Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2019

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 6901 - 6930 of 29591

Full-Text Articles in Entire DC Network

Loss Of Developmental Diapause As Prerequisite For Social Evolution In Bees, Priscila Karla Ferreira Santos, Maria Cristina Arias, Karen M. Kapheim Aug 2019

Loss Of Developmental Diapause As Prerequisite For Social Evolution In Bees, Priscila Karla Ferreira Santos, Maria Cristina Arias, Karen M. Kapheim

Biology Faculty Publications

Diapause is a physiological arrest of development ahead of adverse environmental conditions and is a critical phase of the life cycle of many insects. In bees, diapause has been reported in species from all seven taxonomic families. However, they exhibit a variety of diapause strategies. These different strategies are of particular interest since shifts in the phase of the insect life cycle in which diapause occurs have been hypothesized to promote the evolution of sociality. Here we provide a comprehensive evaluation of this hypothesis with phylogenetic analysis and ancestral state reconstruction (ASR) of the ecological and evolutionary factors associated with …


Phototrophic N2 And Co2 Fixation Using A Rhodopseudomonas Palustris-H2 Mediated Electrochemical System With Infrared Photons, Mathangi Soundararajan, Rhesa Ledbetter, Paul Kusuma, Shuyang Zhen, Paul Ludden, Bruce Bugbee, Scott A. Ensign, Lance C. Seefeldt Aug 2019

Phototrophic N2 And Co2 Fixation Using A Rhodopseudomonas Palustris-H2 Mediated Electrochemical System With Infrared Photons, Mathangi Soundararajan, Rhesa Ledbetter, Paul Kusuma, Shuyang Zhen, Paul Ludden, Bruce Bugbee, Scott A. Ensign, Lance C. Seefeldt

Plants, Soils, and Climate Faculty Publications

A promising approach for the synthesis of high value reduced compounds is to couple bacteria to the cathode of an electrochemical cell, with delivery of electrons from the electrode driving reductive biosynthesis in the bacteria. Such systems have been used to reduce CO2 to acetate and other C-based compounds. Here, we report an electrosynthetic system that couples a diazotrophic, photoautotrophic bacterium, Rhodopseudomonas palustris TIE-1, to the cathode of an electrochemical cell through the mediator H2 that allows reductive capture of both CO2 and N2 with all of the energy coming from the electrode and infrared (IR) photons. R. palustris TIE-1 …


An Experimental Validation Of Masking In Iec 60601-1-8:2006-Compliant Alarm Sounds, M Bolton, Xi Zheng, L Meng, J Edworthy, A Boyd Aug 2019

An Experimental Validation Of Masking In Iec 60601-1-8:2006-Compliant Alarm Sounds, M Bolton, Xi Zheng, L Meng, J Edworthy, A Boyd

School of Psychology

No abstract provided.


Comparison Of Hf Radar Fields Of Directional Wave Spectra Against In Situ Measurements At Multiple Locations, Guiomar Lopez, Daniel C. Conley Aug 2019

Comparison Of Hf Radar Fields Of Directional Wave Spectra Against In Situ Measurements At Multiple Locations, Guiomar Lopez, Daniel C. Conley

School of Biological and Marine Sciences

The coastal zone hosts a great number of activities that require knowledge of the spatial characteristics of the wave field, which in coastal seas can be highly heterogeneous. Information of this type can be obtained from HF radars, which offer attractive performance characteristics in terms of temporal and spatial resolution. This paper presents the validation of radar-derived fields of directional wave spectra. These were retrieved from measurements collected with an HF radar system specifically deployed for wave measurement, using an established inversion algorithm. Overall, the algorithm reported accurate estimates of directional spectra, whose main distinctive characteristic was that the spectral …


Comparison Of The Kinetic Parameters Of Escherichia Coli 0157:H7, Listeria Monocytogenes And Salmonella Typhimurium Derived From The Baranyi And Huang Models In A Chemically Defined Minimal Medium, Jose Isidro Fuentes Aug 2019

Comparison Of The Kinetic Parameters Of Escherichia Coli 0157:H7, Listeria Monocytogenes And Salmonella Typhimurium Derived From The Baranyi And Huang Models In A Chemically Defined Minimal Medium, Jose Isidro Fuentes

