Digital Commons Network^™

Mutation Of The Co-Chaperone Tsc1 In Bladder Cancer Diminishes Hsp90 Acetylation And Reduces Drug Sensitivity And Selectivity, Mark R. Woodford, Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

Open Access Publications

The molecular chaperone Heat shock protein 90 (Hsp90) is essential for the folding, stability, and activity of several drivers of oncogenesis. Hsp90 inhibitors are currently under clinical evaluation for cancer treatment, however their efficacy is limited by lack of biomarkers to optimize patient selection. We have recently identified the tumor suppressor tuberous sclerosis complex 1 (Tsc1) as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Highly variable mutations of TSC1 have been previously identified in bladder cancer and correlate with sensitivity to the Hsp90 inhibitors. Here we showed loss of TSC1 leads to hypoacetylation of Hsp90-K407/K419 …

Structured Inhibitory Activity Dynamics In New Virtual Environments, Moises Arriaga, Edward B. Han

Open Access Publications

Inhibition plays a powerful role in regulating network excitation and plasticity; however, the activity of defined interneuron types during spatial exploration remain poorly understood. Using two-photon calcium imaging, we recorded hippocampal CA1 somatostatin- and parvalbumin-expressing interneurons as mice performed a goal-directed spatial navigation task in new visual virtual reality (VR) contexts. Activity in both interneuron classes was strongly suppressed but recovered as animals learned to adapt the previously learned task to the new spatial context. Surprisingly, although there was a range of activity suppression across the population, individual somatostatin-expressing interneurons showed consistent levels of activity modulation across exposure to multiple …

Elevated Trace Elements In Sediments And Seagrasses At Co2 Seeps, A. K. Mishra, R. Santos, Jm Hall-Spencer

More Faculty of Science and Engineering Research

No abstract provided.

Recent Case Decisions

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Nevada, Diana S. Prulhiere, Rachael H. Smith

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Colorado, David R. Little, Diana S. Prulhiere

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Community Forest In Liberia: The Interface Between Sustainable Charcoal Production And Deforestation, Amavie Clement

Capstone Collection

The available data establishes a direct correlation between charcoal production and forest degradation and deforestation in Liberia. Charcoal is the primary energy source for Liberians, especially in urban areas where the bulk of the population lives. It is expected to be the mainstay energy source for years to come because it is affordable, accessible, and convenient to use compared to other forms of energy (i.e. electricity and petroleum gas). However, the current model of charcoal production, based on indiscriminate felling of trees, poses a danger to the environment as it results in widespread forest degradation and deforestation. Therefore, any successful …

Dental And Mandibular Anomalies In White-Tailed Deer (Odocoileus Virginianus) From Central Georgia, Patrick M. Powers, Alfred J. Mead

Georgia Journal of Science

The frequency of dental and mandibular anomalies in free-ranging white-tailed deer in the southeastern United States is not well documented. Characteristic irregularities include supernumerary and missing teeth, malocclusion, root abscesses due to bacterial infections, and tooth or bone damage due to trauma. In the present study, we examined 778 white-tailed deer dentaries collected from the Piedmont National Wildlife Refuge in central Georgia. All dentaries were inspected for lesions, tooth irregularities, developmental anomalies, and other pathologies. Thirty-two dentaries (4.1%) displayed signs of dental or bone abnormalities. More abnormalities were associated with infection or injury (22/778, 2.8%) compared to unusual tooth development …

Environmental Plant Biology Welcomes 10 New Graduate Students, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Stimulation Of Piezo1 By Mechanical Signals Promotes Bone Anabolism, Xuehua Li, Li Han, Intawat Nookaew, Erin Mannen, Matthew J. Silva, Maria Almeida, Jinhu Xiong

Open Access Publications

Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside in bone matrix, sense changes in mechanical load, and produce signals that alter bone formation by osteoblasts. We report that the ion channel Piezo1 is required for changes in gene expression induced by fluid shear stress in cultured osteocytes and stimulation of Piezo1 by a small molecule agonist is sufficient to replicate the effects of fluid flow on osteocytes. Conditional deletion of

