETD)

It is a well-established phenomenon that dietary components containing CYP3A inducers or inhibitors if co-administered with drugs that are CYP3A4 substrates lead to marked drug-drug interactions. Because vitamin D is known to regulate intestinal CYP3A expression and gut CYP3A expression plays an important role in pre-systemic metabolism of CYP3A drugs, we determined the impact of vitamin D (VD3) status on systemic exposure and efficacy of chemotherapeutic agents that are CYP3A substrates. We employed VD3 sufficient and deficient mice to perform pharmacokinetics (PK) and anti-leukemic efficacy studies.

First, using hCYP3A4 transgenic mouse model we evaluated the intestinal, hepatic and renal expression …

Model-Based Dose-Exposure-Response Assessment For Lead And Backup Spectinamide In A Mouse Model Of Tuberculosis, Santosh Janardan Wagh

Theses and Dissertations (ETD)

Despite decades of research, tuberculosis remains the oldest pathogen-based disease that is the leading cause of death from a single infectious agent. Among many anti-tubercular therapies under investigation, the semisynthetic compounds spectinamides are a promising novel class of anti-tuberculosis agents. One such lead candidate, spectinamide 1810, and backup spectinamide 1599 have demonstrated excellent efficacy, safety, and drug-like properties in various in vitro and in vivo assessments. The dose-ranging and dose fractionation studies were designed to characterize the dose-exposure-response relationship for lead and backup spectinamide in a mouse model of Mycobacterium tuberculosis infection. In this current study, we used 26 and …

Role Of Cerebral Vasculature And Effect Of Circulating Exosomes In Propagation Of Systemic Inflammatory Responses Into The Central Nervous System, Mahesh Chandra Kodali

Theses and Dissertations (ETD)

Sepsis-associated encephalopathy (SAE) is an acutely progressing brain dysfunction induced by systemic inflammation. The mechanism of initiation of neuroinflammation during SAE, which ultimately leads to delirium and cognitive dysfunction, remains elusive. The goal of this project was to study the molecular events of SAE to capture its onset and progression into the central nervous system (CNS), and further identify the cellular players involved in mediating acute inflammatory signaling. Gene expression profiling on the cerebral vessels isolated from the brains of the mice treated with peripheral lipopolysaccharide (LPS) revealed that the cerebral vasculature responds within minutes to acute systemic inflammation by …

Marvelous Beasts

In Case You Missed It

NOVEMBER 2020

Aquaculture Development Plan For Western Australia: Focusing On The Key Foundations Of Growth - November 2020, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

The Aquaculture Plan has been developed in response to a government commitment and informed by input from industry and the Regional Development Commissions. Consultation on this Aquaculture Plan provided further opportunity for comments and discussions within the aquaculture sector as well as relevant external agencies. A final draft was released on the Department of Primary Industries and Regional Development’s (DPIRD) website for a consultation period, affording the opportunity for public feedback.

The Aquaculture Plan is included and referenced in DPIRD’s Primary Industries Plan.

The development of the Aquaculture Plan has also been informed by the Aquaculture Industry Engagement Consortium (2017), …

Brazilian Regulation Aspects And Their Impact On Costs, Alexandre Berbel, Frederico Zaccaro, Philippe Dos Santos, Rogerio Maldonado

Graduate Student Works

This project analyzes the Brazilian regulation for the airline and the current public data provided by the stakeholders. It intends to scientifically support a possible change in Brazil's existing regulation related to airline responsibilities on passenger accommodation for different types of situations, including ANAC 400 and other ramifications. This project aims to compare the Brazilian law with various regulations adopted in other markets where the rules are created considering different circumstances to define responsibilities for the passenger accommodations. This study will analyze the differences, measuring the impacts that changes could bring in terms of costs for the Airlines. It will …

Gene Selection For Optimal Prediction Of Cell Position In Tissues From Single-Cell Transcriptomics Data., Jovan Tanevski, Thin Nguyen, Buu Truong, Nikos Karaiskos, Mehmet Eren Ahsen, Xinyu Zhang, Chang Shu, Ke Xu, Xiaoyu Liang, Ying Hu, Hoang Vv Pham, Li Xiaomei, Thuc D Le, Adi L Tarca, Gaurav Bhatti, Roberto Romero, Nestoras Karathanasis, Phillipe Loher, Yang Chen, Zhengqing Ouyang, Disheng Mao, Yuping Zhang, Maryam Zand, Jianhua Ruan, Christoph Hafemeister, Peng Qiu, Duc Tran, Tin Nguyen, Attila Gabor, Thomas Yu, Justin Guinney, Enrico Glaab, Roland Krause, Peter Banda, Gustavo Stolovitzky, Nikolaus Rajewsky, Julio Saez-Rodriguez, Pablo Meyer

Computational Medicine Center Faculty Papers

Single-cell RNA-sequencing (scRNAseq) technologies are rapidly evolving. Although very informative, in standard scRNAseq experiments, the spatial organization of the cells in the tissue of origin is lost. Conversely, spatial RNA-seq technologies designed to maintain cell localization have limited throughput and gene coverage. Mapping scRNAseq to genes with spatial information increases coverage while providing spatial location. However, methods to perform such mapping have not yet been benchmarked. To fill this gap, we organized the DREAM Single-Cell Transcriptomics challenge focused on the spatial reconstruction of cells from the Drosophila embryo from scRNAseq data, leveraging as silver standard, genes with in situ hybridization …

