Digital Commons Network^™

Ferroptotic Cell Death And Tlr4/Trif Signaling Initiate Neutrophil Recruitment After Heart Transplantation, Wenjun Li, Guoshuai Feng, Jason M Gauthier, Inessa Lokshina, Ryuji Higashikubo, Sarah Evans, Xinping Liu, Adil Hassan, Satona Tanaka, Markus Cicka, Hsi-Min Hsiao, Daniel Ruiz-Perez, Andrea Bredemeyer, Richard W Gross, Douglas L Mann, Yulia Y Tyurina, Andrew E Gelman, Valerian E Kagan, Andreas Linkermann, Kory J Lavine, Daniel Kreisel

Open Access Publications

Non-apoptotic forms of cell death can trigger sterile inflammation through the release of danger-associated molecular patterns, which are recognized by innate immune receptors. However, despite years of investigation the mechanisms which initiate inflammatory responses after heart transplantation remain elusive. Here, we demonstrate that ferrostatin-1 (Fer-1), a specific inhibitor of ferroptosis, decreases the level of pro-ferroptotic hydroperoxy-arachidonoyl-phosphatidylethanolamine, reduces cardiomyocyte cell death and blocks neutrophil recruitment following heart transplantation. Inhibition of necroptosis had no effect on neutrophil trafficking in cardiac grafts. We extend these observations to a model of coronary artery ligation-induced myocardial ischemia reperfusion injury where inhibition of ferroptosis resulted in …

Rrx-001 Followed By Platinum Plus Etoposide In Patients With Previously Treated Small-Cell Lung Cancer, Daniel Morgensztern, Michal Rose, Saiama N Waqar, John Morris, Patrick C Ma, Thomas Reid, Christina E Brzezniak, Karen G Zeman, Arvinda Padmanabhan, Joann Hirth, Alexander I Spira, Jane B Trepel, Sukhmani K Padda

Open Access Publications

BACKGROUND: This exploratory single-arm phase II study evaluated the efficacy and safety of RRx-001 followed by reintroduction of platinum plus etoposide in patients with previously treated small-cell lung cancer (SCLC).

METHODS: Patients were treated with RRx-001 4 mg IV on day 1 of each week of a 21-day cycle followed at progression by re-challenge with etoposide 80-100 IV mg/m

RESULTS: Twenty-six patients were enroled and received at least one dose of RRx-001. The median number of prior lines of therapy was 2 (range 1-9) and 19 (73.1%) patients had platinum-resistant disease. In the intention-to-treat population, one patient (3.8%) had complete …

Visualization Of Positive And Negative Sense Viral Rna For Probing The Mechanism Of Direct-Acting Antivirals Against Hepatitis C Virus, Dandan Liu, Philip R Tedbury, Shuiyun Lan, Andrew D Huber, Maritza N Puray-Chavez, Juan Ji, Eleftherios Michailidis, Mohsan Saeed, Tanyaradzwa P Ndongwe, Leda C Bassit, Raymond F Schinazi, Robert Ralston, Charles M Rice, Stefan G Sarafianos

Open Access Publications

RNA viruses are highly successful pathogens and are the causative agents for many important diseases. To fully understand the replication of these viruses it is necessary to address the roles of both positive-strand RNA ((+)RNA) and negative-strand RNA ((-)RNA), and their interplay with viral and host proteins. Here we used branched DNA (bDNA) fluorescence in situ hybridization (FISH) to stain both the abundant (+)RNA and the far less abundant (-)RNA in both hepatitis C virus (HCV)- and Zika virus-infected cells, and combined these analyses with visualization of viral proteins through confocal imaging. We were able to phenotypically examine HCV-infected cells …

Mobilized Peripheral Blood: An Updated Perspective, Darja Karpova, Michael P Rettig, John F Dipersio

Open Access Publications

Enforced egress of hematopoietic stem cells (HSCs) out of the bone marrow (BM) into the peripheral circulation, termed mobilization, has come a long way since its discovery over four decades ago. Mobilization research continues to be driven by the need to optimize the regimen currently available in the clinic with regard to pharmacokinetic and pharmacodynamic profile, costs, and donor convenience. In this review, we describe the most recent findings in the field and how we anticipate them to affect the development of mobilization strategies in the future. Furthermore, the significance of mobilization beyond HSC collection, i.e. for chemosensitization, conditioning, and …

Tp53 Mutation Status Divides Myelodysplastic Syndromes With Complex Karyotypes Into Distinct Prognostic Subgroups, Detlef Haase, Matthew J. Walter, Et Al.

Open Access Publications

No abstract provided.

