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2019

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Visualizing Ischemic Skin Flap Necrosis Through Phasor Analysis Of Autofluorescence Lifetime Images, Hallie Ramser Toomer Aug 2019

Visualizing Ischemic Skin Flap Necrosis Through Phasor Analysis Of Autofluorescence Lifetime Images, Hallie Ramser Toomer

Graduate Theses and Dissertations

Necrotic skin flaps are difficult to predict and treat due to the lack of quantitative biomarkers. Label-free multiphoton microscopy is well suited for non-invasively monitoring skin metabolism through NAD(P)H and other intrinsic fluorophores, and offers immediate future directions for assessing necrosis in the clinic. The objective of this study was to assess whether phasor FLIM could be used to evaluate skin flap status and treatment efficacy in ex vivo skin sections. Phasor maps revealed differences in growth factor treatment and region, but changes in skin flap autofluorescence at 755nm excitation and 460nm emission were not just related to NAD(P)H. A …

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Effects Of Germination Conditions Of Brown Rice In Relation To Flour Physicochemical Properties And Bread Qualities, Wipada Wunthunyarat Aug 2019

Effects Of Germination Conditions Of Brown Rice In Relation To Flour Physicochemical Properties And Bread Qualities, Wipada Wunthunyarat

Graduate Theses and Dissertations

Gluten-free products from rice are gaining popularity among consumers because of its hypoallergenic characteristic. The absence of gluten results in inferior bread qualities such as hard texture, reduced volume and shorter shelf-life, which can be improved by the addition of external hydrolytic enzymes. Hydrolytic enzymes are activated during germination to stimulate plant growth, and hence these enzymes may function similarly to the external enzymes to improve gluten-free bread from brown rice. Therefore, the objective of this work was to investigate the activities of amylases and protease in germinated brown rice (GBR) from long-grain and short-grain rices under different germination conditions …

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Adsorption Driven Regolith-Atmospheric Water Vapor Transfer On Mars: An Analysis Of Phoenix Tecp Data, Holly Nicole Farris Aug 2019

Adsorption Driven Regolith-Atmospheric Water Vapor Transfer On Mars: An Analysis Of Phoenix Tecp Data, Holly Nicole Farris

Graduate Theses and Dissertations

NASA’s Phoenix mission allowed for investigations of Martian diurnal water vapor cycles through the collection of temperature, relative humidity, and electric conductivity data by the Thermal and Electric Conductivity Probe (TECP) instrument. Using this data and previous experimental data, we propose a regolith-driven adsorption-desorption regime at the Phoenix landing site, where parameters intrinsic to the regolith are controlling localized relative humidity at the surface. To constrain these parameters, we model adsorption as a function of temperature and relative humidity across various Mars-relevant materials, defined by two layer-based adsorption theories: Langmuir (monolayer) and Brunauer-Emmett-Teller or BET (multilayer). Langmuir serves as an …

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The Functional And Structural Analysis Of Drosophila Robo2 In Axon Guidance, Lafreda Janae Howard Aug 2019

The Functional And Structural Analysis Of Drosophila Robo2 In Axon Guidance, Lafreda Janae Howard

Graduate Theses and Dissertations

In animals with complex nervous systems such as mammals and insects, signaling pathways are responsible for guiding axons to their appropriate synaptic targets. Importantly, when this process is not successful during the development of an organism, outcomes include catastrophes such as human neurological diseases and disorders. It is vital to determine the underlying causes of such diseases by understanding the development of the nervous system. There are many pathways that have been identified to play a role in this, however, we lack an understanding of how these pathways can promote such diverse outcomes in different populations of neurons. These pathways …

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Effects Of Multivitamin-Mineral Supplementation On Mental Health Among Young Adults, Ya-Hsuan Chang Aug 2019

Effects Of Multivitamin-Mineral Supplementation On Mental Health Among Young Adults, Ya-Hsuan Chang

Graduate Theses and Dissertations

The percentage of young adults who had mental illnesses has increased from 2008 to 2015. However, few existing studies investigating the potential benefits of multivitamin-mineral (MVM) supplementation on mental health focused on young adults (18-24 years of age), whose eating behaviors are often unhealthy. The purpose of this study was to examine the effects of a MVM supplement on mental health in young adults. One hundred and thirty-three college students (Mage=20.59, SD=1.77; 80.15% female) participated in this randomized, double-blind, placebo-controlled trial. Participants consumed either a MVM supplement or a placebo for 30 days. The supplement contained B Vitamins, Vitamin C, …

