Digital Commons Network^™

Adverse Childhood Experiences Indirectly Affect Child Telomere Length Through Self-Regulation, David Sosnowski

Theses and Dissertations

The goals of present study were: (a) to examine associations between adverse childhood experiences (ACEs) and telomere length during childhood using ACE composite scores both with and without “new” adversities (i.e., parental death and poverty), and (b) to determine if ACEs indirectly affect telomere length through children’s self-regulatory abilities (i.e., effortful control and self-control). The analytic sample consisted of national data from teachers, biological parents, and their children (N = 2,527; M_age = 9.35, SD = .36 years; 52% male; 45% Black). Results from linear regression analyses revealed a statistically significant main effect of updated (but not traditional) …

Enhanced Proteomics Resolves Kcc2 As A Novel Therapeutic Target For Traumatic Brain Injury, Pavel N. Lizhnyak

Theses and Dissertations

The development of traumatic brain injury (TBI) therapeutics and effective translation to clinic remains stubbornly elusive despite the high prevalence of TBI within the United States and across the globe. Interventions must be devised around testable targets, appropriately timed to intercede on secondary results. Here, we have utilized temporal neuroproteomics as an ideal approach to inform on the complex biochemical processing in order to address the well-recognized temporal evolution of TBI pathobiology and interrogate a novel therapeutic target in a mild-moderate rat Controlled Cortical Impact (CCI) within perilesioned somatosensory cortex. First, our findings revealed 2047 proteins significantly impacted within the …

Adaptive Acts: Queer Voices And Radical Adaptation In Multi-Ethnic American Literary And Visual Culture, Michael M. Means

Theses and Dissertations

Adaptation Studies suffers from a deficiency in the study of black, brown, yellow, and red adaptive texts, adaptive actors, and their practices. Adaptive Acts intervenes in this Eurocentric discourse as a study of adaptation with a (queer) POC perspective. My dissertation reveals that artists of color (re)create texts via dynamic modes of adaptation such as hyper-literary allusion, the use of meta-narratives as framing devices, and on-site collaborative re-writes that speak to/from specific cultural discourses that Eurocentric models alone cannot account for. I examine multi-ethnic American adaptations to delineate the role of adaptation in the continuance of stories that contest dominant …

Diuretic And Natriuretic Activity Of Faah Inhibition In The Renal Medulla: A Proposed Role Of Palmitoylethanolamide And Its Regulation By Renal Medullary Interstitial Cells, Sara Dempsey

Theses and Dissertations

Hypertension is a critical public health issue worldwide, and in the United States, it is the leading cause of heart disease, stroke, and kidney failure, contributing to more than 1,100 deaths per day. It is proposed that the renal medulla combats increased blood pressure by releasing a neutral lipid from the lipid droplets of medullary interstitial cells, termed medullipin, which induces diuresis- natriuresis and vasodepression. The renal medulla is enriched with fatty acid lipid ethanolamides including the endocannabinoid anandamide (AEA), palmitoylethanolamide (PEA), and oleoylethanolamide (OEA), along with their primary hydrolyzing enzyme fatty acid amide hydrolase (FAAH). Our lab is investigating …

Distributed Multi-Label Learning On Apache Spark, Jorge Gonzalez Lopez

Theses and Dissertations

This thesis proposes a series of multi-label learning algorithms for classification and feature selection implemented on the Apache Spark distributed computing model. Five approaches for determining the optimal architecture to speed up multi-label learning methods are presented. These approaches range from local parallelization using threads to distributed computing using independent or shared memory spaces. It is shown that the optimal approach performs hundreds of times faster than the baseline method. Three distributed multi-label k nearest neighbors methods built on top of the Spark architecture are proposed: an exact iterative method that computes pair-wise distances, an approximate tree-based method that indexes …

Let’S Face It: The Effect Of Orthognathic Surgery On Facial Recognition Algorithm Analysis, Carolyn Bradford Dragon

Theses and Dissertations

Aim: To evaluate the ability of a publicly available facial recognition application program interface (API) to calculate similarity scores for pre- and post-surgical photographs of patients undergoing orthognathic surgeries. Our primary objective was to identify which surgical procedure(s) had the greatest effect(s) on similarity score.