Clinical Events After Deferral Of Lad Revascularization Following Physiological Coronary Assessment, Sayan Sen, Jasvindar Singh, Et Al

Open Access Publications

No abstract provided.

Interpreting Neurologic Outcomes In A Changing Trial Design Landscape: An Analysis Of Heartware Left Ventricular Assist Device Using A Hybrid Intention To Treat Population, Claudius Mahr, Duc Thinh Pham, Nahush A. Mokadam, Scott C. Silvestry, Jennifer Cowger, Michael S. Kiernan, David A. D'Alessandro, Erin E. Coglianese, Muhammad Faraz Masood, Robert L. Kormos, Mary V. Jacoski, Jeffrey J. Teuteberg

Open Access Publications

No abstract provided.

Efficacy And Safety Of Eluxadoline In Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: Relief Phase 4 Study, Darren M. Brenner, Gregory S. Sayuk, Catherine R. Gutman, Esther Jo, Steven J. R. Elmes, Louis W. C. Liu, Brooks D. Cash

Open Access Publications

No abstract provided.

Association Between Early Anatomic Response To Anti-Vascular Endothelial Growth Factor Therapy And Long-Term Outcome In Diabetic Macular Edema: An Independent Analysis Of Protocol I Study Data, Pravin U. Dugel, Joanna H. Campbell, Szilárd Kiss, Anat Loewenstein, Vanessa Shih, Xiaoshu Xu, Nancy Holekamp, Albert J. Augustin, Allen C. Ho, Victor H. Gonzalez, Scott M. Whitcup

Open Access Publications

No abstract provided.

Determining Population Stratification And Subgroup Effects In Association Studies Of Rare Genetic Variants For Nicotine Dependence, Ai-Ru Hsieh, Li-Shiun Chen, Ying-Ju Li, Cathy S. J. Fann

Open Access Publications

No abstract provided.

Challenges To Curing Primary Brain Tumours, Kenneth Aldape, David H. Gutmann, Et Al.

Open Access Publications

No abstract provided.

Clinical Performance Of A Novel Fully Synthetic Dura Substitute, Umang Khandpur, Wilson Ray, Matthew Macewan

Open Access Publications

No abstract provided.

A Strategy For Building And Using A Human Reference Pangenome, Bastien Llamas, Allison Regier, Et Al

Open Access Publications

In March 2019, 45 scientists and software engineers from around the world converged at the University of California, Santa Cruz for the first pangenomics codeathon. The purpose of the meeting was to propose technical specifications and standards for a usable human pangenome as well as to build relevant tools for genome graph infrastructures. During the meeting, the group held several intense and productive discussions covering a diverse set of topics, including advantages of graph genomes over a linear reference representation, design of new methods that can leverage graph-based data structures, and novel visualization and annotation approaches for pangenomes. Additionally, the …

Somatosensory Predictors Of Response To Pregabalin In Painful Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Placebo-Controlled, Crossover Study, Alexander Hincker, Karen Frey, Lesley Rao, Nina Wagner-Johnston, Arbi Ben Abdallah, Benjamin Tan, Manik Amin, Tanya Wildes, Rajiv Shah, Pall Karlsson, Kristopher Bakos, Katarzyna Kosicka, Leonid Kagan, Simon Haroutounian

Open Access Publications

No abstract provided.

William Robinson Simpson Papers - Accession 571, William Robinson Simpson Jr., Simpson Family, Pride Family, Jones Family, Sitgreaves Family

Manuscript Collection

The William Robinson Simpson Papers consists of photocopies of materials collected by William Robinson Simpson, Jr. (1902-1993) that relate primarily to line of the Simpson Family descended from John Simpson, Sr. (1770-1834). The collection consists primarily with genealogical materials related to the Simpson, Pride, Jones, and Sitgreaves families based mostly in Chester County, SC and York County, SC from the 1800s-1978s. Some of the genealogies extend as far back 400 AD. The collection consists entirely of photocopies of correspondence, receipts, ledger entries, legal documents (wills, power of attorney, etc.), newspaper articles, photographs, family narratives and biographies, and lineage charts.

South Carolina Vocational Association Records - Accession 552, Vocational Association, South Carolina, Career And Technical Education, South Carolina Association

Manuscript Collection

The South Carolina Vocational Association Records consist of correspondence, minutes, bylaws, reports, and memoranda relating to annual conferences, awards, administrators of the organization, and its activities. Subjects include the annual summer conferences from 1981-1984, minutes and agenda of business meetings during this same time, other South Carolina Vocational Association (SCVA) advertised events, as well as original resumes and correspondence for the 1981 director position.

