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Hippocampal Cholinergic Function And Exploratory Behavior Throughout Development In A Genetic Mouse Model Of Alzheimer’S Disease, Ashley Andrea Blackwell

Graduate Research Theses & Dissertations

Dementia of the Alzheimer’s type is the most common form of dementia, affecting millions of people worldwide. Specific genetic mutations increase Alzheimer’s disease-related neuropathology and cognitive impairments. Deficits are observed in spatial orientation throughout the progression of Alzheimer’s disease, including wandering behavior or becoming lost in a familiar environment. Dementia of the Alzheimer’s type patients also exhibit disruptions in radial optic flow, which underlies self-movement cue processing. Currently, no treatments exist for Alzheimer’s disease. Genetic mouse models of Alzheimer’s disease have been developed to investigate the disease onset and progression and, further, to evaluate potential therapies and behavioral assessments. As …

Exercise Training As Adjunct Therapy For Substance Use Disorder, Emily Lynn Roessel

University of the Pacific Theses and Dissertations

Exercise training for clients at out-patient drug rehabilitation centers likely helps with coping skills. However, a better examination of the mechanisms producing changes may help identify effective interventions. PURPOSE: To test the effect of a vigorous exercise prescription on drug abstinence in voluntary rehabilitation patients. METHODS: 25 surveyed participants in a male drug treatment program underwent a 12-week minimum training program. The program included moderate-rigorous exercise and psychotherapy. Three days per week all subjects participated in EP for 90 minutes. Subjects also participated in ABIT 3 days per week where each session lasted 2 hours. Subjects also participated in ESM …

Listener Responses Can Influence The Presentation Of Restricted Interest Topics To Individuals With Asd, Sadaf Fakharzadeh

University of the Pacific Theses and Dissertations

The behavior of individuals diagnosed with autism spectrum disorder (ASD) can influence caregiver responses that lead to countertherapeutic outcomes. However, there are few experimental evaluations of variables that can cause potentially undesirable interactions between those with ASD and their caregivers. Specifically, little is known about the effects of listener interest on the restricted topics presented by caregivers. We evaluated the influence of listener responses exhibited by a confederate acting as a person with ASD on the topics presented by three undergraduate students who were interested in working with individuals diagnosed with ASD. Each session consisted of a 5-min conversation, during …

Encountering The Living God: The Integral Formation Of Teachers As Witnesses In Catholic Elementary And Secondary Schools, Amy E. Roberts

Theses

An examination of the Catholic Church’s documents on Catholic schools shows that the Church holds the primary mission of Catholic schools to be making disciples of Jesus Christ. Because the fulfillment of the mission of Catholic schools depends upon the teacher, teachers need ongoing formation as witnesses, just as they need professional formation. This thesis contends that in order for teachers to be the witnesses that Catholic schools need to fulfill their mission of making disciples, they themselves need an integral formation that puts every dimension of their human nature – body, heart, and mind – in ongoing communio with …

The Importance Of Environmental Interventions In Eliminating Trachoma Infection In Africa: The Case Of Gashoho Health District, Burundi, Desire Ndisabiye

Theses

Gashoho Health District, Burundi, has not achieved the World Health Organisation (WHO) target of elimination of the blinding infectious disease, trachoma, by 2020. The work in this thesis addresses this problem using three different approaches.

Firstly, a cross-sectional study was undertaken to establish the current trachoma prevalence in Gashoho and whether poor sanitation was a risk factor for infection. 468 individuals from 117 households across four villages were clinically examined for signs of trachoma infection, and completed a questionnaire about environmental risk factors. The current prevalence of trachoma in Gashoho was 7.9% (95 % CI 5.0 - 10.6%). Children under …

School Counselor Self-Advocacy And Trait Emotional Intelligence As Predictors Of Professional Quality Of Life In School Counselors, Kindle Dawn Lewis

