Digital Commons Network^™

Anticipation, Accompaniment, And A Good Death In Perinatal Care., Bryanna S. Moore, Brian S. Carter, Bryan Beaven, Katie House, Joel House

Manuscripts, Articles, Book Chapters and Other Papers

The ethics of perinatal care, and the experiences of families who receive such care, remains a nascent area of inquiry. It can be hard to see how existing "good death" constructs apply to the experiences of fetal patients and their families. In this paper, we explore two themes raised by a case at our fetal health center: anticipation and accompaniment. In this case, a mother presented to our fetal health center; her unborn son, our fetal patient, was diagnosed with life-threatening hypoplastic left heart syndrome and endocardial fibroelastosis. The parents were told that their son's life expectancy, upon birth, was …

Gasdermins In Apoptosis: New Players In An Old Game., Corey Rogers, Emad S. Alnemri

Department of Biochemistry and Molecular Biology Faculty Papers

Apoptosis is a form of programmed cell death (PCD) that plays critical physiological roles in removing superfluous or dangerous cell populations that are unneeded or threatening to the health of the host organism. Although the molecular pathways leading to activation of the apoptotic program have been extensively studied and characterized starting in the 1970s, new evidence suggests that members of the gasdermin superfamily are novel pore-forming proteins that augment apoptosis by permeabilizing the mitochondria and participate in the final stages of the apoptotic program by inducing secondary necrosis/pyroptosis. These findings may explain outstanding questions in the field such as why …

Natural Antidiabetic Of Tunjuk Langit (Helminthostachys Zeylanica) Rhizome Extracts, Fania E. Ridhasya, Hilwan Y. Teruna, Rudi Hendra, Muhammad Almurdani

Pharmacology and Clinical Pharmacy Research

The use of medicinal plants in treating diabetes mellitus is increasing in Indonesia. Plenty of plants from different regions may have anti-diabetic effect, including Helminthostachys zeylanica. This plant is commonly used as a traditional medicine to treat inflammation, cough, dysentery, and malaria in Talang Mamak tribe, Indragiri Hulu, Riau, however in China it is used to treat diabetic. Thus, we examined whether the extract of H. zeylanica originated from Riau have potential antidiabetic activity. We assessed the α-glucosidase inhibitory activity of the extract of H. zeylanica rhizome. The results showed the antidiabetic values of n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc), …

Multimedia Input Modes, The Modality Principle, And The Redundancy Principle For University Esl Students’ Learning, Yinan Liu

Dissertations - ALL

This study compared three multimedia input modes in the modality and redundancy principles (Mayer, 2009) in terms of university ESL (English as a Second Language) students’ learning and examined the applicability of the modality and redundancy principles for ESL students. Mayer’s modality and redundancy principles (2009) inform the design of effective multimedia lessons. However, the two principles originally stemmed from experimental studies examining students’ learning in their native language and did not include ESL students in the discussion. Based on the modality and redundancy principles, added on-screen text and graphics lead to an overload in learner’s visual channel, which undermines …

Development And Application Of Nmr Diffusometry And Relaxometry Methodologies To Study Organic-Inorganic Interactions At Nanomaterial Surfaces, Emily Grace Ripka

Dissertations - ALL

Colloidal nanomaterials like semiconductor quantum dots (QDs) have size-, shape-, and composition-dependent optoelectronic properties with applications ranging from photovoltaics, to sensing, to medical diagnostics and treatment. These materials also have very high surfaceto- volume ratios, with intricate surface chemistries which control nearly every aspect of their chemical, physical, and colloidal properties. The interaction of the surface with the environment is limited via capping the surface of the nanomaterials with a shell of organic capping molecules. The environment-dependent binding of this organic shell is thus an extremely important aspect of nanomaterial design, however the methodologies to probe these interactions in-situ are …

Construction 4.0 – Digital Transformation Of One Of The Oldest Industries, Robert Klinc, Žiga Turk

Economic and Business Review

In the early 2010s, the German industry started their reform and revival under the keyword "Industrie Vier Punkt Null". The European Union’s strategies adopted most of the ideas and member states followed. The European construction industry too stared to explore how to benefit from it. In this review paper, we explain the ideas behind Industry 4.0. We present aspects of Industry 4.0: what it means for the customer, business and industry as a whole. Based on that framework we analysed the potentials of Industry 4.0 in the construction industry and where – due to some specifics of the industry – …

Ecdysoneless, A Novel Regulator Of Ca2+ Homeostasis And Metabolism, Aniruddha Sarkar

Theses & Dissertations

The hallmarks of cancer include sustained proliferation and survival in the face of cellular stresses imposed by the oncogenic drive, as well as metabolic rewiring for tumor growth under adverse nutritional conditions. Adaptive alterations in key biochemical networks that underlie metabolic rewiring represent potential opportunities to develop new therapeutic strategies against cancer.

