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2019

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Articles 29041 - 29070 of 29567

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X-Ray Structures Of The High-Affinity Copper Transporter Ctr1, Feifei Ren, Brandon L. Logeman, Xiaohui Zhang, Yongjian Liu, Dennis J. Thiele, Peng Yuan Jan 2019

X-Ray Structures Of The High-Affinity Copper Transporter Ctr1, Feifei Ren, Brandon L. Logeman, Xiaohui Zhang, Yongjian Liu, Dennis J. Thiele, Peng Yuan

Open Access Publications

No abstract provided.


Resting State Functional Connectivity Predictors Of Treatment Response To Electroconvulsive Therapy In Depression, M. Moreno-Ortega, J. Prudic, S. Rowny, G. H. Patel, A. Kangarlu, S. Lee, J. Grinband, T. Palomo, T. Perera, M. F. Glasser, D. C. Javitt Jan 2019

Resting State Functional Connectivity Predictors Of Treatment Response To Electroconvulsive Therapy In Depression, M. Moreno-Ortega, J. Prudic, S. Rowny, G. H. Patel, A. Kangarlu, S. Lee, J. Grinband, T. Palomo, T. Perera, M. F. Glasser, D. C. Javitt

Open Access Publications

No abstract provided.


Pancreatic Stone Protein/ Regenerating Protein Is A Potential Biomarker For Endoplasmic Reticulum Stress In Beta Cells, Stephen Stone, Damien Abreu, Jana Mahadevan, Rie Asada, Kelly Kries, Rolf Graf, Bess A. Marshall, Tamara Hershey, Fumihiko Urano Jan 2019

Pancreatic Stone Protein/ Regenerating Protein Is A Potential Biomarker For Endoplasmic Reticulum Stress In Beta Cells, Stephen Stone, Damien Abreu, Jana Mahadevan, Rie Asada, Kelly Kries, Rolf Graf, Bess A. Marshall, Tamara Hershey, Fumihiko Urano

Open Access Publications

No abstract provided.


Ligand Entry In Human Ileal Bile Acid-Binding Protein Is Mediated By Histidine Protonation, Gergő Horváth, Orsolya Egyed, Changguo Tang, Mihály Kovács, András Micsonai, József Kardos, Orsolya Toke Jan 2019

Ligand Entry In Human Ileal Bile Acid-Binding Protein Is Mediated By Histidine Protonation, Gergő Horváth, Orsolya Egyed, Changguo Tang, Mihály Kovács, András Micsonai, József Kardos, Orsolya Toke

Open Access Publications

No abstract provided.


P5rhh Nanoparticle-Mediated Delivery Of Axl Sirna Inhibits Metastasis Of Ovarian And Uterine Cancer Cells In Mouse Xenografts, Kathryn A. Mills, Jeanne M. Quinn, S. Tanner Roach, Marguerite Palisoul, Mai Nguyen, Hollie Noia, Lei Guo, Jawad Fazal, David G. Mutch, Samuel A. Wickline, Hua Pan, Katherine C. Fuh Jan 2019

P5rhh Nanoparticle-Mediated Delivery Of Axl Sirna Inhibits Metastasis Of Ovarian And Uterine Cancer Cells In Mouse Xenografts, Kathryn A. Mills, Jeanne M. Quinn, S. Tanner Roach, Marguerite Palisoul, Mai Nguyen, Hollie Noia, Lei Guo, Jawad Fazal, David G. Mutch, Samuel A. Wickline, Hua Pan, Katherine C. Fuh

Open Access Publications

No abstract provided.


Chd4 Regulates The Dna Damage Response And Rad51 Expression In Glioblastoma, Lisa D. Mckenzie, John W. Leclair, Kayla N. Miller, Averey D. Strong, Hilda L. Chan, Edward L. Oates, Keith L. Ligon, Cameron W. Brennan, Milan G. Chheda Jan 2019

Chd4 Regulates The Dna Damage Response And Rad51 Expression In Glioblastoma, Lisa D. Mckenzie, John W. Leclair, Kayla N. Miller, Averey D. Strong, Hilda L. Chan, Edward L. Oates, Keith L. Ligon, Cameron W. Brennan, Milan G. Chheda

Open Access Publications

No abstract provided.


