Digital Commons Network^™

Small Molecules That Inhibit Tnf Signalling By Stabilising An Asymmetric Form Of The Trimer, James O'Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel E. Davis, David Mcmillan, Tracy Arakaki, Alex Burgin, David Fox Iii, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P. Cossins, Tim Bourne, Alastair Lawson

Faculty Publications

Tumour necrosis factor (TNF) is a cytokine belonging to a family of trimeric proteins; it has been shown to be a key mediator in autoimmune diseases such as rheumatoid arthritis and Crohn's disease. While TNF is the target of several successful biologic drugs, attempts to design small molecule therapies directed to this cytokine have not led to approved products. Here we report the discovery of potent small molecule inhibitors of TNF that stabilise an asymmetrical form of the soluble TNF trimer, compromising signalling and inhibiting the functions of TNF in vitro and in vivo. This discovery paves the way for …

Political Communication Of Women's Aceh Legislators (Opportunities And Challenges Of Women In Aceh In The Public Sphere), Ainol Mardhiah, Dadang Rahmat Hidayat, Agus Rahmat, Nuryah Asri Sjafirah

Library Philosophy and Practice (e-journal)

The lack of representation of women in Aceh parliament, indicates that women were left behind in every decision-making related to the development of the Aceh region. Though women are the largest group in this area. This paper intends to examine the political communication of women legislative members in Aceh by focusing on: opportunities and challenges for Acehnese women in the public sphere. This study uses qualitative research methods with a case study approach. The results of the study show that with the legalization of the Law no. 12, 2003 on the Public Election and Law on the Aceh Government no. …

New Paradigm New Practices And New Professionalism Needed To Meet Modern World Library Challenges, Muhammad Ramzan Dr, Ashfaq Hussain, Zaheer Ahmad

Library Philosophy and Practice (e-journal)

Since their existence libraries have been acquiring, organizing, disseminating and preserving recorded human knowledge only. However, inventions enforced through information and communication technologies have brought drastic changes in the medium of information storage, dissemination and use. There have been a number of studies in the developed world, which investigated and reported how they created, managed, adopted and reacted to the challenges and opportunities provided by the new information and communication technologies. Now the question is what type of systems, skills and services we need to establish and convert existing libraries into hybrid 21^st Centry Libraries. This paper traces the …

Protocol Efficiently Measuring The Swelling Rate Of Hydrogels, Katherine Zhang, Wuxiang Feng, Congrui Jin

Department of Civil and Environmental Engineering: Faculty Publications

Hydrogels are polymeric materials which can swell in water and retain a significant fraction of water within their structure without dissolving in water. Swelling rate is one of the most important properties of hydrogels. To measure the swelling rate, the profile of swelling capacity versus time of a hydrogel sample is obtained by performing free-absorbency capacity measurements at consecutive time intervals. Traditionally, either the tea-bag method, the sieve method, or the filtration method is used for the free-absorbency capacity measurements depending on the amount of the available sample and the desired precision. However, each method has its own systematic drawbacks. …

The Politics Of Fracking, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Top Business School Four Years Running, Sharon Keeler

UNH Today Archive

No abstract provided.

Gunn V. Gunn Appellant's Reply Brief Dckt. 46977

Not Reported

No abstract provided.

A Different Master Of War: The Influence Of The Folk Music Revival On The Antiwar Movement During The Vietnam Era, Isabelle Gillibrand

Pell Scholars and Senior Theses

Although the folk revival diminished as the United States entered the height of the Vietnam War, it lived on through antiwar activists. Music historians note how folk music was one of the early sparks of antiwar sentiment during the Vietnam era. This research builds on the ideas of previous scholars by analyzing the evolution of folk music from the 1930s to 1960s, how the folk revival's young audience connected to the music, and the influence the folk revival later had during the rise of the Vietnam antiwar movement. The antiwar sentiment expressed in the folk revival carried into antiwar activism, …

Understanding The Effects Of Childhood Trauma: Strategies For Educators, Trista Bentler

Dissertations, Theses, and Projects

Early childhood adversity has major effects on both long and short-term outcomes for children. This paper identifies the definition and causes of various types of trauma, as well as the implications it has on one’s body, brain, and behavior. Through the research and training provided, educators and various school personnel will gain an understanding of trauma and its effects. Furthermore, they will be equipped with a toolbox of strategies and interventions that can be used for all children, but especially those with a history of trauma. A six-part professional development training with trainer’s notes, accompanied by screening tools for trauma …

Likely Nh Dem Voters Happy With Debate And Continued Early Nh Primary; Pessimistic About Defeating Trump 12/19/2019, Unh Survey Center

All UNH Survey Center Polls

Ahead of the sixth Democratic Primary debate, likely Democratic Primary voters in New Hampshire are modestly satisfied with the criteria used by the DNC to determine who can participate in debates and most think the seven candidates who have qualified is too many or just about the right amount. A majority of likely Democratic voters are not concerned about hosting the first-in-the-nation primary despite a relative lack of racial/ethnic diversity in the state and more than half support state law requiring New Hampshire to retain the first primary. Likely Democratic voters are pessimistic about defeating Donald Trump next November, as …

Entrepreneurship Fellowship Winner Plans Luxury Pet Hotel, Megan Baker

News and Events (Discontinued Series)

No abstract provided.