Graduate Student Theses, Dissertations, & Professional Papers

School counselors are integral to the holistic success of students and are needed now more than ever as high rates of youth mental health issues, traumatic events at schools and global crises have become part of every school year. Unfortunately, as with most helping professions, many school counselors are struggling with maintaining a healthy professional quality of life due to chronic stress work environments. School counselors who have higher levels of compassion fatigue (burnout and secondary traumatic stress) and lower levels of compassion satisfaction are more likely to have decreased quality of care for students, decreased self-efficacy, decreased overall wellbeing …

Informative Speech Guidelines And Rubric, Angela Elbanna

Open Educational Resources

An informative speech is a speech where the goal is to inform the audience about a topic. The audience may already have some knowledge of this topic or they may not know anything at all about it. This speech is based on facts and research, not opinion. The speaker should be unbiased and simply present the information to the audience, not attempt to influence or persuade them in any way. Speakers may choose any topic.

Characterization Of A Conserved Transient Receptor Potential Channel Supporting Spermatogenesis In Planarian Flatworms, Haley Nicole Curry

Browse all Theses and Dissertations

The molecular processes underlying the control of external stimuli on development of the reproductive system remain to be understood. The Transient Receptor Potential superfamily of proteins (TRPs) consists of cation channels that respond to external stimuli and are abundant in the somatosensory as well as reproductive systems. Mammalian TRP-Melastatin 3 (TRPM3) channels are activated by heat and the neurosteroid pregnenolone. Here we characterize an ortholog of TRPM3 in the planarian flatworm Schmidtea mediterranea (Smed-TRPM3). Smed-TRPM3 was hypothesized to play a role in germline development due to enriched expression in the reproductive system of sexual planarians. In situ hybridization analysis revealed …

Variation In Available Habitat Impacts The Spatiotemporal Interactions Of A Great Lakes Carnivore Community, Mackenzie E. Rich

Browse all Theses and Dissertations

Interactions between carnivores play a crucial role in regulating lower trophic levels. In order to examine interspecific interactions among Great Lakes carnivores, I used occupancy models to examine habitat selection patterns and quantify interactions between species. I determined temporal patterns of activity for each species and quantified interspecific activity overlap using kernel density estimates. To generate these models and analyze the patterns displayed, I placed 25 cameras across 25 km2 of diverse northern Wisconsin forest. I extracted habitat data from the National Landcover Database using GIS to inform my occurrence models for each detected carnivore species. The only significant influence …

Scalable, Pluggable, And Fault Tolerant Multi-Modal Situational Awareness Data Stream Management Systems, Michael Partin

Browse all Theses and Dissertations

Features and attributes that describe an event (disasters, social movements, etc.) are heterogeneous in nature. For virtually all events that impact humans, technology enables us to capture a large amount and variety of data from many sources, including humans (i.e., social media) and sensors/internet of things (IoTs). The corresponding modalities of data include text, imagery, voice and video, along with structured data such as gazetteers (i.e., location-based data) and government and statistical data. However, even though there is often an abundance of information produced, this information is fragmented across the various modalities and sources. The DisasterRecord system aims to provide …

Characterization Of Proteins Found In Serum And Sputum Samples From Ventilator Associated Pneumonia Patients, Hima Priya Yenuga

Browse all Theses and Dissertations

Ventilator associated pneumonia (VAP) is the most common nosocomial infection leading to increased mortality in ICU patients. The main goal of this project was to evaluate and analyze a number of different biomarkers of disease that may be involved in the transition to pneumonia in patients on ventilators. Patients in this study were in the ICU, required greater than or equal to 48 hours of mechanical ventilation, and had a Clinical Pulmonary Infection Score greater than or equal to 6. For this study we recruited 16 subjects who were on ventilator for more than 48 hours, obtained serum and sputum …

Determining Effects Of The Paf-R And Anti-Hypertensive Drugs Mediated Microvesicle Particle Release In Modulating Anti-Tumor Response Of Lung Cancer, Andrew Stephen Forino

