Digital Commons Network^™

Phylogenetic And Biogeographical History Confirm The Anatolian Origin Of Bornmuellera (Brassicaceae) And Clade Divergence Between Anatolia And The Balkans In The Plio-Pleistocene Transition, Bariş Özüdoğru, Klaus Mummenhoff

Turkish Journal of Botany

Understanding disjunct distribution patterns in the Balkan Peninsula and Anatolia is important in order to reconstruct robust biogeographical hypotheses. This is instrumental in understanding the recolonization patterns of Europe during the Quaternary glaciation/interglaciation periods and the potential role of Anatolia as a refugium. Unfortunately, only a few studies have been conducted to uncover such processes. Here, we used all eight species of the genus Bornmuellera (Brassicaceae) with a scattered distribution in the Balkans and Anatolia to reconstruct its biogeographic history. We applied nuclear internal transcribed spacer (ITS) and plastid trnL-F regions and showed that 1) Bornmuellera is monophyletic and, 2) …

Conformation And Binding Aspects Of Sulfated Carbohydrates By Liquid-State Nmr, William Vignovich

Electronic Theses and Dissertations

Liquid-state NMR has long been an important tool for understanding the conformations and interactions of biomacromolecules. To date these conclusions have primarily been focused upon nucleotides and peptides with little information regarding the conformational structures of carbohydrates. Through the methods described in this manuscript the accurate conformational analysis of a sulfated fucan from Lytechinus variegatus has been assessed. This was achieved through a combination of NOESY spectroscopy and assessment of chemical exchange in hydroxyl protons undergoing fast chemical exchange with excess solvent. This is accomplished through usage of super- cooled H2O: acetone solvent and T1 inversion recovery. This methodology was …

Making The Cut: Nutrition, Hydration, & Performance In Combat Sports, Katharine Halfacre

Electronic Theses and Dissertations

This study investigated nutrition, hydration, supplementation, and body composition in relation to performance among mixed martial arts athletes practicing rapid weight loss. Mixed martial arts athletes practice intentional dehydration and nutritional fasting to achieve rapid weight loss, a practice that can damage health and performance. Male mixed martial arts athletes practicing rapid weight loss participated in the study during a week of competition which was not the same for all athletes. Food/activity journals were collected to assess nutrition, fasting, and supplementation. Urine specific gravity was assessed at baseline, weigh-ins, and endpoint. Body composition and punch velocity were assessed at baseline …

Spatial Context And The Role Of Competition In Oviposition Habitat Selection By Cope’S Grey Treefrog (Hyla Chrysoscelis) And Culex Restuans Mosquitoes, Reed Carroll Scott

Electronic Theses and Dissertations

The Ideal Free Distribution (IFD) is an influential ecological model for predicting distribution of populations. Since its inception, attempts have been made to improve the IFD, including addition of spatial context. Spatial contagion is a newer ecological concept wherein quality of a habitat patch may affect the perception of neighboring patches. Using Cope’s gray treefrog (Hyla chrysoscelis) and Culex mosquitoes (Culex restuans), I conducted a series of outdoor mesocosm experiments to test key predictions of the IFD and address how it interacts with spatial contagion effects. I found some support for the IFD prediction that individual H. chrysoscelis should avoid …

Sperm Storage Reduces The Strength Of The Mate-Finding Allee Effect, María V. Jiménez-Franco, Andrés Giménez, Roberto C. Rodríguez-Caro, Ana Sanz-Aguilar, Francisco Botella, Jose D. Anadon, Thorsten Wiegand, Eva Graciá

Publications and Research

Mate searching is a key component of sexual reproduction that can have important implications for population viability, especially for the mate-finding Allee effect. Interannual sperm storage by females may be an adaptation that potentially attenuates mate limitation, but the demographic consequences of this functional trait have not been studied. Our goal is to assess the effect of female sperm storage durability on the strength of the mate-finding Allee effect and the viability of populations subject to low population density and habitat alteration. We used an individual-based simulation model that incorporates realistic representations of the demographic and spatial processes of our …

Association Of Genetic Risks With Autism Spectrum Disorder And Early Neurodevelopmental Delays Among Children Without Intellectual Disability, Nagahide Takahashi, Taeko Harada, Tomoko Nishimura, Akemi Okamura, Damee Choi, Toshiki Iwabuchi, Hitoshi Kuwabara, Shu Takagai, Yoko Nomura, Nori Takei, Kenji J. Tsuchiya

Publications and Research

IMPORTANCE Autism spectrum disorder (ASD) is highly heritable, and modest contributions of common genetic variants to ASD have been reported. However, the association of genetic risks derived from common risk variants with ASD traits in children from the general population is not clear, and the association of these genetic risks with neurodevelopment in infants has not been well understood.