My thesis focuses on mammalian Ecdysoneless (ECD), a conserved homolog of the fly Ecdysoneless gene product, which engages fundamental cell biological processes of ER stress, Ca²⁺ signaling and metabolism to help sustain the oncogenic drive in tumor cells. Recent studies from our laboratory provide a clear evidence …

Burden And Risk Of Non-Aids Defining Cancers In Hiv-Infected Persons Receiving Antiretroviral Therapy, Brittney L. Dickey

Theses & Dissertations

The burden of cancers not previously associated with an HIV infection, called non-AIDS defining cancers (NADCs), have increased in the years since highly active anti-retroviral therapy has been introduced. The studies in this dissertation attempted to quantify this burden via incidence and mortality compared to the general population. Further, an assessment of risk factors and creation of a predictive risk model, a nomogram, were utilized to better understand how factors associated with demographics, lifestyle, and immune response affected risk for an NADC diagnosis once therapy was initiated and HIV better controlled. Standardized incidence and mortality ratios showed that burden of …

Mechanism Of Bax/Bak Activation In Apoptotic Signaling, Kai Huang

Theses & Dissertations

The Bcl-2 family proteins, including the anti-apoptotic members, pro-apoptotic effectors Bax/Bak, and the BH3-only proteins, are key components of the mitochondrial apoptotic pathway. The BH3-only protein Bid is critical for the mitochondrial pathway of apoptosis after TRAIL-induced death receptor activation. However, the mechanism of Bid activation during TRAIL-induced apoptosis is unclear. By putting back wild-type and mutants of Bid in Bid deficient (Bid KO) and Bid/Bax/Bak TKO colon cancer cells, we demonstrated that cleavage by caspase 8 and mitochondrial targeting are critical events for Bid activation. One of the biggest mysteries in apoptosis is how Bax/Bak was activated by BH3-only …

Cholesterol Biosynthesis In The Nervous System With An Emphasis On Desmosterolosis, Luke Allen

Theses & Dissertations

Cholesterol biosynthesis is integral to proper neurodevelopment due to the reliance on de novo synthesis of cholesterol in the brain. Disruptions in this process have devastating outcomes for human life characterized by several phenotypic manifestations concomitant with developmental delay. The cholesterol biosynthesis disorder desmosterolosis is an extremely rare disorder with a severe clinical phenotype, however, the models used to study this disease are not well characterized. In addition to genetic disruptions in cholesterol biosynthesis, pharmacological perturbation is an understudied side effect of many commonly prescribed drugs. Here we present a characterization of the sterol profile of the mouse model of …

Molecular Insights Into Major Peripheral T-Cell Lymphoma Entities With Advances In A Representative Model System, Tayla B. Heavican

Theses & Dissertations

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Genomic copy number analysis and targeted sequencing revealed unique genomic abnormalities and oncogenic pathways, indicating distinct oncogenic evolution. PTCL-GATA3 exhibited higher genomic complexity characterized by frequent loss or mutation of tumor suppressor genes targeting the CDKN2A/B-TP53 axis and PTEN-PI3K pathways. …

Brca1 & Ctdp1 Brct Domainomics In The Dna Damage Response, Kimiko L. Krieger

Theses & Dissertations

Genomic instability is one of the enabling characteristics of cancer. DNA damage response pathways are important for genomic integrity and cell cycle progression. Defects in DNA damage repair can often lead to cell cycle arrest, cell death, or tumorigenesis. The activation of the DNA damage response includes tightly regulated signaling cascades that involve kinase phosphorylation and modular domains that scaffold phosphorylated motifs to coordinate recruitment of DNA repair proteins. Modular domains are conserved tertiary structures of a protein that can fold, function, and evolve independently from an intact protein. One of the most common modular domains involved in DNA damage …

The Role Of E3 Ubiquitin Ligase Fbxo9 In Normal And Malignant Hematopoiesis, R. Willow Hynes-Smith

Theses & Dissertations

Hematopoiesis is a critical system that provides blood cells necessary for nutrient and oxygen transfer throughout an organism and for protection from harmful agents. It is maintained throughout life by the hematopoietic stem cells (HSCs) that reside within the bone marrow (BM) and are responsible for providing billions of new cells each day. HSCs maintain a careful balance between a quiescent state, that sustains the integrity of the stem cells, and a proliferative state, that provides new cells to replenish those that undergo apoptosis. Hematopoiesis is regulated by a variety of intrinsic pathways and extrinsic signals such as cytokine signaling, …

