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Articles 20731 - 20760 of 24031
Full-Text Articles in Entire DC Network
Academic Freedom And Accountability At Sda Theological Seminaries, René Gehring
Academic Freedom And Accountability At Sda Theological Seminaries, René Gehring
Journal of the Adventist Theological Society
After a review of the legal basis of academic freedom in some western countries, this article briefly explores the historical background of its emergence and the significance regarding theological research. The reasons for respecting certain limitations given by the church and ways to solve tensions between the religious expectations and possibly diverging research outcomes are dealt with, while acknowledging that certain gray areas remain.
The Doctrine Of Atonement In Communal Contexts, Kelvin Onongha
The Doctrine Of Atonement In Communal Contexts, Kelvin Onongha
Journal of the Adventist Theological Society
The atonement is one of the most crucial of all the Christian doctrines, explaining the death of Christ and its significance to the Christian community. However, the atonement like any other Christian doctrine is only as meaningful as the metaphors employed to communicate this teaching. The majority of the world lives in shame and honor cultures where their concepts of sin and salvation differ from those of Christians. This paper aims at presenting a biblical paradigm for communicating this pivotal doctrine to communal contexts in a manner that makes the gospel translatable to such settings without losing its significance and …
Kaaba & Sanctuary: Qur’Anic And Biblical Cosmic Centers—Ontological And Existential Worldviews, Larry L. Lichtenwalter
Kaaba & Sanctuary: Qur’Anic And Biblical Cosmic Centers—Ontological And Existential Worldviews, Larry L. Lichtenwalter
Journal of the Adventist Theological Society
The Qur’anic Kaaba1 and the Biblical heavenly sanctuary articulate respective cosmic centers with corresponding ontological and existential worldviews. Numerous parallels exist. Each cosmic center presents a paradigmatic system toward an understanding of reality. Each unfolds a view of God which brings significant implications for theology and practice. Each effects worldview reflection and formation. Each indicates the direction of prayer. Each comprises the place of spiritual gathering for the believing community. And, each defines the pathway to salvation, the cleansing of worshipers, the promise of divine blessing and peace, as well as oneness with God. It comes as no surprise that …
Education And Eschatology: Why Theological Education Is Necessary, Jiří Moskala
Education And Eschatology: Why Theological Education Is Necessary, Jiří Moskala
Journal of the Adventist Theological Society
I vividly recall the situation when I was 6 years old. It was a sunny Sabbath morning during the summer, and I was going to church. On the way, I met an elder, a very fine man admired by many who asked me what my plans were for the future. With great enthusiasm, I told him that in three months I would enroll in school for my first class. He turned to me, paused, and said: “Jiří, you probably will not even go to school, because Jesus will come soon,” and then he added, “and certainly you will not finish …
Humans Of St. Norbert: Madeline Pamperin ’20, Madeline Pamperin
Humans Of St. Norbert: Madeline Pamperin ’20, Madeline Pamperin
Humans of St. Norbert
Based on the phenomenon "Humans of New York," Humans of St. Norbert mirrors the photoblog, featuring photos and interviews of people on campus.
A Stretch Too Far: Flaws In Comparing Slavery And The Death Penalty, Michael Conklin
A Stretch Too Far: Flaws In Comparing Slavery And The Death Penalty, Michael Conklin
Denver Law Review Forum
No abstract provided.