OBJECTIVE To test whether a polygenic risk score (PRS) for ASD is associated with neurodevelopmental progress at age 18 months and ASD traits at age 6 years among children from the general population.

DESIGN, SETTING, AND PARTICIPANTS In this cohort study, …

Anacreón Castellano, De Francisco De Quevedo, A Coruña, Sielae, 2018. By Elena Gallego Moya And J. David Castro De Castro, Janus, Revista De Estudios Sobre El Siglo De Oro, 9 (2020): 183-190, Adrian Izquierdo

Publications and Research

No abstract provided.

Taking Employment Contracts Seriously, Matthew T. Bodie

Seton Hall Law Review

No abstract provided.

Killing The Cat’S Paw, Sandra F. Sperino

Seton Hall Law Review

No abstract provided.

บทบาทของภาครัฐในการส่งเสริมอุตสาหกรรม: กรณีศึกษาการส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลสาธารณรัฐเกาหลี, ปาลพิมพ์ลดา สุสุรเสริมภูมิ

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยเรื่อง “บทบาทภาครัฐในการส่งเสริมอุตสาหกรรม : กรณีศึกษาการส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลสาธารณรัฐเกาหลี” มีวัตถุประสงค์ในการศึกษาเพื่ออธิบายแนวนโยบายและกลยุทธ์ของรัฐบาลสาธารณรัฐเกาหลีในการดำเนินนโยบายเพื่อส่งเสริมอุตสาหกรรมภาพยนตร์ และวิเคราะห์ผลกระทบจากการดำเนินนโยบายส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลสาธารณรัฐเกาหลีในอุตสาหกรรมภาพยนตร์เกาหลี เพื่อเป็นข้อเสนอแนะเชิงนโยบายให้กับการส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลไทย ซึ่งใช้วิธีการวิจัยเชิงคุณภาพ ด้วยการสัมภาษณ์เชิงลึก และการเก็บรวบรวมข้อมูลจากเอกสารที่เกี่ยวข้อง ผลการศึกษาพบว่า รัฐบาลสาธารณรัฐเกาหลีมีแนวนโยบายในการส่งเสริมอุตสาหกรรมภาพยนตร์เกาหลีคือ “จัดหา ส่งเสริม แต่ไม่ก้าวก่าย” โดยเห็นได้ชัดจากการยกเลิกระบบควบคุมเนื้อหาภาพยนตร์ การอุดหนุนงบประมาณในกระบวนการผลิต และการสนับสนุนในเรื่องการจัดจำหน่าย โดยกลไกสำคัญในการส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลสาธารณรัฐเกาหลีคือ การจัดตั้งหน่วยงานที่มีหน้าที่ในการส่งเสริมอุตสาหกรรมภาพยนตร์โดยเฉพาะ นั่นคือ Korean Film Council (KOFIC ) โดย KOFIC ได้มีการส่งเสริมและสนับสนุนอุตสาหกรรมภาพยนตร์ในหลายด้าน ได้แก่ การสนับสนุนการสร้างภาพยนตร์เกาหลี การสนับสนุนธุรกิจในต่างประเทศ และการวิจัยและการสร้างโครงสร้างพื้นฐาน นอกจากบทบาทของภาครัฐที่ทำให้อุตสาหกรรมภาพยนตร์เกาหลีเติบโตแล้ว ยังมีปัจจัยบริบทแวดล้อมอื่น ๆ คือ ภาคเอกชนและลักษณะนิสัยของคนเกาหลี จากการส่งเสริมอุตสาหกรรมภาพยนตร์ของรัฐบาลเกาหลี ส่งผลให้อุตสาหกรรมภาพยนตร์เกาหลีเติบโตขึ้นอย่างมาก

Association Between Pm2.5 Concentrations And Hospitalization Cases For Schizophrenia And Mood Disorders In Ho Chi Minh City, Vietnam From 2019 To 2020, Do Thi Hoai Thuong

Chulalongkorn University Theses and Dissertations (Chula ETD)

