Digital Commons Network^™

Behavioral Predictors Of Autism Recurrence Are Genetically Independent And Influence Social Reciprocity: Evidence That Polygenic Asd Risk Is Mediated By Separable Elements Of Developmental Liability, Alexa Pohl, Warren R. Jones, Natasha Marrus, Yi Zhang, Ami Klin, John N. Constantino

Open Access Publications

No abstract provided.

A Protocol For The Systematic Review And Meta-Analysis Of Studies In Which Cannabinoids Were Tested For Antinociceptive Effects In Animal Models Of Pathological Or Injury-Related Persistent Pain, Nadia Soliman, Andrea G. Hohmann, Simon Haroutounian, Kimberley Wever, Andrew S.C. Rice, David P. Finn

Open Access Publications

No abstract provided.

Emotional Response Inhibition Is Greater In Older Than Younger Adults, Jill D. Waring, Taylor R. Greif, Eric J. Lenze

Open Access Publications

No abstract provided.

Excitability And Irritability In Preschoolers Predicts Later Psychopathology: The Importance Of Positive And Negative Emotion Dysregulation, Alecia C Vogel, Joshua J Jackson, Deanna M Barch, Rebecca Tillman, Joan L Luby

Open Access Publications

Emotion dysregulation is a risk factor for the development of a variety of psychopathologic outcomes. In children, irritability, or dysregulated negative affect, has been the primary focus, as it predicts later negative outcomes even in very young children. However, dysregulation of positive emotion is increasingly recognized as a contributor to psychopathology. Here we used an exploratory factor analysis and defined four factors of emotion dysregulation: irritability, excitability, sadness, and anhedonia, in the preschool-age psychiatric assessment collected in a sample of 302 children ages 3-5 years enriched for early onset depression. The irritability and excitability factor scores defined in preschoolers predicted …

Cannabinoids, Cannabis, And Cannabis-Based Medicine For Pain Management: A Protocol For An Overview Of Systematic Reviews And A Systematic Review Of Randomised Controlled Trials, Emma Fisher, Christopher Eccleston, Louisa Degenhardt, David P. Finn, Nanna B. Finnerup, Ian Gilron, Simon Haroutounian, Elliot Krane, Andrew S.C. Rice, Michael Rowbotham, Mark Wallace, R. Andrew Moore

Open Access Publications

No abstract provided.

Evidence Of Causal Effect Of Major Depression On Alcohol Dependence: Findings From The Psychiatric Genomics Consortium, Arpana Agrawal, Et Al

Open Access Publications

No abstract provided.

Anesthesiology Control Tower-Feasibility Assessment To Support Translation (Actfast): Mixed-Methods Study Of A Novel Telemedicine-Based Support System For The Operating Room, Teresa Murray-Torres, Aparna Casarella, Mara Bollini, Frances Wallace, Michael S. Avidan, Mary C. Politi

Open Access Publications

No abstract provided.

Factors Influencing Resident Satisfaction And Fellowship Selection In Orthopaedic Training Programs: An American Orthopaedic Association North American Traveling Fellowship Project, Xinning Li, Nicholas Pagani, Emily J. Curry, Bashar Alolabi, Jonathan F. Dickens, Anna N. Miller, Addisu Mesfin

Open Access Publications

No abstract provided.

Rab10: An Alzheimer’S Disease Resilience Locus And Potential Drug Target, Justina P. Tavana, Matthew Rosene, Nick O. Jensen, Perry G. Ridge, John S.K Kauwe, Celeste M. Karch

Open Access Publications

No abstract provided.

Communication Interventions In Adult And Pediatric Oncology: A Scoping Review And Analysis Of Behavioral Targets, Bryan A. Sisk, Ginny L. Schulz, Jennifer W. Mack, Lauren Yaeger, James Dubois

Open Access Publications

No abstract provided.

A Comparison Of Shallow And Deep Learning Methods For Predicting Cognitive Performance Of Stroke Patients From Mri Lesion Images, Sucheta Chauhan, Lovekesh Vig, Michele De Filippo De Grazia, Maurizio Corbetta, Shandar Ahmad, Marco Zorzi

Open Access Publications

No abstract provided.

