Digital Commons Network^™

History Of Fatigue In Multiple Sclerosis Is Associated With Grey Matter Atrophy, Miklos Palotai, Aria Nazeri, Michele Cavallari, Brian C. Healy, Bonnie Glanz, Stefan M. Gold, Howard L. Weiner, Tanuja Chitnis, Charles R.G. Guttmann

Open Access Publications

No abstract provided.

Delineating And Validating Higher-Order Dimensions Of Psychopathology In The Adolescent Brain Cognitive Development (Abcd) Study, Giorgia Michelini, Deanna M. Barch, Yuan Tian, David Watson, Daniel N. Klein, Roman Kotov

Open Access Publications

No abstract provided.

Steady-State Activation Of The High-Affinity Isoform Of The Α4Β2Δ Gabaa Receptor, Spencer R. Pierce, Thomas C. Senneff, Allison L. Germann, Gustav Akk

Open Access Publications

No abstract provided.

Zbtb32 Restrains Antibody Responses To Murine Cytomegalovirus Infections, But Not Other Repetitive Challenges, Arijita Jash, You W. Zhou, Diana K. Gerardo, Tyler J. Ripperger, Bijal A. Parikh, Sytse Piersma, Deepa R. Jamwal, Pawel R. Kiela, Adrianus C. M. Boon, Wayne M. Yokoyama, Chyi S. Hsieh, Deepta Bhattacharya

Open Access Publications

No abstract provided.

Segregated Neural Explants Exhibit Co-Oriented, Asymmetric, Neurite Outgrowth, David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A Crutcher

Open Access Publications

Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This emergent behavior may be similar to the community effect described in …

Blending Insights From Implementation Science And The Social Sciences To Mitigate Inequities In Screening For Hereditary Cancer Syndromes, Laura Senier, Colleen M Mcbride, Alex T Ramsey, Vence L Bonham, David A Chambers

Open Access Publications

Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from implementation science and sociological research on health inequities. Our framework does three things: first, it broadens the arenas of action beyond those typically addressed in implementation science frameworks; second, it argues for recruiting more diverse partners to …

Effect Of Native And Acetylated Dietary Resistant Starches On Intestinal Fermentative Capacity Of Normal And Stunted Children In Southern India, Ramadass Balamurugan, Srinivasan Pugazhendhi, Gowri M Balachander, Tamilselvan Dharmalingam, Elissa K Mortimer, Geetha L Gopalsamy, Richard J Woodman, Rosie Meng, David H Alpers, Mark Manary, Henry J Binder, Ian L Brown, Graeme P Young, Balakrishnan S Ramakrishna

Open Access Publications

The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted ('healthy') children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. …

A Pilot Study On The Kinetics Of Metabolites And Microvascular Cutaneous Effects Of Nitric Oxide Inhalation In Healthy Volunteers, Adriano R Tonelli, Kulwant S Aulak, Mostafa K Ahmed, Alfred Hausladen, Batool Abuhalimeh, Charlie J Casa, Stephen C Rogers, David Timm, Allan Doctor, Benjamin Gaston, Raed A Dweik

Open Access Publications

RATIONALE: Inhaled nitric oxide (NO) exerts a variety of effects through metabolites and these play an important role in regulation of hemodynamics in the body. A detailed investigation into the generation of these metabolites has been overlooked.

OBJECTIVES: We investigated the kinetics of nitrite and S-nitrosothiol-hemoglobin (SNO-Hb) in plasma derived from inhaled NO subjects and how this modifies the cutaneous microvascular response.

FINDINGS: We enrolled 15 healthy volunteers. Plasma nitrite levels at baseline and during NO inhalation (15 minutes at 40 ppm) were 102 (86-118) and 114 (87-129) nM, respectively. The nitrite peak occurred at 5 minutes of discontinuing NO …

Associations Of Autozygosity With A Broad Range Of Human Phenotypes, David W. Clark, Lihua Wang, Mary Feitosa, Dabeeru C. Rao, Et Al.

Open Access Publications

No abstract provided.

