Digital Commons Network^™

The Characterization Of Alzheimer’S Disease And The Development Of Early Detection Paradigms: Insights From Nosology, Biomarkers And Machine Learning, Isabel Milano

CMC Senior Theses

Alzheimer’s Disease (AD) is the only condition in the top ten leading causes of death for which we do not have an effective treatment that prevents, slows, or stops its progression. Our ability to design useful interventions relies on (a) increasing our understanding of the pathological process of AD and (b) improving our ability for its early detection. These goals are impeded by our current reliance on the clinical symptoms of AD for its diagnosis. This characterizations of AD often falsely assumes a unified, underlying AD-specific pathology for similar presentations of dementia that leads to inconsistent diagnoses. It also hinges …

Global Consciousness: A Functionalist Neurophilosophical Perspective, Connor C. Bowen

CMC Senior Theses

The purpose of this thesis is to explore a thought-provoking consequence of the functionalist theory of mind. Given the current organizational structure of Earth and field theories of consciousness in neuroscience, Earth is probably conscious. The argument is explored through an examination of the current organizational structure of Earth and field theories of consciousness in neuroscience, which leads to the conclusion that Earth is conscious. Various theories of mind have been proposed by neuroscientists and philosophers alike in an attempt to qualify what consciousness is and what provides the basis for consciousness to occur. Support, in the form of data …

Exploring Obesity, Adhd Severity, And Disordered Eating Behavior Among College Students, Carolina Rozario

Dissertations and Theses

Obesity is a global epidemic because of the potential health risks. There is evidence that many obese individuals manifest persistent ADHD symptoms, and that both disorders increase risk for binge eating. Nevertheless, how obesity and ADHD may increase risk for binge eating work is unclear. Neuropsychological deficits are common to all disorders and may help to explain the relations observed. The aim of this study was to explore whether neuropsychological dysfunction, especially inhibitory control weaknesses, moderate the association between greater BMI and more severe ADHD and disordered eating behaviors. Thirty-nine undergraduate college students (27 females; Mean age = 20.77, SD …

Pharmaceutical Drugs Of Uncertain Value, Lifecycle Regulation At The Us Food And Drug Administration, And Institutional Incumbency, Matthew Herder

Articles, Book Chapters, & Popular Press

Policy Points

• The US Food and Drug Administration (FDA) has in recent years allowed onto the market several drugs with limited evidence of safety and effectiveness, provided that manufacturers agree to carry out additional studies while the drugs are in clinical use.
• Studies suggest that these postmarketing requirements (PMRs) frequently lack transparency, are subject to delays, and fail to answer the questions of greatest clinical importance. Yet, none of the literature speaks directly to the challenges that the FDA—as a regulatory institution—encounters in enforcing PMRs.
• Through a series of interviews with FDA leadership, this article analyzes and situates those challenges …

The Gender Injustice Of Abortion Laws, Joanna Erdman

Articles, Book Chapters, & Popular Press

This commentary is a response to Katarzyna Sękowska-Kozłowska’s article on the treatment of criminal abortion laws as a form of sex discrimination under international human rights law through a study of the communications, Mellet v. Ireland and Whelan v. Ireland. The commentary offers a reading of these communications, and specifically the sex discrimination analysis premised on inequalities of treatment among women, as an engagement with the structural discrimination that characterises abortion laws, and asa radical vision for gender justice under international human rights law.

Responding Restoratively To Student Misconduct And Professional Regulation – The Case Of Dalhousie Dentistry, Jennifer Llewellyn

Articles, Book Chapters, & Popular Press

The 2015 restorative justice process at Dalhousie University’s Faculty of Dentistry is a case study that reveals the connection at conceptual and practical levels between restorative justice and responsive regulation as common expressions of relational theory and practice. Their relationship is clearest when, as in this case, issues are understood in their full contexts and circumstances require a widening of the circle of issues and parties. At this scale the complexity of the situation and the need for responsive interventions capable of supporting and sustaining a just relationship is revealed.

The Role Of International Environmental Law In Canadian Courts, Phillip Saunders

Articles, Book Chapters, & Popular Press

Book Description

Canadian environmental law is a dynamic and exciting area that is playing an increasingly important role in furthering sustainable development policy. Environmental law has distinctive relevant principles, operating procedures, implications, and importance in comparison with other areas of law, and these distinctions must be appreciated both within the legal community and by all those who are concerned with the way that courts handle environmental cases.