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Control Of Protoporphyrinogen Oxidase-Resistant Palmer Amaranth, Michael Mckinley Houston Aug 2019

Control Of Protoporphyrinogen Oxidase-Resistant Palmer Amaranth, Michael Mckinley Houston

Graduate Theses and Dissertations

Already one of the most troublesome weeds in row crop production in the southern U.S., protoporphyrinogen oxidase (PPO)-resistant Palmer amaranth [Amaranthus palmeri (S.) Wats.] was first documented in Arkansas in 2015. Since this confirmation, PPO-resistant Palmer amaranth has been identified throughout the Midsouth. The following research evaluated both current and future herbicide programs for controlling PPO-resistant Palmer amaranth and quantified field-level resistance to PPO-inhibiting herbicides. On-farm research, located in fields with confirmed PPO-resistant Palmer amaranth, was conducted in 2016 and 2017. In preemergence (PRE) herbicide experiments, PPO-inhibiting herbicides still proved useful when combined with herbicides such as metribuzin and/or pyroxasulfone. …

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Stable Isotope And Geochemical Characterization Of Nutrient Sources In The Big Creek Watershed Of Northwest Arkansas, Kelly Robin Sokolosky Aug 2019

Stable Isotope And Geochemical Characterization Of Nutrient Sources In The Big Creek Watershed Of Northwest Arkansas, Kelly Robin Sokolosky

Graduate Theses and Dissertations

The establishment of a concentrated animal-feeding operation (CAFO) in Newton County, Arkansas near Big Creek, a tributary of the Buffalo National River, has raised concern over potential degradation of water-quality in the watershed. In this study, isotopic tools were combined with standard geochemical approaches to characterize nutrient sources and dynamics in Big Creek. An isotopic and geochemical reference library of potential nutrient sources in the Big Creek watershed was established by direct sampling of representative potential sources, including septic-system effluent, poultry litter, swine and cattle manure, and CAFO waste lagoons. Representative nutrient sources and Big Creek stream samples were analyzed …

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Barriers Of African American Football Student-Athletes In Seeking Mental Health Services, Todd Andrew Wilkerson Aug 2019

Barriers Of African American Football Student-Athletes In Seeking Mental Health Services, Todd Andrew Wilkerson

Graduate Theses and Dissertations

Nearly half (48%) of collegiate football student-athletes are African American (NCAA, 2018). African American student-athletes face adversity at their respective institutions in the forms of racism and unfair treatment (Hill, Hall & Appleton, 2010). African American male student-athletes face educational stressors, campus stressors and athletic stressors. These stressors consist of academics, family, athletics and social relationships (Miller & Hoffman, 2009). Many African American student-athletes do not seek mental health treatment due to their status on campus (Watson, 2006). However, few studies have examined mental health and barriers for African American male student-athletes when seeking mental health services. As such, the …

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Potential Antimicrobials For Controlling Listeria Monocytogenes In Frankfurters, Aaron Rashad Bodie Aug 2019

Potential Antimicrobials For Controlling Listeria Monocytogenes In Frankfurters, Aaron Rashad Bodie

Graduate Theses and Dissertations

Listeria monocytogenes is a pathogenic microorganism that causes Listeriosis. Listeriosis is a highly mortal disease with approximately 20% mortality rate. Listeria is psychrophilic, therefore it is able to survive in the refrigerator. This affects foods at cool storage such as fresh produce and RTE meats. To ensure the safety of RTE meat, post processing treatments are used such as vacuum packing, edible films, dip and treatment. One-way RTE can be treated is with the use of antimicrobials. However, in the past chemical substances were used. Currently, consumers want more natural and organic preservatives to combat health problems from toxic components …

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Nesting Success Of Dickcissel (Spiza Americana) And Non-Breeding Grassland Bird Use Of Northwest Arkansas’ Remnant And Restored Tallgrass Prairies, Alyssa L. Derubeis Aug 2019

Nesting Success Of Dickcissel (Spiza Americana) And Non-Breeding Grassland Bird Use Of Northwest Arkansas’ Remnant And Restored Tallgrass Prairies, Alyssa L. Derubeis