Association Of Polygenic Liability For Alcohol Dependence And Eeg Connectivity In Adolescence And Young Adulthood, Jacquelyn L. Meyers, Emma C Johnson, Arpana Agrawal, Et Al

Open Access Publications

Differences in the connectivity of large-scale functional brain networks among individuals with alcohol use disorders (AUD), as well as those at risk for AUD, point to dysfunctional neural communication and related cognitive impairments. In this study, we examined how polygenic risk scores (PRS), derived from a recent GWAS of DSM-IV Alcohol Dependence (AD) conducted by the Psychiatric Genomics Consortium, relate to longitudinal measures of interhemispheric and intrahemispheric EEG connectivity (alpha, theta, and beta frequencies) in adolescent and young adult offspring from the Collaborative Study on the Genetics of Alcoholism (COGA) assessed between ages 12 and 31. Our findings indicate that …

Contribution And Interaction Of Shiga Toxin Genes To Escherichia Coli O157:H7 Virulence, Gillian A M Tarr, Taryn Stokowski, Smriti Shringi, Phillip I Tarr, Stephen B Freedman, Hanna N Oltean, Peter M Rabinowitz, Linda Chui

Open Access Publications

No abstract provided.

Role Of Apd-Ribosylation In Bone Health And Disease, Chun Wang, Gabriel Mbalaviele

Open Access Publications

The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD

Association Between Itch And Cancer In 3836 Pediatric Pruritus Patients At A Tertiary Care Center, Micah Belzberg, Valerie A Larson, Raveena Khanna, Kyle A Williams, Yevgeniy Semenov, Sonja Ständer, Anna L Grossberg, Shawn G Kwatra

Open Access Publications

No abstract provided.

Transdermal Fluorescence Detection Of A Dual Fluorophore System For Noninvasive Point-Of-Care Gastrointestinal Permeability Measurement, Richard B Dorshow, J R Johnson, Martin P Debreczeny, I Rochelle Riley, Jeng-Jong Shieh, Thomas E Rogers, Carla Hall-Moore, Nurmohammad Shaikh, L Colleen Rouggly-Nickless, Phillip I Tarr

Open Access Publications

The intestinal mucosal barrier prevents macromolecules and pathogens from entering the circulatory stream. Tight junctions in this barrier are compromised in inflammatory bowel diseases, environmental enteropathy, and enteric dysfunction. Dual sugar absorption tests are a standard method for measuring gastrointestinal integrity, however, these are not clinically amenable. Herein, we report on a dual fluorophore system and fluorescence detection instrumentation for which gastrointestinal permeability is determined in a rat small bowel disease model from the longitudinal measured transdermal fluorescence of each fluorophore. This fluorophore technology enables a specimen-free, noninvasive, point-of-care gastrointestinal permeability measurement which should be translatable to human clinical studies.

Mri Quality Control For Low-Field Mr-Igrt Systems: Lessons Learned, H Michael Gach, Austen N Curcuru, Erin J Wittland, Borna Maraghechi, Bin Cai, Sasa Mutic, Olga L Green

Open Access Publications

PURPOSE: To present lessons learned from magnetic resonance imaging (MRI) quality control (QC) tests for low-field MRI-guided radiation therapy (MR-IGRT) systems.

METHODS: MRI QC programs were established for low-field MRI-

RESULTS: Image noise and artifacts were attributed to room noise sources, unsatisfactory system cabling, and broken RF receiver coils. Gantry angle-dependent magnetic field inhomogeneities were more prominent on the MRI-Linac due to the high volume of steel shielding in the gantry. B

CONCLUSIONS: There are significant technological challenges associated with implementing and maintaining MR-IGRT systems. Most of the performance issues were identified and resolved during commissioning.

Metabolically Healthy Obesity: Facts And Fantasies, Gordon I Smith, Bettina Mittendorfer, Samuel Klein

Open Access Publications

Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered "metabolically healthy." However, there is no universally accepted definition of metabolically healthy obesity (MHO). Most studies define MHO as having either 0, 1, or 2 metabolic syndrome components, whereas many others define MHO using the homeostasis model assessment of insulin resistance (HOMA-IR). Therefore, numerous people reported as having MHO are not metabolically healthy, but simply have fewer metabolic abnormalities than those with metabolically unhealthy obesity (MUO). Nonetheless, a small …

Mechanism Of Microtubule Plus-End Tracking By The Plant-Specific Spr1 Protein And Its Development As A Versatile Plus-End Marker, Rachappa Balkunde, Layla Foroughi, Eric Ewan, Ryan Emenecker, Valeria Cavalli, Ram Dixit

Open Access Publications

No abstract provided.

Structural And Functional Evidence That Lipoprotein Lpqn Supports Cell Envelope Biogenesis In Mycobacterium Tuberculosis, Geoff C. Melly, Haley Stokas, Jennifer L. Dunaj, Fong Fu Hsu, Malligarjunan Rajavel, Chih-Chia Su, Edward W. Yu, Georgiana E. Purdy

Open Access Publications

No abstract provided.

Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang

Open Access Publications

No abstract provided.

Duraseal Exact Is A Safe Adjunctive Treatment For Durotomy In Spine: Postapproval Study, Kee D. Kim, Dinesh Ramanathan, Jason Highsmith, William Lavelle, Peter Gerszten, Fernando Vale, Neill Wright

Open Access Publications

No abstract provided.

Phosphorylation Of The Hcn Channel Auxiliary Subunit Trip8b Is Altered In An Animal Model Of Temporal Lobe Epilepsy And Modulates Channel Function, Kendall M. Foote, Kyle A. Lyman, Ye Han, Ioannis E. Michailidis, Robert J. Heuermann, Danielle Mandikian, James S. Trimmer, Geoffrey T. Swanson, Dane M. Chetkovich

Open Access Publications

No abstract provided.

Safety And Efficacy Of Digital Single-Operator Pancreatoscopy For Obstructing Pancreatic Ductal Stones, Olaya I. Brewer Gutierrez, Daniel K. Mullady, Natalie Cosgrove, Et Al.

Open Access Publications

No abstract provided.

Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al

Open Access Publications

No abstract provided.

Respiratory Viral Surveillance Of Healthcare Personnel And Patients At An Adult Long-Term Care Facility, Caroline A O'Neil, Lindsay Kim, Mila M Prill, H Keipp Talbot, Brett Whitaker, Senthilkumar K Sakthivel, Yange Zhang, Jing Zhang, Suxiang Tong, Nimalie Stone, Shikha Garg, Susan I Gerber, Hilary M Babcock

Open Access Publications

We conducted active surveillance of acute respiratory viral infections (ARIs) among residents and healthcare personnel (HCP) at a long-term care facility during the 2015-2016 respiratory illness season. ARIs were observed among both HCP and patients, highlighting the importance of including HCP in surveillance programs.

The Impact Of Surgeon Volume And Training Status On Implant Alignment In Total Knee Arthroplasty, Gregory S Kazarian, Charles M Lawrie, Toby N Barrack, Matthew J Donaldson, Gary M Miller, Fares S Haddad, Robert L Barrack

Open Access Publications

BACKGROUND: Implant malalignment may predispose patients to prosthetic failure following total knee arthroplasty (TKA). A more thorough understanding of the surgeon-specific factors that contribute to implant malalignment following TKA may uncover actionable strategies for improving implant survival. The purpose of this study was to determine the impact of surgeon volume and training status on malalignment.

METHODS: In this retrospective multicenter study, we performed a radiographic analysis of 1,570 primary TKAs performed at 4 private academic and state-funded centers in the U.S. and U.K. Surgeons were categorized as high-volume (≥50 TKAs/year) or low-volume (<50 TKAs/year), and as a trainee (fellow/resident under the supervision of an attending surgeon) or a non-trainee (attending surgeon). On the basis of these designations, 3 groups were defined: high-volume non-trainee, low-volume non-trainee, and trainee. The postoperative medial distal femoral angle (DFA), medial proximal tibial angle (PTA), and posterior tibial slope angle (PSA) were radiographically measured. Outlier measurements were defined as follows: DFA, outside of 5° ± 3° of valgus; PTA, >±3° deviation from the neutral axis; and …

Developmental Pathology Of Congenital Kidney And Urinary Tract Anomalies, Sanjay Jain, Feng Chen

Open Access Publications

No abstract provided.

Card And Rbpa Modify The Kinetics Of Initial Transcription And Slow Promoter Escape Of The Mycobacterium Tuberculosis Rna Polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, Eric A. Galburt

Open Access Publications

No abstract provided.

Dietary Pattern And Risk Of Multiple Myeloma In Two Large Prospective Us Cohort Studies, Dong Hoon Lee, Teresa T. Fung, Fred K. Tabung, Graham A. Colditz, Irene M. Ghobrial, Bernard A. Rosner, Edward L. Giovannucci, Brenda M. Birmann

Open Access Publications

No abstract provided.

Complementary Roles Of Pif1 Helicase And Single Stranded Dna Binding Proteins In Stimulating Dna Replication Through G-Quadruplexes, Melanie A. Sparks, Saurabh P. Singh, Peter M. Burgers, Roberto Galletto

Open Access Publications

No abstract provided.

Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman

Open Access Publications

No abstract provided.