Environment in the Courtroom provides extensive insight into Canadian environmental law. Covering key environmental concepts and the unique nature of environmental damage, environmental prosecutions, sentencing and environmental offences, evidentiary issues in environmental processes …

Impacts Of The Changing Ocean-Sea Ice System On The Key Forage Fish Arctic Cod (Boreogadus Saida) And Subsistence Fisheries In The Western Canadian Arctic—Evaluating Linked Climate, Ecosystem And Economic (Cee) Models, Nadja S. Steiner, William W. L. Cheung, Andres M. Cisneros-Montemayor, Helen Drost, Hakase Hayashida, Carie Hoover, Jen Lam, Tessa Sou, U. Rashid Sumaila, Paul Suprenand, Travis C. Tai, David Vanderzwaag

Articles, Book Chapters, & Popular Press

This study synthesizes results from observations, laboratory experiments and models to showcase how the integration of scientific methods and indigenous knowledge can improve our understanding of (a) past and projected changes in environmental conditions and marine species; (b) their effects on social and ecological systems in the respective communities; and (c) support management and planning tools for climate change adaptation and mitigation. The study links climate-ecosystem-economic (CEE) models and discusses uncertainties within those tools. The example focuses on the key forage species in the Inuvialuit Settlement Region (Western Canadian Arctic), i.e., Arctic cod (Boreogadus saida). Arctic cod can be …

Advancing Research For The Management Of Long-Lived Species: A Case Study On The Greenland Shark, Jena E. Edwards, Elizabeth Hiltz, Franziska Broell, Peter G. Bushnell, Steven E. Campana, Jørgen S. Christiansen, Brynn M. Devine, Jeffrey J. Gallant, Kevin J. Hedges, M. Aaron Macneil, Bailey C. Mcmeans, Julius Nielsen, Kim Præbel, Gregory B. Skomal, John F. Steffensen, Ryan P. Walter, Yuuki Y. Watanabe, David Vanderzwaag, Nigel E. Hussey

Articles, Book Chapters, & Popular Press

Long-lived species share life history traits such as slow growth, late maturity, and low fecundity, which lead to slow recovery rates and increase a population’s vulnerability to disturbance. The Greenland shark (Somniosus microcephalus) has recently been recognized as the world’s longest-lived vertebrate, but many questions regarding its biology, physiology, and ecology remain unanswered. Here we review how current and future research will fill knowledge gaps about the Greenland shark and provide an overall framework to guide research and management priorities for this species. Key advances include the potential for specialized aging techniques and demographic studies to shed light …

Healthy Skepticism: The Relationship Between Funding Source And Conclusion In Nutrition-Related Scientific Articles On Saturated Fat, Lili Muskal

CMC Senior Theses

Recently published scientific articles have led to mixed nutritional advice on dietary saturated fatty acids. Lesser et. al (2007) identified that mixed conclusions in scientific articles on sweetened beverages might be attributed industry funding, as articles funded by the beverage industry are four to eight times more likely to report conclusions in favor of the sponsor’s products. This thesis applies Lesser’s methods to determine whether industry funding influences the inconsistent conclusions on saturated fatty acids. This thesis analyzes 100 articles on foods high in dietary saturated fatty acids. While studies with food industry funding are more likely to produce favorable …

The Use Of Personality Testing In Personnel Selection, Riya Kumar

CMC Senior Theses

Research has shown that more than 45% of American companies are opting to integrate personality tests in their recruitment processes. Given this surge in personality testing, this thesis examines whether personality testing is a valid predictor of job-fit and performance in the context of personnel selection. A large proportion of this paper is focused upon the Big-Five factor model, its limitations, and derivative tests of the model. The impact of technology upon personality testing is also discussed as an emerging field. By tracing and examining the history of personality testing to current day, I have found that personality tests are …

How Organizations And Their Brands Leverage Marketing Partnerships To Enhance Their Success: The Guidelines To Navigating Both Reaffirming And Repositioning Strategic Partnerships, Remi A. Edwards

CMC Senior Theses

Understanding the different factors, influencers, and outcomes that form a successful brand partnership allow for marketers to make informed decisions that benefit their company. This paper provides a comprehensive review of the literature regarding partnership marketing and issues a set of guidelines for marketers to strategically market their brand by way of collaboration. With two distinct strategic frameworks, reaffirming partnerships and repositioning partnerships, this paper seeks illustrate the efficacy of brand collaboration and how to achieve success based on varying brand goals.

