Digital Commons Network^™

4d Electron Microscopy Of T Cell Activation., Yue Lu, Byung-Kuk Yoo, Alphonsus H C Ng, Jungwoo Kim, Sinchul Yeom, Jau Tang, Milo M Lin, Ahmed H Zewail, James R Heath

Articles, Abstracts, and Reports

T cells can be controllably stimulated through antigen-specific or nonspecific protocols. Accompanying functional hallmarks of T cell activation can include cytoskeletal reorganization, cell size increase, and cytokine secretion. Photon-induced near-field electron microscopy (PINEM) is used to image and quantify evanescent electric fields at the surface of T cells as a function of various stimulation conditions. While PINEM signal strength scales with multiple of the biophysical changes associated with T cell functional activation, it mostly strongly correlates with antigen-engagement of the T cell receptors, even under conditions that do not lead to functional T cell activation. PINEM image analysis suggests that …

African Centered Education, The Maji Shujaa Online Academy: A Descriptive Case Study, Beverly Jackson

Dissertations

The purpose of this descriptive case study framed by African centered theory, is to advance the knowledge about the online African centered educational programming, Maji Shujaa Academy. The researcher is the Chief Executive Officer( CEO) and lead teacher/lead developer of online educational media for the Academy. Considerable private African-centered educators with enterprenueural spirit have advanced and created online African centered global educational programming for the students of Africa and African Diaspora population groups today. Yet the available literature is shallow with regard to the workings of online African centered educational programming. This study explores in which the online Academy makes …

Threat Recognition In Incumbent Firms: A Case For Organizational Velocity, Alan Amling

PhD in Business Administration Dissertations

Change is not new, but the speed of change is new. Fueled by a combination of connecting and thinking technologies, the business environment is becoming increasingly dynamic and uncertain. Incumbent firms face a wider variety of threats that vary in frequency of occurrence and financial impact. How effectively firms see these threats, internalize them as important (or not) and act on them in a timely manner (or not) can be critical to their survival. However, the academic literature is incomplete on how firms navigate this threat recognition process from initial observation through action and across different organizational contexts.

This qualitative …

The Current Volume 30 : Issue 10, Nova Southeastern University

Student Newspapers

No abstract provided.

The Concurrent Decline Of Soil Lead And Children’S Blood Lead In New Orleans, Howard W. Mielke, Christopher R. Gonzales, Eric T. Powell, Mark A. S. Laidlow, Kenneth J. Berry, Paul W. Mielke Jr., Sara Perl Egendorf

Publications and Research

Lead (Pb) is extremely toxic and a major cause of chronic diseases worldwide. Pb is associated with health disparities, particularly within low-income populations. In biological systems, Pb mimics calcium and, among other effects, interrupts cell signaling. Furthermore, Pb exposure results in epigenetic changes that affect multigenerational gene expression. Exposure to Pb has decreased through primary prevention, including removal of Pb solder from canned food, regulating lead-based paint, and especially eliminating Pb additives in gasoline. While researchers observe a continuous decline in children’s blood lead (BPb), reservoirs of exposure persist in topsoil, which stores the legacy dust from leaded gasoline and …

School Of Education Continues To Grow Its Impact On Alabama, Beyond, Tyler Greer

Browse All News

No abstract provided.

Personal Faith, Professional Expertise Shape Book To Help Science Educators Tackle Contentious Topics, Staff

Browse All News

No abstract provided.

Salivary Gland Choristoma: A Rare Finding At Gastroesophageal Junction, Isin Y. Comba Md, Richard Henriquez Md, Sundeep Kumar Md, Hilda Merino-Chavez Md, Maria Wallis-Crespo Md, Christopher Cooper Md, Lakhinder Bhatia Md

Gastroenterology

Introduction: Choristoma is tumor-like outgrowth of heterotopic and mature tissue located at anatomically unusual sites. Heterotopic salivary gland tissue (HSGT) has been most commonly described in head and neck region but can rarely involve gastrointestinal (GI) tract with a few cases reported in the literature.

