Digital Commons Network^™

Stunting Is Preceded By Intestinal Mucosal Damage And Microbiome Changes And Is Associated With Systemic Inflammation In A Cohort Of Peruvian Infants, Mara Zambruni, Theresa J Ochoa, Anoma Somasunderam, Miguel M Cabada, Maria L Morales, Makedonka Mitreva, Bruce A Rosa, Gonzalo J Acosta, Natalia I Vigo, Maribel Riveros, Sara Arango, David Durand, Maitreyee N Berends, Peter Melby, Netanya S Utay

Open Access Publications

Stunting, defined as height-for-age

Heterogeneity Diffusion Imaging Of Gliomas: Initial Experience And Validation, Qing Wang, Gloria J. Guzmán Pérez-Carrillo, Maria Rosana Ponisio, Pamela Lamontagne, Sonika Dahiya, Daniel S. Marcus, Mikhail Milchenko, Joshua Shimony, Jingxia Liu, Gengsheng Chen, Amber Salter, Parinaz Massoumzadeh, Michelle M. Miller-Thomas, Keith M. Rich, Jonathan Mcconathy, Tammie L. S. Benzinger, Yong Wang

Open Access Publications

OBJECTIVES: Primary brain tumors are composed of tumor cells, neural/glial tissues, edema, and vasculature tissue. Conventional MRI has a limited ability to evaluate heterogeneous tumor pathologies. We developed a novel diffusion MRI-based method-Heterogeneity Diffusion Imaging (HDI)-to simultaneously detect and characterize multiple tumor pathologies and capillary blood perfusion using a single diffusion MRI scan.

METHODS: Seven adult patients with primary brain tumors underwent standard-of-care MRI protocols and HDI protocol before planned surgical resection and/or stereotactic biopsy. Twelve tumor sampling sites were identified using a neuronavigational system and recorded for imaging data quantification. Metrics from both protocols were compared between World Health …

Categorical Encoding Of Decision Variables In Orbitofrontal Cortex, Arno Onken, Jue Xie, Stefano Panzeri, Camillo Padoa-Schioppa

Open Access Publications

No abstract provided.

Glutathione Synthesis Contributes To Virulence Of Streptococcus Agalactiae In A Murine Model Of Sepsis, Elizabeth A Walker, Gary C Port, Michael G Caparon, Blythe E Janowiak

Open Access Publications

No abstract provided.

Congenital Aortic Valve Stenosis, Gautam K Singh

Open Access Publications

Aortic valve stenosis in children is a congenital heart defect that causes fixed form of hemodynamically significant left ventricular outflow tract obstruction with progressive course. Neonates and young infants who have aortic valve stenosis, usually develop congestive heart failure. Children and adolescents who have aortic valve stenosis, are mostly asymptomatic, although they may carry a small but significant risk of sudden death. Transcatheter or surgical intervention is indicated for symptomatic patients or those with moderate to severe left ventricular outflow tract obstruction. Many may need reintervention.

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Lindsay L. Peterson, Et Al

Open Access Publications

No abstract provided.

The Children's Respiratory And Environmental Workgroup (Crew) Birth Cohort Consortium: Design, Methods, And Study Population, James E. Gern, Leonard B. Bacharier, Et Al

Open Access Publications

No abstract provided.

Building A Culture Of Health And Well-Being At Merck, Cathryn E. Gunther, Virginia Peddicord, Joseph Kozlowski, Yi Li, Danielle Menture, Raymond Fabius, Sharon Glave Frazee, Peter J. Nigro

Open Access Publications

No abstract provided.

Prevalence And Impact Of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living In The Us And Canada, David R. Mcgivern, Hsing-Hua S. Lin, Junyao Wang, Tiffany Benzine, Henry L.A Janssen, Mandana Khalili, Mauricio Lisker-Melman, Robert J. Fontana, Steven H. Belle, Michael W. Fried

Open Access Publications

No abstract provided.

Washu Epigenome Browser Update 2019, Daofeng Li, Silas Hsu, Deepak Purushotham, Renee L. Sears, Ting Wang

Open Access Publications

No abstract provided.