The evidence for adverse effects of ambient particulate matter pollution on mental and behavioral disorders (MBDs) is limited. Until now, few epidemiological studies have focused on this field, especially in developing countries. With the changes in concentrations and sources of air pollution over the past decade in Vietnam lead to high levels of air pollutants, especially particulate matters including PM2.5. Therefore, it is worthwhile to investigate the acute effects of outdoor air pollution on MBDs. However, no Vietnamese study has looked into the short-term effect of PM2.5 on hospitalization for MBDs. To examine the association between PM2.5 and the cases …

'We Were Hoping': The Emmaus Road Encounter As A Novel Approach To Faith-Science Dialogue, Harold A. Laurence V

Seattle Pacific Seminary Theses

This thesis proposes a novel paradigm for faith-science dialogue, drawing a Biblical analogy between two disciples’ Emmaus Road encounter with the risen Jesus (Luke 24:13-35) and contemporary faithful scientists wrestling with narrative conflict between the findings of science and the confession of faith. For science’s reading public, science serves as an alternative mythmaking discourse, whose narratives may indeed conflict with faith. This thesis proposes that theology ought to deploy Biblical preaching to resolve such narrative conflicts. To guide this process, this thesis proposes that Jesus’ two responses to the troubles of the disciples on the road to Emmaus (Luke 24:13-35) …

The Laureate, 19th Edition (2020)

The Laureate

No abstract provided.

Criminal Law As Public Ordering, Alice Ristroph

Faculty Scholarship

No abstract provided.

Pandemic Leadership Failures And Public Health, Gidon Eshel

Animal Sentience

In a plainly worded target article whose sagacity and import can hardly be overstated, Wiebers & Feigin place the recent COVID-19 crisis in historic perspective. They warn us that unless we make sweeping changes the next pandemics are all but preordained. They offer a blueprint for dramatically lowering the likelihood of future pandemics.

Harm, Earth Jurisprudence And Human/Nonhuman Relationships, Tanya Wyatt

Animal Sentience

To prevent the next pandemic and to protect the environment and non-human animals, there needs to be a clear definition of harm and a legal system grounded in Earth Jurisprudence. Drawing on evolutionary principles to redefine harm and to radically alter the legal system to be Earth-centred will help ensure that harmful actions like certain wildlife trade, wildlife trafficking, and intensive farming do not threaten the survival of any life.

A Study On Teacher Candidates’ Questioning Strategies For English Learners Through An Interactive Classroom Simulation, Alex P. Davies Ph.D., Donita Grissom Ph.D., Michele Regalla Ph.D.

Northwest Journal of Teacher Education

This study examines a classroom simulation workshop designed for teacher candidates (TCs) to practice questioning strategies with English learners (ELs) at various English proficiency levels, through the lens of sociocultural theory. Data was collected from an assignment in an ESOL methods course consisting of questions that TCs prepared before the simulation, revised after the simulation, and responses to an open-ended questionnaire. Findings show that TCs made their questions comprehensible for beginner level ELs, however, overextended their question modification to both the intermediate and advanced levels. Implications highlight the importance of practicing questioning strategies that are appropriate for all proficiency levels.

Ground And Aerial Robots For Agricultural Production: Opportunities And Challenges, Santosh Pitla, Sreekala Bajwa, Santosh Bhusal, Tom Brumm, Tami M. Brown-Brandl, Dennis R. Buckmaster, Isabella Condotta, John Fulton, Todd J. Janzen, Manoj Karkee, Mario Lopez, Robert Moorhead, Michael Sama, Leon Schumacher, Scott Shearer, Alex Thomasson

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Crop and animal production techniques have changed significantly over the last century. In the early 1900s, animal power was replaced by tractor power that resulted in tremendous improvements in field productivity, which subsequently laid foundation for mechanized agriculture. While precision agriculture has enabled site-specific management of crop inputs for improved yields and quality, precision livestock farming has boosted efficiencies in animal and dairy industries. By 2020, highly automated systems are employed in crop and animal agriculture to increase input efficiency and agricultural output with reduced adverse impact on the environment. Ground and aerial robots combined with artificial intelligence (AI) techniques …

