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2019

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The First Step To A Nation? The Irish Postal Service And The Home Rule Crisis, Claire Fitzpatrick Jan 2019

The First Step To A Nation? The Irish Postal Service And The Home Rule Crisis, Claire Fitzpatrick

School of Law, Humanities and Social Sciences

No abstract provided.


Africa Starts At The Pyrenees: Humor, Laughter, And Financial Recession In A Spanish Enclave In Morocco, B Campbell Jan 2019

Africa Starts At The Pyrenees: Humor, Laughter, And Financial Recession In A Spanish Enclave In Morocco, B Campbell

School of Law, Humanities and Social Sciences

No abstract provided.


Auditions And … More Auditions, John Matthews, Guevara Vl De Jan 2019

Auditions And … More Auditions, John Matthews, Guevara Vl De

School of Law, Humanities and Social Sciences

No abstract provided.


Widening Gyre: A Poetics Of Ocean Plastics, Mandy Bloomfield Jan 2019

Widening Gyre: A Poetics Of Ocean Plastics, Mandy Bloomfield

School of Law, Humanities and Social Sciences

By focusing on contemporary experimental poetry that engages with ocean plastics, this essay explores the capacity of ecopoetics to make distinctive interventions in the environmental humanities, and in particular the blue humanities. It examines work by Stephen Collis, Adam Dickinson, and Evelyn Reilly to show how poetry’s forms of juxtaposition, linkage, linguistic porosity, indeterminacy, and nonnarrative temporalities suggest fertile modes of cultural engagement with the more-than-human oceans. This poetry cultivates amplified modes of attention to more-than-human scales of space, time, agency, and modes of relation, and it performs highly material ways of understanding historical, economic, and aesthetic forces affecting the …


Musical Borrowing In Sonification, Núria Bonet Jan 2019

Musical Borrowing In Sonification, Núria Bonet

School of Law, Humanities and Social Sciences

Sonification presents some challenges in communicating information, particularly because of the large difference between possible data to sound mappings and cognitively valid mappings. It is an information transmission process which can be described through the Shannon-Weaver Theory of Mathematical Communication. Musical borrowing is proposed as a method in sonification which can aid the information transmission process as the composer’s and listener’s shared musical knowledge is used. This article describes the compositional process of Wasgiischwashäsch (2017) which uses Rossini’s William Tell Overture (1829) to sonify datasets relating to climate change in Switzerland. It concludes that the familiarity of audiences with the …


The Benefits Of Integrating Dental And Dental Therapy And Hygiene Students In Undergraduate Curricula., Daniel Zahra, Louise Belfield, Jon Bennett, Svetislav Zaric, Clare Mcilwaine Jan 2019

The Benefits Of Integrating Dental And Dental Therapy And Hygiene Students In Undergraduate Curricula., Daniel Zahra, Louise Belfield, Jon Bennett, Svetislav Zaric, Clare Mcilwaine

Peninsula Medical School

PURPOSE: The purpose of the current study was to evaluate the impact of integrating the teaching of Bachelor of Dental Surgery (BDS) and Bachelor of Dental Therapy and Hygiene (BScDTH) students in enquiry-based learning (EBL) sessions, using performance on multiple related integrated dental science (IDS) multiple-choice question assessments. METHOD: IDS assessments are sat twice in the first stages of both the BDS and BScDTH programmes. IDS scores from integrated and non-integrated cohorts were collated and compared across test occasions (first or second assessment of the stage) and programmes (BDS and BScDTH). RESULTS: The results revealed that IDS scores were, overall, …


How Group-Based Interventions Can Improve Services For People With Severe Obesity, Dawn Swancutt, Mark Tarrant, Jonathan Pinkney Jan 2019

How Group-Based Interventions Can Improve Services For People With Severe Obesity, Dawn Swancutt, Mark Tarrant, Jonathan Pinkney

Peninsula Medical School

No abstract provided.


Transmural Unipolar Electrogram Change Occurs Within 7s At The Left Atrial Posterior Wall During Pulmonary Vein Isolation, Dr Tomlinson, M Myles, Kn Stevens, A Streeter Jan 2019

Transmural Unipolar Electrogram Change Occurs Within 7s At The Left Atrial Posterior Wall During Pulmonary Vein Isolation, Dr Tomlinson, M Myles, Kn Stevens, A Streeter

Peninsula Medical School

No abstract provided.


Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu Jan 2019

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …


Statins And Parkinson's: A Complex Interaction, Camille B. Carroll, Richard K.H. Wyse, Donald G. Grosset Jan 2019

Statins And Parkinson's: A Complex Interaction, Camille B. Carroll, Richard K.H. Wyse, Donald G. Grosset

Peninsula Medical School

No abstract provided.