Shared And Specific Genetic Risk Factors For Lifetime Major Depression, Depressive Symptoms And Neuroticism In Three Population-Based Twin Samples, Kenneth S Kendler, Charles O Gardner, Michael C Neale, Steve Aggen, Andrew Heath, Lucía Colodro-Conde, Baptiste Couvyduchesne, Enda M Byrne, Nicholas G Martin, Nathan A Gillespie

Open Access Publications

BACKGROUND: Vulnerability to depression can be measured in different ways. We here examine how genetic risk factors are inter-related for lifetime major depression (MD), self-report current depressive symptoms and the personality trait Neuroticism.

METHOD: We obtained data from three population-based adult twin samples (Virginia n = 4672, Australia #1 n = 3598 and Australia #2 n = 1878) to which we fitted a common factor model where risk for 'broadly defined depression' was indexed by (i) lifetime MD assessed at personal interview, (ii) depressive symptoms, and (iii) neuroticism. We examined the proportion of genetic risk for MD deriving from the …

Behavioral Compensations And Neuronal Remodeling In A Rodent Model Of Chronic Intervertebral Disc Degeneration, Elizabeth M. Leimer, Matthew G. Gayoso, Liufang Jing, Simon Y. Tang, Munish C. Gupta, Lori A. Setton

Open Access Publications

No abstract provided.

Blending Insights From Implementation Science And The Social Sciences To Mitigate Inequities In Screening For Hereditary Cancer Syndromes, Laura Senier, Colleen M Mcbride, Alex T Ramsey, Vence L Bonham, David A Chambers

Open Access Publications

Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from implementation science and sociological research on health inequities. Our framework does three things: first, it broadens the arenas of action beyond those typically addressed in implementation science frameworks; second, it argues for recruiting more diverse partners to …

Repetitive Transcranial Magnetic Stimulation With Resting-State Network Targeting For Treatment-Resistant Depression In Traumatic Brain Injury: A Randomized, Controlled, Double-Blinded Pilot Study, Shan H. Siddiqi, Nicholas T. Trapp, Carl D. Hacker, Timothy O. Laumann, Sridhar Kandala, Xin Hong, Ludwig Trillo, Pashtun Shahim, Eric C. Leuthardt, Alexandre R. Carter, David L. Brody

Open Access Publications

No abstract provided.

Repeated Neonatal Isoflurane Exposures In The Mouse Induce Apoptotic Degenerative Changes In The Brain And Relatively Mild Long-Term Behavioral Deficits, Susan E. Maloney, Carla M. Yuede, Catherine E. Creeley, Sasha L. Williams, Jacob N. Huffman, George T. Taylor, Kevin N. Noguchi, David F. Wozniak

Open Access Publications

No abstract provided.

Conditional Knockout Of Ubc13 Produces Disturbances In Gait And Spontaneous Locomotion And Exploration In Mice, David F. Wozniak, Pamela Valnegri, Joshua T. Dearborn, Stephen C. Fowler, Azad Bonni

Open Access Publications

No abstract provided.

Archetypes Of Human Cognition Defined By Time Preference For Reward And Their Brain Correlates: An Evolutionary Trade-Off Approach, Giorgia Cona, Loren Kocillari, Alessandro Palombit, Alessandra Bertoldo, Amos Maritan, Maurizio Corbetta

Open Access Publications

No abstract provided.

Neurocognitive Superaging In Older Adults Living With Hiv: Demographic, Neuromedical And Everyday Functioning Correlates, David B. Clifford, Et Al

Open Access Publications

No abstract provided.

Adherence To Consolidated Standards Of Reporting Trials (Consort) Guidelines For Reporting Safety Outcomes In Trials Of Cannabinoids For Chronic Pain: Protocol For A Systematic Review, Mohammed M. Mohiuddin, Glenio Mizubuti, Simon Haroutounian, Shannon Smith, Fiona Campbell, Rex Park, Ian Gilron

Open Access Publications

No abstract provided.

