Digital Commons Network^™

High Times Ahead: Products Liability In Medical Marijuana, Steven B. Perlmutter

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Robbing The Grave: Amending The Uniform Anatomical Gift Act To Curtail Abuses Within The Whole-Body Donation Industry, Andrew Y. Schiefer

Health Matrix: The Journal of Law-Medicine

No abstract provided.

The Growth Of Chlorella Vulgaris Cultured In Liquid Organic Fertilizer Of Water Hyacint H (Eichhornia Crassipes) At Different Salinities, Wa Iba, Citra Utami, Abdul M. Balubi

Fisheries, Animal and Veterinary Sciences Faculty Publications

This study aims to determine the effect of salinity on the growth of microalgae C. vulgaris cultured in 5% concentration of water hyacinth liquid organic fertilizer. The research used a completely randomized design with four salinity treatments at 30, 35, 40 and 45 ppt in triplicates. The volume of culture media was 150 mL that consisted of 142.5 ml of sterile sea water and 7.5 ml of water hyacinth organic fertilizer. The increase in microalgae cell density was observed every other day using haemocytometer under light microscope. The culture was harvested after they reached stationary phase at day 8. Culture …

Culture, Gender, And The Social Construction Of Borderline Personality Disorder, Allegra L. Comas

Theses, Dissertations, and Projects

This qualitative study investigates the ways in which culture, gender, and language inform the clinical subjectivity of licensed clinical social workers, marriage and family therapists, and psychologists working with women that present with behaviors associated with BPD as ascribed in the DSM III-V. Psychiatrists who produced BPD argue there is a biological basis to the diagnosis, which has never been proven. The majority of literature on BPD primarily focuses on the patients’ behaviors that may meet the legally codified criteria. However, little scholarship is published about the counter-transference and cultural bias of psychotherapists while diagnosing, treatment planning, and using appropriate …

Biology News 2019, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

--Greetings from the Department of Biology
--Upcoming event: Prairie Rendezvous in Celebration of Dr. Daryl Smith
--Staff and faculty news
--May 2019 Study Abroad trips
--Staff and Faculty Transitions
--The Difference He Made-Quotes on Dr. Wiens
--Outreach and Alumni
--Purple and Gold Award Recipient

A Structure Based Approach For Defining Ligand Interaction Requirements With Atp-Binding Cassette Proteins, Christina A. Le

All ETDs from UAB

Membrane proteins belonging to the ATP-Binding Cassette (ABC) superfamily are responsible for transporting substrates into or out of cells. ABC transporters, such as P-glycoprotein (Pgp/ABCB1) defend cells by the active efflux of many chemically diverse cytotoxic compounds. The ABC protein, CFTR/ABCC7, is a passive chloride ion channel that provides fluid homeostasis. Pgp and CFTR of are high clinical interest since mutations in CFTR can result in Cystic Fibrosis (CF) and upregulation of Pgp in tumor cells can result in multidrug resistance (MDR). There has been a major effort to develop clinical drugs to treat CF by either repairing defects in …

The Effects Of Saha And Egcg On Metastatic Potential In Triple-Negative Breast Cancer Cells, Kayla Lewis Steed

All ETDs from UAB

About 1 in 8 women will be diagnosed with breast cancer at some time in their lives, and more than 40,000 women will die due to breast cancer this year. Women do not die from localized breast cancer cases but from metastatic, or Stage IV, breast cancer (MBC). Over 150,000 women are currently living with MBC, and treatments focus on length and quality of life considering there is no cure. Triple-negative breast cancers (TNBC) do not respond to targeted therapies as they are lacking estrogen receptor alpha (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). They …

Bmp2-Derived Molecules For Increasing Osteoinductivity Of Bone Grafts To Enhance Bone Regeneration, Andrew Scott Curry