Browse all Theses and Dissertations

Lung cancer is one of the world’s leading causes of cancer-related deaths with poor prognosis, and difficult to treat malignancy. Several genetic, and environmental factors including cigarette smoking and hypertension have been linked as the common risk factors for lung cancer. To that end, multiple mechanisms have been proposed in regulating tumor growth, angiogenesis, and metastasis, as well as the efficacy of cancer therapy in experimental lung cancer models. Importantly, studies including ours, have shown that exposure to reactive oxygen species (ROS)-generating stimuli such as cigarette smoking, and cancer therapy produced oxidized lipids with platelet-activating factor (PAF) agonistic activity from …

Discovery And Characterization Of Pathways Involved In Fus And Tdp43-Induced Toxicity In Yeast, Weston Joseph Shaw

Browse all Theses and Dissertations

High-throughput genome-scale studies are becoming increasingly common as a means to discover genetic interactions. This methodology is particularly efficient when performed in the budding yeast Saccharomyces cerevisiae. Here, we (1) overexpress a large human gene library in yeast to assess how many of them are toxic, and (2) use the list of genes generated above to refine and analyze human genes previously identified to enhance toxicity of two ALS-associated proteins, FUS and TDP-43. By introducing each of 13,500 human genes into yeast, we demonstrated that the majority of these genes (about 97%) are not toxic to yeast when overexpressed. These …

Early Childhood Educators And Students Lived Experience With Conscious Discipline: Taming The Wild Things, Sierra Rosa Dinges

Graduate Theses/Dissertations

The purpose of this phenomenological study was to discover the essence of student and teacher perceptions of relationships through the implementation and exposure to the program and curriculum Conscious Discipline. The methods used were student interviews, teacher interviews, and a focus group. Participants were video and audio recorded and interviewed, and the focus groups were transcribed. The researcher looked to find themes between the interviews. The study found that teachers’ perspectives of relationships included understanding that behavior is a form of communication of an unmet need. Student perspectives showcased that their perspective of their teacher was positive. Three themes were …

The Impact Of Artificial Intelligence On Forensic Accounting And Testimony--Congress Should Amend "The Daubert Rule" To Include A New Standard, Victor Nicholas A. Metallo

Emory Law Journal Online

This Essay attempts to address the current issues and legal implications surrounding the use of artificial intelligence by forensic accounting experts and its importance to forensic accounting research. It reviews existing law, proposes changes to the Federal Rules of Evidence for using artificial intelligence in the courtroom, and covers emerging technology a forensic accountant may encounter, such as blockchain, cryptocurrency, “smart contracts,” machine learning, and algorithmic entities. Finally, the Essay concludes that the changes to the rules should encompass standards to account for artificial intelligence reliability and argues forensic accounting experts and all forensic experts are needed even more in …

The Use Of Technology To Continue Learning In Palestine Disrupted With Covid-19, Khitam Shraim, Helen Crompton

Teaching & Learning Faculty Publications

This qualitative study examined how decision-makers and teachers have responded to offer education for all Palestinian students at the immediate onset of the COVID-19 outbreak and how technology is being used to continue education online. Semi-structured interviews were conducted with 20 participants from parents, teachers and decision-makers in Palestine. Interview transcripts were coded using a grounded theory design with a constant comparative method. The findings show that participants identified that technologies such as mobile devices, social media and cloud computing would be useful for design and delivery of educational materials as well as raising safety awareness, and communication during the …

Distinct Tissue Specific Functions Of Bone Marrow Regulatory T Cells, And Their Therapeudic Applications In Myeloid Neoplasms, Virginia Camacho

All ETDs from UAB

In the bone marrow, Regulatory T cells (Tregs) constitute nearly 30% of CD4+ T cells, a significantly higher ratio than other tissues. Although a few of the mechanisms by which Tregs regulate normal hematopoiesis have been elucidated, our understanding of this process during leukemogenesis is ex-tremely limited. In this work, we define how Tregs maintain and support the bone marrow microenvironment. We propose that the role of Tregs extends be-yond their canonical immuno-suppressive function and that these cells are re-quired to maintain healthy hematopoiesis. We have defined tissue-specific roles for Tregs in the bone marrow including the maintenance of hematopoietic …

