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The Hsp90 Inhibitor, Auy-922, Ameliorates The Development Of Nitrogen Mustard-Induced Pulmonary Fibrosis And Lung Dysfunction In Mice, Pavel Solopov, Ruben M.L. Colunga Biancatelli, Margarita Marinova, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Increased levels of heat shock protein 90 (HSP90) have been recently implicated in the pathogenesis of pulmonary fibrosis and the use of HSP90 inhibitors constitutes a potential therapeutic approach. Similarly, acute exposure to nitrogen mustard (NM) is related to the development of chronic lung injury driven by TNF-α, TGF-β, ERK and HSP90. Thus, we developed a murine model of NM-induced pulmonary fibrosis by instilling C57BI/6J mice with 0.625 mg/kg mechlorethamine hydrochloride. After 24 h, mice began receiving AUY-922, a second generation HSP90 inhibitor, at 1 mg/kg 2 times per week or 2 mg/kg 3 times per week, for either 10 …

Effects Of Plasma-Activated Water On Skin Wound Healing In Mice, Dehui Xu, Shuai Wang, Bing Li, Miao Qi, Rui Feng, Qiaosong Li, Hao Zhang, Hailan Chen, Michael G. Kong

Bioelectrics Publications

Cold atmospheric plasma (CAP) has been widely used in biomedicine during the last two decades. While direct plasma treatment has been reported to promote wound healing, its application can be uneven and inconvenient. In this study, we first activated water with a portable dielectric barrier discharge plasma device and evaluated the inactivation effect of plasma-activated water (PAW) on several kinds of bacteria that commonly infect wounds. The results show that PAW can effectively inactivate these bacteria. Then, we activated tap water and examined the efficacy of PAW on wound healing in a mouse model of full-thickness skin wounds. We found …

Hsp90 Inhibitors For Ipf/Covid-19, Ruben Manuel Luciano Colunga Biancatelli, Pavel A. Solopov, John Catravas

Bioelectrics Publications

Heat shock protein 90 (HSP90) is an important chaperone that assists the late stage folding of several proteins involved in cell survival in response to environmental stressors. The inhibition of HSP90 is followed by a complex modulation of the proteome and the kinome, that has proved beneficial in cancer and various neurodegenerative diseases. Additionally, accumulating literature suggests that HSP90 may be a key target during the development of pulmonary fibrosis and that its inhibition could serve as a new and exciting therapeutic approach. We have summarized the current evidence about HSP90’s role in Idiopathic Pulmonary Fibrosis (IPF), the results from …

Comeau And Constitutional Interpretation, Hoi L. Kong

The Supreme Court Law Review: Osgoode’s Annual Constitutional Cases Conference

R. v. Comeau raises questions about the place of originalism in the interpretation of a federalism provision of the Constitution Act, 1867, as well as related issues about the doctrine of stare decisis. Indeed, in anticipation of the Supreme Court’s hearing of the case, Léonid Sirota and Benjamin Oliphant wrote in the postscript to their 2017 article entitled “Originalist Reasoning in Canadian Constitutional Jurisprudence”: “[t]he Supreme Court’s decision … may well provide welcome clarifications as to [the] value and importance of originalist reasoning in Canada”. They argued that the case posed a question that represented “‘the biggest single challenge facing …

Csbs Statements, V22, 2020, University Of Northern Iowa. College Of Social And Behavioral Sciences.

CSBS Statements

Contents:

--Neighbors for Peace, Prosperity & Compassion
--Look for the Helpers
--Mapping a Virus
--The Threat to Health Nobody is Talking About
--Mind & Body
--Panthers Caucus
--College News
--Student Spotlight
--Alumni Highlights
--Annual Giving
--Class Notes

The Impact Of Grief Work On Hospice Mental Health Providers Through A Bowen Family Systems Lens, Joshua Hernandez

Department of Family Therapy Dissertations and Applied Clinical Projects

Marriage and family therapists and other mental health professionals and clients can be thought of as their own, divine emotional unit, generating and distributing the anxiety of one to the other. In fact, Kerr and Bowen (1988) described anxiety as a driving force exchanged by every living organism, and the energy surrounded by every human relationship. Within a hospice setting, anxiety can be heightened due to catering to end-of-life care, which can potentially affect the emotional response and reactivity of the mental health professional, changing the course of treatment for the patient and their family. Emerging research within healthcare has …

The Conundrum Of Both/And In A World Of Either/Or: An Interpretive Phenomenological Analysis Of Resilience And Intersectional Identities In Queer Women Of Afro-Caribbean Descent, Stephane Louis