Governance Through Diversion In Neoliberal Times And The Possibilities For Transformative Social Justice, Patricia Gray, Roger Smith Jan 2019

Governance Through Diversion In Neoliberal Times And The Possibilities For Transformative Social Justice, Patricia Gray, Roger Smith

School of Law, Humanities and Social Sciences

Over the last decade, the dramatic increase in the number of young people diverted from formal processing through the youth justice system in England and Wales, and the equally sharp drop in the rate of youth custody suggest that the neoliberal formula for the penal governance of young people who offend has been undergoing significant reshaping. This article draws on research which interrogates the changes that are currently taking place, particularly the proliferation of “out of court” community-based measures of diversion and offense resolution, to develop a more fine-tuned conceptualization of the complexities of neoliberal youth penality. We base our …


It's More Than Just A Referral: Development Of An Evidence-Informed Exercise And Depression Toolkit, Krista Glowacki, Kelly Arbour-Nicitopoulos, Meghan Burrows, Leslie Chesick, Lyn Heinemann, Sarah Irving, Raymond W. Lam, Soultana Macridis, Erin Michalak, Aidan Scott, Adrian Taylor, Guy Faulkner Jan 2019

It's More Than Just A Referral: Development Of An Evidence-Informed Exercise And Depression Toolkit, Krista Glowacki, Kelly Arbour-Nicitopoulos, Meghan Burrows, Leslie Chesick, Lyn Heinemann, Sarah Irving, Raymond W. Lam, Soultana Macridis, Erin Michalak, Aidan Scott, Adrian Taylor, Guy Faulkner

Peninsula Medical School

No abstract provided.


Obeticholic Acid For The Treatment Of Non-Alcoholic Steatohepatitis: Interim Analysis From A Multicentre, Randomised, Placebo-Controlled Phase 3 Trial, Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N. Newsome, David Sheridan, Muhammad Y. Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F. Abdelmalek, Kris V. Kowdley, Aldo J. Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean Francois Dufour, David Shapiro, David Shapiro, Luna Zaru, Leigh Macconell, Reshma Shringarpure, Stephen Harrison, Arun J. Sanyal, Manal F. Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin M. Anstee, Rodolphe Anty, V Araya, Ruiz Ji Arenas, P Arkkila, M Arora, T Asselah, J Au, O Ayonrinde, Rj Bailey, M Balakrishnan, K Bambha, M Bansal, S Barritt, J Bate, J Beato, Susanne Beckebaum, J Behari, P Bellot, Ari Z Ben, M Bennett, M Berenguer, Bt Beretta-Piccoli, T Berg, M Bonacini, L Bonet, B Borg, M Bourliere, Jerome Boursier, W Bowman, D Bradley, M Brankovic, M Braun, J-P Bronowicki, S Bruno, Elisabetta Bugianesi, C Cai, Panero Jl Calleja Jan 2019

Obeticholic Acid For The Treatment Of Non-Alcoholic Steatohepatitis: Interim Analysis From A Multicentre, Randomised, Placebo-Controlled Phase 3 Trial, Zobair M. Younossi, Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, Andreas Geier, Susanne Beckebaum, Philip N. Newsome, David Sheridan, Muhammad Y. Sheikh, James Trotter, Whitfield Knapple, Eric Lawitz, Manal F. Abdelmalek, Kris V. Kowdley, Aldo J. Montano-Loza, Jerome Boursier, Philippe Mathurin, Elisabetta Bugianesi, Giuseppe Mazzella, Antonio Olveira, Helena Cortez-Pinto, Isabel Graupera, David Orr, Lise Lotte Gluud, Jean Francois Dufour, David Shapiro, David Shapiro, Luna Zaru, Leigh Macconell, Reshma Shringarpure, Stephen Harrison, Arun J. Sanyal, Manal F. Abdelmalek, Gary Abrams, Humberto Aguilar, Aijaz Ahmed, Elmar Aigner, Guruprasad Aithal, Aftab Ala, William Alazawi, Agustin Albillos, Michael Allison, Sfa Al-Shamma, Raul Andrade, Pietro Andreone, Mario Angelico, Victor Ankoma-Sey, Quentin M. Anstee, Rodolphe Anty, V Araya, Ruiz Ji Arenas, P Arkkila, M Arora, T Asselah, J Au, O Ayonrinde, Rj Bailey, M Balakrishnan, K Bambha, M Bansal, S Barritt, J Bate, J Beato, Susanne Beckebaum, J Behari, P Bellot, Ari Z Ben, M Bennett, M Berenguer, Bt Beretta-Piccoli, T Berg, M Bonacini, L Bonet, B Borg, M Bourliere, Jerome Boursier, W Bowman, D Bradley, M Brankovic, M Braun, J-P Bronowicki, S Bruno, Elisabetta Bugianesi, C Cai, Panero Jl Calleja

Peninsula Medical School

No abstract provided.