Peer Victimization And Dysfunctional Reward Processing: Erp And Behavioral Responses To Social And Monetary Rewards, Brent I. Rappaport, Laura Hennefield, Autumn Kujawa, Kodi B. Arfer, Danielle Kelly, Emily S. Kappenman, Joan L. Luby, Deanna M. Barch

Open Access Publications

No abstract provided.

The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen

Open Access Publications

No abstract provided.

Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.

Open Access Publications

No abstract provided.

A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter

Open Access Publications

No abstract provided.

Neuroinflammation And White Matter Alterations In Obesity Assessed By Diffusion Basis Spectrum Imaging, Amjad Samara, Tatianna Murphy, Jeremy Strain, Jerrel Rutlin, Peng Sun, Olga Neyman, Nitya Sreevalsan, Joshua S Shimony, Beau M Ances, Sheng-Kwei Song, Tamara Hershey, Sarah A Eisenstein

Open Access Publications

Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in multiple regions, including the hippocampus, and impairments in hippocampal-dependent memory tasks. To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity. We examined diffusion-weighted magnetic resonance imaging (MRI) data in two independent cohorts of obese and non-obese individuals (Cohort 1: 25 obese/21 non-obese; Cohort 2: 18 obese/41 non-obese). We applied Tract-based Spatial Statistics (TBSS) to allow …

Confronting The Opioid Crisis: Practical Pain Management And Strategies: Aoa 2018 Critical Issues Symposium, Hassan R Mir, Anna N Miller, William T Obremskey, A Alex Jahangir, Joseph R Hsu

Open Access Publications

The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management. Clinicians need to understand the pathophysiology and science of addiction to improve perioperative management of pain for their patients. Multiple modalities for pain management exist that decrease the use of narcotics. Physical strategies, cognitive strategies, and multimodal medication can all provide improved pain relief and decrease the use of narcotics. National medical societies are developing clinical practice guidelines for pain management that incorporate multimodal strategies and multimodal medication. Changes to policy that improve …

Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages-Canada) Study: A Pragmatic, Randomized Clinical Trial [Version 1; Peer Review: 2 Approved], Alain Deschamps, Jordan Oberhaus, Angela Mickle, Arbi Ben Abdallah, Michael S Avidan, Et Al

Open Access Publications

No abstract provided.

Clinical Trials In Multiple Sclerosis: Potential Future Trial Designs, Navid Manouchehri, Yinan Zhang, Amber Salter, Rehana Z Hussain, Hans-Peter Hartung, Bernhard Hemmer, Ralf Linker, Benjamin M Segal, Gary Cutter, Olaf Stüve

Open Access Publications

Clinical trials of new treatments in multiple sclerosis (MS) currently require large sample sizes and long durations in order to yield reliable results. The differential responses of an already heterogeneous population of MS patients to individual disease-modifying therapies (DMTs) will further complicate future trials. MS trials with smaller samples and faster outcomes are conceivable through the substitution of current clinical and MRI outcomes with objectively measureable genomic and proteomic biomarkers. Currently, biomarkers that could be utilized for diagnosis and monitoring of MS disease activity are in the early validation phase. The power of single biomarkers or multiple correlated biomarkers to …

Adiposity, Hepatic Triglyceride, And Carotid Intima Media Thickness During Behavioral Weight Loss Treatment In Antipsychotic-Treated Youth: A Randomized Pilot Study, Ginger E. Nicol, Rachel Kolko, Eric J. Lenze, Michael D. Yingling, J. Philip Miller, Amanda R. Ricchio, Julia A. Schweiger, Robert L. Findling, Denise Wilfley, John W. Newcomer

Open Access Publications

No abstract provided.

A Qualitative Study Identifying Barriers And Facilitators Of Physical Activity In Rural Communities, Amanda S. Gilbert, Dixie D. Duncan, Alan M. Beck, Amy A. Eyler, Ross C. Brownson

Open Access Publications

No abstract provided.