Case Description/Methods: An 87-year-old female with past medical history of gastroesophageal reflux disease (GERD), hypertension, and chronic kidney disease was admitted for an acute DVT. Due to worsening anemia, she underwent an upper endoscopy that showed a small nodularity at the GE junction (figure 1a), a large hiatal hernia, and reflux esophagitis in the lower …

Nucleus Pulposus Primary Cilia Alter Their Length In Response To Changes In Extracellular Osmolarity But Do Not Control Tonebp-Mediated Osmoregulation., Hyowon Choi, Vedavathi Madhu, Irving M. Shapiro, Makarand V. Risbud

Department of Orthopaedic Surgery Faculty Papers

The nucleus pulposus (NP) cells adapt to their physiologically hyperosmotic microenvironment through Tonicity-responsive enhancer binding protein (TonEBP/nuclear factor of activated T-cell5 [NFAT5])-mediated osmoregulation. Primary cilia in different organs serve diverse roles including osmosensing, but its contribution to NP cell osmoadaptive response is unknown. A high percentage of cultured primary NP cells possessed primary cilia that changed length in response to osmotic stimuli. Stable silencing of Intraflagellar Transport 88 (Ift88) or Kinesin Family Member 3 A (Kif3a) to inhibit the formation of primary cilia did not affect hyperosmotic upregulation of TonEBP. While ShKif3a blocked hyperosmotic increase of TonEBP-Transactivation Domain (TAD) activity, …

Leu8 And Pro8 Oxytocin Agonism Differs Across Human, Macaque, And Marmoset Vasopressin 1a Receptors, Aaryn Mustoe, Nancy A. Schulte, Jack H. Taylor, Jeffrey A. French, Myron L. Toews

Psychology Faculty Publications

Oxytocin (OXT) is an important neuromodulator of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a receptors (AVPR1a). Marmosets are neotropical primates with a modified OXT ligand (Pro8-OXT), and this ligand shows significant coevolution with traits including social monogamy and litter size. Pro8-OXT produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-OXT). Here, we tested whether OXT/AVP ligands show differential levels of crosstalk at primate AVPR1a. We measured binding affinities and Ca2+ signaling responses of AVP, Pro8-OXT and Leu8-OXT at human, macaque, and marmoset AVPR1a. …

Changes In Southeastern Usa Summer Precipitation Event Types Using Instrumental (1940-2018) And Tree-Ring (1790-2018) Data, T.J. Mitchell, P.A. Knapp, T.W. Patterson

Faculty Publications

We examined short- and long-term changes in precipitation event types using instrumental (1940–2018) and tree-ring (1790–2018) data from North Carolina, USA. We documented the amount and frequency of summer (July–September) precipitation events using daily weather station data. Stationary front precipitation (SFP) represented 71% of total summer rainfall and SFP and convective uplift combined (i.e., quasi-stationary precipitation, QSP) represented 87%. SFP (r = 0.52, p < 0.01) and QSP (r = 0.61, p < 0.01) precipitation reconstructions from a montane longleaf pine latewood chronology both recorded significant declines during 1940–2018, matching the instrumental record. Conversely, no significant change in either SFP or QSP occured during the full reconstruction indicating the instrumental decline was unmatched throughout 1790–1939. Our method demonstrates that variations in latewood growth can be attributed to specific precipitation event types and that the relative contribution of each event type can be quantified over a multi-century period.

Characterizing The Roles Of Nuclear Proteins Dbc1, G9a, And Glp In Adipocyte Function And Metabolic Health, Ashley Ann Able

LSU Doctoral Dissertations

Obesity is a metabolic disorder characterized by excess energy storage in adipose tissue and it increases the risk for Type 2 diabetes. Impaired or altered adipocyte function during obesity can contribute to metabolic dysfunction. DBC1 (deleted in breast cancer 1) and EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2) have been shown to have a role in fat cell development and function. DBC1 is typically localized in the nucleus and can regulate a variety of epigenetic modifiers, transcription factors, and nuclear receptors. EHMTs 1 and 2, also known respectively as GLP and G9a, were initially classified as …

Health, More Than A Biological Issue: Talking About Holistic Health, Jordan Helming, Luralyn M. Helming

Faculty Work Comprehensive List

"As a society, we often ignore psychological, social, and spiritual health, focusing on the much more objective biological health. Doing so is a disfavor to ourselves, because humans encompass all four aspects."

