Digital Commons Network^™

Application Of An Antibiotic Spectrum Index In The Neonatal Intensive Care Unit, Alexandra C Lahart, Christopher C Mcpherson, Jeffrey S Gerber, Barbara B Warner, Brian R Lee, Jason G Newland

Open Access Publications

Antimicrobial stewardship programs typically use days of therapy to assess antimicrobial use. However, this metric does not account for the antimicrobial spectrum of activity. We applied an antibiotic spectrum index to a population of very-low-birth-weight infants to assess its utility to evaluate the impact of antimicrobial stewardship interventions.

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.

Two-Photon Microperimetry: Sensitivity Of Human Photoreceptors To Infrared Light, Daniel Ruminski, Grazyna Palczewska, Maciej Nowakowski, Agnieszka Zielińska, Vladimir J Kefalov, Katarzyna Komar, Krzysztof Palczewski, Maciej Wojtkowski

Open Access Publications

Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged …

Congenital Aortic Valve Stenosis, Gautam K Singh

Open Access Publications

Aortic valve stenosis in children is a congenital heart defect that causes fixed form of hemodynamically significant left ventricular outflow tract obstruction with progressive course. Neonates and young infants who have aortic valve stenosis, usually develop congestive heart failure. Children and adolescents who have aortic valve stenosis, are mostly asymptomatic, although they may carry a small but significant risk of sudden death. Transcatheter or surgical intervention is indicated for symptomatic patients or those with moderate to severe left ventricular outflow tract obstruction. Many may need reintervention.

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Lindsay L. Peterson, Et Al

Open Access Publications

No abstract provided.

The Children's Respiratory And Environmental Workgroup (Crew) Birth Cohort Consortium: Design, Methods, And Study Population, James E. Gern, Leonard B. Bacharier, Et Al

Open Access Publications

No abstract provided.

Building A Culture Of Health And Well-Being At Merck, Cathryn E. Gunther, Virginia Peddicord, Joseph Kozlowski, Yi Li, Danielle Menture, Raymond Fabius, Sharon Glave Frazee, Peter J. Nigro

Open Access Publications

No abstract provided.

Mir-892b Inhibits Hypertrophy By Targeting Klf10 In The Chondrogenesis Of Mesenchymal Stem Cells, Jong Min Lee, Ji-Yn Ko, Hye Young Kim, Jeong-Won Park, Farshid Guilak, Gun-Il Im

Open Access Publications

No abstract provided.

A Fatal Case Of Disseminated Microsporidiosis Due To Anncaliia Algerae In A Renal And Pancreas Allograft Recipient, Neil W. Anderson, Atis Muehlenbachs, Sana Arif, Jackrapong Bruminhent, Paul J. Deziel, Raymund R. Razonable, Mark P. Wilhelm, Maureen G. Metcalfe, Yvonne Qvarnstrom, Bobbi S. Pritt

Open Access Publications

No abstract provided.

Prevalence And Impact Of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living In The Us And Canada, David R. Mcgivern, Hsing-Hua S. Lin, Junyao Wang, Tiffany Benzine, Henry L.A Janssen, Mandana Khalili, Mauricio Lisker-Melman, Robert J. Fontana, Steven H. Belle, Michael W. Fried

Open Access Publications

No abstract provided.

Seasonal Changes In The Prevalence Of Antibiotic-Susceptible Acinetobacter Calcoaceticus-Baumannii Complex Isolates Result In Increased Multidrug Resistance Rates During Winter Months, Jason P. Burnham, Mario F. Feldman, Juan J. Calix

Open Access Publications

No abstract provided.

The Role Of Fecal Microbiota Transplantation In Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape And Future Directions, Michael H. Woodworth, Mary K. Hayden, Vincent B. Young, Jennie H. Kwon

Open Access Publications

No abstract provided.

Washu Epigenome Browser Update 2019, Daofeng Li, Silas Hsu, Deepak Purushotham, Renee L. Sears, Ting Wang

Open Access Publications

No abstract provided.

Clinical Impact Of Revised Cefepime Breakpoint In Patients With Enterobacteriaceae Bacteremia, Kap Sum Foong, Abigail L. Carlson, Munigala Satish, Carey-Ann D. Burnham, David K. Warren

Open Access Publications

No abstract provided.

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–Cb1-R Signaling, Janos Paloczi, Csaba Matyas, Resat Cinar, Zoltan V. Varga, György Hasko, Thomas H. Schindler, George Kunos, Pal Pacher

Open Access Publications

No abstract provided.

The Piranha Genome Provides Molecular Insight Associated To Its Unique Feeding Behavior, Manfred Schartl, Susanne Kneitz, Helene Volkoff, Mateus Adolfi, Cornelia Schmidt, Petra Fischer, Patrick Minx, Chad Tomlinson, Axel Meyer, Wesley C. Warren

Open Access Publications

No abstract provided.

Influence Of Diagnostic Method On Outcomes In Phase 3 Clinical Trials Of Bezlotoxumab For The Prevention Of Recurrent Clostridioides Difficile Infection: A Post Hoc Analysis Of Modify I/Ii, Mark H. Wilcox, Galia Rahav, Erik R. Dubberke, Lori Gabryelski, Kerrie Davies, Claire Berry, Karen Eves, Misoo C. Ellison, Dalya Guris, Mary Beth Dorr

Open Access Publications

No abstract provided.

