Digital Commons Network^™

Detection Of Tar Dna-Binding Protein 43 (Tdp-43) Oligomers As Initial Intermediate Species During Aggregate Formation, Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala

Open Access Publications

No abstract provided.

Disparities In Access To Musculoskeletal Care: Narrowing The Gap: Aoa Critical Issues Symposium, Dane H Salazar, Christopher J Dy, W Stephen Choate, Howard M Place

Open Access Publications

The current health-care system in the United States has numerous barriers to quality, accessible, and affordable musculoskeletal care for multiple subgroups of our population. These hurdles include complex cultural, educational, and socioeconomic factors. Tertiary referral centers provide a disproportionately large amount of the care for the uninsured and underinsured members of our society. These gaps in access to care for certain subgroups lead to inappropriate emergency room usage, lengthy hospitalizations, increased administrative load, lost productivity, and avoidable complications and/or deaths, which all represent a needless burden on our health-care system. Through advocacy, policy changes, workforce diversification, and practice changes, orthopaedic …

The Structure Of Acinetobacter-Secreted Protease Cpaa Complexed With Its Chaperone Cpab Reveals A Novel Mode Of A T2ss Chaperone–Substrate Interaction, Darya V. Urusova, Rachel L. Kinsella, Nichole D. Salinas, M. Florencia Haurat, Mario F. Feldman, Niraj H. Tolia

Open Access Publications

No abstract provided.

Regulation Of Lipophagy In Nafld By Cellular Metabolism And Cd36, Dmitri Samovski, Nada A. Abumrad

Open Access Publications

No abstract provided.

Synthesis And Characterization Of Diazirine Alkyne Probes For The Study Of Intracellular Cholesterol Trafficking, Mckenna Feltes, Samantha Moores, Sarah E. Gale, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.

Building Bridges: Pcsk7 As A Nafld Candidate Gene Connecting Hepatic Inflammation With Hypertriglyceridemia, Rotonya M. Carr, Nicholas O. Davidson

Open Access Publications

No abstract provided.

Association Between The Hla-Drb1*03:01-Dqb1*02:01 Haplotype And Pf4/Heparin Antibodies, Ray Zhang, Brian F. Duffy, Vinzenz Lange, Charles S. Eby, Chang Liu

Open Access Publications

No abstract provided.

The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen

Open Access Publications

No abstract provided.

Operative Vaginal Delivery Is A Safe Option In Women Undergoing A Trial Of Labor After Cesarean, Erin Krizman, Patricia Grzebielski, Kathleen M Antony, Emmanuel Sampene, Matthew Shanahan, J Igor Iruretagoyena, Justin Bohrer

Open Access Publications

No abstract provided.

Oxytocin And Oxytocinase In The Obese And Nonobese Parturients During Induction And Augmentation Of Labor, Annemaria De Tina, Jeremy Juang, Thomas F Mcelrath, Jack D Baty, Arvind Palanisamy

Open Access Publications

No abstract provided.

Regulated Phosphosignaling Associated With Breast Cancer Subtypes And Druggability, Kuan-Lin Huang, Yige Wu, Tina Primeau, Joshua F. Mcmichael, Adam D. Scott, Song Cao, Michael C. Wendl, Kimberly J. Johnson, Jason Held, Sherri Davies, R. Reid Townsend, Feng Chen, David Fenyö, Shunqiang Li, Tao Liu, Li Ding, Et Al.

Open Access Publications

No abstract provided.

Hepatic Monoacylglycerol Acyltransferase 1 Is Induced By Prolonged Food Deprivation To Modulate The Hepatic Fasting Response, Andrew J. Lutkewitte, Kyle S. Mccommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck

Open Access Publications

No abstract provided.

An Overview Of Mechanical Circulatory Support In Single-Ventricle Patients, Jacob R Miller, Timothy S Lancaster, Connor Callahan, Aaron M Abarbanell, Pirooz Eghtesady

Open Access Publications

The population of people with a single-ventricle is continually increasing due to improvements across the spectrum of medical care. Unfortunately, a proportion of these patients will develop heart failure. Often, for these patients, mechanical circulatory support (MCS) represents the only available treatment option. While single-ventricle patients currently represent a small proportion of the total number of patients who receive MCS, as the single-ventricle patient population increases, this number will increase as well. Outcomes for these complex single-ventricle patients who require MCS has begun to be evaluated. When considering the entire population, survival to hospital discharge is 30-50%, though this must …

Synthesis Of Oxidized Phospholipids By Sn-1 Acyltransferase Using 2–15-Hete Lysophospholipids, Gao-Yuan Liu, Sung Ho Moon, Christopher M. Jenkins, Harold F. Sims, Shaoping Guan, Richard W. Gross

Open Access Publications

No abstract provided.

Insulin-Independent Reversal Of Type-1 Diabetes Following Transplantation Of Adult Brown Adipose Tissue Supplemented With Igf-1, Subhadra C. Gunawardana, David W. Piston

Open Access Publications

No abstract provided.

Co-Registered Photoacoustic And Ultrasound Imaging Of Human Colorectal Cancer, Guang Yang, Eghbal Amidi, William C. Chapman Jr., Sreyankar Nandy, Atahar Mostafa, Heba Abdelal, Zahra Alipour, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Open Access Publications

No abstract provided.

High-Density Speckle Contrast Optical Tomography Of Cerebral Blood Flow Response To Functional Stimuli In The Rodent Brain, Tanja Dragojević, Ernesto E. Vidal Rosas, Joseph L. Hollmann, Joseph P. Culver, Carles Justicia, Turgut Durduran

Open Access Publications

No abstract provided.

