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Articles 631 - 660 of 29567
Full-Text Articles in Entire DC Network
How The Atacama Skeleton Might Advance Discussion Of Responsible Conduct Of Research Responsibilities, Thomas May, Mariko Nakano-Okuno
How The Atacama Skeleton Might Advance Discussion Of Responsible Conduct Of Research Responsibilities, Thomas May, Mariko Nakano-Okuno
Human Biology Open Access Pre-Prints
Controversies resulting from genetic testing on skeletal remains of disputed stewardship raise important questions about obligations inherent on genetic researchers to assure ethical chain of custody. In this paper, we analyze and evaluate several proposed positions on whether such research should be published. Following jurisprudential standards for legitimate regulatory systems, we argue that responsible conduct of research requires reasonable attention to chain of custody, but cannot require guarantees, particularly in cases of ancient remains.
Mitochondrial Genome Of An 8,400-Year-Old Individual From Northern China Reveals A Novel Sub-Clade Under C5d, Xiyan Wu, Chao Ning, Qingchuan Bao, Shizhu Gao, Fan Zhang, Sihao Wu, Tianjiao Li, Linyuan Fan, Tao Li, Xuan Yang, Dawei Cai, Yinqiu Cui
Mitochondrial Genome Of An 8,400-Year-Old Individual From Northern China Reveals A Novel Sub-Clade Under C5d, Xiyan Wu, Chao Ning, Qingchuan Bao, Shizhu Gao, Fan Zhang, Sihao Wu, Tianjiao Li, Linyuan Fan, Tao Li, Xuan Yang, Dawei Cai, Yinqiu Cui
Human Biology Open Access Pre-Prints
Ancient DNA studies have always refreshed our understanding of the human past that can’t be tracked by modern DNA alone. Until recently, ancient mitochondrial genomic studies in East Asia are still very limited. Here, we retrieved the whole mitochondrial genome of an 8,400-year- old individual from Inner Mongolia, China. Phylogenetic analyses show that the individual belongs to a previously undescribed clade under haplogroup C5d that was most probably originated in northern Asia and may have a very low frequency in extant populations that is not yet sampled. We further characterized the demographic history of mitochondrial haplogroups C5 and C5d, and …
Bishop Provides Valuable Community Outreach And Fungi Education, Ohio University College Of Arts & Sciences
Bishop Provides Valuable Community Outreach And Fungi Education, Ohio University College Of Arts & Sciences
All Forum Articles
No abstract provided.
Graduate Students Work To Preserve Prairie-Like Sites In Athens County, Ohio University College Of Arts & Sciences
Graduate Students Work To Preserve Prairie-Like Sites In Athens County, Ohio University College Of Arts & Sciences
All Forum Articles
No abstract provided.
Nih Grant Helps Carroll Examine How To Combat Mrsa Infections, Ohio University College Of Arts & Sciences
Nih Grant Helps Carroll Examine How To Combat Mrsa Infections, Ohio University College Of Arts & Sciences
All Forum Articles
No abstract provided.