Department of Family Therapy Dissertations and Applied Clinical Projects

Queer people of color are more at risk for bias and brutality than other sexual or racial minority groups (Follins, Walker, & Lewis, 2014). Homophobic violence is embedded in Afro-Caribbean culture and even substantiated by some of those countries’ laws (Calixte, 2005). While more research is being increasingly done on LGBTQ+ black lived experiences, studies have focused more on discriminatory trauma than everyday triumph. Movements like Black Girls Rock (Bond, 2018) and intersectional black feminism (Nash, 2018) celebrate women of color surviving and thriving the compound effects of racism and sexism. In addition to misogynoir, this research gave consideration to …

The Hidden Value Of Abandoned Applications To The Patent System, Christopher A. Cotropia, David L. Schwartz

Law Faculty Publications

Some inventors abandon their patent applications without ever receiving a patent. Although patent scholars view such abandoned applications as essentially worthless, we question that conventional wisdom. In conducting an empirical analysis of a recently released patent application dataset (in light of a 1999 change requiring publication of most abandoned applications), we find that the United States Patent and Trademark Office (USPTO) often uses abandoned applications as prior art when examining future patent applications. Abandoned applications thus generate an administrative disclosure that prevents the issuance of broader patent rights to later applicants. By narrowing the scope of new patents, abandoned applications …

Feminist Action Against Pornography In Japan: Unexpected Success In An Unlikely Place, Caroline Norma, Seiya Morita

Dignity: A Journal of Analysis of Exploitation and Violence

In late 2016 a feminist movement against problems of commercial sexual exploitation, and especially issues of coerced pornography filming, arose in Japan. This article describes the history of this movement as it mobilized to combat human rights violations perpetrated by the country’s pornographers. The movement’s success came not spontaneously or haphazardly; in fact, it was orchestrated earlier over a full decade-and-a-half by activists who persevered in researching and highlighting pornography’s harms in a civil environment of hostility, isolation and social derision, even among progressive groups and individuals. The Anti-Pornography and Prostitution Research Group (APP) was particularly prominent in this history. …

Discovery And Optimization Of Anti-Cancer Properties Of Traditional Herbal Medicines Using Zebrafish-Human Tumor Xenografts, Ashleigh M. Solheim

Honors College Theses

Cancer is one of the most well-known diseases around the world. It hurts everyone in some way, whether they have it themselves or they know someone that is diagnosed. But the problem is not just this brutal disease, the problem is its invasive treatments. The most common treatments for cancer have harmful and painful side-effects that occur in most cases. As a solution to invasive cancer treatments, this experiment is testing herbal medications Neem, Nilavembu, Ashwagandha and Tulsi as potential nontoxic cancer treatments. First, the maximum tolerable dosage for each herbal agent was found. This dosage was used for the …

What A Theological Appropriation Of Cognitive Linguistics’ Blending Theory Brings To A Scientific Understanding Of The Evolution Of Religion, Robert Masson

Theology Faculty Research and Publications

No abstract provided.

Leviathan's Knot: The High Priest's Sash As The Cosmological Symbol, Andrei Orlov

Theology Faculty Research and Publications

No abstract provided.

The Perils Of Pandemic Exceptionalism, Julian Arato, Kathleen Claussen, J. Benton Heath

Articles

In response to the pandemic, most states have enacted special measures to protect national economies and public health. Many of these measures would likely violate trade and investment disciplines unless they qualify for one of several exceptions. This Essay examines the structural implications of widespread anticipated defenses premised on the idea of “exceptionalism.” It argues that the pandemic reveals the structural weakness of the exceptions-oriented paradigm of justification in international economic law.

Contractual Arbitrage, Stephen J. Choi, G. Mitu Gulati, Robert E. Scott

Faculty Scholarship

Standard-form contracts are likely to be incomplete because they are not tailored to the needs of particular deals. In an attempt to reduce incompleteness, standard-form contracts often contain clauses with vague or ambiguous terms. Terms with indeterminate meaning present opportunities for strategic behavior well after a contract has been executed. This linguistic uncertainty in standard-form commercial contracts creates an opportunity for “contractual arbitrage”: parties may argue ex post that the uncertainties in expression mean something that the contracting parties did not contemplate ex ante. This chapter argues that the scope for contractual arbitrage is a direct function of the techniques …

Atrioventricular Synchronous Pacing Using A Leadless Ventricular Pacemaker: Results From The Marvel 2 Study, Mario Pascual

All Publications

No abstract provided.