All ETDs from UAB

The “gold standard” of bone grafting materials is autograft. Unfortunately, autogenous bone must first be harvested from the patient, leading to complications such as donor site morbidity. Because of this, many surgeons rely on non-autogenous bone grafting materials. While these grafts are more available than autogenous bone, they require extensive processing which significantly reduces their osteoinductivity. Therefore, there is substantial interest in finding ways to add osteoinductive molecules to these grafts. Previously, our lab has focused on utilizing molecules derived from bone morphogenetic protein 2 (BMP2) with an attached hydroxyapatite-binding domain (polyglutamate) to anchor them onto bone grafting materials. Previous …

Toward A Performative Understanding Of Politeness, C. Kyle Rudick, Danielle E. Mcgeough

Faculty Publications

In this article, we argue that critical communication scholars have largely overlooked the study of politeness as a constitutive component of identity, culture, and power. We offer a critical-performative framework for critical scholars interested in studying politeness as a political, discursive, and embodied act. To develop this agenda, we first outline Brown and Levinson’s postpositivist theory of politeness. We then review three challenges to their use of intentionality, Grice’s cooperative principle, and Goffman’s concept of face. These challenges are located in interactional, traditional critical, and discursive understandings of politeness (respectively). Next, we show how a performative understanding of politeness both …

Racial And Gender Differences In The Relationship Between Adverse Childhood Experience And Chronic Health Conditions In Adulthood, Jalal Uddin

All ETDs from UAB

A growing body of studies highlights that many adult diseases and health disparities in late-life are rooted in childhood adversities. However, there is little research that examines how social stratification processes structure the inequality in early-life stress exposure, and the effects of stress exposure on health outcomes may vary based on the intersections of social stratification categories. Drawing on an integrated framework of the life course stress process and intersectionality theory, this study examines the patterns in childhood adverse experiences (ACEs) by race/ethnicity and gender and how race/ethnicity, gender, and adult socioeconomic status (SES) combine to modify the effects of …

Quantifications Of Theranostic Polymer-Based Particles For Image-Guided Drug Delivery, Sithira Ratnayaka

All ETDs from UAB

Modern medicine employs many drugs in its disease treatment methods. This is because they provide the best permanent solutions to complicated ailments. However the usefulness of these drugs is mitigated by several factors, namely that of specific release. Common drug delivery mechanisms lack the specificity needed to ensure that release is limited to the diseased area, which can lead to unnecessary side effects. By utilizing medical imaging, both drug delivery devices and physiology can be observed by physicians, which can greatly increase the specificity of drug delivery. Specifically, utilizing a very inert medical imaging modality, such as ultrasound, guarantees minimum …

O-Glcnac Regulation Of Inhibitory Circuits, Kavitha Abiraman

All ETDs from UAB

Post translational modification of proteins plays a crucial role in regulating their function, and the role of one such modification, termed O-GlcNAcylation, is understudied. O-GlcNAcylation involves the dynamic cycle of adding and removing an O-linked N-acetylglucosamine (O-GlcNAc) by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which are highly expressed in the hippocampus. Enzymes that catalyze O-GlcNAcylation are found at both presynaptic and postsynaptic sites, and O-GlcNAcylated proteins localize to synaptosomes. We have shown that acute and selective increase in O-GlcNAcylation of AMPAR GluA2 subunits underlies expression of a novel form of LTD at CA3-CA1 synapses (O-GlcNAc LTD), as well …

Metal Complexation In Hydrogen-Bonded Microcapsules Of Poly(N-Vinylpyrrolidone) And Tannic Acid For Medical Imaging And Controlled Drug Delivery, Patrick Aaron Alford

All ETDs from UAB

Even the most effective and widely used drugs in modern disease treatment can be compromised by low bioavailability and off-target damage which leads to detrimental side effects. Polymeric drug carriers have been developing in recent times with the aim of rendering the therapeutic cargo inert and protecting it from the body’s natural defense mechanisms until arrival at the target site, upon which a specific stimulus will cause the drug to release from the carrier locally. To this end, antioxidant capability in drug carriers can help mediate the cascade of reactive oxygen species that meet injected materials and, in doing so, …