The Changing Nature Of Work, Leadership, And Organizational Culture In Future Ready Organizations, Saloni Dhir

CMC Senior Theses

Abstract

The relationship between individual and organizational performance is a key challenge for leaders in modern organizations, especially with the current disruption in technology and innovation. This thesis is a literature review and compilation of the relevant empirical evidence on various processes of industrial groups and organizational characteristics such as the changing nature of work, leadership, and company culture in detail. I investigate the complex challenges that millennials and organizations are facing in the current VUCA work environment as well as their potential responses to these changes. I map out the evolution of the concept of work and compare changes …

Are Women Executives Hurting Firm Performance? An Examination Of Gender Diversity On Firm Risk, Performance, And Executive Compensation, Krystal Diane Sung

CMC Senior Theses

In order to assess the continuing imbalance of top executives between genders, I examine the effects of gender diversity within top management teams on firm risk, performance, and executive compensation. Capitalizing on previous analysis, I apply three unique differentiators. First, I utilize current data from 2012 to 2017 from Compustat, CRSP, and ExecuComp. Second, I provide a unique subset view on a firm and individual performance of female CEOs to examine executive compensation. Third, my scope of analysis expands to S&P Composite 1500 companies. I use separate models to estimate the effect of gender diversity on firm risk by examining …

Abstracts 2019: Highlights Of Student Research And Creative Endeavors, Columbus State University

Abstracts: Highlights of Student Research and Creative Endeavors

What follows is a collection of abstracts summarizing the scholarship conducted by undergraduates at Columbus State University during the 20182019 academic year. These projects highlight undergraduates research in a variety of disciplines, ranging from literary analysis to laboratory based sciences. The abstracts represent many ongoing projects on our campus and catalog those that have been published or presented.

This volume begins with projects that have been selected for presentations at international, national, regional and statewide disciplinary conferences. Among them are several that have garnered awards for outstanding undergraduate scholarship. Projects that have received competitive research grants, including our campus Student …

Property Rules For Martian Resources: How The Space Act Of 2015 Increases The Likelihood Of A Single Entity Controlling Access To Mars, Tyler Conte

Journal of Air Law and Commerce

No abstract provided.

Social Cost Of Carbon In Environmental Impact Assessment, Meinhard Doelle

Articles, Book Chapters, & Popular Press

While the social cost of carbon (SCC) has played a prominent role in regulatory decision-making in recent years, use in the environmental impact assessment (EIA) realm has been minimal. This article explores potential roles for SCC in EIA. Using Canada’s proposed new federal impact assessment (IA) regime as a basis, the analysis examines how a jurisdiction could employ SCC to integrate climate change considerations into project-level assessment and decision-making. Potential roles are first discussed in relation to the broad purposes of IA, before focusing on key assessment factors such as consideration of economic costs and benefits, cumulative effects, climate change …

Reducing Return Of Disease Activity In Patients With Relapsing Multiple Sclerosis Transitioned From Natalizumab To Teriflunomide: 12-Month Interim Results Of Teriflunomide Therapy., Stanley Cohan, Keith Edwards, Lindsay Lucas, Tiffany Gervasi-Follmar, Judy O'Connor, Jessica Siuta, Vineetha Kamath, Lore Garten, Chiayi Chen, James Thomas, Kyle E Smoot, Kiren Kresa-Reahl, Kateri Spinelli

Articles, Abstracts, and Reports

Background: Natalizumab is an effective treatment for relapsing multiple sclerosis. Return of disease activity upon natalizumab discontinuance creates the need for follow-up therapeutic strategies.

Objective: To assess the efficacy of teriflunomide following natalizumab discontinuance in relapsing multiple sclerosis patients.

Methods: Clinically stable relapsing multiple sclerosis patients completing 12 or more consecutive months of natalizumab, testing positive for anti-John Cunningham virus antibody, started teriflunomide 14 mg/day, 28 ± 7 days after their final natalizumab infusion. Physical examination, Expanded Disability Status Scale, laboratory assessments, and brain magnetic resonance imaging were performed at screening and multiple follow-up visits.