Methods: Standard treatment progress photographs for 25 retrospectively identified, orthodontic-orthognathic patients were analyzed using the API to calculate similarity scores between the pre- and post-surgical photographs. Photographs from two pre-surgical timepoints were compared as controls. Both relaxed and smiling photographs were included in the study to assess for the added impact of facial pose on …

Capitalist Reproduction In Schooling: The Social Control Of Marginalized Students Through Zero Tolerance Policies, Mary K. Wickline

Theses and Dissertations

Due to increasing media focus, there has been growing concern that U.S. students and the school environment are increasingly violent, leading the public to believe that school discipline should become more strict and punitive (Giroux 2003; Schept, Wall, & Brisman 2014). However, scholars argue that there is little evidence that current practices of school discipline have made the school environment safer, but instead have criminalized the school and are disproportionately targeting students of color and disabled students (Beger 2002; Civil Rights Project 2000; Gregory, Skiba, & Noguera 2010; Hirschfield 2008; McNeal & Dunbar 2010; U.S. Government Office of Accountability 2018). …

Use Of Emoji In Pain Level Assessment In Pediatric Dental Patients, Manpreet K. Dhillon

Theses and Dissertations

USE OF EMOJI IN PAIN LEVEL ASSESSMENT IN PEDIATRIC DENTAL PATIENTS

Purpose: The purpose of this study is to determine the efficacy of a pain scale with Emoji images in comparison to the commonly used Wong-Baker FACES® pain scale. Methods: Healthy, English-speaking patients aged 4-17 presenting to the VCU Pediatric Dental clinic and the operating room and presenting to the MCV Pediatric Emergency Room were asked to rate their pain using the Wong-Baker FACES® and Emoji scales. These patients were then asked to select which pain scale they preferred. Results: A total of 151 children were enrolled in the study. …

Comparison Of Triple Combination Oral Sedation Regimens For Pediatric Dental Treatment, Brett H. Henderson

Theses and Dissertations

Purpose: Compare the efficacy of two benzodiazepines (diazepam or midazolam) in combination with meperidine and hydroxyzine for pediatric dental sedation. Methods: A randomized, double blind observation study of behaviors and outcomes related to two sedation groups. Frankl and Houpt behavior scores were recorded at three time points: injection time, initiation of treatment and at the end of treatment. Postoperative phone call surveys were conducted within eight hours of discharge to assess sleep, activity, and behavior. Results: A total of 40 sedation subjects were included in the study, of which 20 were treated with diazepam triple Combination (Di+M+H) and 20 with …

Investigation Of The Interactions Between The Dream Complex And Hpv16, Kevin Ko

Theses and Dissertations

According to the American Cancer Society, it has been estimated that in 2019 alone, there will be approximately 53,000 new cases of oropharyngeal cancers. Oropharyngeal cancers are the largest subset of head and neck squamous cell carcinomas (HNSCCs), which are the sixth most common cancer across worldwide populations. They, along with other HNSCCs, fall under a category of cancers known as Human papillomavirus (HPV)-associated cancers, and it has been found that upwards of 70% of these cancers can be attributed to high-risk HPV infections.

Specifically, the high-risk HPV gene, E7, plays a key role in relieving cell cycle repression by …

Design, Synthesis And Pharmacological Characterization Of Potential Mu Opioid Receptor Selective Ligands, Abhishek S. Kulkarni

Theses and Dissertations

Selective Mu Opioid Receptor (MOR) antagonists possess immense potential in the treatment of opioid abuse/addiction. Utilizing the “message-address” concept, our laboratory reported a novel, reversible, non-peptide MOR selective antagonist 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4՛-pyridyl)carboxamido]morphinan (NAP). Molecular modeling studies revealed that the selectivity of NAP for the MOR is because of a π-π stacking interaction of its pyridine ring with the Trp318residue in theMOR. Pharmacological characterization showed that NAP is a P-glycoprotein substrate, thereby limiting its use in the treatment of opioid abuse/addiction. Thus, to modify NAP, we replaced the pyridine ring with its isosteric counterpart thiophene. Isosteric replacement …

