Digital Commons Network^™

Allele-Specific Rna Interference Prevents Neuropathy In Charcot-Marie-Tooth Disease Type 2d Mouse Models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, Robert W Burgess

Department of Biochemistry and Molecular Biology Faculty Papers

Gene therapy approaches are being deployed to treat recessive genetic disorders by restoring the expression of mutated genes. However, the feasibility of these approaches for dominantly inherited diseases - where treatment may require reduction in the expression of a toxic mutant protein resulting from a gain-of-function allele - is unclear. Here we show the efficacy of allele-specific RNAi as a potential therapy for Charcot-Marie-Tooth disease type 2D (CMT2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS). A de novo mutation in GARS was identified in a patient with a severe peripheral neuropathy, and a mouse model precisely recreating the mutation …

Writing & Linguistics News, Georgia Southern University

Writing & Linguistics News (2012-2022)

• 2020 AWP Intro Journals Project nominees announced

Humans And The Red-Hot Stove: Hurston's Nature-Caution Theorizing In Their Eyes Were Watching God, Heather Sharlene Higgs Randall

Theses and Dissertations

This paper gives critical attention to the nature versus caution porch conversation in Zora Neale Hurston's Their Eyes Were Watching God, arguing that this is a legitimate addition to the anthropological discussion of nature versus culture. Addressing literary critics as well as scholars of the environmental humanities and of multispecies studies, I argue that Hurston's nature-caution discussion is a helpful epistemology which Hurston employs throughout her novel to suggest a single, unified way of understanding the human and nonhuman.

2019-12-02 Newsletter, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress newsletter from December 2, 2019.

2019-12-02 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from December 2, 2019.

The Eastern Echo, December 2, 2019, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Lanthorn, Vol. 54, No. 17, December 2, 2019, Grand Valley State University

Volume 54, July 15, 2019 - April 27, 2020

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Guitar Studio Concert, St. Norbert College Music Department

Music Performances

The St. Norbert College Guitar Studio under the direction of Dr. Christopher Cramer performed at Dudley Birder Hall on December 2nd 2019.

A Book Of Possibilities – Ethnographically Speaking: Autoethnography, Literature, And Aesthetics, Kelsey Railsback

The Qualitative Report

I would say this book is successful in reference to the authors’ intention to showcase ethnographic projects that “blur the boundaries between social science and literature,” but I would also caution those researchers looking for a how-to book for their dissertation or other qualitative research project. This is a book of possibilities of what (auto)ethnographies can be—inspiring authors and fostering creativity, and I am sure a lot of readers will connect with it.

December 2, 2019, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Department Of Literature News, Georgia Southern University

Literature News (2013-2020)

• Oh, The Places You Can Go: Meet Derek Lewis '97 (Alumni Interview)*

Additive Manufacturing Materials: Fabrication Of Aluminum Matrix Composites, Jakob Hamilton

Theses

This study aims to validate the ability of cryomilling for the production of high-quality aluminum matrix composite (AMC) powder for powder bed fusion (PBF) additive manufacturing (AM). The spectrum of aluminum-based materials available for AM remains limited due to complex melting and solidification dynamics inherent to the process. To overcome these problems, fillers are often added to aluminum matrices to create a class of materials called AMCs that combine the ductility of aluminum with the stiffness of ceramic reinforcements. However, producing particulate composite feedstock powder for PBF that promotes full densification and microstructural homogeneity is nontrivial. Traditional liquid-phase processing through …

Faculty Senate Agenda, Helen Bland

Faculty Senate Agendas

No abstract provided.

College Of Business News, Georgia Southern University

College of Business: News & Publications

• Blog: 5 Final Exam Study Tips to Help You Through that Dreaded Week

Cosm Physics News, Georgia Southern University

Biochemistry, Chemistry & Physics: News & Publications (2012-2023)

• Georgia Southern Planetarium

Mixed Chamber Ensembles, Julie Coucheron, Charae Krueger, Kenn Wagner, John Warren

Bailey School of Music Concert Programs

The mixed chamber ensembles at KSU, led by coaches from various areas of the faculty, present their fall 2019 recital.