Genetic Taster Status As A Mediator Of Neural Activity And Swallowing Mechanics In Healthy Adults, Angela M. Dietsch, Ross M. Westemeyer, William G. Pearson Jr., Douglas H. Schultz
Genetic Taster Status As A Mediator Of Neural Activity And Swallowing Mechanics In Healthy Adults, Angela M. Dietsch, Ross M. Westemeyer, William G. Pearson Jr., Douglas H. Schultz
Center for Brain, Biology, and Behavior: Faculty Publications
As part of a larger study examining relationships between taste properties and swallowing, we assessed the influence of genetic taster status (GTS) on measures of brain activity and swallowing physiology during taste stimulation in healthy men and women. Twenty-one participants underwent videofluoroscopic swallowing study (VFSS) and functional magnetic resonance imaging (fMRI) during trials of high-intensity taste stimuli. The precisely formulated mixtures included sour, sweet-sour, lemon, and orange taste profiles and unflavored controls. Swallowing physiology was characterized via computational analysis of swallowing mechanics plus other kinematic and temporal measures, all extracted from VFSS recordings. Whole-brain analysis of fMRI data assessed blood …
Resin And Magnetic Nanoparticle-Based Free Radical Probes For Glycan Capture, Isolation, And Structural Characterization, Kimberly Fabijanczuk, Kaylee Gaspar, Nikunj Desai, Jungeun Lee, Daniel A. Thomas, J. L. Beauchamp, Jinshan Gao
Resin And Magnetic Nanoparticle-Based Free Radical Probes For Glycan Capture, Isolation, And Structural Characterization, Kimberly Fabijanczuk, Kaylee Gaspar, Nikunj Desai, Jungeun Lee, Daniel A. Thomas, J. L. Beauchamp, Jinshan Gao
Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works
By combining the merits of solid supports and free radical activated glycan sequencing (FRAGS) reagents, we develop a multifunctional solid-supported free radical probe (SS-FRAGS) that enables glycan enrichment and characterization. SS-FRAGS comprises a solid support, free radical precursor, disulfide bond, pyridyl, and hydrazine moieties. Thio-activated resin and magnetic nanoparticles (MNPs) are chosen as the solid support to selectively capture free glycans via the hydrazine moiety, allowing for their enrichment and isolation. The disulfide bond acts as a temporary covalent linkage between the solid support and the captured glycan, allowing the release of glycans via the cleavage of the disulfide bond …
Sexting Among Adolescents: Examining The Association Between Sexting And Self-Esteem, Hanaah Fannin
Sexting Among Adolescents: Examining The Association Between Sexting And Self-Esteem, Hanaah Fannin
Physician Assistant Studies | Student Capstone Presentations
The primary objective of this study is to provide a systematic review of the published literature, examining the association between sexting and self-esteem in adolescents, and to identify gaps in existing knowledge to provide recommendations for future research.
Divergent Trophic Responses Of Sympatric Penguin Species To Historic Anthropogenic Exploitation And Recent Climate Change, Kelton W. Mcmahon, Chantel I. Michelson, Tom Hart, Matthew D. Mccarthy, William P. Patterson, Michael J. Polito
Divergent Trophic Responses Of Sympatric Penguin Species To Historic Anthropogenic Exploitation And Recent Climate Change, Kelton W. Mcmahon, Chantel I. Michelson, Tom Hart, Matthew D. Mccarthy, William P. Patterson, Michael J. Polito
Faculty Publications
No abstract provided.
Microfiber Concentrations In Sand From Nesting Sea Turtle Beaches In Costa Rica, South Carolina, And Florida., Kaylin Leroy, George Boneillo
Microfiber Concentrations In Sand From Nesting Sea Turtle Beaches In Costa Rica, South Carolina, And Florida., Kaylin Leroy, George Boneillo
Honors Theses
Microplastics are an increasing threat to marine environments and the organisms that inhabit them. Since plastic pollution in the ocean is prominent throughout the globe, microplastic is washing ashore, affecting important sea turtle nesting sites. This study quantified microfibers in the sand of various sea turtle nesting sites around the world. Sand samples were collected in Myrtle Beach (South Carolina), Destin (Florida) and the Pacuare Reserve (Costa Rica). The microfibers were retrieved using a super saline solution and then filtered under a hood. Filters were then counted using microscopy. Microfibers were found at every sampling site, with the lowest surface …
Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan
Methods To Impair Hematologic Cancer Progenitor Cells And Compounds Related Thereto, Craig Jordan