Evidence For Altered Neurodevelopment And Neurodegeneration In Wolfram Syndrome Using Longitudinal Morphometry, Heather M. Lugar, Jonathan M. Koller, Jerrel Rutlin, Sarah A. Eisenstein, Olga Neyman, Anagha Narayanan, Ling Chen, Joshua S. Shimony, Tamara Hershey Jan 2019

Evidence For Altered Neurodevelopment And Neurodegeneration In Wolfram Syndrome Using Longitudinal Morphometry, Heather M. Lugar, Jonathan M. Koller, Jerrel Rutlin, Sarah A. Eisenstein, Olga Neyman, Anagha Narayanan, Ling Chen, Joshua S. Shimony, Tamara Hershey

Open Access Publications

No abstract provided.


Genome Organization Of Canada Goose Coronavirus, A Novel Species Identified In A Mass Die-Off Of Canada Geese, Amber Papineau, Yohannes Berhane, Todd N. Wylie, Kristine M. Wylie, Samuel Sharpe, Oliver Lung Jan 2019

Genome Organization Of Canada Goose Coronavirus, A Novel Species Identified In A Mass Die-Off Of Canada Geese, Amber Papineau, Yohannes Berhane, Todd N. Wylie, Kristine M. Wylie, Samuel Sharpe, Oliver Lung

Open Access Publications

No abstract provided.


The Bin1 Rs744373 Snp Is Associated With Increased Tau-Pet Levels And Impaired Memory, N Franzmeier, A Rubinski, J Neitzel, M Ewers, John Morris, Marcus Raichle, David Holtzman, Nigel J. Cairns, Erin Householder, Lisa Taylor-Reinwald, Beau Ances, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, Angela Oliver Jan 2019

The Bin1 Rs744373 Snp Is Associated With Increased Tau-Pet Levels And Impaired Memory, N Franzmeier, A Rubinski, J Neitzel, M Ewers, John Morris, Marcus Raichle, David Holtzman, Nigel J. Cairns, Erin Householder, Lisa Taylor-Reinwald, Beau Ances, Maria Carroll, Sue Leon, Mark A. Mintun, Stacy Schneider, Angela Oliver

Open Access Publications

No abstract provided.


Prediction Of Functional Microrna Targets By Integrative Modeling Of Microrna Binding And Target Expression Data, Weijun Liu, Xiaowei Wang Jan 2019

Prediction Of Functional Microrna Targets By Integrative Modeling Of Microrna Binding And Target Expression Data, Weijun Liu, Xiaowei Wang

Open Access Publications

No abstract provided.


Defining A Murine Ovarian Cancer Model For The Evaluation Of Conditionally-Replicative Adenovirus (Crad) Virotherapy Agents, Rebeca Gonzalez-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer, David T. Curiel Jan 2019

Defining A Murine Ovarian Cancer Model For The Evaluation Of Conditionally-Replicative Adenovirus (Crad) Virotherapy Agents, Rebeca Gonzalez-Pastor, Ahmad Mohammad Ashshi, Adel Galal El-Shemi, Igor P. Dmitriev, Elena A. Kashentseva, Zhi Hong Lu, S. Peter Goedegebuure, Osvaldo L. Podhajcer, David T. Curiel

Open Access Publications

No abstract provided.


Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate But Does Not Change Cardiomyocyte Number In Infant Mice, Tongtong Cao, Daniela Liccardo, Ryan Lacanna, Xiaoying Zhang, Rong Lu, Brian N. Finck, Tani Leigh, Xiongwen Chen, Konstantinos Drosatos, Ying Tian Jan 2019

Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate But Does Not Change Cardiomyocyte Number In Infant Mice, Tongtong Cao, Daniela Liccardo, Ryan Lacanna, Xiaoying Zhang, Rong Lu, Brian N. Finck, Tani Leigh, Xiongwen Chen, Konstantinos Drosatos, Ying Tian

Open Access Publications

No abstract provided.


