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Novel Methods For The Inactivation Of Cruzain For The Prevention And Treatment Of Chagas Disease, Veronica Gonzalez

Open Access Theses & Dissertations

Chagas Disease, also known as American Trypanosomiasis, is endemic to Latin American and is gradually making its way to other countries. The disease is caused by Trypanosoma cruzi, a protozoan parasite that causes lesions and inflammation of organs including the heart, esophagus, and colon. Over 30% of people infected will develop heart disease which can be fatal if untreated. While no vaccine is yet available, research is currently being conducted in finding new treatments for the disease. One target is an enzyme that is believed to help the progression of the disease. Cruzain, a cysteine protease expressed as a pro-enzyme, …

Movimiento Saludable "Movs" Project: Impact On Fruit And Vegetable Intake Using Reflectance Spectroscopy And Relationship With Behavioral Theory Predictors, Karen Marleen Juarez

Open Access Theses & Dissertations

Background. Movimiento Saludable (MOVS), a component of Ciudadanos Comprometidos con la Paz (CCOMPAZ) in Ciudad Juarez, MX is an after-school lifestyle program that was implemented at five schools during 2016 - 2017. The purpose of the MOVS program is to prevent chronic diseases such as obesity and diabetes in children. The MOVS curriculum includes two components: a) physical conditioning through dance, body expression, and free play, and b) nutrition education and healthy meals to increase fruit and vegetable (F/V) intake. The Paso del Norte Institute for Healthy Living (IHL) at UTEP collected the data to conduct an evaluation of the …

Associations Between Perceptions Of U.S. Immigration Enforcement Policies, Physical Health, Psychological Distress, And Health Care Utilization In A Hispanic Border Community, Isabel Katharina Maria Latz

Open Access Theses & Dissertations

Since the beginning of the current U.S. federal administration, immigration policies have become more restrictive and immigration enforcement has been strengthened. This cross-sectional survey study examines associations between perceptions of and experiences with current immigration enforcement policies and self-rated physical health, psychological distress, and health care utilization among Hispanic adults with different residency statuses in the U.S. Paso del Norte region. This study further investigates moderating effects of collective efficacy and engaged coping strategies on associations between policy perceptions and psychological distress.

The study sample included 211 Hispanic adult residents of the U.S. Paso del Norte Region (i.e., El Paso, …

The Female Nature: Representations Of Motherhood And Nature In Dystopian Films, Veronica Andrea Martinez

Open Access Theses & Dissertations

This study will explore female representation and conceptualization of nature in dystopian narratives by examining dystopian films. The study is guided by film theory and ecofeminism to investigate themes of domination of both nature and women. The main goal is to examine the structure, themes, dialogue, and visuals in the films to explore the underlying essence of dystopian narratives and examine roles of reproduction and motherhood of female characters. The study contributes to previous studies on female and nature representation in media.

Platelet Biology And Thrombosis: Juul E-Cigarette Exposure And 5ht2a Receptor Drug Discovery, Jean Emmanuel Montes Ramirez

Open Access Theses & Dissertations

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Hfo Detector Based On Eeg Mean Energy Change Detection, Raul Ontiveros

Open Access Theses & Dissertations

The main goal of this work is to support automated seizure prediction by identifying preictal states using multiple detectors of high-frequency oscillations (HFOs). Assessment of HFOs from a seizure onset zone may be facilitated using automatic HFO detectors. However, studies have shown that HFOs can be generated by physiological or pathological brain processes. Distinguishing between pathological and physiological HFOs is challenging due to a lack of discriminant information in signals' morphology and other characteristics. Other complicating factors include a lack of consistency in definitions of HFO frequency ranges, the need for expert verification of HFO detection, and lack of robustness …

Magnetic Nanoparticles For Hyperthermia For Cancer Treatment, Bianca Paola Meneses Brassea

Open Access Theses & Dissertations

Fe3O4 and NixCu4-x magnetic nanoparticles were synthesized using supercritical conditions of liquids and wet chemistry, respectively. Characterization methods (VSM, SEM, TEM, and magnetic hyperthermia) yielded results that prove feasibility for magnetic hyperthermia for cancer treatment.

