Digital Commons Network^™

Phenotypic Expression Of Two Candidate Genes Of Nonsyndromic Craniosynostosis In Danio Rerio, Annemarie Carver

UROP Posters

Phenotypic Expression of Two Candidate Genes of Nonsyndromic Craniosynostosis in Danio rerio

Annemarie Carver, Dept. of Biology with Dr. Rita Shiang, Dept. of Human and Molecular Genetics

Craniosynostosis, the premature fusion of cranial sutures, can be either syndromic or nonsyndromic. The majority of cases are nonsyndromic, the causes of which are rarely known. Craniosynostosis is relatively common and occurs in about 1 in every 2,000 babies. Bambia is suspected to cause craniosynostosis as a predicted deleterious stabilizing variant has been identified in affected individuals within one family, though when normally or under expressed no phenotypic differences are observed. Slc30a9, a …

Mapping New Olfactory Bulb Neurons At The Single-Cell Level Using Iron Oxide- Assisted Mri, Sarah Izabel

UROP Posters

Mapping New Olfactory Bulb Neurons at the Single-Cell Level Using Iron Oxide- Assisted MRI

Sarah Izabel, Dept. of Biology, with Dr. Jeffrey Dupree, Dept. of Anatomy and Neurobiology

Neurogenesis in the subventricular zone (SVZ) of adult mammalian brains persists throughout life. Precursor cells that are continuously born in the SVZ migrate long-distance to the olfactory bulb (OB), where they differentiate into specific neurons. The distribution of new neurons in the OB has been studied via histological and intravital techniques, which are limited longitudinally and in depth of imaging. In the past decade, in vivo studies using magnetic resonance imaging (MRI) …

Fenofibrate-Loaded Biodegradable Nanoparticles For The Treatment Of Neovascular Age-Related Macular Degeneration, Russell Simmers, Tuo Meng, Fangfang Qiu, Vineet Kulkarni, Jianxing Ma

UROP Posters

Fenofibrate-Loaded Biodegradable Nanoparticles for the Treatment of Neovascular Age-Related Macular Degeneration

Russell Simmers, Depts. of Physics and Chemistry, with Dr. Qingguo Xu, VCU School of Pharmacy

Background: Neovascular age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly population in the industrialized world. The current treatment for neovascular AMD is anti-vascular endothelial growth factor (anti-VEGF) therapy; however, nearly 40-50% of patients do not fully respond to anti-VEGF therapy. Therefore, non-VEGF therapeutics are required for neovascular AMD treatment. Fenofibrate is a peroxisome proliferator-activated receptor alpha (PPARα) agonist and has demonstrated robust therapeutic effects on neovascular AMD in …

The Eco-Martyrs Of 2018 And Maslow: Is Self-Actualization Only For Colonizers?, Johanna Guz-Montgomery, Ian Mcfadden, Victoria Bee, Ashley Sanico, William Purrington, Christopher Latourrette, Rachel Creed, Kelly Rios-Santos, Alan Lankford

UROP Posters

The Eco-Martyrs of 2018 and Maslow: Is Self-Actualization Only for Colonizers?

Johanna Guz-Montgomery, Dept. of Psychology, Ian McFadden, Victoria Bee, Ashley Sanico, William Purrington, Christopher Latourrette, Rachel Creed, Kelly Rios-Santos, and Alan Lankford, with Dr. Richard Bargdill, Dept. of Psychology

Every year the Global Witness organization complies and releases a list of forest, earth, water and animal protectors who have been murdered while defending the earth and people. There have been about 2000 “eco-martyrs” since 2002. Most of these persons are farmers, indigenous people, nature lovers or in other words--ordinary people. In their efforts to stop projects that would lead …

Storytelling Through Play, Allison Heerwagen

UROP Posters

Storytelling Through Play

Allison Heerwagen, Depts. of Graphic Design and Anthropology, with Dr. Bernard K. Means, Dept. of Anthropology

As children interpret and build on narratives with their own imagination, storytelling as a cultural practice involves even the youngest of a community. Children raised with folktales, myths, legends, and more can bring the stories to life through play inspired by the characters, setting, and stories shared with them. The most accessible tools for children to share and build stories are toys that can be used to interpret the beliefs, practices, and imagination of their culture. In addition, many children’s toys …

May Day: The Green Vision Of Chicago’S Gilded Age Anarchists, Colin Fisher

History: Faculty Scholarship

No abstract provided.