Restoration Of Contractile Protein Expression And Colonic Smooth Muscle Function By Hydrogen Sulfide In Dmd Mice, Kulpreet Singh

Theses and Dissertations

Duchenne Muscular Dystrophy (DMD), characterized by the lack of dystrophin, results from a mutation in the Xp21 gene which encodes for the protein dystrophin that links the extracellular matrix to the actin cytoskeleton in skeletal, cardiac and smooth muscle. Slow colonic transit and chronic constipation are common in DMD patients due to the weakening of the abdominal wall muscles and gut smooth muscle. However, the cause of this hypocontractility in DMD patients and the expression of contractile proteins in smooth muscle are unknown. Expression of contractile proteins is regulated by the signaling pathways activated by excitatory (e.g., acetylcholine, ACh) and …

Exploring The Impact Of Diversity Training On The Development And Application Of Cultural Competence Skills In Higher Education Professionals, Kendra Cabler

Theses and Dissertations

In recent years the terms diversity and inclusion have become major buzzwords across industries and fields of study. Within the field of education broadly, and higher education in particular, a shifting student demographic can be seen across the country. Issues of equity and inclusion have become central complexities for present day educational strategists, and organizations committed to cultivating a culture of inclusion must do so with intentionality. In the context of higher education, this often requires the intentional development of professionals within a particular college or university. There has been a great deal of research concerning the development of cultural …

Genetic And Environmental Factors Influence Drosophila Ethanol Sedation, Rebecca E. Schmitt

Theses and Dissertations

Alcohol use disorder is a global health issue that affects a significant portion of the population, with affects including both negative mental and physical consequences. Currently, there are few treatment options available to those who suffer from alcohol use disorder, alcohol abuse, or alcohol dependence. Identifying candidate genes or environmental influences would therefore improve the means for possible treatments or identification of those people at risk for alcohol use disorder. Previous studies in humans have demonstrated an inverse association between initial sensitivity and risk for alcohol abuse. This connection allows investigators, and our laboratory, to investigate genetic and environmental factors …

Work-Life Factors That Impact Job Burnout And Turnover Intention Among Athletic Academic Support Professionals, Jennifer Gellock

Theses and Dissertations

The purpose of the current study was to investigate factors in the work environment that impact job burnout among academic support professionals who work with college student-athletes. Specifically, the factors of job control match, fairness march, rewards match, and workload match were explored. Additionally, the extent to which emotional exhaustion and depersonalization had an effect on turnover intention was explored. Job burnout has been found to have negative impacts on professionals in human services professions. The sample consisted of academic advisors and learning specialists affiliated with National Collegiate Athletic Association (NCAA) Division I programs. Results suggest academic support professionals experience …

Exploring The Intersection Of Designing For Crime And The Future Of The Public Forum, Kathryn M. Benedict

Theses and Dissertations

As more public spaces are under the influence of private stakeholders in cities, it is important to consider the role, both financial and social, that these stakeholders have on the design of the physical space and the users of the space. This analysis will utilize a qualitative methodological approach to understand the contested redevelopment of a public park in Richmond, Virginia as it transitioned from a city-owned space to a public-private partnership. By gaining a better understanding of the major spheres of influence involved in the redevelopment, namely the large public university and the corporations adjacent to the space, it …

Using Latent Semantic Analysis To Evaluate The Coherence Of Traumatic Event Narratives, Gabriella C. Scalzo

Theses and Dissertations

While a growing evidence base suggests that expressive writing about a traumatic event may be an effective intervention which results in a variety of health benefits, there are still multiple competing theories that seek to explain expressive writing’s mechanism(s) of action. Two of the theories with stronger evidence bases are exposure theory and cognitive processing theory. The state of this field is complicated by methodological limitations; operationalizing and measuring the relative constructs of trauma narratives, such as coherence, traditionally requires time- and labor-intensive methods such as using a narrative coding scheme. This study used a computer-based methodology, latent semantic analysis …

Mechanisms Underlying Production Stability In Temperate Deciduous Forests, Shea B. Wales