Thermal Characterization Of Abs/Carbon Fiber, Abs/ Glass Fiber And Petg/Glass Fiber Reinforced Composites Used In Large Area Additive Manufacturing, Fernando Adrian Rodriguez Lorenzana

Open Access Theses & Dissertations

Additive manufacturing has seen continuous advancements, such as the inclusion of large-area additive manufacturing extrusion systems. These systems precede small-scale 3D printing by means of research and technological development for the manufacturing of plastic and fiber industries. Big Area Additive Manufacturing (BAAM), a material extrusion process, is capable of 3D printing large parts using thermoplastic composites by adding fiber reinforcements. The incorporation of fibrous materials, carbon fiber (CF) or glass fiber (GF), is a common practice in which percentage nominal ratios of fiber reinforcement by weight are implemented to the polymer matrix. In general, this enables warpage reduction during printing, …

Identification Of The Cell Type Expressing The Glycine Transporter 1 (Glyt1) In The Thalamus, Patricia A. Lozano

Open Access Theses & Dissertations

Glycine acts as an inhibitory neurotransmitter and a co-agonist of NMDAR at the glutamatergic synapses. Termination of glycinergic neurotransmission is achieved by glycine transporter 1 (GlyT1) and glycine transporter (GlyT2). Both transporters are expressed in the spinal cord, brainstem and cerebellum, but GlyT1 is also expressed in the retina and the forebrain. Previous studies have described the role and cyto- architecture of GlyT1 in the caudal areas of the brain and retina, but not in the structures of the forebrain. Based on our preliminary data, GlyT1 is highly expressed in the thalamus, an area involved in sensory and motor signal …

Prediction Of O-Glycosylation In Proteins For Different Polypeptide Galnac-Transferases, Jonathon Edward Mohl

Open Access Theses & Dissertations

Mucin-type O-Glycosylation is a posttranslational modification of proteins found on secreted and cell surface proteins in most animals which serves multiple important biological functions. Â In humans, mutations and changes in the expression levels of O-glycosylating polypeptide GalNac-transferases (GALNTs) have been linked to diabetes and multiple cancers. In most animals the GALNTs are compose a large family of isoforms with humans having 20 isoforms. Presently, the prediction of the sites that will be O-glycosylated is a difficult task due to each isoforms different substrate preference. In this work ISOGlyP, an isoform specific O-glycosylation prediction program, was redesigned and expanded to …

Precipitation And Transformation Of Iron-Sulfide Nanoparticles In Low-Temperature Aqueous Environment: Effects Of Reactant Iron And Sulfide Sources, Ezequiel A. Moreno Flores

Open Access Theses & Dissertations

Iron sulfide nanoparticles assume an important role within a wide range of geological settings as indicators of redox environmental conditions and elemental cycling mechanisms. Initial precipitates of iron sulfide are exclusively nanoscale sized in low temperature aqueous conditions and have been reported to go through diverse morphological and phase transformations, possibly leading to the ultimate deposits of pyrite in geologic records of various times. A systematic understanding of how the early-stage nanoparticles of iron sulfide may develop into more crystalline iron sulfide forms is still lacking however. The major goal for this study was to illuminate the effects of the …

Potential Of Nanoscale Elements To Control Fusarium Wilt Disease In Tomato (Solanum Lycopersicum), Enhance Macronutrient Use Efficiency, And Increase Its Yield, Ishaq Olarewaju Adisa

Open Access Theses & Dissertations

Nanotechnology has a great potential in ensuring food production, security and safety globally. Over the past decade, research on the use of nanomaterials to supply nutrient elements and protect plants from pest and diseases has significantly increased. Tomato (Solanum lycopersicum) is one of the most consumed vegetables in the world and United State is one of its largest producers globally generating billions of dollars annually in revenue.. Tomato plants are affected worldwide by Fusarium wilt caused by Fusarium oxysporum f. sp. Lycopersici. There is growing concern about excessive use of conventional pesticides in controlling Fusarium and other diseases in tomato …

Nonlinear Optics For Nanoparticle Tracking And Materials Characterization, Angela Christina Aguilar