Mechanisms Of Acute Kidney Injury: The Role Of Ferritin Heavy Chain In Renal Heme-Unology, Laurence Marie Black

All ETDs from UAB

The kidneys are complex, multi-faceted organs that are responsible for regulatory processes, such as fluid homeostasis, hormone production, blood pressure regulation, and systemic toxin removal. Sudden disruption of these processes by acute kidney injury (AKI) causes rapid decline in renal function as well as significant morbidity and mortality. AKI is a significant clinical concern, affecting up to 13.3 million people globally each year and has the propensity to progress to chronic kidney disease (CKD), though the mechanism remains undefined. One reason for this is due to the lack of understanding of models used to study both AKI and CKD, hindering …

An Ex Vivo Model Of Neuroendocrine Tumors: A Net Gain, Brendon R. Herring

All ETDs from UAB

Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that originate in a diverse array of anatomical locations and have widely variable clinical presentations and responses to treatment. Patient-derived xenografts and cell lines are valuable models of tumor biology and for testing personalized therapeutics on tumors prior to their administration to patients. However, as PDX models and cell lines for neuroendocrine tumors are lacking in both number and validity, we have developed a 3D flow perfusion polydimethylsiloxane (PDMS) bioreactor model for the purpose of culturing patient derived NETs. The goal of this thesis is to determine the ability to use …

We Never Considered Teaching: A Critical Narrative Of African American Stem Majors’ Identity As Stem Educators, Paulette Georgina Evans

All ETDs from UAB

The need to diversify and retain non-White STEM teachers in the educator workforce has brought to surface the need to more deeply understand why non-White educators choose teaching as a profession and, equally as important, why they choose to stay. Although there is literature documenting the shortages of African American teachers including how African Americans can be recruited and retained, there is a need to look more closely at how African American undergraduate STEM majors who are in innovative teacher preparation programs articulate their affinity to teaching. The following critical narrative study focuses on how pre-service non-White teachers, particularly African …

St6gal-I Mediated Sialylation Promotes Pancreatic Ductal Adenocarcinoma Progression And Chemoresistance, Asmi Chakraborty

All ETDs from UAB

ST6Gal-I adds α2-6 sialic acids to select N-glycosylated cell surface receptors, thereby modulating receptor function and intracellular signaling. ST6Gal-I is upregulated in various carcinomas and confers cancer stem cell (CSC) properties evidenced by tumorspheroid growth, chemoresistance and tumor initiating potential. In pancreatic ductal adenocarcinoma (PDAC), ST6Gal-I conferred gemcitabine resistance by abrogating DNA damage and altering expression levels of gemcitabine metabolism genes. Further, ST6Gal-I promoted resistance to chronic gemcitabine treatment. Additionally, metastatic clones of a PDAC cell line had increased ST6Gal-I expression and ST6Gal-I knockdown enhanced gemcitabine sensitivity. To investigate the physiological consequences of ST6Gal-I in PDAC, murine models were used. …

Classification Of Native Vegetation Of Oregon - 2019, Jimmy Kagan, Rachel L. Brunner, John Christy

Institute for Natural Resources Publications

This classification is an update of the 2004 classification of native vegetation of Oregon by Kagan, Christy, Murray and Titus. As before, this classification lists the native plant associations known to occur in Oregon, and includes both successional and climax vegetation types that were part of the presettlement landscape of Oregon and can still be found in the state. It serves as an index to the diversity, distribution and relative rarity of the state's native plant associations, and as a guide to their literature. Published and unpublished reports supported by quantitative data were the primary sources for the classification. In …

A Model For Cultivating Global Engagement Beyond Academic Tourism, Victor D. Carmona, Tizziana Carmona

Jesuit Higher Education: A Journal

The message to environmental scholars in Pope Francis’ Encyclical “Laudato Si” is clear: contributions from Science, Technology, Engineering, and Mathematics (STEM) must serve to inform both local and international conversations as well as connect learning communities in developed and developing nations. In the hope of fostering international opportunities that challenge U.S. students to link their academic degrees with social justice elements that calibrate them to the historical reality the overwhelming majority of the world experiences, we outline a teacher-scholar model that serves as a tool for the advancement of social and environmental justice issues in developing countries.