LSU Master's Theses

Microbial growth can be characterized by parameters such as lag time, growth rate, and maximum population density at any specific point of time. Mathematical models that predict microbial growth of foodborne pathogens are increasingly used in the food industry as a viable alternative to traditional methods of microbial enumeration. The Baranyi model has been widely used as the primary model of choice by many authors because of its performance and accuracy. The most recently developed Huang model has been less implemented and few comparisons between the Baranyi and Huang models have been made when modeling pathogenic growth. For this research, …


Direct Evidence Or Mcdonnell Douglas: How Today's Paternity Leave Policies Are Paving The Way For Title Vii's Newest Wave Of Direct Evidence Jurisprudence, Annie Mcclellan Aug 2019

Direct Evidence Or Mcdonnell Douglas: How Today's Paternity Leave Policies Are Paving The Way For Title Vii's Newest Wave Of Direct Evidence Jurisprudence, Annie Mcclellan

University of Cincinnati Law Review

No abstract provided.


The Need For A Lenient Admissibility Standard For Defense Forensic Evidence, Myeonki Kim Aug 2019

The Need For A Lenient Admissibility Standard For Defense Forensic Evidence, Myeonki Kim

University of Cincinnati Law Review

No abstract provided.


Deaf Characters In Young Adult Literature, Kimberly Gangwish Aug 2019

Deaf Characters In Young Adult Literature, Kimberly Gangwish

Journal of Curriculum, Teaching, Learning and Leadership in Education

The multicultural literature movement has its roots in civil rights and the desire to give voice and representation to marginalized cultures. Literature is a societal artifact that can inform and influence the development of cultural identity. Deaf culture is a unique culture that is underrepresented in young adult literature. This underrepresentation places more importance on accurate representations of Deaf culture since young adult fiction may be the only exposure to Deaf culture that both hearing and deaf teenagers may have. Accurate representation in literature is necessary for deaf to see themselves in what they read and for hearing to better …


Infertility In Muslim Refugees: A Review Of The Literature, Simone N. Reaves, Fern R. Hauck Aug 2019

Infertility In Muslim Refugees: A Review Of The Literature, Simone N. Reaves, Fern R. Hauck

Journal of Refugee & Global Health

Many couples worldwide are affected by infertility, which is defined as an inability to conceive after at least one year of regular unprotected sexual intercourse. Many Muslim and Middle Eastern societies place a high societal value on having children and therefore, couples who are unable to conceive for various reasons often find themselves feeling stigmatized and socially isolated. Muslim refugees living in the United States face additional challenges and barriers to care due to their refugee status. This review is a synthesis of existing literature that 1) identifies Islamic viewpoints on infertility and assistive reproductive technology (ART), 2) explores the …


Selective Alteration Of The Root Morphology Of Arabidopsis Thaliana By Synthetic Anion Transporters (Sats), Mohit Patel, Evan Garrad, Steven Korb, Saeedeh Negin, Michael Gokel, Sergey Sedinkin, Shanheng Yin, George Gokel Aug 2019

Selective Alteration Of The Root Morphology Of Arabidopsis Thaliana By Synthetic Anion Transporters (Sats), Mohit Patel, Evan Garrad, Steven Korb, Saeedeh Negin, Michael Gokel, Sergey Sedinkin, Shanheng Yin, George Gokel

Chemistry & Biochemistry Faculty Works

No abstract provided.


Temperature Triggers A Non-Linear Response In Resource–Consumer Interaction Strength, Gustavo S. Betini, Tal Avgar, Kevin S. Mccann, John M. Fryxell Aug 2019

Temperature Triggers A Non-Linear Response In Resource–Consumer Interaction Strength, Gustavo S. Betini, Tal Avgar, Kevin S. Mccann, John M. Fryxell

Wildland Resources Faculty Publications

Although temperature is recognized as a major determinant of many ecological processes, it is still not clear whether temperature increase caused by climate change will strengthen or weaken species interactions. One hypothesis is that interactions will respond non‐monotonically to temperature because thermal performance curves, which determine the strength of these interactions, are also non‐monotonic. To evaluate this hypothesis, we developed a temperature‐dependent consumer–resource model and tested predictions from this model in large freshwater mesocosms populated with green algae (Chlorella vulgaris) and herbivorous zooplankton (Daphnia magna). We found both in the model simulations and empirical investigations that …


Fertilizer Use In China: The Role Of Agricultural Support Policies, Yinhao Wu, Enru Wang, Changhong Miao Aug 2019

Fertilizer Use In China: The Role Of Agricultural Support Policies, Yinhao Wu, Enru Wang, Changhong Miao