Effect Of Surface Roughness On Ultrasonic Inspection Of Electron Beam Melting Ti‐6al‐4v, Evan T. Hanks, Anthony N. Palazotto, David Liu

Faculty Publications

Experimental research was conducted on the effects of surface roughness on ultrasonic non-destructive testing of electron beam melted (EBM) additively manufactured Ti-6Al-4V. Additive manufacturing (AM) is a developing technology with many potential benefits, but certain challenges posed by its use require further research before AM parts are viable for widespread use in the aviation industry. Possible applications of this new technology include aircraft battle damage repair (ABDR), small batch manufacturing to fill supply gaps and replacement for obsolete parts. This paper aims to assess the effectiveness of ultrasonic inspection in detecting manufactured flaws in EBM-manufactured Ti-6Al-4V. Additively manufactured EBM products …

Situational Awareness: Examining Factors That Affect Cyber-Risks In The Maritime Sector, K Tam, Kd Jones

School of Engineering, Computing and Mathematics

Standard risk assessments are used to define and prioritize threats within a sector. However, the rising number of cybersecurity risks in maritime are often temperamental to a range of environmental, technical, and social factors. A change during an incident can significantly alter the risks and, consequently, the incident outcomes. Therefore, agile, changing risk profiles are becoming more necessary in the modern world. In addition to static and dynamic, maritime operational risks can be affected by cyber, cyber-physical, or physical elements. This demonstrates the equal use of information and operational technology (IT/OT); however, most quantitative risk assessment frameworks focus on one …

The Study Of Zeolitic Imidazolate Framework (Zif-8) Doped Polyvinyl Alcohol/Starch/Methyl Cellulose Blend Film, Shaoxiang Lee, Yunna Lei, D Wang, Chunxu Li, Jiaji Cheng, J Wang, Wenqiao Meng, Meng Liu

School of Engineering, Computing and Mathematics

ZIF-8 nanoparticle-doped polyvinyl alcohol (PVA)-S-MC films were prepared via casting method. The effect of different concentrations of ZIF-8 on the physical properties and structural characterization of the films were investigated. The results indicated that ZIF-8 could increase the water resistance and mechanical property of the membrane. Through FTIR, scanning electron microscope (SEM), atomic force microscope (AFM), and TGA analysis, it was found that ZIF-8 changed the phenomenon of macromolecule agglomeration and improved the thermal stability of the membrane. The breathable behavior of the film was also studied through oxygen permeability and water vapor permeability analysis. The result illustrated that the …

Identifying Undetected Dementia In Uk Primary Care Patients: A Retrospective Case-Control Study Comparing Machine-Learning And Standard Epidemiological Approaches, E Ford, P Rooney, S Oliver, R Hoile, Et Al

Peninsula Medical School

Background: Identifying dementia early in time, using real world data, is a public health challenge. As only two-thirds of people with dementia now ultimately receive a formal diagnosis in United Kingdom health systems and many receive it late in the disease process, there is ample room for improvement. The policy of the UK government and National Health Service (NHS) is to increase rates of timely dementia diagnosis. We used data from general practice (GP) patient records to create a machine-learning model to identify patients who have or who are developing dementia, but are currently undetected as having the condition by …

Vendaval Realty, Llc V. Felder

All Decisions

No abstract provided.

Washington’S 'Cutting-Edge' Solution To Combat Sales Tax Fraud, Richard Thompson Ainsworth, Robert Chicoine, Andrew Leahey, Sunder Gee

Faculty Scholarship

Globally, consumption tax compliance (value added tax and retail sales tax) has gone digital – digital invoices are becoming mandatory, centralized monitoring of transactions and tax payments are increasingly common, and artificial intelligence is assessing fraud risks in real-time. When tax is collected, it is increasingly being remitted in near-real-time. This is the trajectory for the modern retail sales tax (RST) imposed by most states in the US. While this may appear to be revolutionary to the average American, it is a well-worn path among global nations using the value added tax (VAT). The RST will eventually be following suit. …

New Possibilities For Stilt Building, Zhuming Liu

Theses

The purpose of the thesis lies in exploring the new possibilities of the stilt building in dealing with two sustainability problems caused by urban development: the Lack of Public Greening in Prosperous, High-density Areas, and the Continuous Sprawl of Private Housing in Suburbs.