Illiberalism And Islam, Aziz Z. Huq
Illiberalism And Islam, Aziz Z. Huq
Public Law and Legal Theory Working Papers
This chapter analyzes the role of anti-Islam and anti-Muslim discourse in North American and European ‘illiberal’ parties, movements, and ideologies. Its first aim is to situate those deployments in a longer history. Occidental engagements with Islam and Muslims, including anti-Islamic tropes, long predate the emergence of liberalism, let along illiberalism. It should not be a surprise that liberalism as it emerged in the nineteenth century partook of such ideas. Contra some theorists, however, I argue that there is no strong evidence that anti-Islam was constitutive of liberal theory or early practice. Rather, it was in the second half of the …
Walleye Sander Vitreus Visceral Fat Accumulation, Cole Daleiden, Seth Renner
Walleye Sander Vitreus Visceral Fat Accumulation, Cole Daleiden, Seth Renner
Journal of Earth and Life Science
For ectothermic species, proper lipid retention is critical to surviving in regions with limited growing seasons. Visceral fat is the dominant form of this energy storage in fish. Build up and depletion of these lipids occur seasonally as activity levels change throughout winter and spring. Due to this annual pattern, the purpose of this study is to determine a trend in the amount of visceral fat Walleye Sander vitreus accumulate in a time of year when metabolic rates are low and transition into the spawning process has yet to occur. Angling was the method of capture conducted during the months …
A Sky Too Close To The Ground: Stories, Jessica Koch
A Sky Too Close To The Ground: Stories, Jessica Koch
Stonecoast MFA Theses and Capstones
A Sky Too Close to the Ground: Stories is a collection of speculative fiction short stories that engage with the theme of lost and found connections to the self and to others. This collection explores grief, heartbreak, joy, closure and madness through the eyes of women, men, children, and animals in settings from the fantastic to the mundane. Each story presents this theme in a distinct way with characters that interact with their own loss or gain uniquely. The collection focuses on the human psychology of the narrative while weaving in speculative elements to emphasize and create a deeper understanding …
A Story To Tell… How To Integrate The Three Modes Of Communication Through A Story Time Program In French, Frederique Grim
A Story To Tell… How To Integrate The Three Modes Of Communication Through A Story Time Program In French, Frederique Grim
The Coastal Review
Bilingual story time programs found in local community libraries not only benefit children, they can also serve a need for L2 college students: the development of their communicative skills in an authentic environment. In addition to linguistic benefits, experiential learning has proven to prepare students for real-world skills, such as networking, mock professional experience and a sense of community engagement. This paper recounts how a world language story time program supports L2 learners’ three modes of communication, as articulated by ACTFL, and necessary for language development. Based on students’ perceptions, this study highlights their increase in motivation and confidence in …
Perfluorooctanesulfonic Acid (Pfos) As A Potential Risk Factor For Late-Onset Alzheimer’S Disease, Veronia Basaly
Perfluorooctanesulfonic Acid (Pfos) As A Potential Risk Factor For Late-Onset Alzheimer’S Disease, Veronia Basaly
Open Access Master's Theses
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for about 60 to 80% of dementia cases worldwide. AD is characterized by two important physiological features: extracellular senile plaques consisting of β-amyloid (Aβ) peptide that is cleaved from a larger protein called the amyloid precursor protein (APP), and intracellular neurofibrillary tangles (NFTs) containing hyperphosphorylated tau protein. The pathogenesis of sporadic or late-onset AD (LOAD) which represents 95% of the cases appears to not be heritable and may be related to epigenetic programming and environmental factors acquired earlier in life. Apolipoprotein allele 4 (ApoE4) protein is encoded by the ApoE …
Influence Of Pfas On The Thermodynamic Membrane Properties And Growth Of A. Borkumensis, Aleksandra Naumann
Influence Of Pfas On The Thermodynamic Membrane Properties And Growth Of A. Borkumensis, Aleksandra Naumann
Open Access Master's Theses
Poly- and Perfluoroalkyl substances (PFAS) are a group of emerging contaminants which are persistent in nature and hazardous for living organisms. They have an anthropogenic origin and have unique properties which have the disadvantage of bioaccumulating in organisms.
This work aims at the investigation of the influence of different relevant PFAS on the membrane properties of A. borkumensis. This information is one important piece on the way to evaluate the overall response of the bacterium in the presence of these molecules. First, the lipids were extracted with a solvent-based method. Afterwards, they were spread at an air-water interface within …
How Landscape Change Affects Commercial And Recreational Fishermen’S Perceptions And Place Meanings, Talya Syvann Ten Brink
How Landscape Change Affects Commercial And Recreational Fishermen’S Perceptions And Place Meanings, Talya Syvann Ten Brink
Open Access Dissertations
It is critical to plan for environmental change in order to mitigate its adverse effects on human wellbeing. This series of manuscripts examines the impacts of landscape change on commercial and recreational fishermen. Each manuscript provides a unique perspective on place meaning and place change. Using a mixed methods approach, data were collected and analyzed on fishermen’s perceptions of familiar places and on the changes that these places undergo. The first manuscript investigates the impact of offshore wind farms on commercial and recreational fishermen, using the first offshore wind farm in North America – the Block Island Wind Farm (Rhode …
Deep Learning For Data-Driven Decision-Making, Zhiqiang Wan
Deep Learning For Data-Driven Decision-Making, Zhiqiang Wan
Open Access Dissertations
As we are entering the big data era, data are becoming high-volume, complex, and heterogeneous. Nowadays, almost every field and sector of the modern society is being impacted by big data, ranging from energy system to health care, and from business to government. The excessive amount of data contains potential and highly useful values. Extracting values from these data and utilize it to support the decision-making process is of paramount importance to improve productivity in business and enhance the well-being of our society. However, data-driven decision-making also arises with many challenges, such as feature selection, data fusion, and real-time decision-making. …
Through The Lens Of Restorative Justice: A Re-Humanizing, Susan Abraham
Through The Lens Of Restorative Justice: A Re-Humanizing, Susan Abraham
NYLS Law Review
No abstract provided.