Geography & Geographic Information Science Faculty Publications

Using a decomposition method, this paper proposes an analytical framework to investigate the mechanisms by which agricultural support policies affect farmers’ use of fertilizers in agriculture in China. The mechanisms are decomposed into “three effects” (structural, scale, and technological effects). It is found that China’s agricultural support polices have significantly contributed to the increased use of agricultural fertilizers through encouraging farmers to bring more land under cultivation (the scale effect). Meanwhile, some policies have also helped reduce fertilizer consumption when farmers were motivated to increase the area of grains crops (the structural effect). The role of technological progress in affecting …


Oer For Math 102 Biostatistics, Olivia Mah Aug 2019

Oer For Math 102 Biostatistics, Olivia Mah

USF OER Faculty Grant Projects

This report consists of six sections: I. Implementation period of the grant II. Summary of results III. Difficulties encountered IV. Looking to the future V. Attachments V. Three tables (A, B, C)


Imaging Of Glucose Metabolism By 13c-Mri Distinguishes Pancreatic Cancer Subtypes In Mice, Shun Kishimoto, Jeffrey R. Brender, Daniel R. Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P. Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L. Choyke, James Mitchell, Andrew N. Lane, Teresa W. M. Fan, W. Marston Linehan, Murali C. Krishna Aug 2019

Imaging Of Glucose Metabolism By 13c-Mri Distinguishes Pancreatic Cancer Subtypes In Mice, Shun Kishimoto, Jeffrey R. Brender, Daniel R. Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P. Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L. Choyke, James Mitchell, Andrew N. Lane, Teresa W. M. Fan, W. Marston Linehan, Murali C. Krishna

Center for Environmental and Systems Biochemistry Faculty Publications

Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with a similar genetic background can be distinguished by their differing rates of the metabolism of 13C labeled glucose tracers, which can be imaged without hyperpolarization by using newly developed techniques for noise suppression. Using this method, cancer subtypes that appeared to have similar metabolic profiles based on steady state metabolic measurement can be distinguished from each other. The metabolic maps from …


Rna-Based Compositions And Adjuvants For Prophylactic And Therapeutic Treatment, Peixuan Guo, Hui Li, Emil F. Khisamutdinov, Daniel L. Jasinski Aug 2019

Rna-Based Compositions And Adjuvants For Prophylactic And Therapeutic Treatment, Peixuan Guo, Hui Li, Emil F. Khisamutdinov, Daniel L. Jasinski

Pharmaceutical Sciences Faculty Patents

The present invention is directed towards an artificial RNA nano structure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a pRNA three-way junction (3WJ) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an …


James Edward Van Meter, Petitioner I, Appellee V. Stephanie Marie Van Meter, Respondent I, Appellant : Reply Brief, Utah Court Of Appeals Aug 2019

James Edward Van Meter, Petitioner I, Appellee V. Stephanie Marie Van Meter, Respondent I, Appellant : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

Appeal from the Third District Court, Salt Lake County, Judge Richard D. McKelvie


Seastar: A Mission To Study Ocean Submesoscale Dynamics And Small-Scale Atmosphere-Ocean Processes In Coastal, Shelf And Polar Seas, Christine Gommenginger, Bertrand Chapron, Andy Hogg, Christian Buckingham, Baylor Fox-Kemper, Leif Eriksson, Francois Soulat, Clement Ubelmann, Francisco Ocampo-Torres, Bruno Buongiorno Nardelli, David Griffin, Paco Lopez-Dekker, Per Knudsen, Ole Andersen, Lars Stenseng, Neil Stapleton, William Perrie, Nelson Violante-Carvalho, Johannes Schulz-Stellenfleth, David Woolf, Jordi Isern-Fontanet, Fabrice Ardhuin, Patrice Klein, Alexis Mouche, Ananda Pascual, Xavier Capet, Daniele Hauser, Ad Stoffelen, Rosemary Morrow, Lotfi Aouf, Øyvind Breivik, Lee-Leung Fu, Johnny A. Johannessen, Yevgeny Aksenov, Lucy Bricheno, Joel Hirschi, Adrien C. H. Martin, Adrian P. Martin, George Nurser, Jeff Polton, Judith Wolf, Harald Johnsen, Alexander Soloviev, Gregg A. Jacobs, Fabrice Collard, Steve Groom, Vladimir Kudryavtsev, John Wilkin, Victor Navarro, Alex Babanin, Matthew Martin, John Siddorn, Andrew Saulter, Tom Rippeth, Bill Emery, Nikolai Maximenko, Roland Romeiser, Hans Graber, Aida Alvera Azcarate, Chris W. Hughes, Doug Vandemark, Jose Da Silva, Peter Jan Van Leeuwen, Alberto Naveira-Garabato, Johannes Gemmrich, Amala Mahadevan, Jose Marquez, Yvonne Munro, Sam Doody, Geoff Burbidge Aug 2019