Internal Medicine Faculty Patents
Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML) and chronic lymphoid leukemia (CLL). Interleukin-3 receptor alpha chain (IL-3Ra or CD123) is strongly expressed on progenitor hematologic cancer cells, but is virtually undetectable on normal bone marrow cells. The present invention provides methods of impairing progenitor hematologic cancer (e.g., leukemia and lymphomic) cells by selectively targeting cells expressing CD123. These methods are useful in the detection and treatment of leukemias and malignant lymphoproliferative disorders. Also provided are compounds useful …
Individual Based Modeling And Analysis Of Pathogen Levels In Poultry Chilling Process, Zachary Mccarthy, Ben Smith, Aamir Fazil, Jianhong Wu, Shawn D. Ryan, Daniel Munther
Individual Based Modeling And Analysis Of Pathogen Levels In Poultry Chilling Process, Zachary Mccarthy, Ben Smith, Aamir Fazil, Jianhong Wu, Shawn D. Ryan, Daniel Munther
Mathematics and Statistics Faculty Publications
Pathogen control during poultry processing critically depends on more enhanced insight into contamination dynamics. In this study we build an individual based model (IBM) of the chilling process. Quantifying the relationships between typical Canadian processing specifications, water chemistry dynamics and pathogen levels both in the chiller water and on individual carcasses, the IBM is shown to provide a useful tool for risk management as it can inform risk assessment models. We apply the IBM to Campylobacter spp. contamination on broiler carcasses, illustrating how free chlorine (FC) sanitization, organic load in the water, and pre-chill carcass pathogen levels affect pathogen levels …
Alanyl-Trna Synthetase Quality Control Prevents Global Dysregulation Of The Escherichia Coli Proteome, Paul Kelly, Nicholas Backes, Kyle Mohler, Christopher Buser, Arundhati Kavoor, Jesse Rinehart, Gregory Phillips, Michael Ibba
Alanyl-Trna Synthetase Quality Control Prevents Global Dysregulation Of The Escherichia Coli Proteome, Paul Kelly, Nicholas Backes, Kyle Mohler, Christopher Buser, Arundhati Kavoor, Jesse Rinehart, Gregory Phillips, Michael Ibba
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Mechanisms have evolved to prevent errors in replication, transcription, and translation of genetic material, with translational errors occurring most frequently. Errors in protein synthesis can occur at two steps, during tRNA aminoacylation and ribosome decoding. Recent advances in protein mass spectrometry have indicated that previous reports of translational errors have potentially underestimated the frequency of these events, but also that the majority of translational errors occur during ribosomal decoding, suggesting that aminoacylation errors are evolutionarily less tolerated. Despite that interpretation, there is evidence that some aminoacylation errors may be regulated, and thus provide a benefit to the cell, while others …
Pediatric Brain Tumor Treatment At Uab Awarded Fda Grant For First-In-Human Study, Alicia Rohan
Pediatric Brain Tumor Treatment At Uab Awarded Fda Grant For First-In-Human Study, Alicia Rohan
Browse All News
No abstract provided.
Carbon Flux And Particle-Associated Microbial Remineralization Rates In The Northern Bering And Southern Chukchi Seas, Stephanie Hicks O'Daly
Carbon Flux And Particle-Associated Microbial Remineralization Rates In The Northern Bering And Southern Chukchi Seas, Stephanie Hicks O'Daly
Oceanography
It has been hypothesized that climate change will reduce the strength and episodic nature of vernal phytoplankton blooms, increase heterotrophy of microbes and zooplankton, and weaken the tight coupling between pelagic and benthic production that is characteristic of Arctic continental shelves. As a part of the Arctic Shelf Growth, Advection, Respiration, and Deposition rates measurement (ASGARD) project, I quantified sinking particle fluxes and incubated sinking particles to measure the rate of microbial respiration associated with those particles. These measurements were used to characterize the strength of the pelagic-benthic connection. After a record-breaking year of warm temperatures and low-ice conditions in …
Pairwise Comparisons Of Shrub Change Across Alpine Climates Show Heterogeneous Response To Temperature In Dall's Sheep Range, Mark Melham
Natural Resources