Application Development For Goods Management System Towards Waste Minimization Options, Wan Ahmad Nadzim

Student Works (2020-2029)

Waste is a global concern. Increasing waste generation levels are causing the increase of waste management costs. In fact, the greatest costs of waste are measured by its impacts to the environment, society and economy. Prevention is better than cure—since all wastes come from goods, thus the best way to manage wastes is to manage goods. An application model of goods management system has been developed using GIS (Geographic Information System) and app prototyping. The primary purpose of goods management is to maximize goods and minimize waste by promoting reduction and reuse. GIS was used to perform spatial analyses on …

Are Vape Pens The New Cigarette? The Fda's Impending Quest To Regulate The E-Cigarette And Its Effect On Society's Youth, Addison J. Morgan

DePaul Journal of Health Care Law

No abstract provided.

Humanized Zebrafish Enhance Human Hematopoietic Stem Cell Survival And Promote Acute Myeloid Leukemia Clonal Diversity, Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nithin Mahajan, Daniel Gaston, Troy Lund, David Rittenberg, Graham Dellaire, Clinton J. V. Campbell, Todd Druley, Jason N. Berman

Open Access Publications

Xenograft models are invaluable tools in establishing the current paradigms of hematopoiesis and leukemogenesis. The zebrafish has emerged as a robust alternative xenograft model but, like mice, lack specific cytokines that mimic the microenvironment found in human patients. To address this critical gap, we generated the first humanized zebrafish that express human hematopoietic-specific cytokines (GM-CSF, SCF, and SDF1α). Termed GSS fish, these zebrafish promote survival, self-renewal and multilineage differentiation of human hematopoietic stem and progenitor cells and result in enhanced proliferation and hematopoietic niche-specific homing of primary human leukemia cells. Using error-corrected RNA sequencing, we determined that patient-derived leukemias transplanted …

Immunomodulatory Activity Of Humanized Anti-Il-7r Monoclonal Antibody Rn168 In Subjects With Type 1 Diabetes, Kevan C Herold, Jing Hughes, Janet B Mcgill, Et Al

Open Access Publications

BACKGROUND: The cytokine IL-7 is critical for T cell development and function. We performed a Phase Ib study in patients with type 1 diabetes (T1D) to evaluate how blockade of IL-7 would affect immune cells and relevant clinical responses.

METHODS: Thirty-seven subjects with T1D received s.c. RN168, a monoclonal antibody that blocks the IL -7 receptor α (IL7Rα) in a dose-escalating study.

RESULTS: Between 90% and 100% IL-7R occupancy and near-complete inhibition of pSTAT5 was observed at doses of RN168 1 mg/kg every other week (Q2wk) and greater. There was a significant decline in CD4+ and CD8+ effector and central …

Results From The First Phase Of The Seafloor Backscatter Processing Software Inter-Comparison Project, Mashkoor A. Malik, Alexandre C.G. Schimel, Giuseppe Masetti, Marc Roche, Julian Le Deunf, Margaret F. J. Dolan, Jonathan Beaudoin, Jean-Marie Augustin, Travis Hamilton, Iain Parnum

Center for Coastal and Ocean Mapping

Seafloor backscatter mosaics are now routinely produced from multibeam echosounder data and used in a wide range of marine applications. However, large differences (>5 dB) can often be observed between the mosaics produced by different software packages processing the same dataset. Without transparency of the processing pipeline and the lack of consistency between software packages raises concerns about the validity of the final results. To recognize the source(s) of inconsistency between software, it is necessary to understand at which stage(s) of the data processing chain the differences become substantial. To this end, willing commercial and academic software developers were …

Accuracy Matters For The Benefits Of Sleep After Retrieval Practice, Steven Dessenberger

Arts & Sciences Graduate Student Theses and Dissertations

Previous research suggests that while sleep and retrieval practice can each improve memory on their own, their benefits cannot be combined to produce an additive effect unless feedback is given during the initial test. These previous findings would seem to support a retrieval-as-consolidation of the testing effect, which states that the benefits of retrieval are the result of memory consolidation, a process that normally occurs during the sleep cycle. The present study sought to determine whether the retrieval-as-consolidation account held true when initial test accuracy was considered as a factor. Using foreign language word pairs, we examined the combined effects …

Student Sustainability Leadership Development At Portland State University: Developing Holistic Sustainability Leaders, Megan Suzanne Schneider

Dissertations and Theses

In order to address the myriad of social, economic, and environmental challenges the world is facing, we need to be able to engage in leadership that fosters collective action towards sustainable solutions. Higher education is an institution that can equip people with the abilities to engage in sustainability leadership. This master's thesis research explores how students develop sustainability leadership through their college experience. Nine students, who had been identified as sustainability leaders through their participation in the Student Sustainability Center (SSC), a co-curricular sustainability program at Portland State University, were selected to be part of this grounded theory research project. …