The Constitutionality Of The Self-Pardon And Its Compatibility With Lockean Prerogative, Michael Kelley
The Constitutionality Of The Self-Pardon And Its Compatibility With Lockean Prerogative, Michael Kelley
NYLS Law Review
No abstract provided.
The Danger Of Dissent: A Century Of Targeting Immigrants, Lenni B. Benson
The Danger Of Dissent: A Century Of Targeting Immigrants, Lenni B. Benson
NYLS Law Review
No abstract provided.
Salcedo V. Hanna, James Mishan
The Monster In The Corner Of The Map: Russian Visitors Describe Nature On Sakhalin Island (1850-1905), Sharyl Corrado
The Monster In The Corner Of The Map: Russian Visitors Describe Nature On Sakhalin Island (1850-1905), Sharyl Corrado
All Faculty Open Access Publications
This article examines evolving constructions of nature on Sakhalin Island in late imperial Russia, emphasising changing Russian views of not only the island, but of science, modernisation, mankind's power over nature and the borders of the empire. From a European land of plenty in the 1850s, welcoming to its Russian visitors, after a quarter-century of penal colonisation, the island had become a monster devouring its prey. This article argues that contradictory and evolving descriptions of Sakhalin's nature reflect tensions Russians faced in a modernising world, as they questioned the relationship between mankind and nature; the reliability of science; and the …
Separating Rope Strands: An Unraveling Of Shame In Gay Men, Chad Allen Lazzari
Separating Rope Strands: An Unraveling Of Shame In Gay Men, Chad Allen Lazzari
Antioch University Dissertations & Theses
This theoretical dissertation uses self psychology, Lacanian theory, and neuropsychoanalysis to explore shame in gay men and formulate an integrative understanding for how this master affect effects self and psyche for same-sex attracted men. Brief introductions to the theories used are provided with links to existing scholarship that informs theoretical leanings. A scholarly case is made for the significance of understanding the origin and lifecycle of shame, as well the importance of differentiating between early relational trauma shame (understood as an “inside out” experience), and a later, socially informed “outside in” experience. An argument is made for how shame “attaches” …
การแปลบทร้อยกรองอิสระจากหนังสือเรื่อง Ceremony ของ Leslie Marmon Silko, นิดา สุสัณฐิตพงษ์
การแปลบทร้อยกรองอิสระจากหนังสือเรื่อง Ceremony ของ Leslie Marmon Silko, นิดา สุสัณฐิตพงษ์
Chulalongkorn University Theses and Dissertations (Chula ETD)
สารนิพนธ์ฉบับนี้มุ่งศึกษาการแปลบทร้อยกรองจากภาษาต่างประเทศเป็นภาษาไทย ซึ่งผู้วิจัยได้หยิบยกบทร้อยกรองอิสระจากหนังสือเรื่อง Ceremony ของ Leslie Marmon Silko มาเป็นกรณีศึกษา โดยมีวัตถุประสงค์เพื่อศึกษาทฤษฎีการแปลและแนวทางการแปลต่าง ๆ ที่เกี่ยวข้อง ตลอดจนแนวทางการวิเคราะห์ตัวบทประเภทบทร้อยกรองอิสระซึ่งมีลักษณะเป็นวรรณกรรมมุขปาฐะ ควบคู่ไปกับการศึกษาประวัติศาสตร์ วัฒนธรรม ภาษาถิ่นและความเชื่อของชนพื้นเมืองอเมริกันอินเดียน เพื่อให้สามารถแปลส่วนหนึ่งของตัวบทที่คัดสรรจากภาษาอังกฤษเป็นภาษาไทยได้อย่างเหมาะสม สำหรับแนวทางการวิเคราะห์ตัวบท ผู้วิจัยได้เลือกใช้แนวทางการวิจารณ์วรรณกรรมอเมริกันร่วมสมัยผ่านมุมมองวรรณกรรมเชิงนิเวศ ของดารินทร์ ประดิษฐทัศนีย์ เพื่อวิเคราะห์ประเด็นปัญหาสิ่งแวดล้อม รวมถึงความสัมพันธ์ของมนุษย์และธรรมชาติที่ได้ถ่ายทอดผ่านเนื้อหาและกลวิธีการประพันธ์ นอกเหนือจากนั้น