Digital Commons Network^™

Ii. Contemplation And Fine Wine: Tasting With Saintsbury, Schopenhauer, And Pater, Charles S. Taylor

Wine Journey: Tasting Dwelling Learning at The Kitchen Table

One never knows when it will happen. I went to my cellar to choose an accompaniment for a chestnut soufflé and a 1995 Domaine Huet Vouvray Clos du Bourg Demi-Sec returned with me . Before opening that wine, I had a set of informed questions...

The Role Of The Chinese Communist Party In The Covid-19 Crisis, Matthew Farrell

Management Faculty Publications

The Chinese Communist Party (CCP) has received plaudits from international press and organizations for their handling of the COVID-19 crisis, with some describing it as a win for China in terms of propaganda. In this essay, I explore an alternative view: That the CCP is responsible for the origin and extent of the pandemic, and that much of their perceived altruism is carefully disguised opportunism and propaganda. Facts are drawn from scholarly work and the popular press to support my arguments. This essay carries strong implications for interpretation of recent events.

The Legal Envelope Theorem, David A. Weisbach, Daniel J. Hemel

Public Law and Legal Theory Working Papers

Non-tax legal rules regulating the workplace, the 6inancial sector, real property, and many other areas affect the ability of governments to collect revenues and provide public goods. Yet tax-collection considerations rarely enter into economic analyses of non-tax legal rules. Usually, tax-collection concerns are shunted aside to separate studies (and separate law-school courses) rather than being integrated into debates in non-tax spheres. This separation between non-tax legal rules and tax-collection considerations bears signi6icant negative consequences for the ability of law and economics to generate descriptively accurate and normatively attractive accounts of important non-tax legal questions.

This Article takes a step toward …

Sizing Up Categories, Lee Anne Fennell

Public Law and Legal Theory Working Papers

Categories intentionally create discontinuities. By breaking the world up into cognizable chunks, they simplify the information environment. But the signals they provide may be inaccurate or scrambled by strategic behavior. This Article considers how law might approach the problem of optimal categorization, given the role of categories in managing and transmitting information. It proceeds from the observation that high categorization costs can be addressed through two opposite strategies—making classifications more fine-grained (splitting), and making classifications more encompassing (lumping). Although continuizing and other forms of splitting offer intuitive answers to inaccurate classification and gaming along category lines, lumping is sometimes a …

Property As The Law Of Complements, Lee Anne Fennell

Public Law and Legal Theory Working Papers

Resources often produce more value in combination than they do separately: think of segments of a highway or parts of a machine. I argue that property’s defining purpose is to group together complements, and that property law and theory should focus on identifying and realizing valuable bundles of resources. While some complementarities align with traditional asset boundaries and can be protected by exclusion rights, realizing others requires crossing or eschewing boundaries to recombine resources in ways that further larger social, economic, or ecological objectives. The gains associated with the entrenching and excluding functions of property thus vie with the gains …

Evaluating Historical Paradigms Of Sterility In Perinatal Microbiology And Ramifications For Pregnancy Outcomes, Jonathan Greenberg

Wayne State University Dissertations

Next-generation sequencing technologies, especially 16S rRNA gene and metagenomic sequencing have allowed investigations of low microbial biomass tissues of the human body. While these sequencing methodologies have provided large amounts of reliable data for higher microbial biomass sites, such as the mouth, intestine, and vagina, tissues of low microbial biomass sites are subject to specific caveats that were not appropriately considered in early investigations of these sites. Low microbial biomass sites of particular interest have included those of the reproductive and urinary systems. Utilization of DNA sequencing methodologies have allowed researchers to challenge existing paradigms of sterility around these sites …

Hormonal Regulation Of Glycine Decarboxylase And Its Metabolic Outcomes, Ruta Milind Jog

Wayne State University Dissertations

The amino acid glycine is involved in generation of multiple critical metabolites including glutathione, heme, and creatinine. Interestingly, in both humans and rodents, circulating glycine levels are significantly reduced in obesity, glucose intolerance, type II diabetes and non-alcoholic fatty liver disease. The glycine cleavage system is the predominant glycine degradation pathway in humans. The rate-limiting enzyme of glycine cleavage system is glycine decarboxylase (GLDC), and loss-of-function mutations of GLDC cause hyperglycinemia. Here, we show that GLDC gene expression is upregulated in livers of mouse models of diabetes and diet-induced obesity as well as in the fasted state in normal animals. …