Microplastic In Water And Wastewater, Dounia Elkhatib

Open Access Dissertations

This thesis addresses three challenges related to the microplastic contamination in water and wastewater treatment plants. The first challenge is the multiple methodologies used to collect, quantify, and characterize microplastics in both wastewater and drinking water. Our study shows a lack of consensus regarding the techniques used at all of the stages (from collection to characterization) required for the quantification of microplastics in urban water systems. This represents a barrier to accurately determine the loads of microplastic contamination and to the comparison of the results obtained among different studies. Our results indicate large discrepancies in the concentrations reported in both …

O'Kei: An American Novel, Boris Pilnyak, Ronald D. Leblanc (Translator)

Faculty Publications

On January 4, 1931, Boris Pilnyak (1894-1938) wrote a letter to Joseph Stalin, pleading with the Soviet leader to grant him permission to travel to the United States in order to conduct research for an ambitious book project he was undertaking that would compare communist Russia favorably to capitalist America. Pilnyak’s request received official approval, and a few months later the writer set off for the U.S., arriving in New York by steamer on March 12, 1931, and remaining in the country until August 3, 1931. During his nearly five-month stay in America, Pilnyak became acquainted with a number of …

Possibility And Constraint In The Lives Of Young Rural Workers In The Us: The Psychology Of Working And Post-Trauma Vocational Trajectories, Donna M. San Antonio Dr.

Faculty Scholarship

Work and wellness have long been linked in the field of psychology, but few researchers have studied this topic with rural emerging adults without a high school diploma. Overall, rural areas in the United States have higher rates of poverty and lower educational attainment than nonrural areas. This narrative inquiry illuminates how precariousness in home and school contexts influenced the work trajectories and aspirations of ten 20- to 25-year-old research participants. Findings contribute to the psychology of working theory by illuminating the individual and contextual factors that generated possibility and constraint in the lives of young workers with limited education …

Reed Magazine, Issue 153, Gale Acuff, Faith Adiele, Luis Aguilar, Sophia Apodaca, Pamela Baker, Maria Baranda, Lou Beach, William Brown, Shayna Bruce, Kait Burton, Sabah Carrim, Joy Castro, Manit Chaotragoongit, Anne Cheilek, Elizabeth Childs, Annie Christain, Eileen Collins, Sarah Dalton, Nam Das, Holly Day, Rozanne Di Silvestro, Hollie Dugas, Monique Ferrell, Forrest Gander, Marie Gethins, Cynthia Good, Van Hall Jr., Marina Hatsopoulos, Emma Hester, Brenda Hillman, Gail Hosking, Richard Hricko, Phillip Hurst, Stephanie F. Imbeau, Daniel M. Jaffe, Jeanne Julian, Dana Kotler, Ramiza Koya, S.K. Kruse, Jennifer Lothrigel, Kurt Luchs, Edward Matthews, Ryan Mcfadden, Cathleen Miller, Naomi Shihab Nye, Giorgio Parisi, Alan Michael Parker, Emmy Perez, Timothy F. Phillips, Andre Rubin, Daniel Saalfeld, Michael Sano, Faith Shearin, Robert Sondgrath, Richard Stim, Rodrigo Toscano, Fracisco Uribe, Katelyn Joy Wilkinson, Pat Willard, John Sibley Williams, Anni Wilson, Tiarra Wu, Jamayka Young

Reed Magazine

No abstract provided.

Annual Report Town Of Center Harbor, New Hampshire For Year Ending December 31, 2019., Center Harbor Town Representatives

Center Harbor, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Muhlenberg Magic, Lehigh Valley Health Network

LVHN documents

No abstract provided.