ผู้วิจัยยังได้ใช้ประยุกต์ใช้แนวทางการวิเคราะห์องค์ประกอบแปดประการของกวีนิพนธ์ ของจอห์น แมกเร เพื่อวิเคราะห์ลักษณะเฉพาะและรูปแบบการประพันธ์ของบทร้อยกรองแต่ละบท ในส่วนของแนวทางการถ่ายทอดบทร้อยกรองอิสระจากภาษาอังกฤษเป็นภาษาไทย ผู้วิจัยได้เลือกใช้กลวิธีการแปลแบบตีความตามแนวทางการแปลกวีนิพนธ์ของอังเดร เลอเฟอแวร์ ควบคู่ไปกับการประยุกต์ใช้รูปแบบและลักษณะเฉพาะของวรรณกรรมมุขปาฐะที่พบในวัฒนธรรมไทย โดยมีจุดประสงค์ที่จะถ่ายทอดบทร้อยกรองอิสระซึ่งสามารถรักษาความหมายได้อย่างครบถ้วนและสามารถสร้างผลกระทบทางอารมณ์แก่ผู้อ่านได้อย่างทัดเทียมและสอดคล้องกับหน้าที่ของตัวบทต้นฉบับ
นวัตกรรมการสร้างสรรค์ตราสินค้าเครื่องแต่งกายบุรุษด้วยการเพิ่มความเงาของสีเพ้นท์ผ้าจากธรรมชาติ สำหรับกลุ่มเจนเดอร์ฟลูอิด (Gender-Fluid) โดยใช้แนวคิดความหลากหลายทางวัฒนธรรมในกรุงเทพมหานคร, อรกานต์ ผดุงวัฒนโรจน์
นวัตกรรมการสร้างสรรค์ตราสินค้าเครื่องแต่งกายบุรุษด้วยการเพิ่มความเงาของสีเพ้นท์ผ้าจากธรรมชาติ สำหรับกลุ่มเจนเดอร์ฟลูอิด (Gender-Fluid) โดยใช้แนวคิดความหลากหลายทางวัฒนธรรมในกรุงเทพมหานคร, อรกานต์ ผดุงวัฒนโรจน์
Chulalongkorn University Theses and Dissertations (Chula ETD)
นวัตกรรมการสร้างสรรค์ตราสินค้าเครื่องแต่งกายบุรุษด้วยนวัตกรรมการเพิ่มความเงาของสีเพ้นท์ผ้าจากธรรมชาติ สำหรับกลุ่มเจนเดอร์ฟลูอิด (Gender-Fluid) โดยใช้แนวคิดความหลากหลายทางวัฒนธรรมในเขตจังหวัดกรุงเทพมหานคร เป็นการวิจัยเพื่อหาแนวทางการออกแบบสินค้าสำหรับกลุ่มเป้าหมายใหม่ที่กำลังเป็นกระแสในปัจจุบันจนถึงอนาคต โดยมีวัตถุประสงค์เพื่ออธิบายถึงแนวทางการออกแบบตามแนวคิดความหลากหลายทางวัฒนธรรมในเขตจังหวัดกรุงเทพมหานครและนวัตกรรมการเพิ่มความเงาจากสีเพ้นท์ผ้ารับเบอร์เบส คัลเลอร์ (Rubber-Based Color) โดยใช้กระบวนการวิจัยเชิงคุณภาพและเชิงปริมาณควบคู่กับกระบวนการออกแบบสร้างสรรค์ เริ่มตั้งแต่การศึกษากลุ่มเป้าหมาย กลุ่มเจนเดอร์ฟลูอิด (Gender-Fluid) ถึงพฤติกรรมการบริโภคสินค้า ช่วงอายุ ความสนใจการตลาดและรายได้ เพื่อสร้างความเข้าใจในกลุ่มเป้าหมายและช่องว่างทางการตลาดทั้งต่างประเทศและในประเทศ ผู้วิจัยมีเครื่องมือที่ใช้ในการวิจัยได้แก่ แบบสอบถามกลุ่มผู้บริโภค ที่ผู้วิจัยสร้างและพัฒนาขึ้น และกลุ่มเป้าหมายเจเนอเรชั่นวายจำนวน 50 คน ผลจากการวิจัยพบว่า การสร้างสรรค์เสื้อผ้าเป็นอัตลักษณ์ตราสินค้าเพื่อตอบสนองความต้องการทางแฟชั่นของกลุ่มผู้บริโภคเจเนอเรชั่นวาย โอกาสการใช้สอยในรูปแบบสังสรรค์กึ่งทำงาน (Party Business) และพฤติกรรมการบริโภคสินค้าของกลุ่มเจนเดอร์ฟลูอิด (Gender-Fluid) สามารถประยุกต์ใช้เพื่อตอบสนองกับความต้องการของกลุ่มผู้บริโภค ช่องว่างทางการตลาด สู่การสร้างสรรค์ตราสินค้าแฟชั่นได้ในอนาคต
Assessing The Impact Of China's Fts's On Trade Creation And Trade Diversion, Bangchu Qiu
Assessing The Impact Of China's Fts's On Trade Creation And Trade Diversion, Bangchu Qiu
Chulalongkorn University Theses and Dissertations (Chula ETD)
This paper estimates trade creation and trade diversion effects of China's effective free trade agreements (FTAs) as of 2019. The annual trade data used in this study cover 32 economies with 25-year span (1995-2019). Using gravity type of model, trade creation and trade creation effects are estimated by applying ordinary least square (OLS) and Poisson Pseudo-Maximum Likelihood (PPML) techniques with various fixed effects. PPML is applied to deal with heteroscedasticity problem. The results show a pure trade creation effect of ACFTA and a pure trade contraction effect of CPFTA in the time fixed model. In the time & pair fixed …
Designing Multimodal Feedback Experiences, Dan Martin
Designing Multimodal Feedback Experiences, Dan Martin
English Faculty Scholarship