Theses and Dissertations

A persistent and reliable future terrestrial carbon (C) sink will depend on how stable forest production is under more variable climate conditions. We examined how age, forest structure, and disturbance history relate to the interannual variability of above-ground wood net primary production (NPPw). Our site in northern Michigan spans two experimental forest chronosequences and three late successional stands; the chronosequences have distinct disturbance histories, originating following either clear cut harvesting (“Cut Only”) or clear cut harvesting and fire (“Cut and Burn”), and range from 21 to 108 years old. Annual NPPw was estimated using dendrochronology and site specific allometric equations. …

Finpathlight: Framework For An Ontology-Based, Multiagent, Hybrid Recommender System Designed To Increase Consumer Financial Capability, Lawrence Bunnell

Theses and Dissertations

This study is a design science research (DSR) project in which a description of the development and evaluation process for several novel technological artifacts will be communicated. Specifically, this study will establish: 1) an ontology of recommender systems issues, 2) an ontology of financial capability goals, and 3) a framework for a Personal Financial Recommender System (PFRS) application designed to improve user financial capability, called FinPathlight. The impetus for the RecSys Issues Ontology is to address a gap in the literature by providing researchers with a comprehensive knowledge classification of the issues and limitations inherent to recommender systems research. …

Proteinic Geontopower, Agustine Zegers

Theses and Dissertations

PGP is a study of how we come into intimate contact with capitalism through our digestive tract. It is a study of the increasing valuing of protein in contemporary diet culture, focusing on how this phenomenon has resulted in mass-scale global soya production. Protein synthesis and distribution are rearticulated in this work as a set of molecular transactions enacted within/out bodies, moving loosely through ligaments and industrial machinery.

PGP is a speculative exercise in communing with a damaged planet through our daily ingestions.

Cell Type And Substrate Dependence Of Fibronectin Properties And Mechanotransduction, Navpreet S. Saini

Theses and Dissertations

Fibronectin is an important protein that is able to bind to other fibronectin molecules and to cell surface receptors. In doing so, the interactions fibronectin can perform is important for the processes of cell migration and tissue formation. Understanding the properties of fibronectin and fibril assembly is useful for areas such as wound healing, where fibronectin molecules are assembled to protect the tissue and to perform other tasks. Because of these reasons, it is important to understand how fibronectin is assembled and how its properties affect the fibril assembly, which in return affects the way the cell matrix operates. Previously …

The Impact Of A Culturally Responsive Intervention On Perceived Career Barriers, Ethnic Identity, Student Motivation And Engagement, And Career Decision Making Self-Efficacy Of Middle School Minority Females, Marsha L. Rutledge

Theses and Dissertations

This study investigated the impact of a culturally responsive intervention on perceived career barriers, ethnic identity, student motivation and engagement, and career decision making self-efficacy of middle school minority females. The author analyzed data from the Female Leadership Academy for Minority Excellence (FLAME) program at a local rural middle school. Data was collected from 34 Black female middle school students who participated in the program. The study was a repeated measures quasi-experimental, quantitative single group pre-test, mid-test, and post-test design. According to results from a series of repeated measures ANOVAs, significant differences were found between pre-group, mid-group, and post-group scores. …

Forecast Combination With Multiple Models And Expert Correlations, David P. Soule

Theses and Dissertations

Combining multiple forecasts in order to generate a single, more accurate one is a well-known approach. A simple average of forecasts has been found to be robust despite theoretically better approaches, increasing availability in the number of expert forecasts, and improved computational capabilities. The dominance of a simple average is related to the small sample sizes and to the estimation errors associated with more complex methods. We study the role that expert correlation, multiple experts, and their relative forecasting accuracy have on the weight estimation error distribution. The distributions we find are used to identify the conditions when a decision …

Leadership Influence And Organizational Culture Influence In Private Schools: A Comparative Multiple Case Study On The Relationship Between Organizational Culture And Strategic Leadership, Julia E. Tucker-Lloyd

Theses and Dissertations

The top leader of an organization influences the organizational culture, and the organizational culture influences the leader. Strategic thinking on the part of the leader is a result of organizational culture and/or will impact organizational culture. This qualitative study is a comparative multiple-case study that examines the relationship between leaders and organizational culture and what the leader’s strategic decision-making and organizational changes indicate about the relationship between leadership and organizational culture. The organizational context of private schools is used to better understand the dynamics between leadership and organizational culture.