Encroachment of woody vegetation into alpine and high latitude systems complicates resource use for specialist wildlife species. We converted Landsat imagery to maps of percent shrub cover in alpine areas of Dall's sheep (Ovis dalli dalli) range. We then compared percent cover to interpolated climate data to infer drivers of shrub change between the 1980s and 2010s and determine if that change is occurring at different rates in climatically distinct alpine areas. We identified areas spatially interconnected by their mean July temperature intervals and compared their rates of shrub change, finding net rates of shrub growth were higher at temperatures …
Response Of Major Modes Of Eastern Arctic Ocean Variability To Climate Change, Till M. Baumann
Response Of Major Modes Of Eastern Arctic Ocean Variability To Climate Change, Till M. Baumann
Atmospheric Sciences
The Arctic Ocean plays a central role in ongoing climate change, with sea ice loss being the most prominent indicator. Recent observations showed that Atlantic inflows play an increasingly important role in the demise of sea ice. This encroaching atlantification of the eastern Arctic Ocean impacts the mean state and the variability of hydrography and current dynamics throughout the basin. Among the most energetic modes of variability are the seasonal cycle and high frequency semidiurnal (∼12-hourly) dynamics in the tidal and inertial frequency band. Limited observations indicated a substantial increase of both, hydrographic seasonal cycles as well as semidiurnal current …
Validating A Gps Collar-Based Method To Estimate Parturition Events And Calving Locations For Two Barren-Ground Caribou Herds, Joelle D. Hepler
Validating A Gps Collar-Based Method To Estimate Parturition Events And Calving Locations For Two Barren-Ground Caribou Herds, Joelle D. Hepler
Biological Sciences
In remote landscapes, it is difficult and expensive to document animal behaviors such as location and timing of parturition. When aerial surveys cannot be conducted as a result of weather, personnel or fiscal constraints, analyses of GPS collar movement data may provide an alternate way to estimate parturition rates and calving ground locations. I validated two methods (population-based method and individual-based method), developed to detect calving events of sedentary woodland caribou, on multiple years of data for two different migratory barren-ground caribou herds in Alaska, the Porcupine and Fortymile herds. I compared model estimates of population parturition rates, individual calving …
Foliage And Winter Woody Browse Quality Of An Important Salix Browse Species: Effects Of Presence Of Alder-Derived Nitrogen And Winter Browsing By Alaskan Moose (Alces Alces Gigas), Justin Burrows
Biological Sciences
In this study, I examined the relationship between soil nitrogen and winter browsing by moose on the physical and chemical characteristics of Salix alaxensis; specifically stem production, leaf nutritional quality, and stem nutritional quality of tissues produced the following growing season. I measured stem biomass production the 2013 growing season and offtake during the 2013-2014 winter browsing season at 16 sites on the Tanana River floodplain near Fairbanks, Alaska. I revisited the sites the following summer and autumn to assess regrowth and to collect soil, foliage, and stem samples. Browsing intensity and total soil nitrogen were similar in sites with …
Host-Parasite Ecophysiology Of Overwintering, Don J. Larson
Host-Parasite Ecophysiology Of Overwintering, Don J. Larson
Biological Sciences
To survive extreme winters, parasites must overwinter either in a host, as free-living larvae, or be reintroduced yearly through migratory hosts. This thesis examines interrelations between host parasite overwintering physiology and behavior in Alaska between the trematode Ribeiroia ondatrae and their host, wood frogs (Lithobates sylvaticus). The first chapter examines overwintering physiology and behavior of wood frogs in the field. The second chapter creates a laboratory method for determining physiological responses of wood frogs to environmental transitions from summer to fall. The third chapter examines if and how R. ondatrae survive within a frozen wood frog. Free-living wood frogs investigated …
Resource Limitation Of Autotrophs And Heterotrophs In Boreal Forest Headwater Streams, Sophie Alden Weaver
Resource Limitation Of Autotrophs And Heterotrophs In Boreal Forest Headwater Streams, Sophie Alden Weaver
Biological Sciences