Open Access Theses & Dissertations

A high-speed 3D imaging method is developed by integrating ultrafast laser pulse shaping, temporal focusing microscopy and defocused imaging. This system does not require mechanical movement of either the stage or laser beam. Axial scanning is achieved by manipulation of group velocity dispersions on the femtosecond laser spectrum via pulse shaping method by applying modulation functions on an acoustic optical modulator which diffracts the laser spectrum. The scanning depth becomes only dependent on electronic signals which can be tuned to kHz speeds. The volumetric high-speed scanning capability was demonstrated on fluorescent microspheres suspended in a volume of 100 x100 x …

Cantor Sets, Cantorvals, And Their Topological Structure, Ángel Adrián Agüero

Open Access Theses & Dissertations

With interesting topological properties, the Cantor set is worth studying for itself. In other areas, topological structures arise that are in fact homeomorphic to the Cantor set. In particular, we see sets that are homeomorphic to the Cantor set which result from the subsums of particular series, as well as linear combinations of algebraic sums of Cantor sets. These also result in what has been termed a Cantorval, which we also investigate.

Raman Computational And Experimental Studies On Label-Free Biological Investigations, John Ciubuc

Open Access Theses & Dissertations

Raman spectroscopy is an optical technique that allows for label-free biological investigations to take place. This approach presents both new perspectives and a means for visualizing investigations. This thesis confronts two biological cases: dopamine (DA) detection at physiological levels and assessment of renal osteodystrophy (ROD). We employed surface-enhanced Raman spectroscopy on silver nanoparticles recording DA concentrations as low as 10−11 molar. Quantum chemical density functional calculations were carried out using Gaussian-09 analytical suite software. Good agreement between the simulated and experimentally determined results indicates the existence of distinct DA molecular forms, such as uncharged DA±, anionic DA−, and dopaminequinone. Disappearance …

Nietzsche And The Aestheticization Of The Natural Sciences, Sean Dillard

Open Access Theses & Dissertations

This Thesis is an exploration of Friedrich Nietzsche's dictum that life only justifies itself aesthetically. Given his attempt to physiologize aesthetics, this project attempts to show the value of the parallels and reciprocities between taste, style, beauty, and good health for scientists - especially natural scientists. It hopes to show something valuable about what late-modern scientific practice lost, especially in the context of the departmentalization of the sciences in universities. Specifically, I argue, disentangling scientific practice from philosophical concerns - the death of what used to be natural philosophy - has resulted in worse scientists, worse scientific practice, and a …

Application Of Urinary Metabolites For Cancer Detection, Qin Gao

Open Access Theses & Dissertations

Prostate cancer (PCa) is the 3rd most common cause of male cancer mortality in the US. Early diagnosis and treatment of PCa will improve the quality of care and reduce mortality. The prostate specific antigen (PSA) is commonly used in the current PCa screening, but its limitation has resulted in an intense search for more reliable biomarkers. Studies showed that dogs could differentiate PCa patients from negative control by sniffing their urine. As the odor profiles are generated by volatile organic compounds (VOCs), the finding suggests that particular VOCs could be linked to PCa, PCa risk levels and other cancers. …

Assessing The Predictive Utility Of The Positive Achievement Change Tool At A Texas Juvenile Justice Agency, Elizabeth Perez Hutchins

Open Access Theses & Dissertations

In the United States, millions of youth are processed in the juvenile justice system each year. Juvenile probation officers, case managers, and clinicians have the daunting task of making critical case-processing decisions for this vulnerable population including program placement, supervision, and treatment. Moreover, juvenile justice professionals must be mindful of numerous factors such as risk to public safety and the juvenile's risk to reoffend when making these decisions. In recent years, juvenile justice agencies have employed the Risk-Need-Responsivity model, the pre-eminent evidence-based model for offender assessment and management, to aide in the decision-making process. Although implementation of risk assessment tools …