Neurotic: Neuroscience Tool For Interactive Characterization, Hillel J. Chiel

Faculty Scholarship

A software tool for synchronization of video with signals would be of broad general use to behavioral neuro-scientists. A new program, called neurotic (NEUROscience Tool for Interactive Characterization), allows users to review and annotate signal data synchronized with video, performs simple initial analyses including signal filtering and spike detection, is easy to use, and supports a variety of file formats. The program also facilitates collaborations by using a portable specification for loading and processing data and retrieving data files from online sources. Two examples are shown in which the software is used to explore experimental datasets with extracellular nerve or …

Covid-19, Serendipity, And Strange Interlude: Gloria In Absurdicum With An Apology To Ovid, Lawrence Charles Parish, W Clark Lambert

Department of Dermatology and Cutaneous Biology Faculty Papers

The absurd edicts initially issued by several governors, including those of Michigan and New York, prohibiting physicians from ordering hydroxychloroquine for patients suspected of or diagnosed with COV-19 are reprehensible. Their reasoning is beyond the pale.

Hydroxychloroquine was first approved by the FDA in 1955 and has a remarkable safety record in its use as a preventative for malaria and in the treatment of several immunologic and/or light induced diseases. Its use came about serendipitously, and its mechanism of action is unclear, but the fact remains that it seems to work.

Christian History As World History A Review Essay, Joel A. Carpenter

University Faculty Publications and Creative Works

This review essay discusses the status of “World Christianity” as a field of study, then highlights the features of the book at hand. It is an exercise in world history more than church history, focusing on how Christianity in various parts of the world responded to the twentieth century’s greatest challenges. The book addresses the rise of millenarianism and fundamentalism, neo-orthodoxy, liberation theology, Pentecostalism, and ecumenism. But its more intent focus is on how Christianity addressed the century’s world wars, colonialism, nationalism, secularism, rise of radical Islam, human rights, migration, and the growing power of the state.

Short-Term Exposure To Unmanned Aerial Vehicles Does Not Alter Stress Responses In Breeding Tree Swallows, Bradley D. Scholten, Abigail R. Beard, Hyeryeong Choi, Dena M. Baker

University Faculty Publications and Creative Works

Recent studies suggest that visual and acoustic anthropogenic disturbances can cause physiological stress in animals. Human-induced stress may be particularly problematic for birds as new technologies, such as drones, increasingly invade their low-altitude air space. Although professional and recreational drone usage is increasing rapidly, there is little information on how drones affect avian behavior and physiology. We examined the effects of drone activity on behavior and physiology in adult, box-nesting tree swallows (Tachycineta bicolor). Specifically, we monitored bird behavior during drone flights and in response to a control object and measured telomere lengths and corticosterone levels as indicators of longer-term …

A Unified Constitutional View Of Financial Punishment: Synthesizing The Excessive Fines Clause And Bearden­ Based Protections, Joshua A. Feinzig

Faculty Scholarship

This Note coordinates the Eighth Amendment Excessive Fines Clause with the Fourteenth Amendment wealth-discrimination protection set forth in Bearden v. Georgia It is generally assumed that the two protections operate independently: while the Excessive Fines Clause protects individuals against exorbitant financial obligations, Bearden limits the state from converting criminal debt into a severe liberty deprivation. But in recognizing how the two doctrines are normatively and functionally reinforcing, this Note proposes a single framework for considering financial punishment's constitutionality.

If the Eighth Amendment protection applies at the imposition of a financial punishment, Bearden provides a "second look" at the constitutionality of …

Mirna- And Cytokine-Associated Extracellular Vesicles Mediate Squamous Cell Carcinomas, Joseph P. Flemming, Brianna L. Hill, Mohammed W. Haque, Jessica Raad, Claudine S. Bonder, Larry A. Harshyne, Ulrich Rodeck, Adam J. Luginbuhl, James K. Wall, Iii, Kenneth Y. Tsai, Peter J Wermuth, Andrew M. Overmiller, Mỹ G. Mahoney

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Single-Walled Carbon Nanotubes For Advanced Optical Materials, Wearable Biosensing, And Bioimaging, Mohammad Moein Safaee