Standard Operating Procedure For Somatic Variant Refinement Of Sequencing Data With Paired Tumor And Normal Samples, Erica K. Barnell, Peter Ronning, Katie M. Campbell, Kilannin Krysiak, Benjamin J. Ainscough, Lana M. Sheta, Shahil P. Pema, Alina D. Schmidt, Megan Richters, Kelsy C. Cotto, Arpad M. Danos, Cody Ramirez, Zachary L. Skidmore, Nicholas C. Spies, Jasreet Hundal, Malik S. Sediqzad, Jason Kunisaki, Felicia Gomez, Lee Trani, Matthew Matlock, Alex H. Wagner, S. Joshua Swamidass, Malachi Griffith, Obi L. Griffith

Open Access Publications

No abstract provided.

Obesity Alters The Muscle Protein Synthetic Response To Nutrition And Exercise, Joseph W Beals, Nicholas A Burd, Daniel R Moore, Stephan Van Vliet

Open Access Publications

Improving the health of skeletal muscle is an important component of obesity treatment. Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the regulation of postprandial macronutrient metabolism, a time period that represents when metabolic derangements are most often observed in adults with obesity. In order for skeletal muscle to retain its capacity for physical activity and macronutrient metabolism, its protein quantity and composition must be maintained through the efficient degradation and resynthesis for proper tissue homeostasis. Life-style behaviors such as increasing physical activity and higher protein diets are front-line treatment strategies to enhance muscle protein remodeling …

Physician Documentation Of Access To Firearms In Suicidal Patients In The Emergency Department, Sonya Naganathan, Kristen L. Mueller

Open Access Publications

No abstract provided.

Early Increase Of Csf Strem2 In Alzheimer's Disease Is Associated With Tau Related-Neurodegeneration But Not With Amyloid-Β Pathology, Marc Suarez-Calvet, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Et Al

Open Access Publications

No abstract provided.

U.S. Adolescent And Adult Women's Experiences Accessing And Using Toilets In Schools, Workplaces, And Public Spaces: A Multi-Site Focus Group Study To Inform Future Research In Bladder Health, Deepa R Camenga, Sonya S Brady, Cecilia T Hardacker, Beverly R Williams, Jeni Hebert-Beirne, Aimee S James, Kathryn Burgio, Jesse Nodora, Jean F Wyman, Amanda Berry, Lisa K Low, Prevention Of Lower Urinary Tract Symptoms (Plus) Research Consortium

Open Access Publications

The World Health Organization recognizes access to clean and safe toilets as crucial for public health. This study explored U.S. adolescent and adult cisgender women's lived experiences accessing toilets in schools, workplaces, and public spaces. As part of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, we conducted 44 focus groups with female participants (n = 360; ages 11-93). Focus groups were stratified by age (11-14, 15-17, 18-25, 26-44, 45-64, 65+) and conducted across 7 geographically diverse U.S. sites from July 2017-April 2018. Using a transdisciplinary approach, we conducted conventional qualitative coding informed by our PLUS conceptual framework …

Associations Among Neighborhood Socioeconomic Deprivation, Physical Activity Facilities, And Physical Activity In Youth During The Transition From Childhood To Adolescence, Morgan N Clennin, Min Lian, Natalie Colabianchi, Andrew Kaczynski, Marsha Dowda, Russell R Pate

Open Access Publications

BACKGROUND: This study aims to examine the longitudinal association of neighborhood socioeconomic deprivation (SED) with physical activity in youth during the transition from elementary to middle school, and to determine if access to physical activity facilities moderates this relationship.

METHODS: Data were obtained from the Transitions and Activity Changes in Kids (TRACK) study, which was a multilevel, longitudinal study designed to identify the factors that influence changes in physical activity as youth transition from elementary to middle school. The analytic sample for the current study included 660 youth with complete data in grades 5 (baseline) and 7 (follow-up). A repeated …

Pcna Accelerates The Nucleotide Incorporation Rate By Dna Polymerase Δ, Tanumoy Mondol, Joseph L. Stodola, Roberto Galletto, Peter M. Burgers

Open Access Publications

No abstract provided.

Me-Class2 Reveals Context Dependent Regulatory Roles For 5-Hydroxymethylcytosine, Christopher E. Schlosberg, Dennis Y. Wu, Harrison W. Gabel, John R. Edwards

Open Access Publications

No abstract provided.

Csf1r Antagonism Limits Local Restimulation Of Antiviral Cd8+ T Cells During Viral Encephalitis, Kristen E. Funk, Robyn S. Klein

Open Access Publications

No abstract provided.

Calvarial Langerhans Cell Histiocytosis In An Adult: Typical Imaging Findings In An Atypical Age Group, Amjad Samara, Jordan Nepute, Hsiang-Chih Lu, Richard J. Perrin, Rami W. Eldaya

Open Access Publications

No abstract provided.

Stroke Detection With 3 Different Pet Tracers, Ayca Dundar, Michael S. Bold, Busranur Agac, Ayse Tuba Kendi, Saul N. Friedman

Open Access Publications

No abstract provided.

Aebp1 Down Regulation Induced Cell Death Pathway Depends On Pten Status Of Glioma Cells, Swati Sinha, Arun Renganathan, Prathima B. Nagendra, Vasudeva Bhat, Brian Steve Mathew, Manchanahalli R. Satyanarayana Rao

Open Access Publications

No abstract provided.

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.