In stream biofilms, autotrophs and heterotrophs are responsible for the majority of in stream nutrient transformations. In boreal forest catchments, discontinuous permafrost can lead to variation in nutrient and energy resources, which can control competition for nutrients between autotrophs and heterotrophs within these biofilms. I was interested in determining what resources control nutrient utilization by autotrophs and heterotrophs in headwater streams in the boreal forest of interior Alaska. I hypothesized that the outcome of competition between autotrophs and heterotrophs for inorganic nutrients would be dependent on the availability of (i) organic carbon, (ii) light, or (iii) inorganic nutrients. To measure …
Phylogenetic Relationships Within The Western United States Species Of Lepidium L., Robert W. Lichvar
Phylogenetic Relationships Within The Western United States Species Of Lepidium L., Robert W. Lichvar
Chemistry and Biochemistry
The genus Lepidium L. is one of two global genera in the Brassicaceae. The genus has been arranged by species (geographic regions) worldwide, but no formal levels below the genus are recognized. Recent efforts to evaluate phylogenetic relationships have been performed at the global scale for about 20 percent of the species in the genus. The genus is recognized as having subtle and variable morphological characteristics to define species limits. Several nuclear and chloroplast DNA methods have been used to construct phylogenetic relationships within the genus. Incongruences between various phylogenetic trees indicate likely hybridization and/or hybrid origin of multiple species …
Development Of A Nonformal Education Program Evaluation Plan: An Evaluation Design For Two Youth Programs In Denali National Park And Preserve, Dana Lindauer
Education
This project proposes an evaluation design for two youth programs that operate out of the Murie Science and Learning Center in Denali National Park and Preserve. The two programs, Denali Backcountry Expeditions and Denali Summer Science Academy, are offered to Alaskan high school and college aged students and are co-managed by the National Park Service and Alaska Geographic. A formative, utilization-focused evaluation for instructors and managers of the programs was created. The evaluation seeks to facilitate targeted program development through articulating program goals and assessing participant outcomes related to these goals. In an effort to establish collaborative goals, eleven stakeholders …
In‐Situ Extraction And Impregnation Of Black Walnut Husk Into Polyethylene Film Using Supercritical Carbon Dioxide With An Ethanol Modifier, Jonathan Wenzel, Veronica R. Moorman, Lihua Wang, Isaiah Spencer-Williams, Mitchell Hall, Cheryl Samaniego, Michelle Ammerman
In‐Situ Extraction And Impregnation Of Black Walnut Husk Into Polyethylene Film Using Supercritical Carbon Dioxide With An Ethanol Modifier, Jonathan Wenzel, Veronica R. Moorman, Lihua Wang, Isaiah Spencer-Williams, Mitchell Hall, Cheryl Samaniego, Michelle Ammerman
Chemistry & Biochemistry Publications
Walnuts are commonly cultivated for their kernel, which is a rich source of antioxidant phenolic compounds. The husk likewise contains antioxidant and antimicrobial compounds, but is typically discarded without further processing. Antioxidant compounds are useful in creating active packaging films, but typically decompose at melt extrusion temperatures in polymer processing. Due to carbon dioxide's low critical point and ability to swell polymer films, supercritical carbon dioxide may be used to impregnate phenolic compounds into polymers. For this study, a novel technique is used to simultaneously produce walnut husk extracts and impregnate the extract into polymer films in the same batch …
Predation Effects On Mid-Marsh Ribbed Mussel Mortality, Cluster Size, And Facilitation Of Cordgrass Growth, Colten Winter, Keith Walters
Predation Effects On Mid-Marsh Ribbed Mussel Mortality, Cluster Size, And Facilitation Of Cordgrass Growth, Colten Winter, Keith Walters
Honors Theses
Reciprocal facilitation between Geukensia demissa, ribbed mussels, and Sporobolus alterniflorus, cordgrass, has a positive effect on salt marsh ecosystems. Mussel clusters enhance cordgrass growth and drought resistance and cordgrass provides attachment and shade for mussel aggregations. Along with benefits for both mussels and cordgrass, the mutualism facilitates increased biodiversity and shoreline stabilization and enhances marsh ecosystem functions. Aspects of mussel patch configuration including cluster size, perimeter and connectivity modulate the reciprocal facilitation effects of cordgrass and mussels on marsh ecosystems. In a northern South Carolina marsh system, mussel patch configuration positively influenced cordgrass biomass. Predation affected mussel patch …