“The Lions Of Tomorrow”: A News Value Analysis Of Child Images In Jihadi Magazines, Amy Louise Watkin, Seán Looney Jan 2019

“The Lions Of Tomorrow”: A News Value Analysis Of Child Images In Jihadi Magazines, Amy Louise Watkin, Seán Looney

School of Law, Humanities and Social Sciences

No abstract provided.


Ward-Based Goal-Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: Study Protocol For A Feasibility Randomised Controlled Trial, Farid Froghi, Fiammetta Soggiu, Federico Ricciardi, Kurinchi Gurusamy, Daniel S. Martin, Jeshika Singh, Sulman Siddique, Christine Eastgate, Maria Ciaponi, Margaret Mcneil, Helder Filipe, Otto Schwalowsky-Monks, Gretchelle Asis, Massimo Varcada, Brian R. Davidson Jan 2019

Ward-Based Goal-Directed Fluid Therapy (Gdft) In Acute Pancreatitis (Gap) Trial: Study Protocol For A Feasibility Randomised Controlled Trial, Farid Froghi, Fiammetta Soggiu, Federico Ricciardi, Kurinchi Gurusamy, Daniel S. Martin, Jeshika Singh, Sulman Siddique, Christine Eastgate, Maria Ciaponi, Margaret Mcneil, Helder Filipe, Otto Schwalowsky-Monks, Gretchelle Asis, Massimo Varcada, Brian R. Davidson

Peninsula Medical School

IntroductionAcute pancreatitis is an inflammatory disease of the pancreas with high risk of developing multiorgan failure and death. There are no effective pharmacological interventions used in current clinical practice. Maintaining fluid and electrolyte balance is the mainstay of supportive management. Goal-directed fluid therapy (GDFT) has been shown to decrease morbidity and mortality in surgical conditions with systemic inflammatory response. There is currently no randomised controlled trial (RCT) investigating the role of GDFT based on cardiac output parameters in patients with acute pancreatitis in the ward setting. A feasibility trial was designed to determine patient and clinician support for recruitment into …


Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin Jan 2019

Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin

Peninsula Medical School

Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied …


137 Usability Testing Of A Non-Motor Symptom App In Pd, T Dominey, S Mullin, E Edwards, J Whipps, S Whipps, C Carroll Jan 2019

137 Usability Testing Of A Non-Motor Symptom App In Pd, T Dominey, S Mullin, E Edwards, J Whipps, S Whipps, C Carroll

Peninsula Medical School

BackgroundNon-motor symptoms (NMS) are a significant cause of morbidity in Parkinson’s, with major impact on quality of life. There is an urgent need to empower people with Parkinson’s (PwP) to self-manage NMS, and facilitate timely intervention. A mobile application (NMS Assist) was developed, which enables regular assessment of NMS and provides self-help information in the form of animations.AimTo evaluate key areas for NMS Assist design improvement.MethodPwP and carers were recruited from local Parkinson’s UK groups. NMS Assist user journeys were designed and carried out, filmed with ‘Mr Tappy’, using ‘think aloud’ methodology. Satisfaction was evaluated by the System Usability Scale …


11.39 Association Of British Neurologists Sustainability Special Interest Group (Abn Sustainability Sig): Formation, Objectives And Invitation, A Cheesman, D Blackburn, C Carroll, A Cohen, J Coebergh, D Sokhi, Sh Wong, J Woolmore Jan 2019

11.39 Association Of British Neurologists Sustainability Special Interest Group (Abn Sustainability Sig): Formation, Objectives And Invitation, A Cheesman, D Blackburn, C Carroll, A Cohen, J Coebergh, D Sokhi, Sh Wong, J Woolmore

Peninsula Medical School

We introduce the ABN Sustainability SIG. We present our aims & objectives, and practical ways of implementing sustainability strategies in Neurology.At the 2016 ABN annual meeting, a keynote speech by Dr. David Pencheon, then director of the National Health Service Sustainability Development Unit, highlighted the relevance and importance of Sustainability in Neurology. This planted the seed for our SIG’s formation. Initial interest was gathered from an ABN newsletter notice, via word-of-mouth and informal discussions at ABN annual meetings (2017, 2018). A series of teleconferences & email discussions enabled the formation of SIG byelaws and application to the ABN council.Our aims …


Optimising Feedback For Early Career Professionals: A Scoping Review And New Framework, Karen Mattick, Nicola Brennan, Simon Briscoe, Chrysanthi Papoutsi, Mark Pearson Jan 2019

Optimising Feedback For Early Career Professionals: A Scoping Review And New Framework, Karen Mattick, Nicola Brennan, Simon Briscoe, Chrysanthi Papoutsi, Mark Pearson

Peninsula Medical School

No abstract provided.


