Digital Commons Network^™

Impacts Of Cannabinoid Epigenetics On Human Development: Reflections On Murphy Et. Al. 'Cannabinoid Exposure And Altered Dna Methylation In Rat And Human Sperm' Epigenetics 2018; 13: 1208-1221, Albert Stuart Reece, Gary Kenneth Hulse

Research outputs 2014 to 2021

Recent data from the Kollins lab ('Cannabinoid exposure and altered DNA methylation in rat and human sperm' Epigenetics 2018; 13: 1208-1221) indicated epigenetic effects of cannabis use on sperm in man parallel those in rats and showed substantial shifts in both hypo- and hyper-DNA methylation with the latter predominating. This provides one likely mechanism for the transgenerational transmission of epigenomic instability with sperm as the vector. It therefore contributes important pathophysiological insights into the probable mechanisms underlying the epidemiology of prenatal cannabis exposure potentially explaining diverse features of cannabis-related teratology including effects on the neuraxis, cardiovasculature, immune stimulation, secondary genomic …

What Temporal Resolution Is Required For Remote Sensing Of Regional Aerosol Concentrations Using The Himawari-8 Geostationary Satellite, Miles Sowden, Ute Mueller, David Blake

Research outputs 2014 to 2021

Few studies have directly addressed the question of what temporal resolution is required for air quality studies using geostationary remote sensing data. If timescales are too large, there is a risk that events affecting air quality may be missed; and if too small, there is a possibility that large data files may be processed frequently, at significant computing cost and potentially without concomitant improvements in the monitoring of air quality. The problem is particularly significant in sparsely populated regional areas such as the Pilbara in Western Australia, where air quality issues arising from a range of events, dispersed over a …

Biosecurity Research And Development In Western Australia - Report By The Biosecurity Council Of Western Australia, Biosecurity Council Of Western Australia

Biosecurity published reports

Research and development (R&D) is crucial to managing Western Australia’s biosecurity risks and threats. There is a perception, however, that these risks and threats could be better recognised nationally, which may result in greater levels of funding for biosecurity R&D activities relevant to Western Australia (WA).

The purpose of this work was to provide advice to the Minister for Agriculture and Food on the status of biosecurity R&D in WA and opportunities to enhance biosecurity R&D funding in the State.

Single-Cell Transcriptomics Reveal A Correlation Between Genome Architecture And Gene Family Evolution In Ciliates, Ying Yan, Xyrus X. Maurer-Alcalá, Rob Knight, Sergei L.Kosakovsky Pond, Laura A. Katz

Biological Sciences: Faculty Publications

Ciliates, a eukaryotic clade that is over 1 billion years old, are defined by division of genome function between transcriptionally inactive germline micronu-clei and functional somatic macronuclei. To date, most analyses of gene family evolution have been limited to cultivable model lineages (e.g., Tetrahymena, Paramecium, Oxytricha, and Stylonychia). Here, we focus on the uncultivable Karyorelictea and its understudied sister class Heterotrichea, which represent two extremes in genome architecture. Somatic macronuclei within the Karyorelictea are described as nearly diploid, while the Heterotrichea have hyperpolyploid somatic genomes. Previous analyses indicate that genome architecture impacts ciliate gene family evolution as the most diverse …

E-Mobility -- Advancements And Challenges, Aswad Adib, Khurram K. Afridi, Mahshid Amirabadi, Fariba Fateh, Mehdi Ferdowsi, Brad Lehman, Laura H. Lewis, Behrooz Mirafzal, Maryam Saeedifard, Mohammad B. Shadmand, Pourya Shamsi

Electrical and Computer Engineering Faculty Research & Creative Works

Mobile platforms cover a broad range of applications from small portable electric devices, drones, and robots to electric transportation, which influence the quality of modern life. The end-to-end energy systems of these platforms are moving toward more electrification. Despite their wide range of power ratings and diverse applications, the electrification of these systems shares several technical requirements. Electrified mobile energy systems have minimal or no access to the power grid, and thus, to achieve long operating time, ultrafast charging or charging during motion as well as advanced battery technologies are needed. Mobile platforms are space-, shape-, and weight-constrained, and therefore, …

Moving Forward From The Scoop Era: Providing Active Efforts Under The Indian Child Welfare Act In Illinois, Cassandra Crandall