Posting about ­­­­­­­­health for the whole person from In All Things - an online journal for critical reflection on faith, culture, art, and every ordinary-yet-graced square inch of God’s creation.

https://inallthings.org/health-more-than-a-biological-issue-talking-about-holistic-health/

Expect The Unexpected: A New Ant From A Backyard In Utah, John T. Longino, Douglas B. Booher

Western North American Naturalist

Urban centers are not where one expects to find new species. Yet, we report here a newly recognized ant, Strumigenys ananeotes sp. nov., in an urban yard in Salt Lake City, Salt Lake County, Utah, USA. The genus Strumigenys is a major radiation of litter ants that are found primarily in the wet tropics and subtropics. They are extremely rare in western North America, known only from sites hundreds of kilometers south and west of Salt Lake City. The new species is related to species from southern Arizona and is presumed native. We propose that it is normally restricted to …

Deep Neural Network Based Iterative Self-Taught Learning On Text Mining, Xiangwen Liu

Theses and Dissertations

[Motivation] Machine learning and deep learning models is the main methodology for discovering hidden knowledge of data. Data plays a significant role in the training process. However, lack of data especially labeled data is precious due to accessibility and high cost. How to use the abundant unlabeled data to enhance the downstream learning process on labeled data is an urgent task in machine learning and pattern recognition. [Methods] An STL (Self-taught learning) model is proposed in this dissertation, which can successfully learn features from downloaded unlabeled text and enhance the downstream tasks on labeled text. In addition, DLI-IT (Drug labeling …

Diverse Cell Junctions With Unique Molecular Composition In Tissues Of A Sponge (Porifera), Jennyfer M. Mitchell, Scott A. Nichols

Biological Sciences: Faculty Scholarship

The integrity and organization of animal tissues depend upon specialized protein complexes that mediate adhesion between cells with each other (cadherin-based adherens junctions), and with the extracellular matrix (integrin-based focal adhesions). Reconstructing how and when these cell junctions evolved is central to understanding early tissue evolution in animals. We examined focal adhesion protein homologs in tissues of the freshwater sponge, Ephydatia muelleri (phylum Porifera; class Demospongiae). Our principal findings are that (1) sponge focal adhesion homologs (integrin, talin, focal adhesion kinase, etc.) co-precipitate as a complex, separate from adherens junction proteins; (2) that actin-based structures resembling focal adhesions form at …

Digital Addiction: A Conceptual Overview, Amarjit Kumar Singh, Pawan Kumar Singh

Library Philosophy and Practice (e-journal)

Abstract

Digital addiction referred to an impulse control disorder that involves the obsessive use of digital devices, digital technologies, and digital platforms, i.e. internet, video game, online platforms, mobile devices, digital gadgets, and social network platform. It is an emerging domain of Cyberpsychology (Singh, Amarjit Kumar and Pawan Kumar Singh; 2019), which explore a problematic usage of digital media, device, and platforms by being obsessive and excessive. This article analyses, reviewed the current research, and established a conceptual overview on the digital addiction. The research literature on digital addiction has proliferated. However, we tried to categories the digital addiction, according …

Data Of Soil, Vegetation And Bird Species Found On Double-Crested Cormorant Colonies In The Southeastern United States, Leah Moran Veum, Brian S. Dorr, Katie Hanson-Dorr, R. J. Moore, Scott A. Rush

United States Department of Agriculture Wildlife Services: Staff Publications

This data article provides the methods and procedures followed to collect and analyse soil, vegetation and bird data on three different treatment islands in Guntersville Reservoir, Alabama. Samples were collected from randomly selected plot points from islands that were placed into three different treatment types: Colony (currently occupied by Double-crested Cormorants) (Phalacrocorax auritus; n 1⁄4 5), Historic (historically occupied by cormorants and currently abandoned; n 1⁄4 3) and Reference (never occupied by cormorants; n 1⁄4 4). We compared vegetation and tree metrics such as structure and diversity, as well as soil chemistry and bird diversity and communities among islands within …