The Piranha Genome Provides Molecular Insight Associated To Its Unique Feeding Behavior, Manfred Schartl, Susanne Kneitz, Helene Volkoff, Mateus Adolfi, Cornelia Schmidt, Petra Fischer, Patrick Minx, Chad Tomlinson, Axel Meyer, Wesley C. Warren

Open Access Publications

No abstract provided.

Influence Of Diagnostic Method On Outcomes In Phase 3 Clinical Trials Of Bezlotoxumab For The Prevention Of Recurrent Clostridioides Difficile Infection: A Post Hoc Analysis Of Modify I/Ii, Mark H. Wilcox, Galia Rahav, Erik R. Dubberke, Lori Gabryelski, Kerrie Davies, Claire Berry, Karen Eves, Misoo C. Ellison, Dalya Guris, Mary Beth Dorr

Open Access Publications

No abstract provided.

Early Increase Of Csf Strem2 In Alzheimer's Disease Is Associated With Tau Related-Neurodegeneration But Not With Amyloid-Β Pathology, Marc Suarez-Calvet, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Et Al

Open Access Publications

No abstract provided.

U.S. Adolescent And Adult Women's Experiences Accessing And Using Toilets In Schools, Workplaces, And Public Spaces: A Multi-Site Focus Group Study To Inform Future Research In Bladder Health, Deepa R Camenga, Sonya S Brady, Cecilia T Hardacker, Beverly R Williams, Jeni Hebert-Beirne, Aimee S James, Kathryn Burgio, Jesse Nodora, Jean F Wyman, Amanda Berry, Lisa K Low, Prevention Of Lower Urinary Tract Symptoms (Plus) Research Consortium

Open Access Publications

The World Health Organization recognizes access to clean and safe toilets as crucial for public health. This study explored U.S. adolescent and adult cisgender women's lived experiences accessing toilets in schools, workplaces, and public spaces. As part of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, we conducted 44 focus groups with female participants (n = 360; ages 11-93). Focus groups were stratified by age (11-14, 15-17, 18-25, 26-44, 45-64, 65+) and conducted across 7 geographically diverse U.S. sites from July 2017-April 2018. Using a transdisciplinary approach, we conducted conventional qualitative coding informed by our PLUS conceptual framework …

Me-Class2 Reveals Context Dependent Regulatory Roles For 5-Hydroxymethylcytosine, Christopher E. Schlosberg, Dennis Y. Wu, Harrison W. Gabel, John R. Edwards

Open Access Publications

No abstract provided.

Aebp1 Down Regulation Induced Cell Death Pathway Depends On Pten Status Of Glioma Cells, Swati Sinha, Arun Renganathan, Prathima B. Nagendra, Vasudeva Bhat, Brian Steve Mathew, Manchanahalli R. Satyanarayana Rao

Open Access Publications

No abstract provided.

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.

Restoring Public Trust In Scientific Research By Reducing Conflicts Of Interest, Arthur M Feldman, Douglas L Mann

Open Access Publications

No abstract provided.

International Meta-Analysis Of Ptsd Genome-Wide Association Studies Identifies Sex- And Ancestry-Specific Genetic Risk Loci, Laura J. Bierut, Elliot C. Nelson, John P. Rice, Nancy L. Saccone, Andrew C. Heath, Et Al.

Open Access Publications

No abstract provided.

Optical Resolution Photoacoustic Microscopy Of Ovary And Fallopian Tube, Bin Rao, Xiandong Leng, Yifeng Zeng, Yixiao Lin, Ruimin Chen, Qifa Zhou, Andrea R. Hagemann, Lindsay M. Kuroki, Carolyn K. Mccourt, David G. Mutch, Matthew A. Powell, Ian S. Hagemann, Quing Zhu

Open Access Publications

No abstract provided.

Fast Objective Coupled Planar Illumination Microscopy, Cody J. Greer, Timothy E. Holy

Open Access Publications

No abstract provided.