Notable Alumni | Grace Eberly Works At The Intersection Of Religion And Healthcare, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Notable Alumni | Grace Eberly Works At The Intersection Of Religion And Healthcare (October 7, 2019), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Efektivitas Dual-Task Training Motorik-Kognitif Dalam Menurunkan Risiko Jatuh Pada Lansia, Nahdiah Purnamasari

Media Kesehatan Masyarakat Indonesia

The aging process causes a setback of various aspects of the body both physically, mentally and
psychologically which indirectly threatens the independence of the elderly and makes them vulnerable to fall.
Exercise is generally useful in increasing muscle strength and improving balance and gait in order to reduce the
risk of falls. The dual-task motor-cognitive exercise amalgamates physical and cognitive training together and
induces synergistic effects when combined in one intervention. This study aimed to determine the effect of dual-task
training on the risk of falls in the elderly. The method used was pre-experimental with one group pre-test post-test
design …

Association Of Urine Levels Of C-Reactive Protein With Clinical Outcomes In Patients With Pneumonia: A Pilot Study, Subathra Marimuthu, Vidyulata Salunkhe, Stephen P. Furmanek, Leslie A Wolf

The University of Louisville Journal of Respiratory Infections

Finding relevant biomarkers as a potential predictor of severity for patients hospitalized with community acquired pneumonia (CAP), in addition to the clinical scoring system, could advance progress towards more effective patient management. The inflammatory marker, C-reactive protein (CRP), which is elevated in the pathogenesis of many infectious diseases, may be a key biomarker target for CAP. Previous studies have shown that serum CRP may be a useful diagnostic marker for pneumonia in hospitalized patients with acute respiratory symptoms. The main aims of this study were to determine the correlation between serum and urine CRP levels in hospitalized patients with CAP, …

The Free Press Vol 51, Issue 5, 10-07-2019, Alyson Peabody

Free Press, The

The quest to be carbon neutral begins--New campus center to replace Woodbury next year--Athletes wear purple for domestic violence awareness--Impeachment investigations continue--Placing a Green Dot in Southern Maine--#METOO at Maine Women’s Summit on economic security--Family for ME brings awareness to children in need of families

Iodine Supplementation Of Lactating Women And Assessment Of Infant Visual Information Processing And Maternal And Infant Thyroid Function: A Randomized Trial, Tafere Gebreegziabher Belay, Tesfaye Woltamo, David G. Thomas, Tay S. Kennedy, Barbara J. Stoecker

All Faculty Scholarship for the College of the Sciences

Iodine deficiency is one of the major causes of brain damage in childhood. However, iodine supplementation during early pregnancy and lactation can prevent the ill effects of iodine deficiency. This study evaluated maternal and infant thyroid function and infant visual information processing (VIP) in the context of maternal iodine supplementation. A community-based, randomized, supplementation trial was conducted. Mother infant dyads (n = 106) were enrolled within the first 10 days after delivery to participate in this study. Mothers were randomly assigned either to receive a potassium iodide capsule (225 μg iodine) daily for 26 weeks or iodized salt weekly for …

Week Of October 7, 2019, New York Medical College

InTouch

• NYMC Celebrates 26th Annual Faculty Author Recognition
• NYMC Honored at "Westchester Doctors of Distinction"
• NYMC Goes Gold
• NYMC Celebrates Hispanic Heritage Month
• NYMC Visits Museum of Jewish Heritage

The Rider (2019-10-07), Victor G. Ramirez

The Rider Archives

Vol.5 No.7

Efektivitas Larutan Bawang Putih Dalam Pengendalian Larva Aedes Agypti, Muhammad Ikhtiar, Sitti Patimah, Nur Fadhilah Rasyidi, Yusriani Yusriani, Hidayat Hidayat

Media Kesehatan Masyarakat Indonesia

Efforts to control Dengue Hemorrhagic Fever using insecticides pose a risk of resistance to mosquitoes
and are not environmentally friendly, so an alternative method of controlling Aedes agypti larvae based on
natural materials is needed. This study aims to compare the effectiveness of abate powder and garlic solution in
controlling Aedes aegypti larvae with various concentrations, by using true experimental design with a completely
randomized design. The samples was Aedes aegypti larvae stage III and IV with total sample of 25 larvae which
put into abate powder and garlic solution with a concentration of 20 mg/100 ml, 40 mg/100 ml, …

Fine-Scale Haplotype Structure Reveals Strong Signatures Of Positive Selection In A Recombining Bacterial Pathogen, Brian Arnold, Mashaal Sohail, Crista B. Wadsworth, Jukka Corander, William P. Hanage, Shamil Sunyaev, Yonatan H. Grad

Articles

Identifying genetic variation in bacteria that has been shaped by ecological differences remains an important challenge. For recombining bacteria, the sign and strength of linkage provide a unique lens into ongoing selection. We show that derived alleles linkage, a pattern that cannot be explained by limited recombination or neutrality as these couplings are significantly stronger for nonsynonymous alleles than synonymous alleles. This general pattern is driven by a small fraction of highly diverse genes, many of which exhibit evidence of interspecies horizontal gene transfer and an excess of intermediate frequency alleles. Extensive simulations show that two distinct forms of positive …

Grand Valley Forum, Volume 044, Number 04, October 7, 2019, Grand Valley State University

2019-2020, Volume 44

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Gut Microbiome Diversity Is Associated With Sleep Physiology In Humans, Robert Smith, Cole Easson, Sarah M. Lyle, Ritishka Kapoor, Chase P. Donnelly, Eileen Davidson, Esha Parikh, Jose Lopez, Jaime L. Tartar

Biology Faculty Articles

The human gut microbiome can influence health through the brain-gut-microbiome axis. Growing evidence suggests that the gut microbiome can influence sleep quality. Previous studies that have examined sleep deprivation and the human gut microbiome have yielded conflicting results. A recent study found that sleep deprivation leads to changes in gut microbiome composition while a different study found that sleep deprivation does not lead to changes in gut microbiome. Accordingly, the relationship between sleep physiology and the gut microbiome remains unclear. To address this uncertainty, we used actigraphy to quantify sleep measures coupled with gut microbiome sampling to determine how the …

Microwave-Assisted Synthesis Of Graphene Supported Hexagonal Magnetite For Applications In Catalysis, Hany A. Elazab, M. A. Radwan, M. A. Sadek

Chemical Engineering

Herein, we report a rapid one-step synthetic method using microwave irradiation for growing magnetite nanocrystals on reduced graphene oxide sheets. This developed strategy allows decorating graphene sheets with magnetite nanocrystals of well-defined morphology as cubes using microwave-driven reduction of iron chloride using hydrazine hydrate as a reducing agent. The size and shape control was achieved via fine-tuning of the reaction conditions. The obtained results demonstrate the applicability of this microwave synthetic approach to control the morphology of the magnetite nanocrystals anchored on graphene sheets. Moreover, graphene sheets will enhance the nucleation and growth of magnetite nanoplates anchored on graphene. This …

Association Between Socioeconomic Status Mobility And Inflammation Markers Among White And Black Adults In The United States: A Latent Class Analysis, Agus Sarachman, Cara Rice, Bethany Bray, Tara Gruenewald, David Almeida

Psychology Faculty Articles and Research

Objective This paper examines whether multidimensional indicators of objective and subjective socioeconomic status (SES) across the life course can be categorized into latent classes of SES mobility and tests the associations of these categories with inflammation markers among White and Black adults.

Methods Data are from 592 non-Hispanic White and 158 non-Hispanic Black participants who completed both the baseline survey and biomarkers assessment of the Midlife in the United States (MIDUS) Refresher study. Groups of different SES mobility were examined using latent class analysis.

Results White and Black participants showed different patterns of SES mobility. Among Blacks, the latent classes …

Faktor Risiko Anemia Pada Wanita Pemetik Teh, Eryasih Setyorini, Faisal Anwar, Hadi Riyadi, Ali Khomsan

Media Kesehatan Masyarakat Indonesia

Anemia is known as a public health problem for many years, based on the results of Riskesdas 2018 it is
known that the prevalence of anemia is 48.9%. This research aims to analyze the risk factors that influence anemia
in female tea pickers in Pangalengan, Bandung, West Java. The research method was cross-sectional with 148
subjects of the so-called Wanita Usia Subur (WUS). They are women of childbearing age, between 18-45 years
old who were married and not pregnant. They were selected purposively in the plantation areas Purbasari, Talun
Santosa and Sedep. This research was part of a research funded …

Hubungan Riwayat Reproduksi Dengan Tumor Payudara Pada Perempuan Usia Muda Di Indonesia (Analisis Riset Ptm 2016), Rizqy Fauzia Ahsani, Putri Bungsu Machmud

Media Kesehatan Masyarakat Indonesia

The incidence of breast tumor increases every year in Indonesia. At present, breast tumors do not only
attack the elderly, but also at young age. Some studies show factors associated with breast tumors. Therefore,
this study aimed to study the association of the reproductive history with tumor incidence in young women in
Indonesia in 2016. This study used a cross-sectional study design and was conducted in December 2018-January
2019 in the Faculty of Public Health of Universitas Indonesia using secondary data from the Riset PTM 2016
(Non-communicable Disease Research 2016). The population in this study were all respondents of the …

Computationally Aided Design Of A High-Performance Organic Semiconductor: The Development Of A Universal Crystal Engineering Core, Anthony J. Petty Ii, Qianxiang Ai, Jeni C. Sorli, Hamna F. Haneef, Geoffrey E. Purdum, Alex M. Boehm, Devin B. Granger, Kaichen Gu, Carla Patricia Lacerda Rubinger, Sean R. Parkin, Kenneth R. Graham, Oana D. Jurchescu, Yueh-Lin Loo, Chad Risko, John E. Anthony

Chemistry Faculty Publications

Herein, we describe the design and synthesis of a suite of molecules based on a benzodithiophene “universal crystal engineering core”. After computationally screening derivatives, a trialkylsilylethyne-based crystal engineering strategy was employed to tailor the crystal packing for use as the active material in an organic field-effect transistor. Electronic structure calculations were undertaken to reveal derivatives that exhibit exceptional potential for high-efficiency hole transport. The promising theoretical properties are reflected in the preliminary device results, with the computationally optimized material showing simple solution processing, enhanced stability, and a maximum hole mobility of 1.6 cm² V⁻¹ s⁻¹.

Challenges To Coordinating Clinical Outreach To Improve Both Interprofessional Practice Initiatives And Global Health, Molli Megan Oldenburg

Biennial Convention (CONV)

Challenges and barriers exist when coordinating clinical outreach experiences to improve bot interprofessional practice and global health. Global health care requires professionals to be diverse and work in an interdisciplinary fashion. Offering such experiences to students will improve our interdisciplinary workforce both locally and globally.

Using A Hybrid Professional Development Course To Facilitate Accelerated Bsn Student Learning, Rhoda A. Owens

Biennial Convention (CONV)

The purpose of this cross-sectional survey study was to develop and implement an accelerated BSN student hybrid delivered professional development course and evaluate student satisfaction and perceived learning. Students reported that the innovative course delivery method promoted their learning and engagement,a supportive learning environment, and were overall satisfied.

Journey To Knowledge And Self-Esteem: Implementation Of Biopsychosocial Model Of Care Through Psoriasis Support Group, Jessy Augustine

Biennial Convention (CONV)

The purpose of this presentation is to demonstrate how a support group along with education on psoriasis have impacted the knowledge, self-esteem, psoriasis-related stress and quality of life of psoriasis patients.