As a functional building method with a long history, stilt building, or known as building with “The Pilotis,” regained its vitality in the 20th century with Le Corbusier. However, the common application mode of today’s stilt building has deviated from Corbusier's original intention, which was to provide sheltered outdoor green space for residents in the city. This …

Faculty Senate Monthly Packet December 2019, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The December 2, 2019 Monthly packet includes the December agenda and appendices and the Faculty Senate minutes and attachments from the meeting held November 4, 2019. Also included are the revised December 2019 agenda and the Committee on Committees (CoC) Annual Report to the Faculty Senate.

Sustainability Assessment Of Wireless Community Grid For Off-Grid Communities: A Case Study For Haiti, Tejan Adhikari

Theses

Affordable, reliable, and sustainable energy service is fundamental to human, social and economic development. Approximately 1.2 billion people lack access to basic energy services. There exists a huge energy access gap between urban centers and rural areas. Approximately 84% of the people deprived of energy access live in rural areas. Existing rural electrification options including grid extension, mini-grids, and stand-alone solar home systems, have limited penetration in rural regions. Entrepreneurs, with support from governments and international institutions, have experimented with different business mechanisms to facilitate energy delivery. A significant amount of investment is being made for rural electrification but many …

Scientometric Profile Of Tripura University Based On Selected Disciplines: A Study, Mithu Anjali Gayan, Sanjay Kumar Singh

Library Philosophy and Practice (e-journal)

Research productivity of Tripura which is one of the North East Indian states is not measured from a point of view of Scientometrics until now. It’s an untouched area of research. An attempt has been made in this study to understand and evaluate research productivity indexed in Web of Science database of selected disciplines from Tripura University as it is the only central university in the state. It is found that since beginning until 2019, 313 documents are indexed in the database from the broad research areas of Chemistry, Mathematics and Physics. The study revealed that Bhattacharjee, D is the …

Application Of Bradford's Law Of Scattering And Obsolescence In The Literature Of Chemistry: A Study Based On Doctoral Theses, Mithu Anjali Gayan, Sanjay Kumar Singh

Library Philosophy and Practice (e-journal)

The proposed study tries to investigate citation pattern of Chemistry theses submitted to Central library Tripura University. The study considered only those theses submitted to Shodhganga, the Indian ETD initiative. Hence data were collected from 20 theses constituting 6214 citations during 2007 to 2016. Bardford’s law is used to find out the core journals in the field of Chemistry. The rank list of journals showed “Phytochemistry” is the most cited journal. The dataset of the study did not follow the Bradford’s law. However, the dataset follow the Leimkuhler’s model. Half life of Chemistry journals is found to be 12.6 years. …

Scientometric Mapping And Visualization Of Environmental Science Research: A Case Study, Sanku Bilas Roy

Library Philosophy and Practice (e-journal)

The present study attempts to emphasize quantitatively the development of environmental science literature in terms of publication output as per Scopus database for thirty years (1989-2018). The focus of this paper is to analysis the literature published by the researchers of the University of Calcutta during the period under study. Total 1093 records have been retrieved for this study. An exponential growth rate has been identified. Authorship trend was towards multi-authored papers. Most prolific authors and most productive journals have been traced. The most productive journal is Environmental Monitoring and Assessment. Co-authorship pattern and Co-occurrence of keywords have also been …

Decision In Art. 78 Proceeding - Darshan, Travis (2017-07-18)

Decisions in Art. 78 Proceedings

No abstract provided.

Decision In Art. 78 Proceeding - Davis, Brenda (2013-08-12)

Decisions in Art. 78 Proceedings

No abstract provided.