Graduate Theses and Dissertations

Dwindling populations of North American grassland birds are linked to habitat loss. Tallgrass prairie only covers 3% of its pre-settlement-era range. Small-scale restoration projects attempt to increase acreage for prairie avifauna, and while some breeding grassland species are present at these sites, nesting success and non-breeding use are still largely unknown. Both life history aspects are required for effective grassland bird conservation. My first objective was to access nest success of the Dickcissel (Spiza americana) at two remnant and two restored tallgrass prairies in Northwest Arkansas. From May-August 2017 and 2018, I found 114 nests that I monitored to determine …

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Emotion Identification And Beliefs About Emotions As Mediators Of Ptsd And Parenting Meta-Emotion Philosophies, Maegan Calvert Aug 2019

Emotion Identification And Beliefs About Emotions As Mediators Of Ptsd And Parenting Meta-Emotion Philosophies, Maegan Calvert

Graduate Theses and Dissertations

Approximately 20% of women are sexually victimized and incarcerated women’s rates of victimization are much higher. In addition, women have a higher rate of PTSD and trauma-related sequelae than men. Interpersonal trauma experiences can have a negative impact on emotional processes such as alexithymia, recognizing others’ emotions, and healthy beliefs about emotional experiences. These difficulties are associated with problematic parenting. However, the mediational processes by which PTSD and disruptive emotional processes affect parenting is unclear. The current study examines the associations among PTSD, alexithymia, negative beliefs about emotions, emotion recognition in children, and parenting meta-emotion philosophies in incarcerated women presenting …

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J Mich Dent Assoc August 2019 Aug 2019

J Mich Dent Assoc August 2019

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA’s 6,200+ members across the state. No publication reaches more Michigan dentists! This month's issue features articles on the top 10 financial mistakes dentists make, a new classification scheme for periodontal diseases and conditions, and a look into evidence-based clinical decision-making.

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Characterization Of The Swine Gut Microbiome Dynamics, Culturomics And Probiotics, Xiaofan Wang Aug 2019

Characterization Of The Swine Gut Microbiome Dynamics, Culturomics And Probiotics, Xiaofan Wang

Graduate Theses and Dissertations

The gastrointestinal tract is a critical place where the immune system concentrates many of its protective functions. It exerts both physical and biochemical defenses against invading foodborne pathogens and other hazards. In pigs, the gut microbiota community assembled postnatal plays a very important role in the development of multiple physiologic aspects, such as development of the gastrointestinal tract, nutrient exchange, immune defense against foreign pathogens and growth performance. Microbiome-host communication changes with age. Despite recent advances in understanding the swine gut microbiome at different growth stages, a comprehensive longitudinal study of the lifelong dynamics of the swine gut microbiome is …

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Phylogenetic Analysis Of Palisota (Commelinaceae) Using Chloroplast And Nuclear Regions, Alexandra H. Crum Aug 2019

Phylogenetic Analysis Of Palisota (Commelinaceae) Using Chloroplast And Nuclear Regions, Alexandra H. Crum

Masters Theses

Palisota (Commelinaceae) differs from other Commelinaceae genera in androecial and pollen characters, a fleshy berry-type fruit, and anatomical characters. Palisota has been divided into two sections based on uniseriate vs. biseriate seed arrangement. Molecular phylogenetic analyses in Commelinaceae have placed Palisota near the base within the family, although its precise position is unclear. We sequenced chloroplast (matK, rbcL, rps16, and trnL-trnF, psbI-psbK, atpB-rbcL, atpF-atpH and psbA-trnH intergenic spacers) and nuclear (AT103) regions in 15 of approximately 26 species of Palisota and 15 outgroup species. Phylogenetic analyses were performed using maximum likelihood and Bayesian methods, with the …

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The Association Between Dietary Niche Variation In Rodents And Climate Change Across The Paleocene-Eocene Thermal Maximum, Hannah K. Vermeer Aug 2019

The Association Between Dietary Niche Variation In Rodents And Climate Change Across The Paleocene-Eocene Thermal Maximum, Hannah K. Vermeer

Masters Theses

Mammalian teeth play a crucial role in food acquisition and breakdown and are therefore closely tied to dietary niche. This study reconstructed the diet of early Paleogene paramyid rodents across the Paleocene-Eocene Thermal Maximum (PETM) climatic event in an effort to understand the role of climate in mammalian dietary niche change. Dietary niches were quantified using three dental topographic measures: Dirichlet normal energy, relief index, and orientation patch count rotated. A Kruskal-Wallis test was conducted over eight time periods to determine if each of the dental topographic measures (i.e., diet) varied over time. Regression analysis of these measures with climatic …