In higher education, feedback is an effective but underappreciated teaching tool that expands students’ opportunities for learning. Students need more formative feedback that can lead to dialogic experiences, and they need more feedback experiences in different mediums and modes. Providing students with multimodal feedback that is formative may lead to more dialogic experiences for students and improve their learning. Multimodal feedback experiences benefit all students, including those from diverse and disabled communities. This paper examines some of the advantages and limitations of written, audio, and video feedback and argues that feedback that is primarily formative and delivered using multiple modes …
California Cannabis Regulations And The Federal Food, Drug & Cosmetic Act: A Product Liability Perspective Of Edible Cannabis, Alexis Lazzeri
California Cannabis Regulations And The Federal Food, Drug & Cosmetic Act: A Product Liability Perspective Of Edible Cannabis, Alexis Lazzeri
UC Law Business Journal
From the passage of Proposition 215 to present day, California’s cannabis industry has transformed from access solely for medical patients to a nearly three billion dollar a year industry with legal medicinal and adult-use consumption. With this rise in accessibility, edible cannabis products are being consumed more than ever. “Edibles” are food and drink products infused with cannabis, a mix of THC (i.e., delta 9 - tetrahydrocannabinol) and CBD (i.e., cannabidiol)—with varying levels of each, depending on the desired effect. CBD is a non-intoxicating compound often used to treat physical ailments and chronic conditions, while THC delivers a euphoric high. …
The Impact Of Climate Change On Cultural Security, Dominika Krupocin, Jesse Krupocin
The Impact Of Climate Change On Cultural Security, Dominika Krupocin, Jesse Krupocin
Journal of Strategic Security
Climate change is one of the greatest challenges and most pressing issues faced by humanity in the modern era. Extreme weather events, changes to world ecosystems, species extinction, disruption of animal and human migration, resource shortages, socio-economic concerns, outbreaks and pandemics, as well as domestic and international conflicts represent only a few select potential climate change consequences. Regrettably, when considering the issues pertinent to climate change, one of the oft-overlooked areas is cultural security. Rising sea levels will lead to some of the world’s islands and coastal cities essentially being erased from Earth, resulting in the destruction, and possibly even …
Hspa12a Unstabilizes Cd147 To Inhibit Lactate Export And Migration In Human Renal Cell Carcinoma, Xinxu Min, Xiaojin Zhang, Yunfan Li, Xiaofei Cao, Hao Cheng, Yuehua Li, Chuanfu Li, Qiuyue Kong, Qian Mao, Peipei Peng, Yan Ni, Jingjin Li, Yulian Duan, Li Liu, Zhengnian Ding
Hspa12a Unstabilizes Cd147 To Inhibit Lactate Export And Migration In Human Renal Cell Carcinoma, Xinxu Min, Xiaojin Zhang, Yunfan Li, Xiaofei Cao, Hao Cheng, Yuehua Li, Chuanfu Li, Qiuyue Kong, Qian Mao, Peipei Peng, Yan Ni, Jingjin Li, Yulian Duan, Li Liu, Zhengnian Ding
ETSU Faculty Works