Functional Analysis Of Glutathione S-Transferase From The Extremophile Halothece Sp. Pcc7418, Chananwat Kortheerakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Glutathione S-transferase (GST) are a set of multifunctional enzymes encoded by large gene families. It has been functionally demonstrated that GSTs play vital roles in cellular detoxification, regulation of redox-dependent process, and stress responses. Although the GST gene family has been extensively studied across taxa, the function of the GST genes in primordial oxygenic phototrophs such as cyanobacteria is poorly understood. In this thesis, GSTs from extremophilic cyanobacterium Halothece sp. PCC7418 (hereafter Halothece GSTs) were identified and functionally characterized. The genome-based analysis showed that there were four GSTs in Halothece 7418 (GST_0647, GST _0729, GST _1478, and GST _3557). Phylogenetic …

Intermodulation Distortions From A Chain Of Coupled Nonlinear Oscillators Near A Hopf Bifurcation, Yanathip Thipmaungprom

Chulalongkorn University Theses and Dissertations (Chula ETD)

The inner ear can produce sounds whose frequencies correspond to linear combinations of the stimulus frequencies, f1 and f2. These sounds, called Distortion Product Otoacoustic Emissions (DPOAEs), can be measured by inserting a microphone into the ear canal. In human, the intensity level of DPOAEs at frequency 2f1-f2 varies significantly with a stimulus frequency and can exhibit a quasi-periodic pattern, a feature termed a DPOAE fine structure. This distinctive characteristic has been generally accepted as a consequence of the interference between two DPOAE signals produced by two spatially separated groups of sensory hair cells, whose characteristic frequencies correspond to the …

The Antiviral Activity Of Lichen Metabolites Against Dengue Virus, Naphat Loeanurit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Dengue fever is one of the mosquito-borne infectious diseases globally. Currently, no specific treatment was established. Depsidones and depsides are one of the most common lichen secondary metabolites produced for the organism’s survival in extreme environments. These compounds have been reported as antivirals against the other virus in Flaviviridae family, hepatitis C virus. In this study, depsidones and depsides were explored for anti-dengue efficacy and cellular toxicity. One depsidone, VK-0014, and two depsides, TT-031 and TT-032, exhibited an anti-DENV2 with effective concentration (EC50) of 17.42 ± 3.21, 2.43 ± 0.19, and 0.91 ± 0.15 µM, respectively. Cytotoxicity concentration (CC50) in …

Determination Of Herbicides In Water Samples By Spectroscopic Techniques, Anna Prukjareonchook

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atrazine and paraquat are widely used to control weeds in the agricultural areas. The residue of herbicides can harm the environment and living things. In this research, nanoporous carbon derived from melamine based polybenzoxazine or NPC-PBZ-m was used as an adsorbent for atrazine and paraquat analysis. NPC-PBZ-m was synthesized by sol-gel and pyrolysis processes. The characteristics of sorbent were investigated by FTIR, BET, XPS, and FE-SEM. For atrazine determination, NPC-PBZ-m pre-concentration column combined with a colorimetric detection based on a Konig’s reaction and HPLC-UV at 222 nm were developed. The parameters affecting the adsorption performance were optimized. The reusability of …

การใช้งานตัวแบบ Agile-Stage-Gate ในกระบวนการพัฒนาผลิตภัณฑ์ใหม่ สำหรับบริษัทสตาร์ทอัพที่มุ่งเน้นพัฒนาเทคโนโลยีด้วยตัวแบบปรับสมดุลของความกดดัน 2 ด้าน, เตชวิทย์ หิริสัจจะ

Chulalongkorn University Theses and Dissertations (Chula ETD)