Cystatin C Regulates The Cytotoxicity Of Infection-Induced Endothelial-Derived Β-Amyloid, Ron Balczon, Kyle A. Morrow, Silas Leavesley, Michael Francis, Trevor C. Stevens, Ezinne Agwaramgbo, Christopher Williams, Reece P. Stevens, Geri Langham, Sarah Voth, Eugene A. Cioffi, Susan E. Weintraub, Troy Stevens

University Faculty and Staff Publications

Infection of rat pulmonary microvascular endothelial cells with the bacterium Pseudomonas aeruginosa induces the production and release of cytotoxic oligomeric tau and beta amyloid (Aβ). Here, we characterized these cytotoxic amyloids. Cytotoxic behavior and oligomeric tau were partially resistant to digestion with proteinase K, but cytotoxicity was abolished by various denaturants including phenol, diethylpyrocarbonate (DEPC), and 1,1,1,3,3,3-hexafluoro-2-isopropanol (HFIP). Ultracentrifugation for 8 h at 150 000 g was required to remove cytotoxic activity from the supernatant. Ultracentrifugation, DEPC treatment, and immunodepletion using antibodies against Aβ also demonstrated that cytoprotective protein(s) are released from endothelial cells during P. aeruginosa infection. Mass spectrometry …

Eukaryotic Initiation Factor 5a2 (Eif5a2) Contributes To Ovarian Tumor Growth And Metastasis, Guannan Zhao

Theses and Dissertations (ETD)

Ovarian cancer has the highest mortality rate among all gynecological malignancies due to lack of effective biomarkers for early diagnosis. The majority of ovarian cancer patients are already at an advanced stage when diagnosed. In addition, ovarian cancers often become chemoresistant and metastatic, and recur following initial chemotherapy.

Attenuation Of Interferon Responses In The Obese Host And Ramifications For Influenza Virus Evolution, Rebekah Reed Honce

Theses and Dissertations (ETD)

The most insidious pandemic of modern life does not arise from an infectious agent but rather from malnutrition. With its global incidence tripling over the past three decades, obesity is a major public health concern. Obesity’s rising prevalence has also illuminated its impact on communicable diseases. Following the 2009 H1N1 influenza A virus pandemic, obesity was identified as a risk factor for increased disease severity and mortality in infected individuals. Obesity causes a chronic state of meta-inflammation with systemic implications for immunity, including delayed antiviral responses to influenza virus infection, poor recovery, and impaired immunological memory. However, the majority of …

Genetic Variation And Sex Mediate Differential Responses To ∆-9-Tetrahydrocannabinol Among Inbred Mice, Cory Parks

Theses and Dissertations (ETD)

The plant Cannabis sativa has been used by people for both recreational and medicinal use for thousands of years, but scientific investigation of the plant and its components didn’t begin until the early nineteen hundreds when Cannabis components known as phytocannabinoids were characterized and later isolated. In the 1970’s, ∆9-tetrahydrocannabinol (THC) was isolated and recognized as the major constituent responsible for the psychoactive and intoxicating effects associated with consumption of cannabis. This opened the door for intensive research in the field that lead to the discovery of the endogenous cannabinoid system and its associated receptors, effectors of signaling, and biosynthetic …

Trypa-No! Contributes To The Elimination Of Gambiense Human African Trypanosomiasis By Combining Tsetse Control With “Screen, Diagnose And Treat” Using Innovative Tools And Strategies, Joseph Mathu Ndung’U, Alain Boulangé, Albert Picado, Albert Mugenyi, Allan Mortensen, Andrew Hope, Brahim Guihini Mollo, Bruno Bucheton, Charles Wamboga, Charles Waiswa, Dramane Kaba, Enock Matovu, Fabrice Courtin, Gala Garrod, Geoffrey Gimonneau, Georgina Bingham, Hassane Mahamat Hassane, Inaki Tirados, Isabel Saldanha, Jacques Kabore, Jean Baptiste Rayaisse, Jean Mathieu Bart, Jessica Lingley, Johan Esterhuizen, Joshua Longbottom, Justin Pulford, Lingue Kouakou, Lassina Sanogo, Lucas Cunningham, Mamadou Camara, Mathurin Koffi, Michelle Stanton, Mike Lehane, Moise Saa Kagbadouno, Oumou Camara, Paul Bessell, Peka Mallaye, Philippe Solano, Richard Selby, Sophie Dunkley

Department of Entomology: Faculty Publications

Gambiense human African trypanosomiasis (g-HAT) is the chronic form of sleeping sickness caused by Trypanosoma brucei gambiense in West and Central Africa, while Trypanosoma brucei rhodesiense causes an acute form in eastern Africa. g-HAT is targeted for elimination as a public health problem by 2020 and 0 transmission by 2030 [1,2]. Control of g-HAT is largely based on identification and treatment of infected individuals, supplemented by control of the tsetse fly vectors [3]. There has been growing evidence that when both tsetse control and case identification activities are carried out simultaneously in the same geographies, elimination of the disease is …