Northern Illinois University Law Review

This Comment argues that Illinois should adopt the view that active efforts are a higher standard than reasonable efforts and implement procedures encouraging state agencies and courts to implement these requirements. Following the Supreme Court's rationale in Mississippi Choctaw Band of Indians v. Holyfield, one of the only Supreme Court cases addressing the ICWA, this Comment argues that a uniform definition and application of "active efforts" should exist in every jurisdiction. Furthermore, this Comment emphasizes that "active efforts" require more than "reasonable efforts," and that these standards are different. Part I of this Comment reviews the history of the ICWA. …

Online News Representation Of Missing/Murdered Indigenous Women In Washington, New Mexico, And Arizona, Kelli Bowers

McNair Scholars Manuscripts

There is limited research on the rates of violence against the many missing and murdered indigenous women (MMIW) in the United States, especially in urban areas. There is also little news coverage given to women who are victims of this violence. The absence of research on this topic and the shortage of news coverage leads to a lack of understanding by the general public on the issue as a whole. This is a qualitative content analysis of the representation of MMIW in Washington, New Mexico, and Arizona. I will analyze the newspaper reporting of MMIW in these states and the …

Updating Molecular Diagnostics For Detecting Methicillin- Susceptible And Methicillin-Resistant Staphylococcus Aureus Isolates In Blood Culture Bottles, Fred C. Tenover, Isabella A. Tickler, Victoria M. Le, Scott Dewell, Rodrigo E. Mendes, Richard V. Goering, Mrsa Consortium

Biology Faculty Publications

Molecular diagnostic tests can be used to provide rapid identification of staphylococcal species in blood culture bottles to help improve antimicrobial stewardship. However, alterations in the target nucleic acid sequences of the microorganisms or their antimicrobial resistance genes can lead to false-negative results. We determined the whole-genome sequences of 4 blood culture isolates of Staphylococcus aureus and 2 control organisms to understand the genetic basis of genotypephenotype discrepancies when using the Xpert MRSA/SA BC test (in vitro diagnostic medical device [IVD]). Three methicillin-resistant S. aureus (MRSA) isolates each had a different insertion of a genetic element in the staphylococcal cassette …

Broad Substrate-Specific Phosphorylation Events Are Associated With The Initial Stage Of Plant Cell Wall Recognition In Neurospora Crassa, Maria Augusta C. Horta, Nils Thieme, Yuqian Gao, Kristin E. Burnum-Johnson, Carrie D. Nicora, Marina A. Gritsenko, Mary S. Lipton, Karthikeyan Mohanraj, Leandro José De Assis, Liangcai Lin, Chaoguang Tian, Gerhard H. Braus, Katherine A. Borkovich, Monika Schmoll, Luis F. Larrondo, Areejit Samal, Gustavo H. Goldman, J. Philipp Benz

Peninsula Medical School

Fungal plant cell wall degradation processes are governed by complex regulatory mechanisms, allowing the organisms to adapt their metabolic program with high specificity to the available substrates. While the uptake of representative plant cell wall mono- and disaccharides is known to induce specific transcriptional and translational responses, the processes related to early signal reception and transduction remain largely unknown. A fast and reversible way of signal transmission are post-translational protein modifications, such as phosphorylations, which could initiate rapid adaptations of the fungal metabolism to a new condition. To elucidate how changes in the initial substrate recognition phase of Neurospora crassa …

Continuing Education Newsletter, Continuing Education, Georgia Southern University

Division of Continuing & Professional Education

• Happy Holidays From The Division Of Continuing Education
• All About Birds
• The Division's Mission
• GATA Self-Defense for Women
• Beekeeping 101

Binge Eating Disorder And The Nutrition Care Process, Kaddie Levine

Nutrition & Dietetics Student Publications

Exploring the fundamentals of the nutrition care process in binge eating disorder patients. A student dietitian's take on binge eating disorder treatment and what to look for when making nutrition therapy recommendations.