The Macaque Cerebellar Flocculus Outputs A Forward Model Of Eye Movement, Gyutae Kim, Jean Laurens, Tatyana A. Yakusheva, Pablo M. Blazquez Jan 2019

The Macaque Cerebellar Flocculus Outputs A Forward Model Of Eye Movement, Gyutae Kim, Jean Laurens, Tatyana A. Yakusheva, Pablo M. Blazquez

Open Access Publications

No abstract provided.


Psychosocial Moderation Of Polygenic Risk For Cannabis Involvement: The Role Of Trauma Exposure And Frequency Of Religious Service Attendance, Jacquelyn L. Meyers, Emma C. Johnson, Vivia V. Mccutcheon, Kathleen K. Bucholz, Arpana Agrawal, Et Al. Jan 2019

Psychosocial Moderation Of Polygenic Risk For Cannabis Involvement: The Role Of Trauma Exposure And Frequency Of Religious Service Attendance, Jacquelyn L. Meyers, Emma C. Johnson, Vivia V. Mccutcheon, Kathleen K. Bucholz, Arpana Agrawal, Et Al.

Open Access Publications

No abstract provided.


Achieving Tight Control Of A Photoactivatable Cre Recombinase Gene Switch: New Design Strategies And Functional Characterization In Mammalian Cells And Rodent, Kyle Meador, Christina L. Wysoczynski, Aaron J. Norris, Jason Aoto, Michael R. Bruchas, Chandra L. Tucker Jan 2019

Achieving Tight Control Of A Photoactivatable Cre Recombinase Gene Switch: New Design Strategies And Functional Characterization In Mammalian Cells And Rodent, Kyle Meador, Christina L. Wysoczynski, Aaron J. Norris, Jason Aoto, Michael R. Bruchas, Chandra L. Tucker

Open Access Publications

No abstract provided.


Zbtb32 Restrains Antibody Responses To Murine Cytomegalovirus Infections, But Not Other Repetitive Challenges, Arijita Jash, You W. Zhou, Diana K. Gerardo, Tyler J. Ripperger, Bijal A. Parikh, Sytse Piersma, Deepa R. Jamwal, Pawel R. Kiela, Adrianus C. M. Boon, Wayne M. Yokoyama, Chyi S. Hsieh, Deepta Bhattacharya Jan 2019

Zbtb32 Restrains Antibody Responses To Murine Cytomegalovirus Infections, But Not Other Repetitive Challenges, Arijita Jash, You W. Zhou, Diana K. Gerardo, Tyler J. Ripperger, Bijal A. Parikh, Sytse Piersma, Deepa R. Jamwal, Pawel R. Kiela, Adrianus C. M. Boon, Wayne M. Yokoyama, Chyi S. Hsieh, Deepta Bhattacharya

Open Access Publications

No abstract provided.


Blending Insights From Implementation Science And The Social Sciences To Mitigate Inequities In Screening For Hereditary Cancer Syndromes, Laura Senier, Colleen M Mcbride, Alex T Ramsey, Vence L Bonham, David A Chambers Jan 2019

Blending Insights From Implementation Science And The Social Sciences To Mitigate Inequities In Screening For Hereditary Cancer Syndromes, Laura Senier, Colleen M Mcbride, Alex T Ramsey, Vence L Bonham, David A Chambers

Open Access Publications

Genomic screening to identify people at high risk for adult-onset hereditary conditions has potential to improve population health. However, if not equitably accessible, genomics-informed screening programs will exacerbate existing health inequities or give rise to new ones. To realize the disease prevention potential of these screening tools, we need strategies to broaden their reach. We propose a conceptual framework that merges insights from implementation science and sociological research on health inequities. Our framework does three things: first, it broadens the arenas of action beyond those typically addressed in implementation science frameworks; second, it argues for recruiting more diverse partners to …


Association Of Polygenic Liability For Alcohol Dependence And Eeg Connectivity In Adolescence And Young Adulthood, Jacquelyn L. Meyers, Emma C Johnson, Arpana Agrawal, Et Al Jan 2019