กระบวนการพัฒนาผลิตภัณฑ์ใหม่หนึ่งที่ได้รับการพิสูจน์ด้วยหลักฐานเชิงประจักษ์ถึงประสิทธิผลของการใช้งาน คือ ตัวแบบ Agile-stage-gate เนื่องด้วยความคล่องตัวในการดำเนินการและการรับมือกับอุปสรรคของโครงการ งานวิจัยก่อนหน้าจำนวนหนึ่งนำเสนอผลเชิงบวกในการใช้งานตัวแบบ Agile-stage-gate ในบริษัทขนาดใหญ่ที่ได้รับการยอมรับในการพัฒนาผลิตภัณฑ์ใหม่ อย่างไรก็ตามในบริบทของบริษัทสตาร์ทอัพที่มุ่งเน้นพัฒนาเทคโนโลยีที่ต้องเผชิญกับความกดดันที่ขัดแย้งกันของความยืดหยุ่นและความสามารถในการคาดการณ์ได้ รวมถึงข้อจำกัดด้านทรัพยากรและระดับความไม่แน่นอนที่สูงกว่าบริษัทที่ได้รับการยอมรับ ดังนั้นการใช้งานตัวแบบ Agile-stage-gate ในบริบทของบริษัทสตาร์ทอัพจำเป็นต้องมีการศึกษาเพิ่มเติมเพื่อพิสูจน์ประสิทธิภาพการใช้งานตัวแบบ งานวิจัยนี้อาศัยการศึกษาวิจัยเชิงคุณภาพตามยาวในบริษัทสตาร์ทอัพกรณีศึกษาในประเทศไทยเพื่อทำความเข้าใจการใช้งานตัวแบบ Agile-stage-gate ซึ่งบริษัทดังกล่าวมีโครงการที่ใช้งานตัวแบบนี้ในกระบวนการพัฒนาผลิตภัณฑ์ใหม่ทั้งที่ดำเนินการได้สำเร็จและไม่สำเร็จ ผู้วิจัยอาศัยการวิจัยเปรียบเทียบในหลายโครงการของบริษัทกรณีศึกษาเพื่อทำความเข้าใจกิจกรรมพื้นฐานที่สามารถทำให้การดำเนินโครงการสำเร็จ รวมถึงการสร้างตัวแบบเชิงกระบวนการเพื่อส่งเสริมการใช้งานตัวแบบ Agile-stage-gate ในการพัฒนาผลิตภัณฑ์ใหม่ในบริบทของบริษัทสตาร์ทอัพด้วยโครงสร้างข้อมูลจากการวิจัย ผลลัพธ์จากงานวิจัยนี้นำเสนอตัวแบบปรับสมดุลของความกดดัน 2 ด้านซึ่งแสดงทั้งความใหม่และความเหมือนในการจัดการโครงการในปัจจุบันเพื่อสนับสนุนการใช้งานตัวแบบ Agile-stage-gate รวมถึงการนำเสนอเครื่องมือและแนวทางเพิ่มเติมในการดำเนินการจากตัวแบบดังกล่าวเพื่อประยุกต์ใช้งานตัวแบบ Agile-stage-gate ในบริบทของบริษัทสตาร์ทอัพที่มุ่งเน้นพัฒนาเทคโนโลยีให้ประสบความสำเร็จ และในส่วนของการนำออกสู่เชิงพาณิชย์ ผู้วิจัยนำเสนอรายงานเส้นทางการขึ้นทะเบียนผลิตภัณฑ์ในประเทศไทยของต้นแบบเครื่องมือแพทย์จากโครงการกรณีศึกษารวมถึงรายการทดสอบที่จำเป็นเพื่อแสดงความสอดคล้องของการพิสูจน์ความปลอดภัยและสมรรถนะการใช้งานของต้นแบบเครื่องมือแพทย์ดังกล่าว

Compositional Modeling: A Classical Imitative Pedagogy For The Modern Era, Robert Harris Jeter

Theses and Dissertations--Music

Students of composition develop two skills simultaneously: craft and creativity. Since students are more naturally inclined to focus on one of these skills over the other, finding the proper balance is an educational challenge. An effective pedagogical system for composition cultivates both of these necessary skills.

Imitation was a preferred pedagogical approach during the Classical period. In his 1848 book School of Practical Composition, Carl Czerny instructs his readers to apply the extensive rules of composition by strictly following a compositional model. Although this methodology lost favor during the nineteenth century, the imitative techniques presented by Czerny are flexible enough …

Melatonin For The Treatment Of Sepsis: The Scientific Rationale, Ruben Manuel Luciano Colunga Biancatelli, Max Berrill, Yassen H. Mohammed, Paul E. Marik

Bioelectrics Publications

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial dysfunction are common features of septic patients that can cause multiorgan failure and death. Melatonin, alongside its traditionally accepted role as the master hormonal regulator of the circadian rhythm, is a promising adjunctive drug for sepsis through its anti-inflammatory, antiapoptotic and powerful antioxidant properties. Several animal models of sepsis have demonstrated that melatonin can prevent multiorgan dysfunction and improve survival through restoring mitochondrial electron transport chain (ETC) …

Impaired Self-Awareness And Brain Injury Outcomes: Comparing The Awareness Questionnaire And Patient Competency Rating Scale In A Post-Acute Rehab Setting, Sitara Shanmugam