Seastar: A Mission To Study Ocean Submesoscale Dynamics And Small-Scale Atmosphere-Ocean Processes In Coastal, Shelf And Polar Seas, Christine Gommenginger, Bertrand Chapron, Andy Hogg, Christian Buckingham, Baylor Fox-Kemper, Leif Eriksson, Francois Soulat, Clement Ubelmann, Francisco Ocampo-Torres, Bruno Buongiorno Nardelli, David Griffin, Paco Lopez-Dekker, Per Knudsen, Ole Andersen, Lars Stenseng, Neil Stapleton, William Perrie, Nelson Violante-Carvalho, Johannes Schulz-Stellenfleth, David Woolf, Jordi Isern-Fontanet, Fabrice Ardhuin, Patrice Klein, Alexis Mouche, Ananda Pascual, Xavier Capet, Daniele Hauser, Ad Stoffelen, Rosemary Morrow, Lotfi Aouf, Øyvind Breivik, Lee-Leung Fu, Johnny A. Johannessen, Yevgeny Aksenov, Lucy Bricheno, Joel Hirschi, Adrien C. H. Martin, Adrian P. Martin, George Nurser, Jeff Polton, Judith Wolf, Harald Johnsen, Alexander Soloviev, Gregg A. Jacobs, Fabrice Collard, Steve Groom, Vladimir Kudryavtsev, John Wilkin, Victor Navarro, Alex Babanin, Matthew Martin, John Siddorn, Andrew Saulter, Tom Rippeth, Bill Emery, Nikolai Maximenko, Roland Romeiser, Hans Graber, Aida Alvera Azcarate, Chris W. Hughes, Doug Vandemark, Jose Da Silva, Peter Jan Van Leeuwen, Alberto Naveira-Garabato, Johannes Gemmrich, Amala Mahadevan, Jose Marquez, Yvonne Munro, Sam Doody, Geoff Burbidge

Marine & Environmental Sciences Faculty Articles

High-resolution satellite images of ocean color and sea surface temperature reveal an abundance of ocean fronts, vortices and filaments at scales below 10 km but measurements of ocean surface dynamics at these scales are rare. There is increasing recognition of the role played by small scale ocean processes in ocean-atmosphere coupling, upper-ocean mixing and ocean vertical transports, with advanced numerical models and in situ observations highlighting fundamental changes in dynamics when scales reach 1 km. Numerous scientific publications highlight the global impact of small oceanic scales on marine ecosystems, operational forecasts and long-term climate projections through strong ageostrophic circulations, large …


Antimicrobials From An Epigenetics Based Fungal Metabolite Screening Program, Danielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw Aug 2019

Antimicrobials From An Epigenetics Based Fungal Metabolite Screening Program, Danielle H. Demers, Bill J. Baker, Ala Azhari, Renee M. Fleeman, Dennis E. Kyle, Lindsey Neil Shaw

USF Patents

Novel antimicrobial compounds against drug targets such as Eskape pathogens, Leishmania donovani, Mycobacterium tuberculosis, Clostridium difficile, Naegleria fowleri, and cancer are presented herein.


Small Molecules That Mimic Or Antagonize Actions Of Granulocyte Colony-Stimulating-Factor (G-Csf), Juan Sanchez-Ramos, Vasyl Sava, Shijie Song, Said Sebti Aug 2019

Small Molecules That Mimic Or Antagonize Actions Of Granulocyte Colony-Stimulating-Factor (G-Csf), Juan Sanchez-Ramos, Vasyl Sava, Shijie Song, Said Sebti

USF Patents

Described herein are compound for the modulation of the G-CSF receptor. The compounds may act as agonists, antagonists, and/or mixed or partial agonists/antagonists of G-CSF. Further provided herein are methods of treating a condition, including, for example, a neurodegenerative disease, by administering a compound as detailed herein.