Results: Fifty-five patients were enrolled …

The Dna Dependent Protein Kinase Catalytic Subunit Maintains Genomic Stability, Brandon Lee Sklavanitis

Graduate Research Theses & Dissertations

GBM is the most common CNS derived malignancy diagnosed each year. The median survival time to date is between 14.6 to 16.7 months for patients suffering from the disease. Clinical trials and research has yet to yield a breakthrough treatment. The invasive nature of GBM to surrounding tissue typically poses a challenge for complete surgical resection of the tumor, and radiotherapy remains a predominant treatment modality. The NHEJ pathway is main repair pathway responsible for repairing lethal radiation damage. As a result, this study used the CRISPR-Cas9 system to genetically engineer two GBM cell lines lacking expression of an essential …

Association Among Dispositional Mindfulness, Attention Control, And Academic Achievement In Children, Dan V. Strissel

Graduate Research Theses & Dissertations

Mindfulness is everywhere. Smartphone applications, self-help books, manualized interventions, and non-profit organizations are but some of the avenues used to illuminate the singular power mindfulness can bestow. Curiously, some of the leading mindfulness researchers, despite their shared agreement of the conferrable benefits once practiced and applied, have professed fundamental disagreements about the nature and development of mindfulness, its measurability as a scientific construct, and whether it can ever be properly dissociated from Buddhist conceptualizations for use in secular contexts. In the case of mindfulness in children, for whom classroom-based manualized interventions have been produced, even less is known than is …

Presence And Characterization Of Microplastics In Drinking (Tap/Bottled) Water And Soft Drinks, Mansurat Golden Abdulmalik Ali

Theses and Dissertations

This study investigates the presence of microplastics in human consumable products using 33 samples; Fifteen tap water samples, nine bottled water and nine soft drink samples, collected and purchased in Grand Forks, ND.

Tap water analysis confirm all samples contain microplastics, majority of which were fibres and fragments with 48.6% and 41.8% abundance. The average concentration was 182 mpp/L (range 66 mpp/L – 472 mpp/L) with 2.5 µm – 3 mm size range. Bottled water and soft drinks were also contaminated with microplastics with an average of 101 mpp/L (range 49 mpp/L – 166 mpp/L) and particle size ranging from …

Review Of Sex Determination In Fish And Reptiles And Estimation Of Sex Ratio Heritability In The Common Snapping Turtle, Kyle Hilliard

Theses and Dissertations

Sex-determining mechanisms in fish and reptiles are incredibly diverse. We first review sex-determination in these groups, including approaches that can be used to identify sex-determining genes and the large body of research showing genetic variation for sex ratio in species with temperature-dependent sex determination (TSD). We then show that sex ratio variation among clutches is due to additive genetic effects in one TSD species, the common snapping turtle. This finding contradicts previous claims that non-genetic maternal factors such as yolk steroid hormones are driving sex determination in this species. Heritable variation for sex determination in the snapping turtle may allow …

Tools For Understanding Static Structure Factors And Their Application To Simulations Of Liquids, Travis Mackoy

Graduate Research Theses & Dissertations

Molecular dynamics (MD) simulations can be used to compute static structure factors (��(��)) and provide an interpretation of the underlying periodic atomic ordering. MD simulations complement experimentally measured ��(��) by allowing qualitative assignment of peaks to various ordering, such as cation-anion ordering in ionic liquids, via decomposition of ��(��) into partial ��(��). Here we present a method for classifying interatomic distances that allows for quantitative peak assignment and visualization of atoms that contribute most to each peak in calculated ��(��) for soft materials. The method is illustrated by investigating ��(��) for the ionic liquid 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl)imide (C4C1pyrrTFSI), which shows two …

Effects Of Different Dual Tasking Modalities On The Standing Balance Performance Of College Students, John Patrick Manning

Graduate Research Theses & Dissertations

Center of pressure (CoP) and related-metrics are widely accepted indicators of balance performance. Traditional indices of balance performance (e.g. sway area) have been seen as incapable of fully characterizing CoP dynamics, therefore newer measures have been used in contemporary literature to characterize regularity, complexity, and dimensionality of CoP signals. A popular method of increasing standing task difficulty is through the addition of a cognitive task, referred to as dual-task. PURPOSE: The present study sought to investigate the potential of a hierarchical attentional difficulty within the dual-task paradigm and to propose way to order those difficulties by examining differences in static …

Students’ Perspectives Regarding Their Emotional Engagement In Middle School Learning Environments, Brendan Joseph Mccormick

Graduate Research Theses & Dissertations

This dissertation examines emotional engagement as a vital component of creating optimal learning environments for mid-adolescent students. Through a qualitative research design, seventh and eighth grade student volunteers from Cornfield Middle School shared perspectives on their emotional engagement experiences in middle school learning environments. Thirty-four students participated in three rounds of data collection—an open-ended survey about flow experiences, a homogeneous focus group discussion, and a follow-up survey. The results from each data collection procedure were coded and arranged into themes of positive and negative emotions experienced in certain academic contexts.