This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. Background: Metastasis accounts for 90% of cancer-associated mortality in patients with renal cell carcinoma (RCC). However, the clinical management of RCC metastasis is challenging. Lactate export is known to play an important role in cancer cell migration. This study investigated the role of heat shock protein A12A (HSPA12A) in RCC migration. Methods: HSPA12A expression was examined in 82 pairs of matched RCC tumors and corresponding normal kidney tissues from patients by immunoblotting and immunofluorescence analyses. The …
A Non-Canonical Role For P27Kip1 In Restricting Proliferation Of Corneal Endothelial Cells During Development, Dennis M. Defoe, Huiying Rao, David J. Harris, Preston D. Moore, Jan Brocher, Theresa A. Harrison
A Non-Canonical Role For P27Kip1 In Restricting Proliferation Of Corneal Endothelial Cells During Development, Dennis M. Defoe, Huiying Rao, David J. Harris, Preston D. Moore, Jan Brocher, Theresa A. Harrison
ETSU Faculty Works
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The cell cycle regulator p27Kip1 is a critical factor controlling cell number in many lineages. While its anti-proliferative effects are well-established, the extent to which this is a result of its function as a cyclin-dependent kinase (CDK) inhibitor or through other known molecular interactions is not clear. To genetically dissect its role in the developing corneal endothelium, we examined mice harboring two loss-of-function alleles, a null …
Mesowear Analysis Of The Tapirus Pplkensis Population From The Gray Fossil Site, Tennessee, Usa, Julia A. Schap, Joshua X. Samuels
Mesowear Analysis Of The Tapirus Pplkensis Population From The Gray Fossil Site, Tennessee, Usa, Julia A. Schap, Joshua X. Samuels
ETSU Faculty Works
Various methods exist for measuring and analyzing dental wear patterns in mam-mals, and these patterns have been extensively studied in ungulates. Mesowear has proven useful as a method to compare large numbers of individuals, particularly fossil individuals, observe trends through time or between groups, and estimate paleoenvi-ronmental conditions. Levels of attrition (tooth-on-tooth wear) and abrasion (tooth-on-food wear) can be readily compared by observing the shape of the cusp and relative crown height of the tooth. This study uses a modified method of mesowear analysis, examining actual cusp angles of the population of Tapirus polkensis from the Gray Fossil Site, a …
Covid-19: Proposing A Ketone-Based Metabolic Therapy As A Treatment To Blunt The Cytokine Storm, Patrick C. Bradshaw, William A. Seeds, Alexandra C. Miller, Vikrant R. Mahajan, William M. Curtis
Covid-19: Proposing A Ketone-Based Metabolic Therapy As A Treatment To Blunt The Cytokine Storm, Patrick C. Bradshaw, William A. Seeds, Alexandra C. Miller, Vikrant R. Mahajan, William M. Curtis
ETSU Faculty Works
Human SARS-CoV-2 infection is characterized by a high mortality rate due to some patients developing a large innate immune response associated with a cytokine storm and acute respiratory distress syndrome (ARDS). This is characterized at the molecular level by decreased energy metabolism, altered redox state, oxidative damage, and cell death. Therapies that increase levels of (R)-beta-hydroxybutyrate (R-BHB), such as the ketogenic diet or consuming exogenous ketones, should restore altered energy metabolism and redox state. R-BHB activates anti-inflammatory GPR109A signaling and inhibits the NLRP3 inflammasome and histone deacetylases, while a ketogenic diet has been shown to protect mice from influenza virus …