A Field Study Of Bioaccessible Lead In Detroit Soils: Insight Into The Effectiveness Of Phosphate-Based Lead Sequestration, Sabrina R. Good

Wayne State University Theses

Historical and contemporary use of lead (Pb) in gasoline, paints, and industry have caused lead to be ubiquitous in the urban soil environment, disproportionately affecting low-income minority children. As soil is a major exposure pathway for children, an effective remediation technique for lead-contaminated soil is urgently needed. Common remediation techniques, such as excavation or soil capping, are expensive and environmentally destructive, especially on a city-wide residential basis. Decreasing the bioavailability of lead, or the fraction which is retained by the human body, may be a more economically and environmentally conscious option for remediating lead in urban environments.

Research has demonstrated …

Findable, Impactful, Citable, Usable, Sustainable (Ficus): A Heuristic For Authors Of Digital Publishing Projects, Nicky Agate, Cheryl E. Ball, Alison Belan, Monica Mccormick, Joshua Neds-Fox

Library Scholarly Publications

We came together in Spring 2018 at a two-day think tank hosted by Duke University Libraries and supported by The Andrew W. Mellon Foundation, with dozens of other librarians, publishers, and scholarly communication stakeholders, to work on the question of sustainably publishing large digital projects. The outcome of that discussion turned into an extended project at TriangleSCI 2018 and culminated in the heuristic presented here.The heuristic can be used as a checklist to help authors (and their project team) assess their needs when it comes to making their digital projects findable, impactful, citable, usable, and sustainable (creating the acronym FICUS).

Fiery Fast Teamwork, Belen Jurado

KUCC -- Kutztown University Composition Conference

Guayguil, Ecuador -- New Year's celebration; Ecuador - Social life and customs.

Synthesis Of Bradyrhizose And The Equatorial Glycosides Of 3-Deoxygenation-D-Mango-Oct-2-Ulosonic Acid, Philemon O. Ngoje

Wayne State University Dissertations

ABSTRACT

SYNTHESIS OF BRADYRHIZOSE AND THE EQUATORIAL GLYCOSIDES OF 3- DEOXY-D-MANNO-OCT-2-ULOSONIC ACID

Chapter one provides a general view on the background to the research in two parts. The first part begins with an introduction on the significance of the lectin-carbohydrate interactions in leguminous plants. Then the structure and role of O-antigen lipopolysaccharides in the symbiotic nitrogen cycle, and the mechanism and significance of the cycle in leguminous plants growth are introduced. The role, isolation and characterization of bradyrhizose are also introduced; and the previous syntheses of bradyhizose and of related bicyclic compounds presented.

The second part of chapter one starts …

Constitutional Discourse And The Rhetoric Of Treason, J. Richard Broughton

UC Law Constitutional Quarterly

This Article asserts that treason talk is a form of constitutional discourse. Further, the Article explains that although treason remains a crime worth taking seriously in American criminal and constitutional law, colloquial invocations of treason have the potential to undermine treason’s seriousness and erode its constitutional and historical foundations, as well as diminish an appreciation of its limits. That is particularly true when treason is invoked by a sitting president, whose unique role in constitutional government—and potential to influence criminal prosecutions— requires special caution with respect to public rhetoric about treason. This Article then cites two specific and complicated areas …

Acute Physiological Response By The Plethodontid Salamander Eurycea Cirrigera (Southern Two-Lined Salamander) To Predation Stress From Alarm Chemicals And Predator Kairomones, G A. Marvin

Biology

Plethodontid salamanders may reduce predation risk via behavioral responses to predator kairomones and alarm chemicals from injured salamanders. However, it not known whether such predator cues prompt acute physiological responses, which may enhance arousal and the physical ability to escape from a predator. I examined whether predator chemical cues elicit an acute cardiac response in Eurycea cirrigera (Green, 1831) (Southern Two-lined Salamander). I compared heart rates before and after exposure to the odor of the large predatory Pseudotriton ruber (Sonnini de Manoncourt and Latreille, 1801) (Red Salamander) and exposure to alarm chemicals from homogenized skin of conspecifics. For two controls, …