Modeling Resilience In Resetttled Syrian Refugees With Disabilities Living In The United States, Nicholas Ryan Sherwood

All ETDs from UAB

Since 2011, the ongoing conflict in Syria displaces millions of individuals, many of whom have resettled across foreign borders. The US currently hosts 21,000 Syrian refugees, and of these, approximately 5,000 have at least one type of disability. This thesis asks of these individuals: given your experience as a person with a disability who has survived state-sanctioned violence and navigated forced migration, what have been your greatest sources of strength and resilience? Utilizing systems theory and a transdisciplinary approach, this thesis examines how three forms of identity promote community, interpersonal, and intrapersonal resilience within the target population.

Transition Into Adulthood: Cannabis Use And Mental Health, Katie Mcintyre

All ETDs from UAB

The US is currently experiencing sweeping changes in the legal status of cannabis, the most common illicit drug used in America. Due to its classification as a Schedule I substance we know very little about how cannabis use impacts mental health since illicit drugs are not legally allowed to be researched in a laboratory setting. The current research on cannabis use (CU) and mental health (MH) is expansive and conflicting. One side of the debate suggests CU in adolescence has a direct effect on MH, the other side suggests CU could be an indirect coping mechanism of poor MH. One …

Habitat Associations And Community Interactions Of Non-Native Species In The Southern Basin Of Lake Michigan, Erin O'Shaughnessey

Master's Theses

Non-native crayfishes, mollusks, and macrophytes can have large impacts on biodiversity and damage ecosystem services in freshwaters. In 2015 we discovered an established population of the globally widespread invader red swamp crayfish (Procambarus clarkii) in the North Shore Channel of the Chicago Area Waterway System. This population overlaps with a population of rusty crayfish (Faxonius rusticus), a previous invader that is widely distributed and usually the dominant crayfish species across the Great Lakes region. I studied the interactions between these two species while directly competing over shelter and food. In the field, each species was studied to determine the rate …

Opioid Misuse Detection In Hospitalized Patients Using Convolutional Neural Networks, Brihat Sharma

Master's Theses

Opioid misuse is a major public health problem in the world. In 2016, 11.3 million people were reported to misuse opioids in the US only. Opioid-related inpatient and emergency department visits have increased by 64 percent and the rate of opioid-related visits has nearly doubled between 2009 and 2014. It is thus critical for healthcare systems to detect opioid misuse cases. Patients hospitalized for consequences of their opioid misuse present an opportunity for intervention but better screening and surveillance methods are needed to guide providers. The current screening methods with self-report questionnaire data are time-consuming and difficult to perform in …

Role Of Daxx As A Predictive Biomarker In Breast Cancer, Michelle Lucia Fernandez

Master's Theses

Breast cancer is the most commonly diagnosed form of cancer in women, besides skin cancer, and second only to lung cancer for cause of mortality. It is divided into three subtypes, depending on different molecular or pathologic characteristics, including estrogen or progesterone receptor-positive (ER/PR+), human epidermal growth factor receptor-2-positive (HER2+) and triple negative breast cancer (TNBC). There are several therapies used to target these subtypes, but there is still a chance that the cancer will recur into a more aggressive, resistant form even if the therapies were successful before. This recurrence is believed to be due to the Cancer Stem …

Molecular And Biochemical Phenotypes Underlying Reactive Astrocytosis In Primary Optic Nerve Head Astrocytes, Anita Kirti Ghosh