Patient And Public Involvement In Medical Performance Processes: A Systematic Review, Mirza Lalani, Rebecca Baines, Marie Bryce, Martin Marshall, Sol Mead, Stephen Barasi, Julian Archer, De Bere S Regan Jan 2019

Patient And Public Involvement In Medical Performance Processes: A Systematic Review, Mirza Lalani, Rebecca Baines, Marie Bryce, Martin Marshall, Sol Mead, Stephen Barasi, Julian Archer, De Bere S Regan

Peninsula Medical School

No abstract provided.


Sofosbuvir/Velpatasvir For 12 Weeks In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease Undergoing Dialysis, Sergio M. Borgia, Janet Dearden, Eric M. Yoshida, Stephen D. Shafran, Ashley Brown, Ziv Ben-Ari, Matthew E. Cramp, Curtis Cooper, Matthew Foxton, Conrado Fernandez Rodriguez, Rafael Esteban, Robert Hyland, Sophia Lu, Brian J. Kirby, Amy Meng, Svetlana Markova, Hadas Dvory-Sobol, Anu O. Osinusi, Rafael Bruck, Javier Ampuero, Stephen D. Ryder, Kosh Agarwal, Raymond Fox, David Shaw, Shariq Haider, Bernard Willems, Yoav Lurie, Jose Luis Calleja, Edward J. Gane Jan 2019

Sofosbuvir/Velpatasvir For 12 Weeks In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease Undergoing Dialysis, Sergio M. Borgia, Janet Dearden, Eric M. Yoshida, Stephen D. Shafran, Ashley Brown, Ziv Ben-Ari, Matthew E. Cramp, Curtis Cooper, Matthew Foxton, Conrado Fernandez Rodriguez, Rafael Esteban, Robert Hyland, Sophia Lu, Brian J. Kirby, Amy Meng, Svetlana Markova, Hadas Dvory-Sobol, Anu O. Osinusi, Rafael Bruck, Javier Ampuero, Stephen D. Ryder, Kosh Agarwal, Raymond Fox, David Shaw, Shariq Haider, Bernard Willems, Yoav Lurie, Jose Luis Calleja, Edward J. Gane

Peninsula Medical School

BACKGROUND & AIMS: Although off-label use of sofosbuvir-containing regimens occurs regularly in patients with hepatitis C virus (HCV) infection undergoing dialysis for severe renal impairment or end-stage renal disease (ESRD), these regimens are not licensed for this indication, and there is an absence of dosing recommendations in this population. This study evaluated the safety and efficacy of sofosbuvir/velpatasvir in patients with HCV infection with ESRD undergoing dialysis. METHODS: In this phase II, single-arm study, 59 patients with genotype 1-6 HCV infection with ESRD undergoing hemodialysis or peritoneal dialysis received open-label sofosbuvir/velpatasvir (400 mg/100 mg) once daily for 12 weeks. Patients …


Trends In Phenotype In The English Paediatric Neurofibromatosis Type 2 Cohort Stratified By Genetic Severity, Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D. Gareth Evans, Allyson Parry, Patrick Axon, Juliette Gair, Carolyn Smyth, Shazia K. Afridi, Rupert Obholzer, Vanessa Everett, Nicola Jarvis, Kirsty Henshaw, C. Oliver Hanemann, Wendy Howard, Anne May, Carolyn Redman, Rohini Rattihalli, Helen Tomkins Jan 2019

Trends In Phenotype In The English Paediatric Neurofibromatosis Type 2 Cohort Stratified By Genetic Severity, Dorothy Halliday, Beatrice Emmanouil, Grace Vassallo, Karine Lascelles, James Nicholson, Saleel Chandratre, Geetha Anand, Martin Wasik, Pieter Pretorius, D. Gareth Evans, Allyson Parry, Patrick Axon, Juliette Gair, Carolyn Smyth, Shazia K. Afridi, Rupert Obholzer, Vanessa Everett, Nicola Jarvis, Kirsty Henshaw, C. Oliver Hanemann, Wendy Howard, Anne May, Carolyn Redman, Rohini Rattihalli, Helen Tomkins

Peninsula Medical School

No abstract provided.


Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang Jan 2019

Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang

Peninsula Medical School

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both …


Evaluation Of The Detection Of Gba Missense Mutations And Other Variants Using The Oxford Nanopore Minion, M Leija‐Salazar, Fritz J. Sedlazeck, Marco Toffoli, Stephen Mullin, Katya Mokretar, Maria Athanasopoulou, Aimee Donald, Reena Sharma, Derralynn Hughes, Anthony H.V. Schapira, Christos Proukakis Jan 2019

Evaluation Of The Detection Of Gba Missense Mutations And Other Variants Using The Oxford Nanopore Minion, M Leija‐Salazar, Fritz J. Sedlazeck, Marco Toffoli, Stephen Mullin, Katya Mokretar, Maria Athanasopoulou, Aimee Donald, Reena Sharma, Derralynn Hughes, Anthony H.V. Schapira, Christos Proukakis

Peninsula Medical School

No abstract provided.


Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng Jan 2019

Gender Incongruence In Children, Adolescents And Adults, Susan Bewley, Damian Clifford, Margaret Mccartney, Richard Byng

Peninsula Medical School

More individuals are requesting medical assistance for gender uncertainty or dysphoria and provision of adult NHS gender identity services (GIS) is changing. Despite minimal medical input to polarised debates, several issues are potentially concerning: reports of poor care; rapid rises in referrals of children and young people to GIS; public conflation of biological sex with socially influenced gender roles; and extensive uncertainty in the evidence base to guide practice. Medical practice should happen within robust human rights frameworks where individual patients always have their concerns heard. Generalists, with expertise in whole-person care, handling uncertainty and complexity, have a key role …


Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo Jan 2019

Mitochondria In Neurodegenerative Diseases, Fang Lin, Shou Qing Luo

Peninsula Medical School

No abstract provided.


Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira Jan 2019

Evolution And Clustering Of Prodromal Parkinsonian Features In Gba1 Carriers, Stephen Mullin, Michelle Beavan, Jonathan Bestwick, Alisdair Mcneill, Christos Proukakis, Timothy Cox, Derralynn Hughes, Atul Mehta, Henrik Zetterberg, Anthony H.V. Schapira

Peninsula Medical School

No abstract provided.


Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng Jan 2019

Gender Incongruence In Children, Adolescents, And Adults: Response To Dr White, M Mccartney, S Bewley, D Clifford, R Byng

Peninsula Medical School

No abstract provided.


Exploring How Patients Respond To Gp Recommendations For Mental Health Treatment: An Analysis Of Communication In Primary Care Consultations, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe Jan 2019

Exploring How Patients Respond To Gp Recommendations For Mental Health Treatment: An Analysis Of Communication In Primary Care Consultations, Joseph Ford, Felicity Thomas, Richard Byng, Rose Mccabe

Peninsula Medical School

BackgroundPatient take-up and adherence to antidepressants and talking therapy is low. However, little is known about how GPs recommend these treatments and whether patients accept them.AimTo examine how GPs recommend antidepressants and talking therapy, and how patients respond.Design & settingA total of 52 recorded primary care consultations for depression, anxiety, and stress were analysed.MethodUsing a standardised coding scheme, five ways doctors recommend treatment were coded, conveying varying authority and endorsement. The treatment recommendation types were as follows: more directive pronouncements (I’ll start you on X); proposals (How about we start X?); less directive suggestions (Would you like to try X?); …


Teasing Apart The Impact Of Illness And Iq On Functional Neuroimaging Findings In Schizophrenia, S Graham, Tm Oh, V Manning, J Jiang, Ib Yeh, S Kang, Pj Mckenna Jan 2019

Teasing Apart The Impact Of Illness And Iq On Functional Neuroimaging Findings In Schizophrenia, S Graham, Tm Oh, V Manning, J Jiang, Ib Yeh, S Kang, Pj Mckenna

Peninsula Medical School

Schizophrenia is a major psychiatric disorder associated with cognitive impairment. Functional brain imaging (fMRI) studies of schizophrenia patients reveal a complex pattern of brain differences in the prefrontal cortex. Both decreased (hypofrontality) and increased (hyperfrontality) activity have been reported in patients – inconsistencies that this paper argues could be explained by differences in IQ between patients and healthy controls. This study demonstrates a novel method to tease apart IQ and schizophrenia effects on brain activity. Twelve schizophrenia patients were matched to twelve healthy controls matched to patients’ estimated (premorbid) IQ before their illness, and twelve healthy controls matched to patients’ …