Open Access Dissertations

Single-walled carbon nanotubes (SWCNTs) functionalized with synthetic or natural polymers are a class of advanced optical nanomaterials that have recently found applications in a wide range of molecular diagnostics platforms as biosensors and bioimaging agents. Despite their widespread applications, there is an urgent need to develop standard characterization assays to evaluate their optical, physical, and interfacial properties in vitro and in complex biological environments. The results from such assays are essential for defining general design principles for nanotube-based optical probes and biosensing devices. Moreover, to fully exploit the nanotube's unique properties for health monitoring, it is essential to employ micro- …

Distribution Of Novel And Legacy Organic Pollutants In Seabirds From Contrasting Marine Environments, Anna Ruth Robuck

Open Access Dissertations

Despite their ubiquity in the environment, large data gaps exist surrounding the distribution, biotic accumulation, and possible impacts of many high priority organic pollutants, particularly those considered emerging contaminants. Emerging pollutants, or contaminants of emerging concern (CECs), represent a dynamic and rapidly evolving group of substances, some of which have been extant for decades. Chapter 1 provides background about CECs covered in this dissertation, and highlights key data gaps explored within this work.

The first three manuscripts of this dissertation (Chapters 2 – 5) focus on per- and polyfluoroalkyl substances, or PFAS. PFAS are a family of CECs that demonstrate …

Investigating Nat Products & Pharmaceuticals Targeting Inflammation In Neurodegenerative Diseases, Shelby L. Johnson

Open Access Dissertations

Alzheimer’s and Parkinson’s disease (AD and PD, respectively) are the two most common neurodegenerative diseases. Currently, no interventions have been successful in stopping the progression of these diseases. Here, we utilize two independent strategies: the use of natural products and repurposed pharmaceuticals to target neuroinflammation in models of neurodegeneration.

Natural products have been used for their medicinal properties for centuries in traditional eastern medicine practices. Mucuna pruriens (Mucuna) is a well-known natural source of levodopa, typically prescribed in Ayurveda for PD. A novel levodopa reduced seed extract exhibited protective effects against oxidative stress and PD specific toxic agents, both in …

Gold And Copper-Cysteamine Nanoparticles For Radiation Therapy Enhancement On Cancer, Bindeshwar Sah

Open Access Dissertations

Radiation therapy is a common technique to kill cancer cells. The purpose of this experiment is the enhancement of radiation effect on the treatment of tumors. The main difficulty of radiation therapy is that it can damage cancerous cells as well as healthy cells. Gold nanoparticles can enhance effects of the radiation treatment on tumors due to the interaction of radiation with gold nanoparticles to produce extra electrons through the Auger effect. This causes reduced side effects on healthy cells though using less radiation dose and maximizes radiation damage on cancer cells through the extra electrons produced by the gold …

Ecologies Of Materiality And Aesthetics In British Modernist War-Time Literature, 1890-1939, Molly Volanth Hall

Open Access Dissertations

This dissertation examines landscape representation in English novels, memoirs, manifestos, and poetry between 1890 and 1939 responding to World War I and the larger dynamics of imperialism of which it is a part. Analyzing how such works reflect and reshape dominant environmental perception during the early twentieth century’s marked acceleration of mass warfare and ecological change, it reads for the way images of mud, stone, land, and soil—collected under the term base matters—express the entanglement of environmental and national structures of feeling ranging from fear to dissociation. These base matters dominate characters’ and authors’ changing perception of the material world …

Retroactive Adjudication, Samuel Beswick

All Faculty Publications

This Article defends the retroactive nature of judicial lawmaking. Recent Supreme Court judgments have reignited debate on the retroactivity of novel precedent. When a court announces a new rule, does it apply only to future cases or also to disputes arising in the past? This Article shows that the doctrine of non-retroactive adjudication offers no adequate answer. In attempting to articulate a law of non-retroactivity, the Supreme Court has cycled through five flawed frame-works. It has variously characterized adjudicative non-retroactivity as (1) a problem of legal philosophy; (2) a discretionary exercise for balancing competing right and reliance interests; (3) a …

Safeguard Or Barrier: An Empirical Examination Of Bar Exam Cut Scores, Victor D. Quintanilla, Sam Erman, Michael B. Frisby

Articles by Maurer Faculty

In 2019, nearly 70,000 people took the bar exam. More than forty percent failed. Given the existing scores required to pass those exams (the “cut score”), nearly 30,000 test-takers otherwise qualified to practice law were lost to the profession. Had the cut score been lower, many would now be lawyers. So it goes every year, with staggering costs. Legal educators devote substantial resources to teaching tens of thousands of people legal skills that never get put to use in law practice. A national crisis in access to justice grows more entrenched. Applicants invest three years and countless thousands of dollars …

Suffolk University Academic Catalog And Student Handbook, College Of Arts And Sciences And Sawyer Business School, 2020-2021, Suffolk University

College of Arts and Sciences and Sawyer Business School Academic Catalogs

This catalog contains information for both the undergraduate and graduate programs. The student handbook is included here as a separate pdf document.