Abscopal Effect Following Proton Beam Radiotherapy In A Patient With Inoperable Metastatic Retroperitoneal Sarcoma, Randall J Brenneman, Nima Sharifai, Benjamin Fischer-Valuck, Comron Hassanzadeh, Jeffrey Guzelian, John S A Chrisinger, Jeff M Michalski, Peter Oppelt, Brian C Baumann

Open Access Publications

No abstract provided.

Shared Autonomic Pathways Connect Bone Marrow And Peripheral Adipose Tissues Across The Central Neuraxis, Natalie K Y Wee, Madelyn R Lorenz, Yusuf Bekirov, Mark F Jacquin, Erica L Scheller

Open Access Publications

Bone marrow adipose tissue (BMAT) is increased in both obesity and anorexia. This is unique relative to white adipose tissue (WAT), which is generally more attuned to metabolic demand. It suggests that there may be regulatory pathways that are common to both BMAT and WAT and also those that are specific to BMAT alone. The central nervous system (CNS) is a key mediator of adipose tissue function through sympathetic adrenergic neurons. Thus, we hypothesized that central autonomic pathways may be involved in BMAT regulation. To test this, we first quantified the innervation of BMAT by tyrosine hydroxylase (TH) positive nerves …

Perturbing Cohesin Dynamics Drives Mre11 Nuclease-Dependent Replication Fork Slowing, Denisse Carvajal-Maldonado, Andrea K. Byrum, Jessica Jackson, Sarah Wessel, Delphine Lemacon, Laure Guitton-Sert, Annabel Quinet, Stephanie Tirman, Simona Graziano, Jean-Yves Masson, David Cortez, Susana Gonzalo, Nima Mosammaparast, Alessandro Vindigni

Open Access Publications

No abstract provided.

Spatiotemporal Dynamics Of Multidrug Resistant Bacteria On Intensive Care Unit Surfaces, Alaric W. D'Souza, Robert F. Potter, Meghan Wallace, Angela Shupe, Sanket Patel, Xiaoqing Sun, Danish Gul, Jennie H. Kwon, Saadia Andleeb, Carey-Ann D. Burnham, Gautam Dantas

Open Access Publications

No abstract provided.

Five-Year Outcomes Of The S1106 Study Of R-Hyper-Cvad Vs R-Bendamustine In Transplant-Eligible Patients With Mantle Cell Lymphoma, Manali Kamdar, Hongli Li, Robert W. Chen, Lisa M. Rimsza, Michael L. Leblanc, Timothy S. Fenske, Thomas C. Shea, Paul M. Barr, Tycel J. Phillips, John P. Leonard, Brad S. Kahl, Jonathan W. Friedberg, Sonali M. Smith

Open Access Publications

No abstract provided.

Evaluating Park Use And Satisfaction: The Case Of Trojan Park In St. Louis Missouri, Diana C. Parra, Alexandria Van Zandt, Peter Wang, Micah Goodman, Janardan Abhishek, Debra Haire-Joshu, Ross C. Brownson

Open Access Publications

No abstract provided.

Metabolomic Networks Connect Host-Microbiome Processes To Human Clostridioides Difficile Infections, John I. Robinson, William H. Weir, Jan R. Crowley, Tiffany Hink, Kimberly A. Reske, Jennie H. Kwon, Carey-Ann D. Burnham, Erik R. Dubberke, Peter J. Mucha, Jeffrey P. Henderson

Open Access Publications

No abstract provided.

Hyper-Activation Of Stat3 Sustains Progression Of Non-Papillary Basal-Type Bladder Cancer Via Fosl1 Regulome, William Vermi, Et Al

Open Access Publications

No abstract provided.

Inhibition Of E-Selectin (Gmi-1271) Or E-Selectin Together With Cxcr4 (Gmi-1359) Re-Sensitizes Multiple Myeloma To Therapy, Barbara Muz, Feda Azab, Mark Fiala, Justin King, Daniel Kohnen, William E. Fogler, Ted Smith, John L. Magnani, Ravi Vij, Abdel Kareem Azab

Open Access Publications

No abstract provided.