Sources Of Health Information Affecting Awareness In Using Latrine Among Riverside Inhabitants Of Rural Indonesia, Ima Hidayati Utami, Susanne Dida, Purwanti Hadisiwi, Bambang Dwi Prasetyo

Library Philosophy and Practice (e-journal)

Open defecation (OD) has devastating consequences for public health (UNICEF, 2018). In Indonesia, despite OD practice has been steadily decreasing in the last ten years, about 25 million people continue to practice OD in 2019. The study aimed to identify sources of sanitation and hygiene information received by riverside villagers, to identify defecation practiced by riverside villagers, and to examine the correlation between sources of information received with their defecation practice. Using a descriptive quantitative approach, data was collected from Sumberjaya village, a village under a sub-district having the highest OD rate in Malang Regency. A set of questionnaire was …

Challenges Hindering Automation Of Library Services And Measures For Speeding Up The Automation Process: Experience From The Institute Of Adult Education, Barnabas Bwango, Christian Mubofu

Library Philosophy and Practice (e-journal)

The study examined the challenges hindering library services automation and measures for speeding up the automation process. The study was conducted at the Institute of Adult Education (IAE) in Dar es Salaam region. The choice of the study area based on the availability of large library compared to those in other regional centres. Data were gathered 76 respondents using questionnaire as the main data collection method. Findings revealed that the challenges hindering library services automation at the institute of adult education are Lack of good planning, Inadequate communication between participants, Weak participation to both library staff and library users, Lack …

Supply Shock Versus Demand Shock: The Local Effects Of New Housing In Low-Income Areas, Brian J. Asquith, Evan Mast, Davin Reed

Upjohn Institute Working Papers

We study the local effects of new market-rate housing in low-income areas using microdata on large apartment buildings, rents, and migration. New buildings decrease nearby rents by 5 to 7 percent relative to locations slightly farther away or developed later, and they increase in-migration from low-income areas. Results are driven by a large supply effect—we show that new buildings absorb many high-income households—that overwhelms any offsetting endogenous amenity effect. The latter may be small because most new buildings go into already-changing areas. Contrary to common concerns, new buildings slow local rent increases rather than initiate or accelerate them.

Concentrations, Sources, And Health Risks Of Particulate Matter In Southeast Us.: Current Status And Future Changes, Fenglin Han

LSU Doctoral Dissertations

Evaluation of long-term air quality trends and prediction of future air quality may help to design and demonstrate effectiveness of control strategies and guide future air quality management. As one of the six criteria air pollutants (CAPs) regulated by the US Environmental Protection Agency (EPA), particulate matter with aerodynamic diameter of 2.5 µm or less (PM_2.5) is of great interests since it has adverse effects on human health, visibility and climate. This study aims to understand the current status and future changes in concentrations, sources, and health risks of PM_2.5 in Southeast US. Firstly, observations were analyzed …

Timing Is Key To Providing Modified Assessments For Students With Specific Learning Difficulties, Cp Gray, Sa Burr

Peninsula Medical School

Introduction Medical students who are diagnosed with a specific learning difficulty (SpLD) will typically receive a reasonable adjustment within examinations in the form of modified assessment provision (MAP). This study investigated whether the timing of SpLD diagnosis and subsequent implementation of MAP has an impact on performance in applied medical knowledge multiple choice question (MCQ) assessments. Method The MCQ performance of 108 students diagnosed with SpLD who received a MAP was monitored and compared with 1960 students who received an unmodified assessment, over 5 years of a medical program. Students who received a SpLD diagnosis in the latter years of …

Genome-Wide Analysis And Characterization Of F-Box Gene Family In Gossypium Hirsutum L, S Zhang, Z Tian, H Li, Y Guo, Et Al

School of Biological and Marine Sciences

Background F-box proteins are substrate-recognition components of the Skp1-Rbx1-Cul1-F-box protein (SCF) ubiquitin ligases. By selectively targeting the key regulatory proteins or enzymes for ubiquitination and 26S proteasome mediated degradation, F-box proteins play diverse roles in plant growth/development and in the responses of plants to both environmental and endogenous signals. Studies of F-box proteins from the model plant Arabidopsis and from many additional plant species have demonstrated that they belong to a super gene family, and function across almost all aspects of the plant life cycle. However, systematic exploration of F-box family genes in the important fiber crop cotton (Gossypium hirsutum) …

One-Photon Pair Annihilation In Pulsed Plane-Wave Backgrounds, S. Tang, A. Ilderton, B. King

School of Engineering, Computing and Mathematics

No abstract provided.

Commencement Marks Accomplishments Well Worth Celebrating, December 19, 2019, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Parole Interview Transcript/Decision - Fusl000017 (2017-05-23)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000017 (2015-11-18)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000017 (2013-11-20)

Parole Interview Transcripts and Decisions

No abstract provided.

Parole Interview Transcript/Decision - Fusl000017 (2011-11-08)

Parole Interview Transcripts and Decisions

No abstract provided.