Optimization Of Electrospray Ionization For Liquid Chromatography Time-Of-Flight Mass Spectrometry Analysis Of Preservatives In Wood Leachate Matrix, Kukowski Klara, Gysbers Brianna, Stephen Fisher, Alena Kubatova

Chemistry Faculty Publications

Triazoles and 3-iodo-2-propynyl butylcarbamate (IPBC) are commonly used wood preservatives active against a wide range of fungi and bacteria. As they are prone to leaching, their amounts need to be monitored by the industry to determine preservative loss from the products and for environmental impact assessment. Therefore, a liquid chromatography–electrospray–time-of-flight mass spectrometry (LC–ESI–TOFMS) method was developed and optimized for simultaneous quantification of triazoles and IPBC in aqueous wood extracts, specifically wood leachate. Analyte pre-concentration on a solid-phase extraction cartridge prior to the analysis yielded > 94% recoveries. ESI method parameters (e.g., solvent system, electrolyte type, electrolyte concentration, capillary and fragmentor voltages) …

Comparative Chromosome Mapping Of Musk Ox And The X Chromosome Among Some Bovidae Species, Anastasiya A. Proskuryakova, Anastasia I. Kulemzina, Polina L. Perelman, Dmitry V. Yudkin, Natalya A. Lemskaya, Innokentii M. Okhlopkov, Egor V. Kirillin, Marta Farré, Denis M. Larkin, M. Roelke-Parker, Stephen James O'Brien, Mitchell Bush, Alexander S. Graphodatsky

Biology Faculty Articles

Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals within a species. The bovid X chromosome is also remarkably variable, with several morphological types in the family. Here we built a detailed chromosome map of musk ox (Ovibos moschatus), a relic species originating from Pleistocene megafauna, with dromedary and human probes using chromosome painting. We trace chromosomal rearrangements during Bovidae evolution by comparing species already studied by chromosome painting. The musk ox karyotype differs from the ancestral pecoran karyotype by six fusions, one fission, …

The Temporal Dynamics Of The Link Between Configural Face Processing And Dehumanization, Steven G. Young, Ryan E. Tracy, John Paul Wilson, Robert J. Rydell, Kurt Hugenberg

Department of Psychology Faculty Scholarship and Creative Works

The human face conveys a wealth of information, including traits, states, and intentions. Just as fundamentally, the face also signals the humanity of a person. In the current research we report two experiments providing evidence that disruptions of configural face encoding affect the temporal dynamics of categorization during attempts to distinguish human from non-human faces. Specifically, the present experiments utilize mouse-tracking and find that face inversion elicits confusion amongst human and non-human categories early in the processing of human faces. This work affords the first examination of how facial inversion affects the dynamic processes underlying categorization of human and non-human …

Food Insecurity And The Unsustainable Hunting Of Wildlife In A Unesco World Heritage Site, Cortni Borgerson, Be Noel Razafindrapaoly, Delox Rajaona, Be Jean Rodolph Rasolofoniaina, Christopher D. Golden

Department of Anthropology Faculty Scholarship and Creative Works

Madagascar faces dual challenges in biodiversity conservation and public health. In order to identify strategies to reduce the unsustainable hunting of threatened species while maintaining or improving child nutrition, we quantified interactions among ecosystem indicators (lemur density and habitat biodiversity indices), health indicators (stunting, underweight, wasting, and anemia), nutrition, food security, and wildlife hunting through interviews of 1,750 people in 387 households and surveys of 28 wildlife transects with 156 habitat plots at 15 sites on Madagascar's Masoala Peninsula, a UNESCO World Heritage Site. The surveyed population ate 6,726 forest animals (mammals and birds), or a mean of 3.27 kg …

Trans Sports Illustrated: Identities And Experiences Of Transgender Athletes Assigned Female At Birth, Sophia Neely

College of Education Theses and Dissertations

This empirical study explores how transgender athletic adults assigned female at birth narrate their identities and experiences related to gender and sports participation. Using the methodology of social science portraiture filtered through a lens of queer feminist theory, semi-structured interviews were conducted with two trans men and three nonbinary participants. The participants are diverse in terms of age (21 to 54), race (white, Asian American, and African American), current primary sports interest (squash, CrossFit, powerlifting, baseball, and rock climbing), and pronouns (he/him/his, ze/zir/zirs, and they/them/theirs). Media reports and extant research on transgender athletes tend to recount bleak histories of exclusion, …

Trust And Influence In The Gulf Of Mexico’S Fishery Public Management Network, Anthony Lima, Dongkyu Kim, Andrew M. Song, Gordon M. Hickey, Owen Temby

School of Earth, Environmental, & Marine Sciences Faculty Publications

Sustainable fishery management is a complex multi-sectoral challenge requiring substantial interagency coordination, collaboration, and knowledge sharing. While scholars of public management network theory and natural resource management have identified trust as one of the key ideational network properties that facilitates such interaction, relatively few studies have operationalized and measured the multiple dimensions of trust and their influence on collaboration. This article presents the results of an exploratory study examining the Gulf of Mexico fishery management network comprised of more than 30 stakeholder organizations. Using an empirically validated survey instrument, the distribution of four types of trust, three gradations of influence, …