Hdac1 Is A Required Cofactor Of Cbfβ-Smmhc And A Therapeutic Target In Inversion 16 Acute Myeloid Leukemia, Lisa E. Richter

Theses & Dissertations

Acute myeloid leukemia (AML) is a neoplastic disease characterized by the uncontrolled proliferation and accumulation of immature myeloid cells. A common mutation in AML is the inversion of chromosome 16 [inv(16)], which generates a fusion between the genes for core binding factor beta (CBFB) and smooth muscle myosin heavy chain (MYH11), forming the oncogene CBFB-MYH11. The expressed protein, CBFβ-SMMHC, forms a heterodimer with the key hematopoietic transcription factor RUNX1. Although CBFβ-SMMHC was previously thought to dominantly repress RUNX1, recent work suggests that CBFβ-SMMHC functions together with RUNX1 to activate transcription of specific target genes.

Targeting the …

The Role Of Reactive Oxygen Species In Regulating Macrophage And Fibroblast Activation Within The Breast Cancer Tumor Microenvironment, Brandon J. Griess

Theses & Dissertations

The tumor microenvironment (TME) is a key determining factor in breast cancer, especially the more aggressive subtype triple negative breast cancer (TNBC). The activated fibroblasts and macrophages within the TME have many tumor promoting functions. Therefore, targeting their activation presents a novel therapeutic approach in TNBC. My work studied the role of reactive oxygen species (ROS) during fibroblast and macrophage activation in breast cancer.

My studies showed that expression of the secreted antioxidant enzyme, EcSOD, is silenced in breast cancer samples, in part, via increased promoter methylation. The re-expression of EcSOD inhibited c-Met activation in the TNBC cell line, MDA-MB231. …

Defining The Role Of Tyrosine Phosphorylation In The Regulation Of Connexin43 In Cardiac Diseases, Li Zheng

Theses & Dissertations

Connexins are integral membrane proteins that oligomerize to form gap junction channels. Ions and small molecules diffuse intercellularly through these channels, allowing individual cellular events to synchronize into the functional response of an entire organ. Gap junction channels composed of Connexin43 (Cx43) mediate electrical coupling and impulse propagation in the normal working myocardium. In the failing heart, Cx43 remodeling (decreased expression, altered phosphorylation state, loss at intercalated discs, and increased presence at lateral membranes) contributes to rhythm disturbances and contractile dysfunction. While there is considerable information regarding key interactions of Cx43 in the regulation of gap junction channels, unfortunately, the …

Paul Otlet And The Ultimate Prospect Of Documentation, Olivier Le Deuff, Arthur Perret

Proceedings from the Document Academy

Paul Otlet (1868-1944) has left information science a vast written legacy. He imagined future developments of documentation around new devices. His anticipations have attracted some misunderstandings and criticism. Otlet’s more daring projections were considered utopian but they are best studied in the historical context of his time. We present the relationship between the concepts of documentation and hyperdocumentation, the ultimate prospect of documentation, and the proximity between Otlet’s work and current conceptions of transhumanism in view of his Mundaneum project.

Leadership In The Sixth Mass Extinction, Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

How Students Learn And Instructors Can, Too: Effective College Teaching According To Eyler (2018), Karin Dejonge-Kannan

Journal on Empowering Teaching Excellence

Book Review

Eyler, J. R. (2018). How Humans Learn: The Science and Stories behind Effective College Teaching. West Virginia University Press.

• 293 pages
• Available in hardback, paperback, and digital format
• Price $85 (hc), $22 (pb), $17 (ebook)
• Keywords: learning, teaching, college students, classroom practice

Reviewer:

Karin deJonge-Kannan, Principal Lecturer

Department of Languages, Philosophy, and Communication Studies

Utah State University

[email protected]

Southern Adventist University Commencement Program December 19, 2019, Southern Adventist University

Commencement Programs

Program for Southern Adventist University December graduation. The commencement service took place on December 19, 2019.

Vol.47 N.22 December 19th 2019, Vocie Media Ventures

Black Voice News

No abstract provided.