Association Of Polygenic Liability For Alcohol Dependence And Eeg Connectivity In Adolescence And Young Adulthood, Jacquelyn L. Meyers, Emma C Johnson, Arpana Agrawal, Et Al

Open Access Publications

Differences in the connectivity of large-scale functional brain networks among individuals with alcohol use disorders (AUD), as well as those at risk for AUD, point to dysfunctional neural communication and related cognitive impairments. In this study, we examined how polygenic risk scores (PRS), derived from a recent GWAS of DSM-IV Alcohol Dependence (AD) conducted by the Psychiatric Genomics Consortium, relate to longitudinal measures of interhemispheric and intrahemispheric EEG connectivity (alpha, theta, and beta frequencies) in adolescent and young adult offspring from the Collaborative Study on the Genetics of Alcoholism (COGA) assessed between ages 12 and 31. Our findings indicate that …


Contribution And Interaction Of Shiga Toxin Genes To Escherichia Coli O157:H7 Virulence, Gillian A M Tarr, Taryn Stokowski, Smriti Shringi, Phillip I Tarr, Stephen B Freedman, Hanna N Oltean, Peter M Rabinowitz, Linda Chui Jan 2019

Contribution And Interaction Of Shiga Toxin Genes To Escherichia Coli O157:H7 Virulence, Gillian A M Tarr, Taryn Stokowski, Smriti Shringi, Phillip I Tarr, Stephen B Freedman, Hanna N Oltean, Peter M Rabinowitz, Linda Chui

Open Access Publications

No abstract provided.


Role Of Apd-Ribosylation In Bone Health And Disease, Chun Wang, Gabriel Mbalaviele Jan 2019

Role Of Apd-Ribosylation In Bone Health And Disease, Chun Wang, Gabriel Mbalaviele

Open Access Publications

The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD


Transdermal Fluorescence Detection Of A Dual Fluorophore System For Noninvasive Point-Of-Care Gastrointestinal Permeability Measurement, Richard B Dorshow, J R Johnson, Martin P Debreczeny, I Rochelle Riley, Jeng-Jong Shieh, Thomas E Rogers, Carla Hall-Moore, Nurmohammad Shaikh, L Colleen Rouggly-Nickless, Phillip I Tarr Jan 2019

Transdermal Fluorescence Detection Of A Dual Fluorophore System For Noninvasive Point-Of-Care Gastrointestinal Permeability Measurement, Richard B Dorshow, J R Johnson, Martin P Debreczeny, I Rochelle Riley, Jeng-Jong Shieh, Thomas E Rogers, Carla Hall-Moore, Nurmohammad Shaikh, L Colleen Rouggly-Nickless, Phillip I Tarr

Open Access Publications

The intestinal mucosal barrier prevents macromolecules and pathogens from entering the circulatory stream. Tight junctions in this barrier are compromised in inflammatory bowel diseases, environmental enteropathy, and enteric dysfunction. Dual sugar absorption tests are a standard method for measuring gastrointestinal integrity, however, these are not clinically amenable. Herein, we report on a dual fluorophore system and fluorescence detection instrumentation for which gastrointestinal permeability is determined in a rat small bowel disease model from the longitudinal measured transdermal fluorescence of each fluorophore. This fluorophore technology enables a specimen-free, noninvasive, point-of-care gastrointestinal permeability measurement which should be translatable to human clinical studies.


Metabolically Healthy Obesity: Facts And Fantasies, Gordon I Smith, Bettina Mittendorfer, Samuel Klein Jan 2019

Metabolically Healthy Obesity: Facts And Fantasies, Gordon I Smith, Bettina Mittendorfer, Samuel Klein

Open Access Publications

Although obesity is typically associated with metabolic dysfunction and cardiometabolic diseases, some people with obesity are protected from many of the adverse metabolic effects of excess body fat and are considered "metabolically healthy." However, there is no universally accepted definition of metabolically healthy obesity (MHO). Most studies define MHO as having either 0, 1, or 2 metabolic syndrome components, whereas many others define MHO using the homeostasis model assessment of insulin resistance (HOMA-IR). Therefore, numerous people reported as having MHO are not metabolically healthy, but simply have fewer metabolic abnormalities than those with metabolically unhealthy obesity (MUO). Nonetheless, a small …