Comparative Study Of 10 X-Str Markers In Populations Of Northeast Argentina, G. Paula Di Santo Meztler, Laura A. Glesmann, Esther Esteban, Santiago Del Palacio, Marta G. Méndez, Cecilia Inés Catanesi
Comparative Study Of 10 X-Str Markers In Populations Of Northeast Argentina, G. Paula Di Santo Meztler, Laura A. Glesmann, Esther Esteban, Santiago Del Palacio, Marta G. Méndez, Cecilia Inés Catanesi
Human Biology Open Access Pre-Prints
In northeast Argentina, different Amerindian communities share territory and history with settlers, mainly Europeans. Due to miscegenation, the current Argentinian population has a particular structure that can be de- scribed through the X chromosome variation. Our objectives are: to describe the variation of 10 X-STRs in urban populations of the Argentinian regions known as Gran Chaco and Mesopotamia; to report the forensic parameters of these STRs, and to estimate the European and indigenous genetic components in these regions. Population and forensic parameters were estimated for 419 individuals from the analysed populations, including two indigenous groups, Wichí and Mocoví, previously reported. …
Replication Study: Biomechanical Remodeling Of The Microenvironment By Stromal Caveolin-1 Favors Tumor Invasion And Metastasis, Mee Rie Sheen, Jennifer L. Fields, Brian Northan, Judith Lacoste, Lay-Hong Ang, Steven Fiering
Replication Study: Biomechanical Remodeling Of The Microenvironment By Stromal Caveolin-1 Favors Tumor Invasion And Metastasis, Mee Rie Sheen, Jennifer L. Fields, Brian Northan, Judith Lacoste, Lay-Hong Ang, Steven Fiering
Dartmouth Scholarship
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Fiering et al., 2015) that described how we intended to replicate selected experiments from the paper ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ (Goetz et al., 2011). Here we report the results. Primary mouse embryonic fibroblasts (pMEFs) expressing caveolin 1 (Cav1WT) demonstrated increased extracellular matrix remodeling in vitro compared to Cav1 deficient (Cav1KO) pMEFs, similar to the original study (Goetz et al., 2011). In vivo, we found higher levels of intratumoral stroma remodeling, determined by fibronectin fiber orientation, in tumors …
N-Amino Peptide Beta-Sheet Mimics For The Treatment Of Alzheimer's Disease, Juan R. Del Valle
N-Amino Peptide Beta-Sheet Mimics For The Treatment Of Alzheimer's Disease, Juan R. Del Valle
USF Patents
Disclosed herein are compounds comprising short N-aminated peptides and compositions comprising the same. The disclosed compounds and compositions maybe used in methods of inhibiting amyloid-beta aggregation and treating Alzheimer's disease.
Multistate Ornstein-Uhlenbeck Space Use Model Reveals Sex-Specific Partitioning Of The Energy Landscape In A Soaring Bird, Joseph M. Eisaguirre
Multistate Ornstein-Uhlenbeck Space Use Model Reveals Sex-Specific Partitioning Of The Energy Landscape In A Soaring Bird, Joseph M. Eisaguirre
Mathematics and Statistics
Understanding animals’ home range dynamics is a frequent motivating question in movement ecology. Descriptive techniques are often applied, but these methods lack predictive ability and cannot capture effects of dynamic environmental patterns, such as weather and features of the energy landscape. Here, we develop a practical approach for statistical inference into the behavioral mechanisms underlying how habitat and the energy landscape shape animal home ranges. We validated this approach by conducting a simulation study, and applied it to a sample of 12 golden eagles Aquila chrysaetos tracked with satellite telemetry. We demonstrate that readily available software can be used to …
Ecological Interactions Among Important Groundfishes In The Gulf Of Alaska, Cheryl L. Barnes
Ecological Interactions Among Important Groundfishes In The Gulf Of Alaska, Cheryl L. Barnes
Fisheries
Complex ecological interactions such as predation and competition play an important role in shaping the structure and function of marine communities. In fact, these processes can have greater impacts than those related to fishing. We assessed ecological interactions among economically important fishes in the Gulf of Alaska - a large marine ecosystem that has recently undergone considerable shifts in community composition. Specifically, we developed an index of predation for Walleye Pollock (Gadus chalcogrammus) to examine spatiotemporal changes in consumption, quantify portfolio effects, and better understand diversity-stability relationships within the demersal food web. We also evaluated the potential for competition between …