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An Assessment Of Periphyton Communities In Five Upper Peninsula Streams, Mi, Aaron Jeffrey Christiansen Aug 2019

An Assessment Of Periphyton Communities In Five Upper Peninsula Streams, Mi, Aaron Jeffrey Christiansen

Masters Theses

This project quantified lotic periphyton community change from May 2018-October 2018 in five, first and second-order Lake Superior tributary streams. Using periphyton communities, land use, geology, and abiotic factors pertinent to stream ecosystems we evaluated periphyton community succession. Using periphytometers, periphyton communities were collected and identified monthly to quantify community succession. Total phosphorus and total Kjeldahl nitrogen were measured monthly during the study. Depth, velocity, specific conductivity, and canopy cover were measured to quantify some of the physical factors within the streams. Nonmetric multidimensional scaling analysis indicated that the periphyton communities were similar between streams (ADONIS p-value =0.73) but was …

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Habitat Use And Tributary Occupancy Of The Threatened River Redhorse (Moxostoma Carinatum) In The Grand River, Mi, Usa., Nicholas Michael Preville Aug 2019

Habitat Use And Tributary Occupancy Of The Threatened River Redhorse (Moxostoma Carinatum) In The Grand River, Mi, Usa., Nicholas Michael Preville

Masters Theses

The resiliency of our aquatic ecosystems hinges on our ability to protect the native species that reside within them. The river redhorse (Moxostoma carinatum) is one such example and populations have become low enough to warrant listing by the State of Michigan. Causes of decline include overfishing, habitat alteration, and lack of knowledge of basic life-history attributes including their use of non-spawning habitat and spawning locations. In order to understand the river redhorse’s habitat use we implanted 15 individuals with radio transmitters and tracked their locations over the course of a summer. Tagged river redhorse were found to …

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Dynamic Carbon Cycling In Muskegon Lake – A Great Lakes Estuary, Katie Lynn Knapp Aug 2019

Dynamic Carbon Cycling In Muskegon Lake – A Great Lakes Estuary, Katie Lynn Knapp

Masters Theses

Ecosystem metabolism is the coupling of carbon and oxygen through photosynthesis and respiration. Gross primary production (GPP) is the carbon fixation by photosynthesis, ecosystem respiration (R) is carbon remineralization by bacterial and plankton respiration, and net ecosystem production (NEP) is the balance. Metabolism estimates determine if ecosystem is a sink or source of carbon to the atmosphere. When a lake has a positive NEP, or the GPP:R ratio is greater than 1, it is considered autotrophic and less carbon is being lost to the atmosphere than taken in, whereas if NEP is negative (GPP:R-1d-1, respectively and the BOD …

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Biological Invasions On A Large Scale: Investigating The Spread Of Baby’S Breath (Gypsophila Paniculata) Across North America, Sarah K. Lamar Aug 2019

Biological Invasions On A Large Scale: Investigating The Spread Of Baby’S Breath (Gypsophila Paniculata) Across North America, Sarah K. Lamar

Masters Theses

Invasive species are a serious threat to biodiversity worldwide. While the impacts of invasive species increase annually, many gaps in our understanding of how these species invade, adapt, and thrive in the novel ecosystems into which they are introduced remain. This thesis aimed to add to our knowledge of invasion science, using the perennial forb Gypsophila paniculata as a study system. Gypsophila paniculata is a shrub native to the Eurasian steppe that was introduced into North America in the late 1800’s. After introduction, G. paniculata quickly spread and now occupies diverse ecosystems across N. America. In chapter II of this …

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Using Landscape Genetics To Understand Connectivity Of An Island Population Of Eastern Massasauga Rattlesnakes (Sistrurus Catenatus), Nathan Kudla Aug 2019

Using Landscape Genetics To Understand Connectivity Of An Island Population Of Eastern Massasauga Rattlesnakes (Sistrurus Catenatus), Nathan Kudla

Masters Theses

Populations that experience low levels of gene flow commonly display increased levels of inbreeding, lower genetic diversity, and reduced adaptive potential. Landscape genetics allows for spatial and genetic information to be analyzed simultaneously to better understand how the landscape influences gene flow. The eastern massasauga rattlesnake (Sistrurus catenatus) is a federally threatened viper found in wetlands throughout the Great Lakes region. Many remaining populations are small and isolated due primarily to habitat loss. Atypical from a range-wide perspective, eastern massasaugas on Bois Blanc Island (BBI), Michigan live in a relatively undisturbed landscape with a potential for high connectivity …