Magnetosome Gene Duplication As An Important Driver In The Evolution Of Magnetotaxis In The Alphaproteobacteria, Haijian Du, Wenyan Zhang, Wensi Zhang, Weijia Zhang, Hongmiao Pan, Yongxin Pan, Dennis A. Bazylinski, Long-Fei Wu, Tian Xiao, Wei Lin

Life Sciences Faculty Research

The evolution of microbial magnetoreception (or magnetotaxis) is of great interest in the fields of microbiology, evolutionary biology, biophysics, geomicrobiology, and geochemistry. Current genomic data from magnetotactic bacteria (MTB), the only prokaryotes known to be capable of sensing the Earth’s geomagnetic field, suggests an ancient origin of magnetotaxis in the domain Bacteria. Vertical inheritance, followed by multiple independent magnetosome gene cluster loss, is considered to be one of the major forces that drove the evolution of magnetotaxis at or above the class or phylum level, although the evolutionary trajectories at lower taxonomic ranks (e.g., within the class level) remain largely …

Integrating Primary Care Into Community Mental Health Centres In Texas, Usa: Results Of A Case Study Investigation, Rebecca Wells, Ellen D Breckenridge, Sasha Ajaz, Aman Narayan, Daniel Brossart, James H Zahniser, Jolene Rasmussen

Faculty, Staff and Student Publications

INTRODUCTION: Despite evidence that people with serious mental illness benefit from receiving primary care within mental health care settings, there is little research on this type of integration. The objective of this study was to characterize how providers and patients experienced implementation of primary care into specialty mental health services.

METHODS: During site visits, study team members interviewed staff and conducted focus groups with patients at 10 United States community mental health centres then beginning to integrate primary into their practices. One year later, follow up phone interviews with key centre staff informants validated and updated findings. Data analysis included …

Philosophy And Religious Studies News, Georgia Southern University

Philosophy & Religious Studies: News & Publications (2019-2021)

• A Taste of Biblical Hebrew
• Introduction to Buddhism class visits The Vietnamese Buddhist Association of Savannah, Georgia, Inc.
• What Can I Do With My Philosophy Major?

Pathways To Parenthood: Attitudes And Preferences Of Eight Self-Identified Queer Women Living In Tampa Bay, Fl, Emily Noelle Baker

USF Tampa Graduate Theses and Dissertations

This small-scale ethnographic study looks at the how queer women living in Florida imagine navigating family building decisions under the current climate of policies such as a lack of federal non-discrimination protections and the largely unregulated use of assisted reproductive technologies. Despite the federal legalization of same-sex marriage in the United States in 2015, state and county legislations continue to vary greatly on the extent of support they will provide for LGBTQ families. The goal of this research is to evaluate parenting desire, intentions, and preferences for queer women living in Tampa Bay since the passage of the Marriage Equality …

Emergent Masculinities : Gendered Power And Social Change In The Biafran Atlantic Age, Ndubueze L. Mbah

Ohio University Press Open Access Books

In Emergent Masculinities, Ndubueze L. Mbah argues that the Bight of Biafra region’s Atlanticization—or the interaction between regional processes and Atlantic forces such as the slave trade, colonialism, and Christianization—between 1750 and 1920 transformed gender into the primary mode of social differentiation in the region. He incorporates over 250 oral narratives of men and women across a range of social roles and professions with material culture practices, performance traditions, slave ship data, colonial records, and more to reveal how Africans channeled the socioeconomic forces of the Atlantic world through their local ideologies and practices. The gendered struggles over the means …

Dysregulation Of Mitochondrial Ca2+ Uptake And Sarcolemma Repair Underlie Muscle Weakness And Wasting In Patients And Mice Lacking Micu1, Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L. Seifert, Marshall W. Hogarth, Davi A. Mazala, Kai Ting Huang, Rita Horvath, Jyoti K. Jaiswal, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Muscle function is regulated by Ca²⁺, which mediates excitation-contraction coupling, energy metabolism, adaptation to exercise, and sarcolemmal repair. Several of these actions rely on Ca²⁺ delivery to the mitochondrial matrix via the mitochondrial Ca²⁺ uniporter, the pore of which is formed by mitochondrial calcium uniporter (MCU). MCU's gatekeeping and cooperative activation are controlled by MICU1. Loss-of-protein mutation in MICU1 causes a neuromuscular disease. To determine the mechanisms underlying the muscle impairments, we used MICU1 patient cells and skeletal muscle-specific MICU1 knockout mice. Both these models show a lower threshold for MCU-mediated Ca²⁺ uptake. Lack of …