The results show that the CFMS students experienced a range …

Examining The Relationship Between Self-Compassion And Emotion Regulation Strategies Using Ambulatory Assessment Methods, Lindsay Mae Miller

Graduate Research Theses & Dissertations

Self-compassion focuses on how individuals treat themselves during periods of suffering. Overall, self-compassion is positively associated with adaptive mental health outcomes and negatively associated with psychopathology. One potential mechanism by which self-compassion may influence other constructs is emotion regulation. Unfortunately, most research about emotion regulation is conducted using retrospective reporting, meaning that the data are subject to memory biases. Ambulatory assessment methods allow for more frequent sampling, thus decreasing the reliance on recall. Using this methodology, the present study examined how differences in self-compassion were related to emotion regulation in daily life. Contrary to predictions, few ambulatory measures (depression, anxiety, …

Codon-Specific Translation By M1g37 Methylation Of Trna, Ya-Ming Hou, Isao Masuda, Howard Gamper

Department of Biochemistry and Molecular Biology Faculty Papers

Although the genetic code is degenerate, synonymous codons for the same amino acid are not translated equally. Codon-specific translation is important for controlling gene expression and determining the proteome of a cell. At the molecular level, codon-specific translation is regulated by post-transcriptional epigenetic modifications of tRNA primarily at the wobble position 34 and at position 37 on the 3′-side of the anticodon. Modifications at these positions determine the quality of codon-anticodon pairing and the speed of translation on the ribosome. Different modifications operate in distinct mechanisms of codon-specific translation, generating a diversity of regulation that is previously unanticipated. Here we …

Comparative Tumorigenic Amino Acid Starvation And Integrated Stress Responses In Epithelial Vs. Mesenchymal Hcc Cells With Asct2 Or Lat1 Transporter Knockouts, Stephanie Lois Cooper Woodin

Graduate Research Theses & Dissertations

The previously established roles of the amino acid glutamine have recently been expanded to include not only protein and nucleotide synthesis, as well as contributing significantly to energy production via mitochondrial hydrolysis of glutamine to glutamate, but also the role of this molecule in the reductive carboxylation of α-ketoglutarate resulting in carbon atoms used in cell membrane biosynthesis. Additionally, glutamine participates in maintaining glutathione homeostasis as well as regulation of anabolic signaling. Given its central role in anabolic processes, glutamine is preferentially transported into human cancer cells at a significant rate as compared to normal cells. This distinction has prompted …

Bayesian Functional Data Analysis Over Dependent Regions And Its Application For Identification Of Differentially Methylated Regions, Suvo Chatterjee

Graduate Research Theses & Dissertations

Bayesian functional data analysis (BFDA) provides flexible statistical inferences under harsh circumstances such as a large volume of data, considerable measurement errors and missing observations. Considering a sequence of segments and functional data analysis on each segment, where neighboring segments can be dependent, demanding computation is indispensable and analysis is sometimes infeasible for large number of segments. We consider a utilization of BFDA to identify differentially methylated regions (DMRs). Out of numerous existing methodologies to detect DMRs, there still does not exist a standard approach to identify DMRs especially under the assumption of dependency among genomic regions. In this dissertation, …

Behavioral Interference Of Memory Reconsolidation As A Treatment For Post-Traumatic Stress Symptoms, Benjamin Darnell

Graduate Research Theses & Dissertations

Post-traumatic stress disorder (PTSD) is best conceptualized as a failure of the stress response to naturally resolve following trauma exposure (e.g., Orcutt, Bonanno, Hannan, & Miron, 2014). Current treatments are effective for some, but not all who suffer from PTSD (e.g., Bradley, Greene, Russ, Dutra, & Westen, 2005; Lee et al., 2016), and relapse is common (Ursano et al., 2004; Davidson et al., 2001). Considering that PTSD is a memory-based disorder, a treatment that could augment trauma memories has the potential to address the limitations of current interventions. Research on memory suggests that, if a memory is retrieved under the …