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Evaluating Remote Site Incubators To Support Restoration Of Arctic Grayling In Michigan, Alan J. Mock Aug 2019

Evaluating Remote Site Incubators To Support Restoration Of Arctic Grayling In Michigan, Alan J. Mock

Masters Theses

Remote site incubators (RSIs) have been used to rear salmonid fish eggs along streams in the Pacific Northwest since the 1980s. Recently, the successful use of RSIs for Arctic Grayling Thymallus arcticus restoration in Montana has sparked a renewed interest to reestablish the species in Michigan. To support future reintroduction efforts of Arctic Grayling in Michigan, I evaluated RSIs in three Michigan streams during 2018 and 2019 using Rainbow Trout Oncorhynchus mykiss eggs (as surrogates for Arctic Grayling). My objectives were to: (1) compare hatching success between two different RSI designs (19-L vs. 265-L RSIs), and (2) test whether the …

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Ohio University Establishes Landscape And Turf Pest Management Plan (August 1, 2019), University Communications And Marketing Aug 2019

Ohio University Establishes Landscape And Turf Pest Management Plan (August 1, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

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Designing And Sample Size Calculation In Presence Of Heterogeneity In Biological Studies Involving High-Throughput Data., Sudhir Srivastava Aug 2019

Designing And Sample Size Calculation In Presence Of Heterogeneity In Biological Studies Involving High-Throughput Data., Sudhir Srivastava

Electronic Theses and Dissertations

The designing and determination of sample size are important for conducting high-throughput biological experiments such as proteomics experiments and RNA-Seq expression studies, thus leading to better understanding of complex mechanisms underlying various biological processes. The variations in the biological data or technical approaches to data collection lead to heterogeneity for the samples under study. We critically worked on the issues of technical and biological heterogeneity. The quantitative measurements based on liquid chromatography (LC) coupled with mass spectrometry (MS) often suffer from the problem of missing values (MVs) and data heterogeneity. We considered a proteomics data set generated from human kidney …

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Characterizing The Role Of Extracellular Matrix In Non-Small Cell Lung Carcinoma Metastasis Using A 3d Microenvironment Mimetic In-Vitro Culture System., Douglas John Owulaku Saforo Aug 2019

Characterizing The Role Of Extracellular Matrix In Non-Small Cell Lung Carcinoma Metastasis Using A 3d Microenvironment Mimetic In-Vitro Culture System., Douglas John Owulaku Saforo

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer related death in the United States and worldwide. Five-year survival rates for non-small cell lung carcinoma patients have not improved in decades, and a majority of patients succumb to metastasis. Identification of therapeutic targets for metastatic disease is essential for the development of novel therapies. However, current 2-dimensional (2D) in vitro models are not reflective of the tumor microenvironment (TME) and are inadequate in identifying therapeutic targets. We adapted a 3-dimensional (3D) extracellular matrix (ECM) in vitro model to a hypoxic incubator to approximate physiological hypoxia of the TME in a microenvironment …

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A Distinct Pattern Of Sterile Inflammation Induced By Zinc Oxide Nanowires., Ruqaih Salem Alghsham Aug 2019

A Distinct Pattern Of Sterile Inflammation Induced By Zinc Oxide Nanowires., Ruqaih Salem Alghsham

Electronic Theses and Dissertations

In recent years, there has been an increasing interest in nanotechnology. Engineered nanomaterials (ENMs) become an increasingly important area in nanotechnology. Recent developments in ENMs have drawn commercial and research attention in many areas such as agriculture, medicine, and Industry. High-aspect ratio zinc oxide nanowires (ZnONWs) have become one of the most significant ENMs due to their remarkable physical properties which makes them useful in a wide-range of applications. However, questions have been raised about ZnONW safety uses and biological consequences. In this dissertation, we investigated the inflammatory potential of ZnONWs in mouse models. C57BL/6 mice were exposed to ZnONW …

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Transforming Moss P. Patens With Lignin Peroxidase Through Heterologous Protein Expression., Jesse Lee Rozsa Aug 2019

Transforming Moss P. Patens With Lignin Peroxidase Through Heterologous Protein Expression., Jesse Lee Rozsa