Please contact the Archives if you need assistance navigating this catalog or finding information on policies, degree requirements, or course descriptions.

Sergei Prokofiev's Third Piano Sonata, Op. 28: Stylistic Analysis And Performance Suggestions, Youngju Lee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sergei Prokofiev (1891-1953) was one of the greatest Russian pianists and composers of the twentieth century. He established his own musical style by combining classical form and modern compositional techniques. He composed a variety of piano music including nine piano sonatas. This paper is a study of the third piano sonata in A minor, op. 28.

Prokofiev’s music can be classified into three periods: a Russian Period, a Foreign Period, and a Soviet Period. It is possible to identify Prokofiev’s compositional styles by studying his piano sonatas because he composed piano sonatas during the entire course of his life. In …

Neuromechanical Tuning For Arm Motor Control, Russell Lee Hardesty Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Movement is a fundamental behavior that allows us to interact with the external world. Its importance to human health is most evident when it becomes impaired due to disease or injury. Physical and occupational rehabilitation remains the most common treatment for these types of disorders. Although therapeutic interventions may improve motor function, residual deficits are common for many pathologies, such as stroke. The development of novel therapeutics is dependent upon a better understanding of the underlying mechanisms that govern movement. Movement of the human body adheres to the principles of classic Newtonian mechanics. However, due to the inherent complexity of …

Clincial Translational Science Research Of The Functional Role Of Large Conductance Potassium Channels In Selective Destruction Of Triple Negative Breast Cancer Cells, Gina Sizemore

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

The preliminary background that puts this research into context is threefold; it is the aggressive nature of triple negative breast cancer (TNBC), the complexity surrounding its pathology, and the significant lack of targeted treatment for this disease. To clarify the focus of my research, I have concentrated on identifying a targeted treatment for TNBC. In the process, I have identified cycles of reciprocity between treatment, clinical diagnosis, staging, and pathology that will be addressed in smaller papers. However, the weight of this work is in the discovery of a novel target for triple negative breast cancer. The value of …

Haruka's World, Julia M. Chin

The Mercury

No abstract provided.

Indigenous Healing In New Zealand: An Anthropological Analysis Of "Traditional" And "Modern" Approaches To Well-Being, Lillian T. Brice

Honors Theses

Drawing on contemporary anthropological approaches used by scholars of well-being and medical anthropology (i.e. Michael Jackson and Lisa Stevenson), I explore how indigenous healers in New Zealand blend “traditional” and “modern” elements to establish a creative and inclusive system. Specifically, I explore the use of herbal treatments, ritual chanting, and ceremonies that encapsulate Māori cultural values. I also explore the impact of biomedicine and New-Age wellness approaches on indigenous healing. I argue that Māori healing moves beyond the binary of “tradition” and “modern” as healers merge the past and present and combine the foreign and native. My research is based …

University Of New Hampshire Undergraduate Academic Catalog, 2020-2021, University Of New Hampshire

Undergraduate Catalog

No abstract provided.

Mobilizing The Social Power Of Iconic And Performative Texts For Justice And Reform, James Watts

Religion - All Scholarship

In the ten years of its existence, SCRIPT has succeeded in promoting and publishing an increasing variety of scholarship on iconic and performative texts. Culturally specific studies have provided the basis for comparative theorizing about the phenomena. This body of scholarship has put us in a better position to analyze current events involving iconic books and performative texts. It can also enable us to make creative suggestions for strengthening movements for justice and social reform by ritualizing iconic and performative texts. Here, I provide three examples of how to employ SCRIPT research to strengthen contemporary movements for social and environmental …

Concerning A Supplemental Appropriation To The Department Of Agriculture., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Concerning A Supplemental Appropriation To The Department Of Public Health And Environment., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

Concerning Powers Of Bureau Of Animal Protection Agents., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.