Increasing Impacts Of Extreme Droughts On Vegetation Productivity Under Climate Change, Chonggang Xu, Nate G. Mcdowell, Rosie A. Fisher, Liang Wei, Sanna Sevanto, Bradley O. Christoffersen, Engsheng Weng, Richard S. Middleton

School of Earth, Environmental, & Marine Sciences Faculty Publications

Terrestrial gross primary production (GPP) is the basis of vegetation growth and food production globally1 and plays a critical role in regulating atmospheric CO2 through its impact on ecosystem carbon balance. Even though higher CO2 concentrations in future decades can increase GPP2, low soil water availability, heat stress and disturbances associated with droughts could reduce the benefits of such CO2 fertilization. Here we analysed outputs of 13 Earth system models to show an increasingly stronger impact on GPP by extreme droughts than by mild and moderate droughts over the twenty-first century. Due to a dramatic increase in …

Trends And Associated Factors Of Use Of Opioid, Heroin, And Cannabis Among Patients For Emergency Department Visits In Nevada: 2009–2017, Pearl C. Kim, Ji Won Yoo, Chris R. Cochran, Seong Min Park, Sungyoun Chun, Yong-Jae Lee, Jay J. Shen

School of Medicine Faculty Research

To examine trends and contributing factors of opioid, heroin, and cannabis-associated emergency department (ED) visits in Nevada. The 2009 to 2017 Nevada State ED database (n = 7,950,554 ED visits) were used. Use of opioid, heroin, and cannabis, respectively, was identified by the International Classification of Diseases, 9th & 10th Revisions. Three multivariable models, one for each of the 3 dependent variables, were conducted. Independent variables included year, insurance status, race/ethnicity, use of other substance, and mental health conditions. The number of individuals with opioid, heroin, cannabis-associated ED visits increased 3%, 10%, and 23% annually from 2009 to 2015, particularly …

2019-November-01-Faculty/Staff Professional Activities, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Organic Agriculture Teaching And Learning In 2025: Transforming The Future Learning Landscape, Randa Jabbour, Charles A. Francis, Mary Barbercheck, Katharina S. Ullman

Department of Agronomy and Horticulture: Faculty Publications

University instructors are compelled to anticipate future changes in farming and food systems that will impact their students. Sixteen educators met in 2018 to envision the future of organic agriculture courses needed by 2025. Likely future global issues include food access, especially for people of limited economic means; climate change; and fossil fuel costs. Changes that will impact education are increasing demand for quality food, more organic production, and globalization of food systems due to consolidation. Probable course content changes are increasing focus on whole farm systems; designing for resilience in changing physical, economic, environmental, and political climates; and increasing …

Cul3 Regulates Cyclin E1 Protein Abundance Via A Degron Located Within The N-Terminal Region Of Cyclin E, Brittney Marie Davidge, Katia De Oliveira Rebola, Larry N. Agbor, Curt D. Sigmund, Jeffrey D. Singer

Biology Faculty Publications and Presentations

mammalian cells. Increased levels of cyclin E are found in some cancers. Additionally, proteolytic removal of the cyclin E N-terminus occurs in some cancers and is associated with increased cyclin E–Cdk2 activity and poor clinical prognosis. Cyclin E levels are tightly regulated and controlled in part through ubiquitin-mediated degradation initiated by one of two E3 ligases, Cul1 and Cul3. Cul1 ubiquitylates phosphorylated cyclin E, but the mechanism through which Cul3 ubiquitylates cyclin E is poorly understood. In experiments to ascertain how Cul3 mediates cyclin E destruction, we identified a degron on cyclin E that Cul3 targets for ubiquitylation. Recognition of …

Species-Specific Effects Of Passive Warming In An Antarctic Moss System, Hannah M. Prather, Angélica Casanova-Katny, Andrew F. Clements, Matthew Chmielewski, Mehmet Ali Balkan, Erin Shortlidge, Todd Rosenstiel, Sarah Eppley

Biology Faculty Publications and Presentations

Polar systems are experiencing rapid climate change and the high sensitivity of these Arctic and Antarctic ecosystems make them especially vulnerable to accelerated ecological transformation. In Antarctica, warming results in a mosaic of ice-free terrestrial habitats dominated by a diverse assemblage of cryptogamic plants (i.e. mosses and lichens). Although these plants provide key habitat for a wide array of microorganisms and invertebrates, we have little understanding of the interaction between trophic levels in this terrestrial ecosystem and whether there are functional effects of plant species on higher trophic levels that may alter with warming. Here, we used open top chambers …