Theoretical Perspectives Of The Baltimore Ecosystem Study: Conceptual Evolution In A Social–Ecological Research Project, Steward T. A. Pickett, Mary L. Cadenasso, Matthew E. Baker, Lawrence E. Band, Christopher G. Boone, Geoffrey L. Buckley, Peter M. Groffman, J. Morgan Grove, Elena G. Irwin, Sujay S. Kaushal, Shannon L. Ladeau, Andrew J. Miller, Charles H. Nilon, Michele Romolini, Emma J. Rosi, Christopher M. Swan, Katalin Szlavecz

Center for Urban Resilience Scholarship

The Earth’s population will become more than 80% urban during this century. This threshold is often regarded as sufficient justification for pursuing urban ecology. However, pursuit has primarily focused on building empirical richness, and urban ecology theory is rarely discussed. The Baltimore Ecosystem Study (BES) has been grounded in theory since its inception and its two decades of data collection have stimulated progress toward comprehensive urban theory. Emerging urban ecology theory integrates biology, physical sciences, social sciences, and urban design, probes interdisciplinary frontiers while being founded on textbook disciplinary theories, and accommodates surprising empirical results. Theoretical growth in urban ecology …

Humanity’S Best Friend: A Dog-Centric Approach To Addressing Global Challenges, Naomi Sykes, Piers Beirne, Alexandra Horowitz, Ione Jones, Linda Kalof, Elinor Karlsson, Tammie King, Howard Litwak, Robbie A. Mcdonald, Luke John Murphy, Neil Pemberton, Daniel Promislow, Andrew Rowan, Peter W. Stahl, Jamshid Tehrani, Clive D. L. Wynne, Eric G. Strauss, Greger Larson

Center for Urban Resilience Scholarship

No other animal has a closer mutualistic relationship with humans than the dog (Canis familiaris). Domesticated from the Eurasian grey wolf (Canis lupus), dogs have evolved alongside humans over millennia in a relationship that has transformed dogs and the environments in which humans and dogs have co-inhabited. The story of the dog is the story of recent humanity, in all its biological and cultural complexity. By exploring human-dog-environment interactions throughout time and space, it is possible not only to understand vital elements of global history, but also to critically assess our present-day relationship with the natural world, and to begin …

Venomics As A Drug Discovery Platform: Identifying Conopeptides With Pharmacological Activity, Meghan Kathleen Grandal

MUSC Theses and Dissertations

Cone snail venom is a mixture of disulfide-constrained peptides (conotoxins), hormone-like peptides, and proteins that have been ‘weaponized’ for predation and defense. Venom peptides, or conopeptides, have efficiently evolved to bind receptors and ion channels that modulate the neuromuscular, cardiovascular, and central nervous systems in prey species. With over 850 species of cone snails, each with unique venom concoctions, cone snail venom is a valuable source of novel pharmacological probes and potential drug leads. However, the complexity of the venom poses a challenge for drug discovery. Contributing to the complexity is 1) a wide range in molecular weight 2) peptide …

Drivers Of Start-Up Delays In Global Randomized Clinical Trials, Jennifer Lai

MUSC Theses and Dissertations

Background: Global, randomized clinical trials are extremely complex. Trial start-up is a critical phase and has many opportunities for delay which adversely impact the study timelines and budget. Understanding factors that contribute to delay may help clinical trial managers to work more efficiently, hastening patient access to potential new therapies. Methods: We reviewed the available literature related to start-up of global, Phase III clinical trials and then created a fishbone diagram detailing drivers contributing to start-up delays. The issues identified were used to craft a checklist to assist clinical trial managers in more efficient trial start-up. Results: We identified key …

Functional Relevance Of Renal Histamine Receptors In The Kidney, Mikhail Fomin

MUSC Theses and Dissertations

The immunology of kidney disease is complex and involves factors from both the innate and the adaptive immune systems. Histamine is an important immunomodulator, as well as a regulator of allergic inflammation, gastric acid secretion, and neurotransmission. Although an increase in histamine level and expression of histamine-metabolizing enzymes have been shown in the kidney, renal pathological and physiological effects of histamine have not been clearly defined. The goal of this study was to provide insight into the physiological importance of the histamine-related pathways in the kidney, with emphasis on the collecting duct (CD), a distal part of the nephron important …

Rage Signaling As A Pharmacological Target In Amyotrophic Lateral Sclerosis, Liping Liu

MUSC Theses and Dissertations

Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of both upper and lower motor neurons. Astrocytes are key for maintaining central nervous system homeostasis and are important determinants of motor neuron fate in ALS. Accordingly, IPSC-derived astrocytes from ALS patients or astrocytes from diverse ALS mouse models, including mice overexpressing the ALS-linked mutant hSOD1G93A, induce motor neuron death in co-culture. Previously our lab reported that motor neurons isolated from receptor for advanced glycation end products (RAGE) knockout mice are resistant to the ALS-astrocyte derived neurotoxicity. Therefore, our working hypothesis states that inhibition of RAGE signaling can suppress astrocyte-mediated …

Investigating The Source And Structure Of Unexplained Variance In Natural Scenes Fmri Data, Maggie Mae Mell

MUSC Theses and Dissertations

No abstract provided.