Utah Women And Stem, Susan R. Madsen, Elizabeth Goryunova, Robbyn T. Scribner

Marketing and Strategy Faculty Publications

Employment opportunities in Science, Technology, Engineering, and Math (STEM) sectors in Utah are estimated to reach 101,000 by 2018 (Carnevale, Smith, & Melton, 2011). These jobs are recognized nationwide as being well-compensated and generally recession-proof. Yet Utah women continue to hold a lower percentage of STEM-sec-tor jobs than women nationally; in fact, Utah is ranked last in the United States in terms of the percent of women employed in STEM. In addition, Utah women work in STEM occupations at a rate that is less than half that of Utah men (Institute for Women’s Policy Research (IWPR), 2013). Recognizing the role …

Miles Quoted On Heat Stress And Desert Birds, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Development Of Novel Apurinic/Aprymidinic Endonuclease/Redox-Factor 1 Inhibitors For The Treatment Of Human Melanoma, Bella Sharifi

Pharmaceutical Sciences (MS) Theses

Apurinic/apyrimidinic DNA repair endonuclease-1 (APE1), first recognized as an important DNA excision repair enzyme, is also known as Redox Factor-1 (Ref-1) involved in the activation of many nuclear transcription factors in both redox-dependent and independent manner. It has been well-documented that the overexpression of APE/Ref-1 contributes to the development of chemo-resistance and is associated with tumor progression in many human malignancies [1].

Our previous study in melanoma demonstrated that the development of novel inhibitors targeting the redox regulation domain of APE/Ref-1 is a promising strategy for melanoma treatment. To date, limited successes have been reported in developing novel …

Dark-Binding Process Relevant To Preventing Photosensitized Oxidation: Conformation-Dependent Light And Dark Mechanisms By A Dual-Functioning Diketone, Sarah J. Belh, Niluksha Walalawela, Stas Lekhtman, Alexander Greer

Publications and Research

Few photosensitizers function in both light and dark processes as they usually have no function when the lights are turned off. We hypothesized that light and dark mechanisms in an α-diketone will be decoupled by dihedral rotation in a conformation- dependent binding process. Successful decoupling of these two functions is now shown. Namely, anti- and syn-skewed conformations of 4,4′-dimethylbenzil promote photosensitized alkoxy radical production, whereas the syn conformation promotes a binding shutoff reaction with trimethyl phosphite. Less rotation of the diketone is better suited to the photosensitizing function since phosphite binding arises through the syn conformer of lower stability. The …

Mukhtar's Instruction Helps Students 'Feel We Can Truly Impact The World', Haley Herfurth

Browse All News

No abstract provided.

Green Strategic Planning Approach For International Shipping Activities, Xiaofang Wu, Luoping Zhang, Huan Feng

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Sustainability is a long-term and ultimate goal for international shipping, although it is slowly making progress. The shipping perspective that moves away from “port-to-port” operations to “door-to-door” services also requires international shipping to take a long-term and holistic view instead of fragmented efforts. How to achieve the long-term sustainability goal becomes a key issue for door-to-door international shipping. Hence, green strategic planning for door-to-door international shipping was proposed with green development that puts forward the eco-centric point of view as its basic theory for sustainability. This study used a strategic decision-making approach, a so-called multi-dimensional decision-making (MDDM), coupled with the …

Data-Driven Multiscale Modeling Reveals The Role Of Metabolic Coupling For The Spatio-Temporal Growth Dynamics Of Yeast Colonies., Jukka Intosalmi, Adrian C Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri Lähdesmäki, Aimée M Dudley, Alexander Skupin

Articles, Abstracts, and Reports

BACKGROUND: Multicellular entities like mammalian tissues or microbial biofilms typically exhibit complex spatial arrangements that are adapted to their specific functions or environments. These structures result from intercellular signaling as well as from the interaction with the environment that allow cells of the same genotype to differentiate into well-organized communities of diversified cells. Despite its importance, our understanding how this cell-cell and metabolic coupling lead to functionally optimized structures is still limited.

RESULTS: Here, we present a data-driven spatial framework to computationally investigate the development of yeast colonies as such a multicellular structure in dependence on metabolic capacity. For this …

Data-Driven Multiscale Modeling Reveals The Role Of Metabolic Coupling For The Spatio-Temporal Growth Dynamics Of Yeast Colonies, Jukka Intosalmi, Adrian C. Scott, Michelle Hays, Nicholas Flann, Olli Yli-Harja, Harri Lähdesmäki, Aimée M. Dudley, Alexander Skupin

Computer Science Faculty and Staff Publications

Background: Multicellular entities like mammalian tissues or microbial biofilms typically exhibit complex spatial arrangements that are adapted to their specific functions or environments. These structures result from intercellular signaling as well as from the interaction with the environment that allow cells of the same genotype to differentiate into well-organized communities of diversified cells. Despite its importance, our understanding how this cell–cell and metabolic coupling lead to functionally optimized structures is still limited.

Results: Here, we present a data-driven spatial framework to computationally investigate the development of yeast colonies as such a multicellular structure in dependence on metabolic capacity. For this …

Uab's Aeiva Presents Artist Allyson Comstock, "Antarctica: A Disappearing Continent" From Jan. 13-March 21, Shannon Thomason

Browse All News

No abstract provided.