Baseline And Stress-Induced Corticosterone Levels Across Birds And Reptiles Do Not Reflect Urbanization Levels, Allison S. Injaian, Clinton D. Francis, Jenny Q. Ouyang, Davide M. Dominoni, Jeremy W. Donald, Matthew J. Fuxjager, Wolfgang Goymann, Michaela Hau, Jerry F. Husak, Michele A. Johnson, Bonnie K. Kircher, Rosemary Knapp, Lynn B. Martin, Eliot T. Miller, Laura A. Schoenle, Tony D. Williams, Maren N. Vitousek

Global Health Faculty Publications

Rates of human-induced environmental change continue increasing with human population size, potentially altering animal physiology and negatively affecting wildlife. Researchers often use glucocorticoid concentrations (hormones that can be associated with stressors) to gauge the impact of anthropogenic factors (e.g. urbanization, noise and light pollution). Yet, no general relationships between human-induced environmental change and glucocorticoids have emerged. Given the number of recent studies reporting baseline and stress-induced corticosterone (the primary glucocorticoid in birds and reptiles) concentrations worldwide, it is now possible to conduct large-scale comparative analyses to test for general associations between disturbance and baseline and stress-induced corticosterone across species. Additionally, …

White-Handed Gibbons Discriminate Context-Specific Song Compositions., Julie Andrieu, Samuel G Penny, Hélène Bouchet, Suchinda Malaivijitnond, Ulrich H. Reichard, Klaus Zuberbühler

Publications

White-handed gibbons produce loud and acoustically complex songs when interacting with their neighbours or when encountering predators. In both contexts, songs are assembled from a small number of units although their composition differs in context-specific ways. Here, we investigated whether wild gibbons could infer the 'meaning' when hearing exemplars recorded in both contexts (i.e. 'duet songs' vs. 'predator songs'). We carried out a playback experiment by which we simulated the presence of a neighbouring group producing either its duet or a predator song in order to compare subjects' vocal and locomotor responses. When hearing a recording of a duet song, …

Metacognition: How To Improve Students' Reflections On Learning, Lisa K. Son, Nicole Brittingham Furlonge, Pooja K. Agarwal, Retrievalpractice.Org

Faculty Works

No abstract provided.

A Glimpse Of University Of Montana Students' Opinions On Beef Production And Consumption, Jennifer Kieffer

Undergraduate Theses, Professional Papers, and Capstone Artifacts

This study looks at University of Montana (UM) students’ opinions on the topics of beef production and consumption. Investigating students’ opinions on beef production and consumption will provide a better understanding of student beliefs regarding local, grass-finished beef. This information will be useful to beef producers in Western Montana. This study collected data via dot survey. The survey included four questions with five to six prescribed answers for participants to choose from. In total, 198 beefeating UM students of varying ages participated in the survey. All data was collected at the same time, over the duration of two hours, in …

Clarksville, New Hampshire 2019 Annual Town Report And Annual Report Of School Directors., Clarksville Town Representatives

Clarksville, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

The Spinnaker 2020 Recap Issue, University Of North Florida

Spinnaker

Student newspaper for the UNF community. Date: 2020

Serum 25-Hydroxyvitamin D Levels In Children With Mild And Severe Atopic Asthma, Rhoda Ndinda Masaku

Master of Medicine in Paediatrics and Child Health

Background: Asthma is a chronic respiratory illness affecting an estimated 334 million people worldwide, including 14% of the total pediatric population. It results in significant morbidity, and therefore the etiologies and risk factors associated with asthma are of great interest. Serum 25- hydroxyvitamin D (25(OH)D) has substantial immunomodulatory effects on the innate immune system. It reduces the probability of viral respiratory infections and asthma exacerbations by potentiating the anti-inflammatory action of corticosteroids. Objectives: This study was conducted to determine if there was a difference in serum 25-hydroxyvitamin D levels between children with mild and severe atopic asthma and explored the …