Master's Theses

Glaucoma is a progressive optic neuropathy that manifests in a pathological triad of optic nerve head remodeling, damage to optic nerve axons, and retinal ganglion cell death. Optic nerve head astrocytes (ONHAs) are the primary cell type in the optic nerve head. ONHAs undergo reactive astrocytosis, an activated phenotype characterized by altered gene and protein expression and increased cell migration and proliferation, early in the disease pathology. Reactive astrocytosis is thought to underlie optic nerve head remodeling. The first goal of this thesis was to determine if exposure of primary adult rat ONHAs to hyperbaric pressure (25-30 mm Hg above …

Longitudinal Urinary Microbiome Studies: A Need To Transition To Voided Urine, Baylie Hochstedler

Master's Theses

It is now established that the bladder is not sterile; it contains communities of microbes (microbiota). While the healthy bladder microbiota have been defined using expanded quantitative urine culture (EQUC) and urines obtained by transurethral catheterization (TUC), longitudinal and population studies have not previously been possible. These studies cannot be done using TUC urines, as it would be impractical to catheterize participants daily. Instead, we must transition to using voided urines.In order to make this switch, we have addressed three main issues raised by using voided urine. First, we showed that EQUC out performs standard urine culture on voided urines …

Developing A Brain‐Based, Non‐Invasive Treatment For Pain, Logan Thorne Dowdle

MUSC Theses and Dissertations

Chronic pain cost society more than $500 billion each year and contributes to the ongoing opioid overdose crisis. Substantial risks and low efficacy are associated with opiate usage for chronic pain. This dissertation seeks to fill the urgent need for a new pain treatment using a neural-circuit based approach in healthy controls and chronic pain patients. First, we performed a single-blind study examining the causal effects of transcranial magnetic stimulation (TMS), compared to a well-matched control condition. Using interleaved TMS/fMRI we explored brain activation in response to dorsolateral prefrontal cortex (DLPFC) stimulation in 20 healthy controls. This study tested the …

The Potential Mechanisms Of Impaired Pneumococcal Vaccine Responses In Aging Hiv-Positive Individuals, Myroslawa Happe

MUSC Theses and Dissertations

The introduction of antiretroviral therapy has significantly reduced HIV-related morbidity and mortality and transformed HIV infection into a chronic disease. Consequently, the life expectancy of HIV-positive individuals considerably improved leading to a rapid growth of the aging HIV-positive population. Together, advanced age and HIV infection increase susceptibility to potentially deadly infections caused by Streptococcus pneumoniae. Despite preventative approaches, such as pneumococcal vaccination, it remains a challenge to induce potent and durable immune responses against pneumococcal polysaccharides in HIV-positive persons and invasive pneumococcal disease rates remain 35-fold higher as compared to healthy individuals. Poor responses to vaccine antigens in HIV+ individuals …

A Qualitative Research Study On Unaccompanied Minors From Latin America, Lorena Caldera

Doctoral Dissertations

The focus of this study is on a unique immigrant population — unaccompanied minors who have migrated to the U.S. from Latin America, particularly Mexico, Honduras, Guatemala, and El Salvador. The purpose of this qualitative research study is to explore, describe, and understand the migration stories of unaccompanied minors who have migrated to the U.S. from Latin America. Using Lee’s (1966) “Theory of Migration,” this study aimed to uncover the push and pull factors that are motivating youth migration to the U.S. from Latin America, including the social pressures, economic factors, lack of educational and economic opportunities, life-threatening violence, safety …

The Impact Of A Neuroeducation-Based Wellness Curriculum On Generation Z: Implementing Mind-Body Connection, Natalie M. Capiro, Alexandra L. Gleason, Stefanie Powers

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Twenty-first century culture has a significant impact on the cognitive-psychological development of modern-day students. Cultural factors that contribute to this include the excessive use of technology, increased focus on higher academic achievement, more parental involvement, a sedentary lifestyle, and fewer in-person social interactions. Concurrently, the curricular emphasis on physical and mental wellness has been weak leading to a rise of mental health issues amongst adolescent students.

Ample research indicates that the social and emotional bodies of the brain are developing and functioning differently because of cultural factors and societal trends. It is crucial for educators to take a deeper look …