Cell-Type Specific Extracellular Matrix Signaling In The Opioid-Addicted Synapse, Vivian C. Chioma

MUSC Theses and Dissertations

To date, heroin abuse is a leading cause of drug overdose-related deaths in the United States, highlighting a need for further research elucidating effects of maladaptive neuroadaptations following prolonged heroin use. Activation of the tetrapartite synapse in nucleus accumbens core (NAcore), which comprises of pre- and post-synapse, astrocytic processes, and surrounding extracellular matrix (ECM), has been linked to increased relapse vulnerability. Specifically, degradation of ECM by activated matrix metalloproteinases (MMPs) is involved in extracellular synaptic remodeling both constitutively and transiently in extinguished and drug seeking conditions, respectively. Although increases in MMP-2,9 fluorescence can be localized to soma and dendritic processes …

Effects Of The Abused Inhalant Toluene On Mpfc-Dependent Cognitive Behaviors And Associated Neural Activity, Kevin Michael Braunscheidel

MUSC Theses and Dissertations

Volatile organic solvents like toluene induce euphoria and intoxication when inhaled at high concentrations. Inhalant misuse is linked to behavioral, cognitive, and anatomical deficits in humans leading to a reduced productivity and quality of life. Yet, preclinical studies on the effect of inhalants on executive control in animal models are limited. We address this gap in knowledge using rodent models in two ways: first, by examining the long-lasting effects of repeated toluene inhalation during adolescence on several measures of executive function in adulthood and second, by studying the effects of acute toluene inhalation on risk/reward decision making and related neurocircuitry. …

Mycobacterium Tuberculosis Beijing Lineage And Risk For Tuberculosis In Child Household Contacts, Peru, Chuan-Chin Huang, Alexander L. Chu, Mercedes C. Becerra, Jerome T. Galea, Roger Calderón, Carmen Contreras, Rosa Yataco, Zibiao Zhang, Leonid Lecca, Megan B. Murray

Social Work Faculty Publications

Few studies have prospectively compared the relative transmissibility and propensity to cause disease of Mycobacterium tuberculosis Beijing strains with other human-adapted strains of the M. tuberculosis complex. We assessed the effect of Beijing strains on the risk for M. tuberculosis infection and disease progression in 9,151 household contacts of 2,223 culture-positive pulmonary tuberculosis (TB) patients in Lima, Peru. Child contacts exposed to Beijing strains were more likely than child contacts exposed to non-Beijing strains to be infected at baseline, by 12 months of follow-up, and during follow-up. We noted an increased but nonsignificant tendency for child contacts to develop TB. …

Algeria: A Case Study Of Decolonization And Its Implications, Brianna Ward

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Network Structure Of Vertebrate Scavenger Assemblages At The Global Scale: Drivers And Ecosystem Functioning Implications, Esther Sebastián-González, Zebensui Morales-Reyes, Francisco Botella, Lara Naves-Alegre, Juan M. Pérez-García, Patricia Mateo-Tomás, Pedro P. Olea, Marcos Moleón, Jomar M. Barbosa, Fernando Hiraldo, Eneko Arrondo, José A. Donázar, Ainara Cortés-Avizanda, Nuria Selva, Sergio A. Lambertucci, Aishwarya Bhattacharjee, Alexis L. Brewer, Erin F. Abernethy, Kelsey L. Turner, James C. Beasley, Travis L. Devault, Hannah C. Gerke, Olin E. Rhodes Jr, Andrés Ordiz, Camilla Wikenros, Barbara Zimmermann, Petter Wabakken, Christopher C. Wilmers, Justine A. Smith, Corinne Kendall, Darcy Ogada, Ethan Frehner, Maximilian L. Allen, Heiko U. Wittmer, James R. A. Butler, Johan T. Du Toit, Antoni Margalida, Pilar Oliva-Vidal, David Wilson, Klemen Jerina, Miha Krofel, Rich Kostecke, Richard Inger, Esra Per, Yunus Ayhan, Hasan Ulusoy, Doğanay Vural, Akino Inagaki, Shinsuke Koike, Arockianathan Samson, Paula L. Perrig, Emma Spencer, Thomas M. Newsome, Marco Heurich, José D. Anadón, Evan R. Buechley, José A. Sánchez-Zapata