Feasibility And Acceptability Of A Game-Based Symptom-Reporting App For Children With Cancer: Perspectives Of Children And Parents, Lauri Linder, Amy Rose Newman, Kristin Stegenga, Yin-Shun Chiu, Sarah E. Wawrzynski, Heidi Kramer, Charlene Weir, Scott Narus, Roger Altizer

College of Nursing Faculty Research and Publications

Background

Children with cancer have difficulty identifying and describing the multiple symptoms they experience during hospitalization and between clinical encounters. Mobile health resources, including apps, are potential solutions to support child-centric symptom reporting. This study evaluated the feasibility and acceptability of a newly developed game-based symptom-reporting app for school-age children with cancer.

Procedure

Nineteen school-age children (6–12 years of age) receiving treatment for cancer at a COG institution in the Intermountain West of the United States used a game-based symptom-reporting app between clinical visits. Feasibility was evaluated through a summary of actual days of app use and interaction with each …

The Picrat Model For Technology Integration In Teacher Preparation, Royce Kimmons, Charles R. Graham, Richard E. West

Faculty Publications

Technology integration models are theoretical constructs that guide researchers, educators, and other stakeholders in conceptualizing the messy, complex, and unstructured phenomenon of technology integration. Building on critiques and theoretical work in this area, the authors report on their analysis of the needs, benefits, and limitations of technology integration models in teacher preparation and propose a new model: PICRAT. PIC (passive, interactive, creative) refers to the student’s relationship to a technology in a particular educational scenario. RAT (replacement, amplification, transformation) describes the impact of the technology on a teacher’s previous practice. PICRAT can be a useful model for teaching technology integration, …

Principles Of Home Rule For The Twenty-First Century, Richard Briffault, Nestor M. Davidson, Paul A. Diller, Sarah Fox, Laurie Reynolds, Erin A. Scharff, Richard Schragger, Rick Su

Faculty Scholarship

The National League of Cities’ “Principles of Home Rule for the Twenty-First Century” updates the American Municipal Association’s 1953 “Model Constitutional Provisions for Municipal Home Rule.” The AMA approach was widely adopted, but those provisions are now over 65 years old and intervening social, demographic, economic, and political changes necessitates a new approach to the legal structure of state-local relations. The NLC’s approach is organized around four basic principles, which are cashed-out in a model constitutional home rule provision, with commentary. The first principle states that a state’s law of home rule should provide local governments the full capacity to …

Proof At The Salem Witch Trials, Leonard M. Niehoff

Articles

As of the writing of this article, President Donald Trump's tweets have included roughly 400 references to "witch hunts." In a sense, this is unsurprising. The Salem witch trials have a special place in our national identity and vocabulary. Most Americans understand the reference, even if they know few of the historical details. And the phrase "witch hunt" serves as a useful shorthand for any frenzied chase after something that does not exist. The Salem trials also inspire a peculiar fascination: Perhaps no other site of deadly mass hysteria has become a major tourist destination.

Still, most practicing litigators probably …

All Faiths & None: A Guide To Protecting Religious Liberty For Everyone, Elizabeth Reiner Platt, Katherine M. Franke, Keisha E. Mckenzie, Katharine Rhodes Henderson

Faculty Scholarship

Religious liberty rights have been immeasurably damaged over the past several years — often in the name of protecting religious liberty.

Government officials have embraced Islamophobic policies and rhetoric; shut the door on refugees fleeing religious persecution; elevated the religious rights of their political allies over the rights — religious and otherwise — of other communities; used religion as a tool of economic deregulation; and denigrated the beliefs of religious minorities, atheists, and religious progressives.

To achieve true freedom for those of all faiths and none, a complete overhaul of religious liberty policy, and a new understanding of what this …

Natural Rights, Positive Rights, And The Right To Keep And Bear Arms, Jud Campbell

Law Faculty Publications

The first judicial opinions interpreting the right to bear arms embraced vastly divergent views of the right, leading scholars to perceive these decisions as being in disarray. This article argues that these conflicts reflect exactly the sorts of disagreements that one would expect given that Americans viewed the right to bear arms as a natural right and as a positive right. Indeed, the first right-to-bear-arms decisions exemplified tensions that emerged when judges confronted claims about natural rights and positive rights in a changing social and legal landscape. As a natural right, the right to carry firearms could only be limited …

The Handmaid Of Justice: Power And Procedure In The Inferior Courts, Kellen R. Funk

Faculty Scholarship

Summing up the history of procedure from the codification movement of the nineteenth century to the Federal Rules practice of today, Robert Bone observed, “Each generation of procedure reformers, it seems, diagnoses the malady and proposes a cure only to have the succeeding generation’s diagnosis treat the cure as a cause of the malady.” While playfully highlighting the contingencies and unexpected consequences of procedural history, Professor Bone was not advocating a cyclical view of history, in which “cost and delay” continually recur as the bugaboos of procedural reformers who can’t quite figure out how to solve the problem. Instead, Bone …