Development Of Ligand-Kinase Binding Affinity Predictive Model, Govinda Kc

Open Access Theses & Dissertations

Prediction of interaction between drugs or drug like compounds and targets, is of high importance in drug discovery process as it provides important insights into therapeutic potential and possible adverse effects. As the experimental testing would be highly expensive, laborious and time consuming, screening the molecules computationally before performing experiments would be cost effective, faster and convenient as a method of approach. In this study, I have developed computational models, leveraging machine learning techniques, to predict drug-kinase binding affinities. The predictive model is mainly built using the Random Forest (RF) machine learning method. This study is focused on kinases because …

Synthesis Of Advanced Functional Nanomaterials For Sustainable Water Treatment Technologies, Md Tariqul Islam

Open Access Theses & Dissertations

Water is the most essential resource for the sustenance of life. Water is also necessary for agriculture, industry, household, and environmental conservation. However, due to large population growth and industrial expansion, access to clean water is becoming increasingly difficult around the world. Current water treatment technologies have not changed in over one hundred years and require a large infrastructure due to their low efficiencies and large-scale needs. In this context, the utilization of advanced functional nanomaterials and the adaptation of nanotechnology could potentially allow for miniaturizing water treatment and develop de-centralized solutions for rural areas. This Dissertation presents the design, …

Assessing The Temporal Dynamics Of The Lower Urinary Tract Microbiota And The Effects Of Lifestyle, Travis Kyle Price

Dissertations

Urinary tract infections (UTIs) are among the most common bacterial infections in humans, accounting for $3.5 billion in health care expenditures yearly in the United States alone. Yet, treatments for UTI have seen little innovation over the past decade. As demonstrated in other body sites, such as the vagina and gastrointestinal (GI) tract, acute and infectious diseases often have indirect microbial contributions which serve as intriguing new targets for therapies. The recent discovery of the existence of a resident community of bacteria (i.e., microbiota) in the bladders of both women and men, represents a novel avenue for targeting UTIs. However, …

Feminism And School Leadership: A Qualitative Study Utilizing Effective Women Principals' Self-Perceptions To Determine What Makes Them Successful, Christina Maria Sylvester

Dissertations

Women are underrepresented in a variety of fields, including educational leadership. Upon assuming leadership roles, women often struggle to effectively lead due to a pervasive context of sexism and genderism in the workplace. Schools are not immune to this phenomenon. Since women comprise approximately 50% of the population, it seems logical that they should assume a comparable percentage of leadership roles in education, but this is not the case. Beyond parity, it is important that there are not only more women leaders in educational administration but also that those women in leadership roles are supported within a context that enables …

Qualitative And Quantitative Analysis Of Therapeutic Solutions Using Raman And Infrared Spectroscopy, Alaa A. Makki, Franck Bonnier, Renaud Respaud, Fatma Chtara, Ali Tfayli, Clovis Tauber, Dominique Bertrand, Hugh Byrne, Elhadi Mohammed, Igor Chourpa

Articles

Anticancer drugs are prescribed and administrated to an increasing number of patients on a daily basis. As a consequence, a number of concerns have been raised about the patient health and safety in the case that the drugs administered are not at the required concentration or even worse not the correct ones. Quality control of therapeutic solutions has therefore been extensively implemented in hospital environments, in order to avoid any failure in the intense workflow faced by administering pharmacists. In the present study, infrared (IR) and Raman spectroscopy have been employed for the analysis of 3 commercially available therapeutic solutions …

Legislating Morality: Moral Theory And Turpitudinous Crimes In Immigration Jurisprudence, Abel Rodríguez, Jennifer A. Bulcock

Faculty Publications

Congress could have framed the country’s immigration policies in any number of ways. In significant part, it opted to frame them in moral terms. The crime involving moral turpitude is among the most pervasive and pernicious classifications in immigration law. In the Immigration and Nationality Act, it is virtually ubiquitous, appearing everywhere from the deportability and mandatory detention grounds to the inadmissibility and naturalization grounds. In effect, it acts as a gatekeeper for those who wish to enter and remain in the country, obtain lawful permanent residence, travel abroad after admission, or become United States citizens. With limited exceptions, noncitizens …

Strict Liability For Genetic Privacy Violations In The Age Of Big Data, Benjamin Sundholm

Faculty Publications

(Excerpt)