Mechanism Of Microtubule Plus-End Tracking By The Plant-Specific Spr1 Protein And Its Development As A Versatile Plus-End Marker, Rachappa Balkunde, Layla Foroughi, Eric Ewan, Ryan Emenecker, Valeria Cavalli, Ram Dixit Jan 2019

Mechanism Of Microtubule Plus-End Tracking By The Plant-Specific Spr1 Protein And Its Development As A Versatile Plus-End Marker, Rachappa Balkunde, Layla Foroughi, Eric Ewan, Ryan Emenecker, Valeria Cavalli, Ram Dixit

Open Access Publications

No abstract provided.


Structural And Functional Evidence That Lipoprotein Lpqn Supports Cell Envelope Biogenesis In Mycobacterium Tuberculosis, Geoff C. Melly, Haley Stokas, Jennifer L. Dunaj, Fong Fu Hsu, Malligarjunan Rajavel, Chih-Chia Su, Edward W. Yu, Georgiana E. Purdy Jan 2019

Structural And Functional Evidence That Lipoprotein Lpqn Supports Cell Envelope Biogenesis In Mycobacterium Tuberculosis, Geoff C. Melly, Haley Stokas, Jennifer L. Dunaj, Fong Fu Hsu, Malligarjunan Rajavel, Chih-Chia Su, Edward W. Yu, Georgiana E. Purdy

Open Access Publications

No abstract provided.


Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang Jan 2019

Myeloid Acat1/Soat1 Ko Attenuates Pro-Inflammatory Responses In Macrophages And Protects Against Atherosclerosis In A Model Of Advanced Lesions, Elaina M. Melton, Haibo Li, Jalen Benson, Paul Sohn, Li-Hao Huang, Bao-Liang Song, Bo-Liang Li, Catherine C.Y. Chang, Ta-Yuan Chang

Open Access Publications

No abstract provided.


Phosphorylation Of The Hcn Channel Auxiliary Subunit Trip8b Is Altered In An Animal Model Of Temporal Lobe Epilepsy And Modulates Channel Function, Kendall M. Foote, Kyle A. Lyman, Ye Han, Ioannis E. Michailidis, Robert J. Heuermann, Danielle Mandikian, James S. Trimmer, Geoffrey T. Swanson, Dane M. Chetkovich Jan 2019

Phosphorylation Of The Hcn Channel Auxiliary Subunit Trip8b Is Altered In An Animal Model Of Temporal Lobe Epilepsy And Modulates Channel Function, Kendall M. Foote, Kyle A. Lyman, Ye Han, Ioannis E. Michailidis, Robert J. Heuermann, Danielle Mandikian, James S. Trimmer, Geoffrey T. Swanson, Dane M. Chetkovich

Open Access Publications

No abstract provided.


Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al Jan 2019

Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al

Open Access Publications

No abstract provided.


Developmental Pathology Of Congenital Kidney And Urinary Tract Anomalies, Sanjay Jain, Feng Chen Jan 2019

Developmental Pathology Of Congenital Kidney And Urinary Tract Anomalies, Sanjay Jain, Feng Chen

Open Access Publications

No abstract provided.


Card And Rbpa Modify The Kinetics Of Initial Transcription And Slow Promoter Escape Of The Mycobacterium Tuberculosis Rna Polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, Eric A. Galburt Jan 2019

Card And Rbpa Modify The Kinetics Of Initial Transcription And Slow Promoter Escape Of The Mycobacterium Tuberculosis Rna Polymerase, Drake Jensen, Ana R. Manzano, Christina L. Stallings, Eric A. Galburt

Open Access Publications

No abstract provided.


Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman Jan 2019

Are The Intrinsically Disordered Linkers Involved In Ssb Binding To Accessory Proteins?, Min Kyung Shinn, Alexander G. Kozlov, Bihn Nguyen, Wlodek M. Bujalowski, Timothy M. Lohman

Open Access Publications

No abstract provided.