This study uses an interview protocol with CEOs of private schools, …

Behavioral And Immune Implications Of Chronic Predator Exposure In Adolescent Mice, Kimaya R. Council

Theses and Dissertations

Evidence suggests that toxic stressors introduced early in development have prolonged effects on neuronal function due, in part, to the maturation of the hypothalamic- pituitary- adrenal (HPA) axis during adolescence. Early life stress has been implicated as a driver of mood and anxiety disorders, like depression and post-traumatic stress disorder - the extent to which appears to be sex dependent. While it is known that early life stress results in several consequences in adulthood, the mechanisms by which these changes manifest are unclear. Stress-induced changes in mood and behavior are often associated with alterations in inflammatory reactivity in both the …

Effect Of A 14-Day Mindfulness Intervention On Daily Desire Experiences And Desire Regulation, Nabila Farhin Jahan

Theses and Dissertations

A growing body of research suggests that mindfulness, a receptive attentiveness to one’s present moment experiences, has the potential to adaptively regulate habitual behaviors. No prior study has tested the effect of mindfulness interventions on people’s daily desire experiences to inform the potential for adaptive desire regulation. The present exploratory randomized controlled trial examined the effect of a 14-day smartphone-based mindfulness intervention (versus a coping control intervention) on the frequency, intensity, duration, and enactment of everyday desires in 19 participants. The desire domains included basic need-based desires (i.e., for food, drink, sleep) and secondary desires (e.g., for sex, media, social …

Antinociceptive Tolerance To Morphine Is Driven By Colonic Inflammation And Mediated By Peripheral Opioid Receptors, Essie S. Komla

Theses and Dissertations

Opioids are powerful analgesics. Despite their high efficacy for the management of moderate to severe pain, their clinical utility is limited due to the occurrence of adverse effects. The main problem associated with opioid use is the differential rate of tolerance development to the various pharmacological effects of opioids, with tolerance to respiratory depression occurring at a slower rate than analgesic and euphoric effects. The development of analgesic tolerance, where the efficacy of the drug progressively diminishes with repeated administration, requires higher doses of the drug to achieve a maximum effect. Reports have implicated inflammation as a major driver of …

Sensory Overlay: Promoting Inclusivity And Accessibility For Americans With Disabilities Along The Midtown Greenway In Uptown Minneapolis, Alina El Tamimi

Landscape Architecture Theses

Urban spaces are often hostile environments for individuals with disabilities. The bigger American cities grow the harder they become to navigate for those with disabilities as they provide more challenges and obstacles. Cities and public spaces are often designed with ADA (Americans with Disabilities Act) compliance. Unfortunately, these designs always feel like an afterthought. It feels as though necessities for individuals with disabilities is set aside and are only provided due to the requirements. Individuals with cognitive or sensory disabilities are often completely disregarded. Even though recently more and more urban projects are being designed with amenities for people with …

Bear Den Landing: Creating Resilient Environments & Tribal Communities Through Ecological Planning & Public Participation On Fort Berthold Reservation, Morgan Davis-Kollman

Landscape Architecture Theses

Over half of the 135,000 miles of oil and gasoline pipelines in the U.S. were installed before 1969, with implementation of pipes occurring before maturation of steel or coating technology. Leaks and spills are becoming increasingly common within the realm of man-made environmental hazards. North Dakota is the second largest in oil production, suffering from 85 paramount oil spills in last 20 years. North Dakota tribal lands are faced with declining environmental issues as a majority of reservations located in areas of hazard, creating a state of crisis within their livable environment. A broken pipeline burst more than a million …

Global Awareness Of Marketing Students, Michael Latta

AMTP Proceedings 2019

Undergraduate and MBA Marketing programs typically include education goals such as:

“To prepare students for a changing domestic and global business environment characterized by organizational and cultural values, diversity, opportunity, and growth.”

They also include learning objectives such as:

“Students will be able to demonstrate the ability to think strategically about the global business environment.”

Presumably this approach to educating undergraduate and MBA students will prepare them to become ‘global citizens.’ The question may be asked about what undergraduate and MBA marketing students know about changes in global extreme poverty, education access for women around the world, and number of …