PCOM Psychology Dissertations

The aim of the present study was to examine impaired self-awareness among persons with moderate-to-severe brain injuries, and how it related to functional outcomes in a post-acute rehabilitation setting. Specifically, two self-report measures, the Awareness Questionnaire (AQ) and the Patient Competency Rating Scale (PCRS), were used to assess deficits in awareness by comparing the patients’ ratings with the clinicians’ ratings. In addition, the study also explored impaired self-awareness as it related to poorer community reintegration (as measured by the MPAI-4 Participation Index Subscale). Of the 40 participants in this study, 40% of participants were found to have impaired self-awareness (based …

Evaluation Of Recombinant Human Vascular Endothelial Growth Factor Vegf121-Loaded Poly-L-Lactide Microparticles As A Controlled Release Delivery System, Sunil Abraham, Srinivasa Prasad Rangaswamy, Amutha Chinnaiah

Turkish Journal of Biology

Vascular endothelial growth factor A (VEGF-A) is an important growth factor that plays a major role in angiogenesis. With different isoforms distributed in various tissues, the shortest isoform of VEGF-A is VEGF121, one of the physiologically functional variants next to VEGF165. It is well known that VEGF has a shorter half-life, and the stability of the protein must be considered in therapeutic aspects. Poly-l-lactide (PLA) microparticles can release the encapsulated protein in a sustained release mode. In this study, the VEGF121 gene was cloned and expressed in a prokaryotic expression system (Escherichia coli). The recombinant VEGF121 was encapsulated with PLA …

Sex Effect On The Correlation Of Immunoglobulin G Glycosylation With Rheumatoid Arthritis Disease Activity, Altan Ercan

Turkish Journal of Biology

Rheumatoid arthritis (RA) is a chronic autoimmune disease which affects females more than males with a presence of autoantibodies. Immunoglobulin G (IgG) produced by adaptive arm has 2 functional domains, Fc and Fab. The Fc domain binds Fc gamma receptors and C1q proteins of the innate arm. Therefore, the IgG Fc domain serves as a bridge between the innate and adaptive arms and is regulated by an evolutionarily conserved N-glycosylation with variable structures. These glycans are classified as agalactosylated G0, monogalactosylated G1, and digalactosylated G2, which are further modified by core-fucosylation (F) and bisecting N-acetylglucosamine (B) moieties such as G0F …

The Methanolic Extract Of Garcinia Atroviridis (Mega) Reduces Body Weight And Food Intake, And Improves Lipid Profiles By Altering The Lipid Metabolism: A Rat Model, Wai Feng Lim, Suriati Mohd Nasir, Lay Kek Teh, Richard Johari James, Mohd Hafidz Mohd Izhar, Mohd Zaki Salleh

Turkish Journal of Biology

Garcinia species are widely used for their slimming effects via increased fat burning and suppression of satiety. However, scientific evidence for the biological effects of Garcinia atroviridis (GA) is lacking. We investigated the phytochemical composition, safety profiles, and antioxidant and antiobesity effects of methanolic extracts of Garcinia atroviridis (MeGa) in obese female rats. Repeated dose toxicity studies were conducted according to the OECD guidelines. Upon sacrifice, haematological, biochemical, lipid profile, and serum-based metabolomics analyses were performed to evaluate metabolic expression changes and their related pathways. MeGa contains several phytochemical groups and GA fruit acids. MeGa was found to be nontoxic …

Expression Of Soluble, Active, Fluorescently Tagged Hephaestin In Cos And Cho Cell Lines, Eli̇f Si̇bel Aslan, Kenneth N. White, Basharut A. Syed, Kaila S. Srai, Robert W. Evans

Turkish Journal of Biology

Hephaestin (Hp) is a trans-membrane protein, which plays a critical role in intestinal iron absorption. Hp was originally identified as the gene responsible for the phenotype of sex-linked anaemia in the sla mouse. The mutation in the sla protein causes accumulation of dietary iron in duodenal cells, causing severe microcytic hypochromic anaemia. Although mucosal uptake of dietary iron is normal, export from the duodenum is inhibited. Hp is homologous to ceruloplasmin (Cp), a member of the family of multi copper ferroxidases (MCFs) and possesses ferroxidase activity that facilitates iron release from the duodenum and load onto the serum iron transport …