Qsofa Score And Lqsofa Score As Predictors Of Outcome In An Elderly Population With Chest Infection Treated In The Emergency Department. A Case Series, Dimitrios Velissaris, Vasileios Karamouzos, Nikolaos Dimitrios Pantzaris, Loukas Kakoullis, Charalampos Pierrakos, Menelaos Karanikolas, Charalampos Gogos

Open Access Publications

No abstract provided.

Visual Field Loss In Patients With Diabetes In The Absence Of Clinically-Detectable Vascular Retinopathy In A Nationally Representative Survey, Yicheng K. Bao, Yan Yan, Mae Gordon, Janet B. Mcgill, Michael Kass, Rithwick Rajagopal

Open Access Publications

No abstract provided.

Graft Immaturity And Safety Concerns In Transplanted Human Kidney Organoids, Sun Ah Nam, Kohei Uchimura, Benjamin D. Humphreys, Et Al.

Open Access Publications

No abstract provided.

Development Of A Standardized Communication Intervention Bundle For Use At A Medical Training Hospital Intensive Care Unit, Katherine Pollard, Brian Todd Wessman

Open Access Publications

No abstract provided.

Neutrophils Promote Vla-4–Dependent B Cell Antigen Presentation And Accumulation Within The Meninges During Neuroinflammation, Chelsea R. Parker Harp, Angela S. Archambault, Matthew Cheung, Jesse W. Williams, Rafael S. Czepielewski, Patrick C. Duncker, Aaron J. Kilgore, Aidan T. Miller, Benjamin M. Segal, Alfred H. J. Kim, Gwendalyn J. Randolph, Gregory F. Wu

Open Access Publications

No abstract provided.

Dissemination And Stakeholder Engagement Practices Among Dissemination & Implementation Scientists: Results From An Online Survey, Christopher E. Knoepke, M. Pilar Ingle, Daniel D. Matlock, Ross C. Brownson, Russell E. Glasgow

Open Access Publications

No abstract provided.

Urinary Tract Infections After Combat-Related Genitourinary Trauma, Stephen Y. Liang, Brendan Jackson, Janis Kuhn, Faraz Shaikh, Dana M. Blyth, Timothy J. Whitman, Joseph L. Petfield, M. Leigh Carson, David R. Tribble, Jay R. Mcdonald, Infectious Disease Clinical Research Program Trauma Infectious Disease Outcomes Study Group

Open Access Publications

No abstract provided.

Stunting Is Preceded By Intestinal Mucosal Damage And Microbiome Changes And Is Associated With Systemic Inflammation In A Cohort Of Peruvian Infants, Mara Zambruni, Theresa J Ochoa, Anoma Somasunderam, Miguel M Cabada, Maria L Morales, Makedonka Mitreva, Bruce A Rosa, Gonzalo J Acosta, Natalia I Vigo, Maribel Riveros, Sara Arango, David Durand, Maitreyee N Berends, Peter Melby, Netanya S Utay

Open Access Publications

Stunting, defined as height-for-age

Heterogeneity Diffusion Imaging Of Gliomas: Initial Experience And Validation, Qing Wang, Gloria J. Guzmán Pérez-Carrillo, Maria Rosana Ponisio, Pamela Lamontagne, Sonika Dahiya, Daniel S. Marcus, Mikhail Milchenko, Joshua Shimony, Jingxia Liu, Gengsheng Chen, Amber Salter, Parinaz Massoumzadeh, Michelle M. Miller-Thomas, Keith M. Rich, Jonathan Mcconathy, Tammie L. S. Benzinger, Yong Wang

Open Access Publications

OBJECTIVES: Primary brain tumors are composed of tumor cells, neural/glial tissues, edema, and vasculature tissue. Conventional MRI has a limited ability to evaluate heterogeneous tumor pathologies. We developed a novel diffusion MRI-based method-Heterogeneity Diffusion Imaging (HDI)-to simultaneously detect and characterize multiple tumor pathologies and capillary blood perfusion using a single diffusion MRI scan.

METHODS: Seven adult patients with primary brain tumors underwent standard-of-care MRI protocols and HDI protocol before planned surgical resection and/or stereotactic biopsy. Twelve tumor sampling sites were identified using a neuronavigational system and recorded for imaging data quantification. Metrics from both protocols were compared between World Health …

Categorical Encoding Of Decision Variables In Orbitofrontal Cortex, Arno Onken, Jue Xie, Stefano Panzeri, Camillo Padoa-Schioppa

Open Access Publications

No abstract provided.

Application Of An Antibiotic Spectrum Index In The Neonatal Intensive Care Unit, Alexandra C Lahart, Christopher C Mcpherson, Jeffrey S Gerber, Barbara B Warner, Brian R Lee, Jason G Newland

Open Access Publications

Antimicrobial stewardship programs typically use days of therapy to assess antimicrobial use. However, this metric does not account for the antimicrobial spectrum of activity. We applied an antibiotic spectrum index to a population of very-low-birth-weight infants to assess its utility to evaluate the impact of antimicrobial stewardship interventions.

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.

Two-Photon Microperimetry: Sensitivity Of Human Photoreceptors To Infrared Light, Daniel Ruminski, Grazyna Palczewska, Maciej Nowakowski, Agnieszka Zielińska, Vladimir J Kefalov, Katarzyna Komar, Krzysztof Palczewski, Maciej Wojtkowski

Open Access Publications

Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged …