Digital Commons Network^™

Heterogeneity And Plasticity Of Human Breast Cancer Cells In Response To Molecularly-Targeted Drugs, Emira Bousoik, Ramina Nabiee, Farideh Amirrad, Ashley Nichols, Rebecca Witt, Parvin Mahdipoor, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Non-responsive subpopulation of tumor cells, and acquired resistance in initially responsive cells are major challenges for cancer therapy with molecularly-targeted drugs. While point mutations are considered the major contributing factor to acquired resistance, in this study we explored the role of heterogeneity and plasticity of selected human breast cancer cell lines (MDA-MB-231, MDA-MB-468, and AU565) in their initial and adjusted response, respectively, to ruxolitinib, everolimus, and erlotinib. After determination of lethal concentration for 50% cell death (LC50), cells were exposed to selected drugs using three different approaches: single exposure to 4 × LC50 and collection of surviving cells, multiple exposures …

Hall Of Fame Alumnus Wins Prestigious Lasker Award, Edwin B. Smith

University of Mississippi News

Dr. Max Cooper honored with 'America's Nobel Prize' for groundbreaking immunology work

Evaluation Of Reproductive Phenology And Ecology Of Wild Turkey (Meleagris Gallopavo) Across The Southeastern United States, Landon Robert Schofield

LSU Master's Theses

The primary driver of population growth and sustainability of gallinaceous birds is annual recruitment. Habitat selection by wild turkeys (Meleagris gallopavo spp.) during reproductive activities could influence production at multiple temporal and spatial scales. Vegetation conditions at nest sites that could drive nest success have not been clearly identified, which suggests that other factors may drive reproductive success.

Female wild turkeys maintain dominance hierarchies, which could influence how reproductively active females distribute themselves across the landscape during reproductive periods. Using high-frequency GPS data collected from reproductively active females, I analyzed nesting attempts for Eastern (n = 381), …

On Waves Propagating Through An Emergent Poroelastic Medium, Yuan-Jyh Lan

Journal of Marine Science and Technology–Taiwan

This paper describes a theoretical study of the problem of linear waves propagating over an emergent poroelastic medium. Lan-Lee’s poro-elastomer theory is extended to derive a new analytical solution for describing this problem, with the free surface boundary condition discussed in the context of a poroelastic medium, a topic that has rarely been covered by previous studies. In the present approach, the problem domain is divided into three subregions and a negligible water-exposed region. Using general solutions for each region and the matching dynamic and kinematic conditions for neighboring regions, a set of simultaneous equations is developed and numerically solved. …

Perceptions Of Offshore Wind Farms And Community Development: Case Study Of Fangyuan Township, Chunghua County, Taiwan, Ku-Jung Lin, Chia-Pao Hsu, Hung-Yu Liu

Journal of Marine Science and Technology–Taiwan

Surrounded by the ocean, Taiwan has many rich marine cultural resources that have benefited its coastal communities and led to the development of diverse traditional marine industries. A typical example is the unique tradition of “Sea Buffalos Working in the Oyster Field”, which has been practiced for over a century in Fangyuan Township of Changhua County. The cultural landscape of buffalos and workers cultivating oyster fields has been recognized as a precious cultural heritage by both local and international parties. However, Fangyuan Township is facing a turning point due to the installation of offshore wind turbines. Development-promoting public agencies and …

Cpue Standardization For The Pacific Saury (Cololabis Saira) Fishery In The Northwest Pacific, Wen-Bin Huang, Chih-Hao Hsieh, Tai-Sheng Chiu, Wei-Ting Hsu, Chih-Shin Chen

Journal of Marine Science and Technology–Taiwan

In stock assessment and fisheries management, the standardization of catch per unit effort (CPUE) is critical to derive an effective index of the abundance of exploited fish stocks. In addition to developing various statistical models, a method including the relative fishing power (RFP) of individual vessels has been developed from an intuition concept and applied to bottom trawl fisheries using logbookbased data. This is a convenient and traightforward approach for standardizing the catch-effort data of a fishery. The Pacific saury is a pelagic fish species, and its stock in the Northwest Pacific has been targeted by international fleets since the …

Intrinsic Cleavage Inhibition By Thermophilic Type Ii-S Restriction Endonucleases, Dino Jake Ciccone

Master of Science in Chemical Sciences Theses

Restriction endonucleases (REs) are the cornerstone research tools used in molecular biology and biotechnology. These enzymes are essential to several ground-breaking achievements, including DNA cloning, gene editing, and genome mapping. A subset of these enzymes, Type II-S restriction endonucleases (IISREs), cleave double-stranded DNA (dsDNA) not governed by sequence specificity, but rather at a fixed distance from their recognition sequence. These enzymes maintain complete cleavage promiscuity, allowing utilization in techniques such as Golden Gate assembly, Serial Analysis of Gene Expression (SAGE), and Restriction Endonuclease Protection, Selection, and Amplification (REPSA). However, laboratories generated evidence that intrinsically cleavage refractory sequences exist. Understanding the …

The Current Volume 30 : Issue 8, Nova Southeastern University

Student Newspapers

No abstract provided.

Faculty Senate Chronicle For September 5, 2019, Heather M. Loughney

The University of Akron Faculty Senate Chronicle

No abstract provided.

Composition And Distribution Of Fish Larvae Surrounding The Upwelling Zone In The Waters Of Northeastern Taiwan In Summer, Yi-Chen Wang, Ming-An Lee

Journal of Marine Science and Technology–Taiwan

We investigated the species composition and distribution of fish larvae surrounding the upwelling zone in the waters of northeastern Taiwan in July 2011. The surface water had higher temperatures (25.7°C-28.3°C) and lower salinity (33.67-34.05 psu) than did lower water columns. A divergent trend was observed between temperature and salinity in the waters above 80 m. Moreover, we identified a cold-core eddy at the upwelling of the Kuroshio subsurface at waters approximately 60 m beneath the surface. In total, 1834 fish larvae were collected from eight stations; 85 taxa contributing to 60 families were identified. The abundance of fish larvae varied …

Using Collaborative Testing In A Clinical Nurse Leader Program: One Program's Experience, Regina Miecznikoski Phillips

Biennial Convention (CONV)

Faculty are challenged to find interactive ways to engage students, particularly nontraditional learners, in challenging content. In this 5-credit pathophysiology CNL course, collaborative testing was used to enhance learning while engaging students. This paper describes the collaborative testing process, outlines rewards and challenges, provides evaluation data and details future implications.

A Guide To Career Development And Work-Life Balance, Jennifer L. Saylor, Jennifer S. Graber, Amy Nagorski Johnson, Leigh Ann Difusco

Biennial Convention (CONV)

The purpose of this presentation is to provide a guide for all Sigma members describing ways to improve work-life balance while engaged in career development. This guide addresses stress management and healthy lifestyle behaviors.

Attitudinal Disposition Of Adults Toward People With Mental Disorders In Oke-Ose Community, Ilorin East, Nigeria, Joel Adeleke Afolayan, Olayinka Abolore Onasoga, Hannah Adedoyin Ademiloye

Biennial Convention (CONV)

The research looked at the attitudes of adults to mental health disorders in a local community in Oke-ose, Kwara State, Nigeria. Such factors influencing the acceptability and non-acceptability on mental health disorders were also elicited for.

A Collaborative Model For Addressing A Lead Crisis Affecting A City's Children, Marilyn J. Lotas

Biennial Convention (CONV)

This collaborative project, led by a SON, brings together a city health department, mayor's office, school district and hospital system to address the lead crisis impacting the city's children. Health professional schools in the area have included their students' participation in the project as part of their curricula.

State V. Johnson Appellant's Brief Dckt. 47064

Not Reported

No abstract provided.

Best Practices For Nurses And Nurse Practitioners Working With Farmworkers During Hurricane Recovery, Jean Ann Davison

Biennial Convention (CONV)

The purpose of this project was to:

1. Assess the impact of Hurricane Florence among Eastern Carolina farmworkers.

2. Provide health screenings and outreaches to this vulnerable population to assist in recovery from Hurricane Florence.

3. Define and disseminate best practices for nurses and students to work with migrant farmworkers.

The Teaching Experience Of An Innovative Interprofessional Course On The Concept Of Caring, Roger D. Carpenter

Biennial Convention (CONV)

This presentation describes an interprofessional undergraduate course teaching the concept of caring. Classic and contemporary works help students explore caring over the past, present, and future through interpersonal, theoretical, ethical, and socio-political lenses. Students articulate an approach to putting caring into action as a professional, scholar, and global citizen

Volume 117, Number 2 - Tuesday, October 15, 2019, Saint Mary's College Of California

The Collegian

No abstract provided.

Cleavage Resistant Photoluminescent Proteins And Applications Thereof, Robert Beitle Jr., Rudra Palash Mukherjee, Thallapuranam Krishnaswamy Suresh Kumar, Joshua Sakon, David S. Mcnabb

Patents Granted

Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.

Staphylococcus Aureus Infects Osteoclasts And Replicates Intracellularly, Jennifer L Krauss, Philip M Roper, Anna Ballard, Chien-Cheng Shih, James A J Fitzpatrick, James E Cassat, Pei Ying Ng, Nathan J Pavlos, Deborah J Veis

Open Access Publications

Osteomyelitis (OM), or inflammation of bone tissue, occurs most frequently as a result of bacterial infection and severely perturbs bone structure. OM is predominantly caused by

Forcespun Polydiacetylene Nanofibers As Colorimetric Sensor For Food Spoilage Detection, Marisol Valdez, Santosh K. Gupta, Karen Lozano, Yuanbing Mao

Mechanical Engineering Faculty Publications

Highlights

• PDA nanofiber mats are fabricated by Forcespinning® technique.

• The PDA nanofibers can monitor and assess meat deterioration and freshness.

• The PDA nanofibers possess fast response, excellent sensitivity and long shelf life.

• PDA nanofibers made from ECDA monomer have superior performance.

Abstract

Due to health and economic concerns, increasing attention has been attracted to the safety and quality control of food, particularly meat and seafood. Ammonia and biogenic amines (BAs), such as trimethylamine, putrescine and cadaverine, are released during the decomposition of meat protein. Therefore, the sensitive detection of the released BAs is crucial to the assessment of the safety …

Effect Of River Engineering, Excessive Nitrogen, And Climate Change, On Hydroecology Of Upper Mississippi River, Deepak Parajuli

Research Papers

No abstract provided.

The Prospector, October 15, 2019, Utep Student Publications

The Prospector

Headline: Covering the Border

Thermithiobacillus, R Boden, L Hutt

School of Biological and Marine Sciences

No abstract provided.

Multi-Annual Embayment Sediment Dynamics Involving Headland Bypassing And Sediment Exchange Across The Depth Of Closure, Nieves G. Valiente, Robert Jak Mccarroll, Gerd Masselink, Tim Scott, Mark Wiggins

School of Biological and Marine Sciences

No abstract provided.

Camptothecin-Based Dendrimersomes For Gene Delivery And Redox-Responsive Drug Delivery To Cancer Cells, Partha Laskar, Sukrut Somani, Sarah Jane Campbell, Margaret Mullin, Patricia Keating, Rothwelle J. Tate, Craig Irving, Hing Y. Leung, Christine Dufès

School of Medicine Publications

Combination therapy involving chemotherapeutic drugs and genes is emerging as a promising strategy to provide a synergistic therapeutic effect, to overcome drug resistance while reducing the severe side effects associated with conventional chemotherapeutic drugs. However, the lack of nanomedicines able to simultaneously carry anti-cancer drugs and nucleic acids limits the application of this therapeutic strategy. To overcome this issue, we proposed to synthesize a pro-drug dendrimer by conjugating the PEGylated, positively charged generation 3-diaminobutyric polypropylenimine dendrimer to the anti-cancer drug camptothecin with a redox-sensitive disulphide linkage, and evaluate its efficacy to co-deliver the complexed DNA and camptothecin to cancer cells. …

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2018, Timothy Gauthier

All Publications

No abstract provided.

College Of Education News, College Of Education, Georgia Southern University

College of Education: News & Publications (2003-2023)

• Georgia Southern hosts nearly 300 high school students for Future Georgia Educator Day
• Georgia Southern education professor, Dalai Lama join for first international Human Education in the Third Millennium project in India
• Georgia Southern faculty take 20 state teachers to learn in the swamp

Brachiopod Shell Thickness Links Environment And Evolution, U Balthasar, J Jin, L Hints, M Cusack

School of Geography, Earth and Environmental Sciences

While it is well established that the shapes and sizes of shells are strongly phylogenetically controlled, little is known about the phylogenetic constraints on shell thickness. Yet, shell thickness is likely to be sensitive to environmental fluctuations and has the potential to illuminate environmental perturbations through deep time. Here we systematically quantify the thickness of the anterior brachiopod shell which protects the filtration chamber and is thus considered functionally homologous across higher taxa of brachiopods. Our data comes from 66 genera and ten different orders and shows well-defined upper and lower boundaries of anterior shell thickness. For Ordovician and Silurian …

Hospital Ward Temperatures Related To Hypothermic Risk In Orthopaedic Patients, S. Goodhew, J. Duthie, H. Shirreff, P. Riddlestone, J. Metcalfe, J. M. Latour, M. Fox

School of Art, Design and Architecture

No abstract provided.