Nutraceutical Co-Crystal Compositions, Michael John Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong Aug 2019

Nutraceutical Co-Crystal Compositions, Michael John Zaworotko, Heather Clarke, Arora Kapildev, Padmini Kavuru, Roland Douglas Shytle, Twarita Pujari, Lissette Marshall, Tien Teng Ong

USF Patents

Co-crystals comprising at least one nutraceutical compound and at least one co-crystal former with or without impurities. These co-crystals may be included in compositions (optionally also including other components such as pharmaceutically acceptable excipients, other nutritional supplements, etc.) having utility as pharmaceuticals, nutraceuticals, nutritional supplements, and foodstuffs.


Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang Aug 2019

Astragaloside Iii Enhances Anti-Tumor Response Of Nk Cells By Elevating Nkg2d And Ifn-Γ, Xingmeng Chen, Xi Chen, Junxiao Gao, Han Yang, Yue Duan, Benjamin Feng, Xin He, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu, Jin Chang

Peer Reviewed Articles

Natural killer (NK) cells play an irreplaceable role in the development of colon cancer, in which antitumor function of NK cells was impaired. Astragaloside III is a natural compound from Astragalus that has been shown to have immunomodulatory effects in various systems. However, few studies have evaluated the antitumor effects of Astragaloside III through stimulating systemic immunity and regulating NK cells. In this study, flow cytometry, immunohistochemical analysis, and immunofunctional assays were performed to elucidate the functions of Astragaloside III in restoring antitumor function of NK cells. We demonstrated that Astragaloside III significantly elevated the expression of natural killer group …


James Edward Van Meter, Petitioner/ Appellee V. Stephanie Marie Van Meter, Respondent / Appellant : Appellee Brief, Utah Court Of Appeals Aug 2019

James Edward Van Meter, Petitioner/ Appellee V. Stephanie Marie Van Meter, Respondent / Appellant : Appellee Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

Appellee, James Van Meter

Appellee, James Van Meter

Appellant, Stephanie Van Meter


Vision In An Abundant North American Bird: The Red-Winged Blackbird, Esteban Fernández-Juricic, Patrice E. Baumhardt, Luke P. Tyrrell, Amanda Elmore, Shelagh T. Deliberto, Scott J. Werner Aug 2019

Vision In An Abundant North American Bird: The Red-Winged Blackbird, Esteban Fernández-Juricic, Patrice E. Baumhardt, Luke P. Tyrrell, Amanda Elmore, Shelagh T. Deliberto, Scott J. Werner

United States Department of Agriculture Wildlife Services: Staff Publications

Avian vision is fundamentally different from human vision; however, even within birds there are substantial between species differences in visual perception in terms of visual acuity, visual coverage, and color vision. However, there are not many species that have all these visual traits described, which can constrain our ability to study the evolution of visual systems in birds. To start addressing this gap, we characterized multiple traits of the visual system (visual coverage, visual acuity, centers of acute vision, and color vision) of the Red-winged Blackbird (Agelaius phoeniceus), one of the most abundant and studied birds in North America. We …


Systematic Optimization For Production Of The Anti-Mrsa Antibiotics Wap-8294a In An Engineered Strain Of Lysobacter Enzymogenes, Xusheng Chen, Shanren Li, Lingjun Yu, Amanda Miller, Liangcheng Du Aug 2019

Systematic Optimization For Production Of The Anti-Mrsa Antibiotics Wap-8294a In An Engineered Strain Of Lysobacter Enzymogenes, Xusheng Chen, Shanren Li, Lingjun Yu, Amanda Miller, Liangcheng Du

Department of Chemistry: Faculty Publications

WAP-8294A is a group of cyclic lipodepsipeptides and considered as the first-in-class new chemical entity with potent activity against methicillin-resistant Staphylococcus aureus. One of the roadblocks in developing the WAP-8294A antibiotics is the very low yield in Lysobacter. Here, we carried out a systematic investigation of the nutritional and environmental conditions in an engineered L. enzymogenes strain for the optimal production of WAP-8294A. We developed an activity-based simple method for quick screening of various factors, which enabled us to optimize the culture conditions. With the method, we were able to improve the WAP-8294A yield by 10-fold in small-scale cultures and …


Assaulted Marsh, Sarah Schaier Aug 2019

Assaulted Marsh, Sarah Schaier

UNH Today Archive

No abstract provided.