Rock Hill Power Company Records - Accession 1482, Rock Hill Power Company, Rock Hill Water And Light Company, Rock Hill Water, Light, And Power Company, Rock Hill Water And Electric Company, Rock Hill Little Theater

Manuscript Collection

The Rock Hill Power Company Records contains thirty nine individual records owned by the Rock Hill Power Company and Rock Hill Water and Electric Company between the years 1856 to 1941. The records consist of abstracts of data, titles and deeds, agreements between the Rock Hill Power Company and other entities, minutes and proceedings letters, lawyer opinion regarding rights to supply water to Rock Hill, and a surveyor sketch. This collection of particular interest to researchers interested in the Rock Hill, SC’s early efforts to bring electric lights to the city in the early 1890s and Rock Hill’s legal authority …

Branding And Marketing For An Environmental Nonprofit Organization: Revitalizing A Brand In Southern Illinois, Erik Fitzgerald

Research Papers

Due to its ‘social image’ nonprofits have avoided marketing in the past, focusing their efforts on fundraising and promotional activities. Growing competition within the nonprofit sector has forced these organizations to re-evaluate how they think about marketing. Marketing- oriented nonprofits are out-performing their competitors who have been slow to adapt to this increasingly competitive environment. This project takes a look at a local nonprofit, the Friends of the Shawnee National Forest, that has yet to adopt this marketing orientation. This research gives insight into how a small environmental nonprofit in southern Illinois can use branding and marketing strategies to increase …

Delivery, Facilitas, And Copia : Job Market Preparation And The Revival Of The Fifth Canon., Joseph Turner

Faculty and Staff Scholarship

This essay argues that English Studies departments should implement training programs in oral delivery strategies for graduate students seeking tenure track employment. A sample a 13-week training program, modeled on elements of classical rhetorical pedagogy, can help students develop and refine stills in oral delivery necessary for academic job interviews.

Dismantling Structural Inequality: Lock Ups, Systemic Chokeholds, And Race-Based Policing - A Symposium Summary, Cedric Merlin Powell, Laura R. Mcneal

Faculty and Staff Scholarship

The prominence of the carceral state in American society serves to undermine basic principles of democracy and justice, disproportionately displacing people of color and excluding them from all viable avenues of citizenship.

Personal Universes: A Solution To The Multi-Agent Value Alignment Problem, Roman V. Yampolskiy

Faculty and Staff Scholarship

AI Safety researchers attempting to align values of highly capable intelligent systems with those of humanity face a number of challenges including personal value extraction, multi-agent value merger and finally in-silico encoding. State-of-the-art research in value alignment shows difficulties in every stage in this process, but merger of incompatible preferences is a particularly difficult challenge to overcome. In this paper we assume that the value extraction problem will be solved and propose a possible way to implement an AI solution which optimally aligns with individual preferences of each user. We conclude by analyzing benefits and limitations of the proposed approach.

An Explainable Autoencoder For Collaborative Filtering Recommendation, Pegah Sagheb Haghighi, Olurotimi Seton, Olfa Nasraoui

Faculty and Staff Scholarship

Autoencoders are a common building block of Deep Learning architectures, where they are mainly used for representation learning. They have also been successfully used in Collaborative Filtering (CF) recommender systems to predict missing ratings. Unfortunately, like all black box machine learning models, they are unable to explain their outputs. Hence, while predictions from an Autoencoderbased recommender system might be accurate, it might not be clear to the user why a recommendation was generated. In this work, we design an explainable recommendation system using an Autoencoder model whose predictions can be explained using the neighborhood based explanation style. Our preliminary work …

The Frequency Of Dust Lanes In Edge-On Spiral Galaxies Identified By Galaxy Zoo In Kids Imaging Of Gama Targets, Benne W. Holwerda, Lee Kelvin, Ivan Baldry, Chris Lintott, Mehmet Alpaslan, Kevin A. Pimbblet, Jochen Liske, Thomas Kitching, Steven Bamford, Jelte De Jong, Maciej Bilicki, Andrew Hopkins, Joanna Bridge, R. Steele, A. Jacques, S. Goswami, S. Kusmic, W. Roemer, S. Kruk, C. C. Popescu, K. Kuijken, L. Wang, A. Wright

Faculty and Staff Scholarship

Dust lanes bisect the plane of a typical edge-on spiral galaxy as a dark optical absorption feature. Their appearance is linked to the gravitational stability of spiral disks; the fraction of edge-on galaxies that displays a dust lane is a direct indicator of the typical vertical balance between gravity and turbulence: a balance struck between the energy input from star formation and the gravitational pull into the plane of the disk. Based on morphological classifications by the Galaxy Zoo project on the Kilo Degree Survey (KiDS) imaging data in the Galaxy and Mass Assembly (GAMA) fields, we explore the relation …