Enhancing Single Walled Carbon Nanotube Deposition For The Study Of Extracellular Analytes, Joseph A. Stapleton

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Extracellular signaling is a dynamic process responsible for coordinating large scale biological processes. As such, understanding extracellular signaling is important to our determination of normal function and pathophysiological development. High resolution spatial and temporal information are critical to completely understanding these processes. Unfortunately, current methods of detection are lacking in either spatial or temporal resolution of extracellular products, limiting researchers’ ability to understand complex biological processes. A new group of sensors based on fluorescent single walled carbon nanotubes (SWNT) have shown the potential to provide both high quality spatial and temporal resolution for the sensing of analytes. However, while SWNT …

Adding Value To Lignocellulosic Biorefinery: Efficient Process Development Of Lignocellulosic Biomass Conversion Into Polyhydroxybutyrate, Mengxing Li

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Polyhydroxybutyrate (PHB) is bacteria synthesized polymer that has comparable mechanical properties as petroleum-based plastics and high biocompatibility. Current commercial PHB production process is not cost effective. Raw materials make up about 50% of the production cost. Lignocellulosic biomass are cheap, abundant feedstocks that can be converted into PHB to add profit and sustainability to lignocellulosic biorefinery. Lignocellulosic biorefinery upstream process produces polymeric sugar rich stream and lignin-enriched stream. Polymeric sugars are then hydrolyzed into a sugar stream with glucose, xyloseand arabinose mainly present. To the best of the author’s knowledge, limited studies have been done on sugar mixture conversion into …

Prevalence Of Malaria Reported During Summer And Winter At A Tertiary Care Hospital In Karachi, Pakistan, Fazal M. Arain, Aisha Memon, Roohi Jamal, Ahmed Raheem Buksh, Mohammad Asim Beg

Department of Biological & Biomedical Sciences

This study was designed to determine the prevalence and type of malaria cases that presented throughout the year 2014 in a tertiary care hospital in Karachi, Pakistan. A total of 1099 cases, (377 females, 722 males) were reported. Plasmodium vivax (P. vivax) was discovered in 93.7% cases compared to 6.3% Plasmodium falciparum (P. falciparum). Based on the highest and lowest weather temperatures, in summer (June, July and August) and in winter (December, January and February) were differentiated. The number of cases were greater during summer months compared to winter. Interestingly, the ratio of P. falciparum to P. vivax during winter …

Transcriptomic Analyses And Computational Modeling Reveal That Fatty Acid Transport Protein 2 (Fatp2) Impacts The Transcriptional Activity Of Pparα Thus Altering The Lipid Metabolic Landscape, Vincent M. Perez

Department of Biochemistry: Dissertations, Theses, and Student Research

Fatty acid transport protein 2 (FATP2) is highly expressed in liver, small intestine, and kidney where it functions in both the uptake of exogenous long chain fatty acids (LCFAs) and in the activation of very long chain fatty acids (VLCFAs). Here we address the phenotypic impacts of deleting FATP2 with the following three separate approaches: [1] Utilizing an unbiased next-generation sequencing analysis of FATP2-null (fatp2-/-) mice fed a standard chow diet; [2] Utilizing an unbiased next-generation sequencing analysis of fatp2-null (fatp2-/-) mice fed a high-fat ketogenic diet (KD) and fasted for 24-hours [3] Building dynamic computer models built with data …

Stroke Recovery Drugs, Maria Humayun

Detroit Stroke Conference 2019

No abstract provided.

Secondary Stroke Prevention: A Global Issue That Needs A Global Solution, Shaneela Malik

Detroit Stroke Conference 2019

No abstract provided.

Developing Moral Education To Combat Human Trafficking, Shima Rostami

Dissertations

Leaders are challenged daily to improve their organization's products and outcomes. “When the character of leaders is low, so are their standards” (Maxwell, 2010, p. 41), and accordingly the products and programs. No field or profession was exempt from this challenge at the leadership level. On this note, human trafficking as a humanitarian crisis was of particular interest for activists, but one that may still suffer from this same weakness at the leadership level. Consequently, having a concern for how to improve the character and standards of the leaders in the anti-human trafficking movement, the Investigator of this study questioned …