Model-Robust Inference For Clinical Trials That Improve Precision By Stratified Randomization And Adjustment For Additional Baseline Variables, Bingkai Wang, Ryoko Susukida, Ramin Mojtabai, Masoumeh Amin-Esmaeili, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

We focus on estimating the average treatment effect in clinical trials

that involve stratified randomization, which is commonly used. It is

important to understand the large sample properties of estimators that

adjust for stratum variables (those used in the randomization

procedure) and additional baseline variables, since this can lead to

substantial gains in precision and power. Surprisingly, to the best

of our knowledge, this is an open problem. It was only recently that a

simpler problem was solved by Bugni et al. (2018) for the case with no

additional baseline variables, continuous outcomes, the analysis of

covariance (ANCOVA) estimator, and …

Repeated Vaginal Exposures To The Common Cosmetic And Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain In Nd4 Mice, Erica Arriaga-Gomez, Jacyln Kline, Elizabeth Emanuel, Nefeli Neamonitaki, Tenzin Yangdon, Hayley Zacheis, Dogukan Pasha, Jinyoung Lim, Susan Bush, Beebie Boo, Hanna Mengistu, Ruby Kinnamon, Robin Shields-Cutler, Wattenberg Wattenberg, Devavani Chatterjea

Faculty Publications

A history of allergies doubles the risk of vulvodynia-a chronic pain condition of unknown etiology often accompanied by increases in numbers of vulvar mast cells. We previously established the biological plausibility of this relationship in mouse models where repeated exposures to the allergens oxazolone or dinitrofluorobenzene on the labiar skin or inside the vaginal canal of ND4 Swiss Webster outbred mice led to persistent tactile sensitivity and local increases in mast cells. In these models, depletion of mast cells alleviated pain. While exposure to cleaning chemicals has been connected to elevated vulvodynia risk, no single agent has been linked to …

Senate Executive Committee Minutes October 28, 2010, Bronx Community College Senate Executive Committee

BCC Governance Archives

Minutes for the meeting of the Senate Executive Committee on October 28, 2019.

What's Happening: October 28, 2019, Maine Medical Center

What's Happening

No abstract provided.

Synthesis And Analysis Of Separation Processes For Extracellular Chemicals Generated From Microbial Conversions, Wenzhao Wu, Kirti Maheshkumar Yenkie, Christos T. Maravelias

Henry M. Rowan College of Engineering Departmental Research

Recent advances in metabolic engineering have enabled the production of chemicals via bio-conversion using microbes. However, downstream separation accounts for 60–80% of the total production cost in many cases. Previous work on microbial production of extracellular chemicals has been mainly restricted to microbiology, biochemistry, metabolomics, or techno-economic analysis for specific product examples such as succinic acid, xanthan gum, lycopene, etc. In these studies, microbial production and separation technologies were selected apriori without considering any competing alternatives. However, technology selection in downstream separation and purification processes can have a major impact on the overall costs, product recovery, and purity. To this …

Theoretical And Empirical Foundations Of Divorce Education: Connecting Program Theory And Curricular Content, Alisha M. Hardman, Emily H. Becher, Ellie Mccann, Sharon E. Powell, Jennifer Garbow, Neeraj Rajasekar, Mary S. Marczak

Journal of Human Sciences and Extension

Many parent and family education programs lack a clearly articulated program theory that is solidly founded in the social science literature and used to guide rigorous evaluation. This article describes the program theory for Parents Forever, a divorce education program developed by the Minnesota Extension to serve divorcing parents. The Parents Forever program theory is theoretically based and empirically-informed. The program theory is based on three significant frameworks, which serve as the theoretical foundation for the program: human ecosystems, life course development, and family resilience. These theories are explored and discussed. Three primary change mechanisms relevant for divorcing families serve …