Quantum Metalanguage And The New Cognitive Synthesis, Alexey V. Melkikh, Andrei Khrennikov, Roman V. Yampolskiy

Faculty and Staff Scholarship

Problems with mechanisms of thinking and cognition in many ways remain unresolved. Why are a priori inferences possible? Why can a human understand but a computer cannot? It has been shown that when creating new concepts, generalization is contradictory in the sense that to be created concepts must exist a priori, and therefore, they are not new. The process of knowledge acquisition is also contradictory, as it inevitably involves recognition, which can be realized only when there is an a priori standard. Known approaches of the framework of artificial intelligence (in particular, Bayesian) do not determine the origins of knowledge, …

Emergence Of Addictive Behaviors In Reinforcement Learning Agents, Vahid Behzadan, Roman Yampolskiy, Arslan Munir

Faculty and Staff Scholarship

This paper presents a novel approach to the technical analysis of wireheading in intelligent agents. Inspired by the natural analogues of wireheading and their prevalent manifestations, we propose the modeling of such phenomenon in Reinforcement Learning (RL) agents as psychological disorders. In a preliminary step towards evaluating this proposal, we study the feasibility and dynamics of emergent addictive policies in Q-learning agents in the tractable environment of the game of Snake. We consider a slightly modified version of this game, in which the environment provides a “drug” seed alongside the original “healthy” seed for the consumption of the snake. We …

Why Are Sheep Sheepish? How Perception Affects Animal Stereotyping, Robert G. Franklin Jr.

Animal Sentience

Marino & Merskin present compelling evidence that many stereotypes of sheep are incorrect. One factor that may play an important role in animal stereotyping is the physical appearance of animals, which can directly lead to stereotyping through automatic mental processes. Sheep have a round and babyish appearance that directly evokes judgments of warmth and docility. Depictions of sheep in art, and especially cartoons, reinforce this stereotype.

Tangled Twilight. Destiny, Horror, And Transformation In Nature: American Culture Of Progress During The Vietnam War 1965-1975, Alexander Newkirk

Dissertations and Theses @ UNI

This work is an exploration of shifting American attitudes toward key cultural myths during and after the Vietnam War from 1965-1975. Using sources such as memoir, film, and relevant historiography of the time this thesis emphasizes an exploration of the shifting attitudes of Americans during the Cold War. An epoch defined by a “utopian” vision of American history that was codified in a Post War period. This included a tradition of enlightenment values, liberal consensus, a technocratic order, and a deep abiding myth in progress. While this period has been extensively studied, I suggest there has not been enough attention …

Influence Of External And Internal Factors On Financial Advisors' Guidance Of Clients In The Area Of Charitable Giving, Angela J. Gorsuch Widner

Dissertations and Theses @ UNI

Charitable giving plays a vital role in the ability of nonprofit organizations to carry out their missions to contribute to the well-being of society. Research suggests that most wealthy Americans have an interest in being philanthropic and giving to nonprofit organizations. Financial advisors often play a substantial role in helping their clients understand the complex policies related to charitable giving. As the experts, financial advisors play an important consultative role in making sense of the benefits that can come as a result of charitable giving.

The purpose of this study was to explore how financial advisors work with clients in …

Beyond "Born This Way": Reconsidering Trans Narratives, Ashley Elizabeth Meyers

Dissertations and Theses @ UNI

When most Americans hear the words “trans” or “transgender”, celebrities like Caitlyn Jenner, Chaz Bono, or Laverne Cox likely come to mind along with their highly public stories of medical and social transition. While these celebrity representations have served to increase visibility for the trans community throughout the United States over the past decade, trans representation remains limited in terms of intersectionality and a narrow focus on celebrity stories and themes of essentialization, dysphoria, and medical transition. At the same time, research on trans narratives also remains focused almost exclusively on trans women and men who experience dysphoria and undergo …

William Stokes Papers - Accession 882, William Stokes, American Civil War

Manuscript Collection

The William Stokes Papers mainly consist of personal correspondence from William Stokes (1833-1905) to his wife, Eliza Jane Boulware Stokes (1837-1916), during the American Civil War. William Stokes served in the Confederate Army during the American Civil War with the 4^th Regiment South Carolina Calvary as Lieutenant Colonel. After the conclusion of the war he would be given the rank of Brigadier General by then Governor Wade Hampton. He was born on October 20, 1833, and died on June 30, 1905. The collection includes pre-Civil War, Civil War, and post-Civil War letters and military orders. Also includes writings by …