Digital Commons Network^™

Prescription Trends In Branded Versus Generic Glatiramer Acetate Utilization Among Insurers For The Treatment Of Multiple Sclerosis In The United States, Stephen G. Smith

MUSC Theses and Dissertations

Purpose: Multiple Sclerosis (MS) is a chronic condition managed by disease modifying pharmaceutical therapies (DMTs). Health care cost is increasing due to high prescription drug spending. The high cost of branded DMTs highlights the potential value of lower cost generic therapies. Using generic DMTs could reduce the spending in the prescription drug sector. Recently, generic glatiramer acetate (GA) that treats relapsing remitting multiple sclerosis has become available. Appropriate insurer policies and practices are imperative to promote the use and utilization of generics like GA. Notably, no study has specifically evaluated the differences in utilization uptake of branded vs generic GA …

The Effects Of Chronic Age Consumption On Prostate Carcinogenesis, Pamela Woods

MUSC Theses and Dissertations

Prostate cancer is the second most common cancer in men and one of the leading causes of cancer deaths among men in America. Interestingly, it has been shown that immigration and the adaption of a Western-Diet can significantly increase the risk of prostate cancer development in men, suggesting diet may play a key role in prostate cancer development. Advanced glycation end products (AGEs) are reactive metabolites that are produced during normal metabolism and accumulate in our tissues and organs as we get older. AGE content in the Western-Diet has significantly increased over the years leading to an increase of AGE …

Transmissibility And Potential For Disease Progression Of Drug Resistant Mycobacterium Tuberculosis: Prospective Cohort Study, Mercedes C. Becerra, Chuan-Chin Huang, Leonid Lecca, Jaime Bayona, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Zibiao Zhang, Sidney Atwood, Ted Cohen, Carole D. Mitnick, Paul Farmer, Megan Murray

Social Work Faculty Publications

Objective: To measure the association between phenotypic drug resistance and the risk of tuberculosis infection and disease among household contacts of patients with pulmonary tuberculosis.

Setting: 106 district health centers in Lima, Peru between September 2009 and September 2012.

Design: Prospective cohort study.

Participants: 10 160 household contacts of 3339 index patients with tuberculosis were classified on the basis of the drug resistance profile of the patient: 6189 were exposed to drug susceptible strains of Mycobacterium tuberculosis, 1659 to strains resistant to isoniazid or rifampicin, and 1541 to strains that were multidrug resistant (resistant to isoniazid and rifampicin).

Main outcome …

Metabolomic Markers In Tongue-Coating Samples From Damp Phlegm Pattern Patients Of Coronary Heart Disease And Chronic Renal Failure, Yiming Hao, Xue Yuan, Jin Yan, Minh Pham, Dekai Rohlsen, Peng Qian, Feng Cheng, Yiqin Wang

Pharmacy Faculty Publications

In this paper, we used tongue coating to obtain metabolites in patients with coronary heart disease (CHD) and chronic renal failure (CRF). The metabolites were analyzed to discover the substance that serves as the underlying basis of the damp phlegm pattern. This analysis is based on the Traditional Chinese Medicine (TCM) theory of “different diseases have the same pattern.” The metabolic spectrum was obtained through the Gas Chromatography Mass Spectrometry coupling techniques and analyzed by searching the METLIN and HMDB databases. Some metabolites related to amino acids and glucose metabolism were identified in the tongue-coating samples from damp phlegm pattern …

Does Preprandial Oral Lactase Supplement Reduce Abdominal Pain In Lactose-Intolerant Adult Patients After A Lactose-Containing Meal?, Margaryta Tolchynska

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not preprandial oral lactase supplement reduces abdominal pain in lactose-intolerant adult patients after a lactose-containing meal.

STUDY DESIGN: A systematic review of three randomized, blinded, controlled primary research studies published between the years of 2010 and 2018.

DATA SOURCES: One randomized controlled trial (RCT), one randomized comparative study, and one randomized crossover study evaluating the efficacy of 9,000 units of preprandial oral lactase supplement in reducing abdominal pain due to lactose intolerance (LI). All studies were published in peer-reviewed journals and found via the use of PubMed, …

"Free Indirect Suicide: An Unfinished Fugue In H Minor", Seo-Young J. Chu

Publications and Research

In this lyric essay/work of creative nonfiction (listed among “Notable Essays & Literary Nonfiction” in Best American Essays 2020), Seo-Young Chu uses poetry, autotheory, and creative nonfiction to explore the generational trauma/postmemory han she inherited from her parents and the importance of destigmatizing mental illness through dialogue.