"The Traps Started During My Childhood": The Role Of Substance Abuse In Women's Responses To Adverse Childhood Experiences (Aces), Breanna Boppre, Cassandra Boyer Aug 2019

"The Traps Started During My Childhood": The Role Of Substance Abuse In Women's Responses To Adverse Childhood Experiences (Aces), Breanna Boppre, Cassandra Boyer

Criminal Justice Faculty Research

The gendered pathways perspective seeks to identify the biological, psychological, and social realities that lead to women’s law-breaking behavior. Prior research in this area demonstrates the link between women’s adverse childhood experiences (ACEs) and involvement in the criminal justice system later in life. The current study fills an important gap in the literature by providing a phenomenological description of the impacts ACEs had upon 19 community supervised women’s lives. Their stories illuminate the need to consider multiple forms of ACEs, from physical and sexual abuse to the death of a loved one. Interviewees’ most prevalent response to ACEs was substance …


Monitoring Silane Sol-Gel Kinetics With In-Situ Optical Turbidity Scanning And Dynamic Light Scattering, Abul Bashar Mohammad Giasuddin, David W. Britt Aug 2019

Monitoring Silane Sol-Gel Kinetics With In-Situ Optical Turbidity Scanning And Dynamic Light Scattering, Abul Bashar Mohammad Giasuddin, David W. Britt

Biological Engineering Faculty Publications

Organosilanes (e.g., R’-SiOR3) provide hydrophobic functionality in thin-film coatings, porous gels, and particles. Compared with tetraalkoxysilanes (SiOR4), organosilanes exhibit distinct reaction kinetics and assembly mechanisms arising from steric and electronic properties of the R’ group on the silicon atom. Here, the hydrolysis and condensation pathways of n-propyltrimethoxy silane (nPM) and a tri-fluorinated analog of nPM, 3,3,3-trifluoropropyl trimethoxy silane (3F), were investigated under aqueous conditions at pH 1.7, 2.0, 3.0, and 4.0. Prior to hydrolysis, 3F and nPM are insoluble in water and form a lens at the bottom (3F) or top (nPM) of the solutions. This …


Β-Fluorofentanyls Are Ph-Sensitive Mu Opioid Receptor Agonists, Ricardo Rosas Jr., Xi-Ping Huang, Bryan L. Roth, Chris Dockendorff Aug 2019

Β-Fluorofentanyls Are Ph-Sensitive Mu Opioid Receptor Agonists, Ricardo Rosas Jr., Xi-Ping Huang, Bryan L. Roth, Chris Dockendorff

Chemistry Faculty Research and Publications

The concept recently postulated by Stein and co-workers (Science2017, 355, 966) that mu opioid receptor (MOR) agonists possessing amines with attenuated basicity show pH-dependent activity and can selectively act at damaged, low pH tissues has been additionally supported by in vitro studies reported here. We synthesized and tested analogs of fentanyl possessing one or two fluorine atoms at the beta position of the phenethylamine side chain, with additional fluorines optionally added to the benzene ring of the side chain. These compounds were synthesized in 1 to 3 steps from commercial building blocks. The novel bis-fluorinated analog …


Dissociable Learning Processes, Associative Theory, And Testimonial Reviews: A Comment On Smith And Church (2018, Andy J. Wills, Charlotte E.R. Edmunds, Pelley M Le, Fraser Milton, Ben R. Newell, Dominic M. Dwyer, David R. Shanks Aug 2019

Dissociable Learning Processes, Associative Theory, And Testimonial Reviews: A Comment On Smith And Church (2018, Andy J. Wills, Charlotte E.R. Edmunds, Pelley M Le, Fraser Milton, Ben R. Newell, Dominic M. Dwyer, David R. Shanks

School of Psychology

No abstract provided.


Opinion: To Advance Sustainable Stewardship, We Must Document Not Only Biodiversity But Geodiversity, Franziska Schrodt, Joseph J. Bailey, D Kissling, Iain Stewart Aug 2019

Opinion: To Advance Sustainable Stewardship, We Must Document Not Only Biodiversity But Geodiversity, Franziska Schrodt, Joseph J. Bailey, D Kissling, Iain Stewart

School of Geography, Earth and Environmental Sciences

Rapid environmental change is driving the need for complex and comprehensive scientific information that supports policies aimed at managing natural resources through international treaties, platforms, and networks. One successful approach for delivering such information has been the development of Essential Variables for climate (1), oceans (2), biodiversity (3), and sustainable development goals (4) (ECVs, EOVs, EBVs, and ESDGVs, respectively). These efforts have improved consensus on terminology, and identified essential sets of measurements for characterizing and monitoring changes on our planet. In doing so, they have advanced science and informed policy. As an important but largely unanticipated consequence, conceptualizing these variables …