Publications and Research

The organization of ecological assemblages has important implications for ecosystem functioning, but little is known about how scavenger communities organize at the global scale. Here, we test four hypotheses on the factors affecting the network structure of terrestrial vertebrate scavenger assemblages and its implications on ecosystem functioning. We expect scavenger assemblages to be more nested (i.e. structured): 1) in species-rich and productive regions, as nestedness has been linked to high competition for carrion resources, and 2) regions with low human impact, because the most efficient carrion consumers that promote nestedness are large vertebrate scavengers, which are especially sensitive to human …

Higher Sensitivity Of Female Cells To Ethanol: Methylation Of Dna Lowers Cyp2e1, Generating More Ros, Carlos G. Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, R. A. Lockshin, Zahra Zakeri

Publications and Research

Background: Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this difference in the controlled situation of their response to ethanol.

Methods: We evaluated the expression of mRNA for alcohol dehydrogenase (ADH), aldehyde dehyrogenases (ALDH), and a cytochrome P450 isoenzyme (Cyp2e1) in male and female mice, comparing the expressions to toxicity under several experimental conditions evaluating redox and other states.

Results: Females are more sensitive to ethanol. Disulfiram, which inhibits alcohol dehydrogenase (ADH), increases cell death in males, eliminating the sex …

Polygenic Risk Score Analysis Revealed Shared Genetic Background In Attention Deficit Hyperactivity Disorder And Narcolepsy, Nagahide Takahashi, Tomoko Nishimura, Taeko Harada, Akemi Okumura, Damee Choi, Toshiki Iwabuchi, Hitoshi Kuwabara, Shu Takagi, Yoko Nomura, Jeffrey H. Newcorn, Nori Takei, Kenji J. Tsuchiya

Publications and Research

Attention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. Psychostimulants are effective for the symptomatic control of ADHD (primary recommended intervention) and the two sleep disorders (frequent off-label use). However, the common biological mechanism for these disorders has not been well understood. Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. We investigated a possible genetic association between …

Molecular And Phenotypic Diversification Of A Cryptic Group Of Terrestrial Frogs From The Southern Andes Of Ecuador, Veronica Urgiles Penafiel

Electronic Theses and Dissertations, 2020-2023

The Ecuadorean Andes sustains one of the most remarkable frog diversifications. In this region, nearly one in three known species of amphibians belong to the Pristimantis genus, which contains the majority of the direct-developing terrestrial frog species. Although efforts are ongoing to understand the diversity of Pristimantis, large regions of the ecosystems they occupy remain understudied, and speciation and diversity of this genus remains poorly understood. Within this context, an interesting taxon with many unresolved questions regarding patterns and process of diversification is the Pristimantis orestes species complex which is distributed across the Paramo landscape and montane forests in the …

Transcendence, William Rincon

Electronic Theses and Dissertations, 2020-2023

Transcendence is a novel that examines masculinity and self-acceptance in the modern era: How do we move on from wrongs done by others and our own mistakes? A coming-of-age novel, Transcendence follows Cassiel, a young man in his mid-twenties, as he searches for his absent father and finds himself in a monastery where monks have strange abilities. He decides to learn meditation and find the source of his unhappiness through trials that test his discipline and faults. With the promise of enlightenment and learning what happened to his long-lost father, Cassiel completes each trial and comes closer to finding the …

Development Of 3d Porous Chitosan-Based Platform For In Vitro Culture, Kailei Xu

Electronic Theses and Dissertations, 2020-2023

Three-dimensional (3D) cell cultures have been widely used in biological research since two-dimensional (2D) cultures have many limitations including alteration of cell morphology, metabolic pathways and gene expression. Therefore, the application of 2D cell cultures in pharmaceutical companies for drug screening causes reproducibility issues in animal studies, which strongly influences the efficiency of drug development. The aim of my studies is to develop 3D cell culture models to better mimic the extracellular matrix (ECM) in tumor microenvironment, not only for deeper understanding of interaction between cells and ECM, but also for the application in drug screening. Three different compositions of …