Overlapping Copyright And Trademark Protection In The United States: More Protection And More Fair Use?, Jane C. Ginsburg, Irene Caboli

Faculty Scholarship

This chapter addresses the phenomenon of overlapping rights under US law and complements Chapter 25 authored by Professors Derclay and Ng-Loy on the overlap of trademark, copyright, and design protection under several other Common Law and Civil Law jurisdictions. Because the United States does not provide sui generis protection for industrial design, but instead protects design through trademark law (notably by protecting trade dress) and design patents, this chapter focuses on the overlap between trademark and copyright protection. The Lalique bottles created for Nina Ricci perfumes, for example, may enjoy both trademark and copyright protection in the United States. Similarly, …

Private And Public Law, Thomas W. Merrill

Faculty Scholarship

This chapter explores the relationship between private and public law. In civil law countries, the public-private distinction serves as an organizing principle of the entire legal system. In common law jurisdictions, the distinction is at best an implicit design principle and is used primarily as an informal device for categorizing different fields of law. Even if not explicitly recognized as an organizing principle, however, it is plausible that private and public law perform distinct functions. Private law supplies the tools that make private ordering possible — the discretionary decisions that individuals make in structuring their lives. Public law is concerned …

The Eagle Theory, Thomas W. Merrill

Faculty Scholarship

This Article evaluates three interpretations of the Takings Clause capable of generating a regulatory takings doctrine. The first, the Epstein interpretation, puts primary emphasis on what it means to provide “just compensation” for takings; the second, the Penn Central interpretation, centers on what it means to “take” property; the third, which I call the Eagle theory, in honor of Steven Eagle, this year’s Brigham-Kanner prize recipient, focuses on when the government has taken “private property.” The Article argues that the Eagle theory has the most plausible basis in the original understanding of the Takings Clause, rests on a theory about …

Words Have A Weight: Language As A Source Of Inner Grounding And Flexibility In Abstract Concepts, Guy Dove, Laura Barca, Luca Tummolini, Anna M. Borghi

Faculty and Staff Scholarship

The role played by language in our cognitive lives is a topic at the centre of contemporary debates in cognitive (neuro)science. In this paper we illustrate and compare two theories that offer embodied explanations of this role: the WAT (Words As social Tools) and the LENS (Language is an Embodied Neuroenhancement and Scaffold) theories. WAT and LENS differ from other current proposals because they connect the impact of the neurologically realized language system on our cognition to the ways in which language shapes our interaction with the physical and social environment. Examining these theories together, their tenets and supporting evidence, …

Making Sense Of Customary International Law, Monica Hakimi

Faculty Scholarship

This Article addresses a longstanding puzzle about customary international law (CIL): How can it be, at once, so central to the practice of international law — routinely invoked and applied in a broad range of settings — and the source of such persistent confusion and derision? The centrality of CIL suggests that, for the many people who use it, it is not only comprehensible but worthwhile. They presumably use it for a reason. But then, what accounts for all the muddle and disdain?

The Article argues that the problem lies less in the everyday operation of CIL than in the …

Why Should We Care About International Law?, Monica Hakimi

Faculty Scholarship

International lawyers are used to having their discipline dismissed. A conspicuous strand of thought in U.S. foreign policy circles — known as realist — posits that international law does not matter. Realists of course recognize that states and other global actors speak the language of international law. But they view this discourse as cheap talk or epiphenomenal. They contend that state decisions on the international plane are animated not by the dictates of international law but by material interests and power. States act consistently with international law insofar as they have independent reasons for acting that way. If those reasons …

Do We Need A New Conception Of Authorship?, Shyamkrishna Balganesh

Faculty Scholarship

Thank you to the organizers for having me. I’m delighted to be here. I’m going to take a step away from conceptual art, and go a little bit into history and a little bit into doctrine – and do the usual law professor thing. We law professors like to say that one of the great things about the job is that we get to overrule the Supreme Court ten thousand times a day, but the bad thing about the job is no one cares. And so, I’m going to try and make this such that you care.

Here’s the core …

The End Of Antitrust History Revisited, Lina M. Khan

Faculty Scholarship

This Review engages Tim Wu’s book, The Curse of Bigness, to explain the significance of the current rupture in antitrust and to situate it within a broader intellectual trajectory. Debates over the foundational purpose of antitrust are not new, and examining how this latest clash fits alongside previous contestations is essential for understanding what has yielded the current contestability and assessing the competing visions.

Part I of this Review summarizes Wu’s chief contributions in his recent work, focusing on three tenets that form the basis of the book. Part II offers an analytic breakdown of the overhaul in antitrust …