Electronic Theses and Dissertations

Lignin peroxidase is an enzyme secreted by white-rot fungi Phanerochaete chrysosporium. Our laboratory is attempting to produce several lignin degrading enzymes in our protein expression system that utilizes the moss, Physcomitrella patens. During our experiments we discovered that this particular species of fungus produces altered splicing variants that are not represented in the previously reported reference sequence. Despite several attempts to produce a positive transformant containing a desired transgene encoding; lignin peroxidase, production of the proper construct eluded our efforts, possibly due to toxic effects associated with lignin peroxidase expression. Our laboratory has created a stepping stone for other laboratories …

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Plant Protein Prenylation In Environmental Responses And Protein Production., Parul Singh Aug 2019

Plant Protein Prenylation In Environmental Responses And Protein Production., Parul Singh

Electronic Theses and Dissertations

Lipid post-translational modifications enhance a protein’s interaction with membranes and other proteins. In this dissertation, I studied a recently identified Arabidopsis gene, PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT-LIKE (PPAL), by mapping a second-site mutation that rescues the original mutation phenotype and could be an additional factor involved in sugar homeostasis/sensing. I found that mutant phenotype associated with suppressor line was too weak and variable to consistently score, which resulted in not finding any linked markers. I also generated crosses between ppal-1 and ABA biosynthesis and signal transduction mutants to find any possible connection between these pathways and PPAL. By …

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Functional Opponency In Working Memory Capacity Predicts Cognitive Flexibility In Problem Solving., Charles A. Van Stockum Jr. Aug 2019

Functional Opponency In Working Memory Capacity Predicts Cognitive Flexibility In Problem Solving., Charles A. Van Stockum Jr.

Electronic Theses and Dissertations

Cognitive flexibility is a hallmark of individuals with higher working memory capacity (WMC). Yet, research demonstrates that higher WMC individuals are sometimes more likely to adopt rigid problem-solving approaches. The present research examines a novel account for these contradictory findings—that different WMC mechanisms interact in ways that both support and constrain cognitive flexibility. Across three studies, participants completed the water jug task—a problem-solving task requiring them to first establish and then break mental set using a complex strategy. Participants then completed measures targeting three WMC mechanisms: attention control, primary memory, and secondary memory. Study 1 demonstrated that primary memory and …

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Exploring Individual And Dyadic Associations Of Dispositional Mindfulness As An Ameliorative Factor Of Anxiety And Roommate Satisfaction Among Undergraduate Roommates., Kala Phillips Aug 2019

Exploring Individual And Dyadic Associations Of Dispositional Mindfulness As An Ameliorative Factor Of Anxiety And Roommate Satisfaction Among Undergraduate Roommates., Kala Phillips

Electronic Theses and Dissertations

For many young adults, the college experience is stressful and the adjustment to college life can present many unique challenges. Up to one-half of undergraduates report anxiety, with prevalence rates that appear to be on the rise. Social transitions, such as living with a roommate, can also present challenges. The current study explored dispositional mindfulness, a capacity for attending to present-moment experiences, as a potential ameliorative factor of anxiety and roommate satisfaction. Dyadic associations of dispositional mindfulness were also explored among roommate dyads. Fifty undergraduate roommate dyads (N=100) provided self-report measures of demographics, dispositional mindfulness, anxiety, and three facets of …

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Characterization Of A More Clinically Relevant Human Leukemia Xenograft Model To Examine Perturbation Of Met/Sam Metabolism As A Novel Therapeutic Paradigm For Mll-R Leukemia In Vivo., Aditya Barve Aug 2019

Characterization Of A More Clinically Relevant Human Leukemia Xenograft Model To Examine Perturbation Of Met/Sam Metabolism As A Novel Therapeutic Paradigm For Mll-R Leukemia In Vivo., Aditya Barve

Electronic Theses and Dissertations

Acute myeloid leukemia (AML), is a heterogeneous clonal disorder characterized by an accumulation of malignant myeloid progenitors in the bone marrow (BM), hindering normal hematopoiesis. AML exhibits dramatic heterogeneity in terms of cytogenetics, morphology, and chemotherapeutic sensitivity. Therefore, the investigation of novel, efficacious AML therapeutics will require advanced preclinical in vivo model systems, capable of recapitulating patient specific disease heterogeneity, and induction chemotherapy outcomes. A major focus and eventual outcome of this work was the establishment and development of a more clinically relevant mouse xenograft model of patient AML, that efficiently harbors patient derived xenografts (PDXs), and unlike more prevalent …

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