The ethical issues implicated by the misuse of genetic information have been smoldering for over half a century, and the age of big data has turned them into a five-alarm fire. In recent years, medical researchers and commercial enterprises have been using technological advancements to develop a variety of innovative ways to use genetic information. For example, it is becoming increasingly common for people to learn more about their health and family history by paying direct-to-consumer (“DTC”) companies to analyze their genetic data. DTC companies store the results of these tests electronically and often share them with pharmaceutical companies …

Arrests As Guilt, Anna Roberts

Faculty Publications

An arrest puts a halt to one’s free life and may act as prelude to a new process. That new process—prosecution—may culminate in a finding of guilt. But arrest and guilt—concepts that are factually and legally distinct—frequently seem to be fused together. This fusion appears in many of the consequences of arrest, including the use of arrests in assessing “risk,” in calculating “recidivism,” and in identifying “offenders.” An examination of this fusion elucidates obstacles to key aspects of criminal justice reform. Efforts at reform, whether focused on prosecution or defense, police or bail, require a robust understanding of the differences …

Generation, Identification And Characterization Of Novel Monoclonal Antibodies Against Ctla-4, Pd-1 And Btla For The Treatment Of Cancer, Rosabril Acuna

Open Access Theses & Dissertations

Members of the CD28 co-inhibitory receptor family, Cytotoxic T-lymphocyte- associated antigen 4 (CTLA-4), Program death-1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) are type I transmembrane proteins expressed on a variety of immune cells. Co- inhibitory receptors deliver "off" signals that play an important role in down regulating immune cell activation. Manipulation of inhibitory signals have shown to be a powerful strategy in the treatment of autoimmune diseases, infectious diseases and various forms of cancer. In fact, the FDA (Food and Drug Administration) has approved the use of monoclonal antibodies against CTLA-4 (Ipilimumab) for the treatment of metastatic melanoma, against …

Dimensionality Of Magnetism In Trirutile Cota2o6 And Its Derivatives, Raju Baral

Open Access Theses & Dissertations

In this thesis, we addressed the question of low dimensionality of trirutile compound CoTa2O6 and studied how the low dimensionality evolved with doping of Mg on Co-site. In order to study low dimensionality in CoTa2O6 and its derivative compounds Co1-xMgxTa2O6 (x = 0.1, 0.3, 0.5, 0.7, and 1), we used different techniques: X-ray diffraction, magnetic susceptibility, magnetization, specific heat and elastic neutron diffraction. We have addressed the question of low dimensional magnetism of CoTa2O6 by preparing phase-pure samples of the compound. In CoTa2O6 a broad feature is observed in magnetic susceptibility at 10 K and an antiferromagnetic phase transition is …

Applications Of A New Genetic Algorithm To Solve The Centralized Carrier Collaboration And Multihub Location Problem Considering Environmental Impacts, Eduardo Jose Castillo Fatule

Open Access Theses & Dissertations

The Centralized Carrier Collaboration and Multi-hub Location Problem (CCCMLP) represents a strategy that small-to-medium sized less-than-truckload (LTL) carrier companies can use in order to improve their profit margins. It is a strategy that is being explored in order to make these companies more sustainable as they are forced to reinvent their processes and supply chains. In this work, I will present a metaheuristic approach to optimizing their hub establishment and routing policies in order to better their expected profit margins and reduce their environmental impacts. The study considers the costs of transportation, loading and unloading, maintenance, operations, and inventory holding …

Movement Ecology Of A Cryptic Ambush Predator: Integrating Radio Telemetry And Tri-Axial Accelerometry To Evaluate Spatial Strategies And Activity Patterns By Western Diamond-Backed Rattlesnakes (Crotalus Atrox), Dominic L. Desantis

Open Access Theses & Dissertations

An animal's decision to move from one location to another within its environment is determined by a complex blend of internal and external factors. Teasing apart the relative roles of specific variables in this web of interacting mechanisms has been a long-standing challenge in animal movement ecology. Historically, this problem was viewed as a sort of black box for which a myriad of methodological limitations precluded rigorous study. Recently, a diversity of animal-borne transmitters and dataloggers (i.e., bio-loggers) have circumvented many of these traditional limitations and transformed field studies of animal movement, behavior, and physiology - in some cases, allowing …