Graduate Catalog And Student Handbook 2019-2020, Nova Southeastern University

Abraham S. Fischler College of Education and School of Criminal Justice Graduate Course Catalogs

No abstract provided.

Consent For Emergency Treatment: Emergency Department Patient Recall And Understanding, Ashley Lafountain

Scholarship in Medicine - All Papers

Informed consent is an important ethical and legal requirement that underlies the concept of patient autonomy. This prospective survey study was conducted to assess patient recall and understanding of consent for treatment in adult emergency department (ED) patients at an urban level 1 trauma center with annual volume of 95,000, Miami Valley Hospital. Out of a total 293 patients, most individuals reported only receiving a verbal explanation of the consent document (45%) or not reading the document at all (36%). About half of the patients recalled consenting to treatment (N=144, 49%) and over one third of patients could not recall …

Declared Majors And Minors 2018-19, Umm Institutional Research

Campus Documents and Reports

No abstract provided.

Louisville Jewish Hospital’S “Tikkun Olam”: A Case Example Of Continuity For American Jewish Hospitals, Hannah Thompson

Libraries Award for Undergraduate Scholarship

According to Mary Wagner, the author of Jewish Hospitals Yesterday and Today, Jewish Hospitals emerged in the mid-19th century in the U.S. for several reasons: the Jewish American community’s need to combat anti-Semitism, to provide services for its large and then-growing immigrant population, and to establish a place for Jewish medical professionals to work, since anti-Semitism prevented them from being employed elsewhere. Although, American Jews became increasingly more accepted as part of the broader American social and political milieu throughout the early 20th century, Jewish Hospitals persisted in cities across the U.S. until the 1970s. To date roughly 22 …

Opportunistic Foraging On Nestling Regurgitants By Adult Snowy Egrets (Egretta Thula), Ashley E. Jackson, Betsy A. Evans

Florida Field Naturalist

No abstract provided.

Lice And Mites Collected From A Wood Thrush (Hylocichla Mustelina), A Black-And-White Warbler (Mniotilta Varia), A Common Grackle (Quiscalus Quiscula), And A Northern Mockingbird (Mimus Polyglottos) On Vaca Key, Florida, Lawrence J. Hribar

Florida Field Naturalist

No abstract provided.

Front Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Does Intertidal Oyster Reef Restoration Affect Avian Community Structure And Behavior In A Shallow Estuarine System? A Post-Restoration Analysis, Michelle Shaffer, Melinda Donnelly, Linda Walters

Florida Field Naturalist

No abstract provided.

Review Of The Birds Of Escambia, Santa Rosa, And Okaloosa Counties, Florida, With Bird Migration, Weather, And Fallout, Robert L. Crawford

Florida Field Naturalist

No abstract provided.

Fall Report: August-November 2018, Kevin E. Dailey

Florida Field Naturalist

No abstract provided.

Front Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

New Host Records And Range Extensions For Helminth Parasites From Wading Birds In Southeastern Florida, Sarah E. Gumbleton, David W. Kerstetter, Amy C. Hirons, Christopher A. Blanar

Florida Field Naturalist

No abstract provided.

Index & Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Florida Scrub-Jays (Aphelocoma Coerulescens) Decapitate And Eat Heads Of Florida Ivory Millipedes (Chicobolus Spinigerus), Michelle L. Dent, Natasha R. Lehr

Florida Field Naturalist

No abstract provided.

Abstracts Of Student Presentations And Posters At The Fall 2018 Meeting Of The Florida Ornithological Society, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Spring Report: March-May 2019, Kevin E. Dailey

Florida Field Naturalist

No abstract provided.

Cover, Florida Field Naturalist

Florida Field Naturalist

No abstract provided.

Father Figures In The Tenant Of Wildfell Hall: Bronte's Perspective On Victorian Era Masculinity, Mary Grace King

The Criterion

Anne Bronte presents two different depictions of fatherhood in The Tenant of Wildfell Hall that correspond to different expressions of masculinity. Anne Bronte comments on masculinity in the Victorian Era by presenting these different examples in the characters of Mr. Markham and Mr. Huntingdon as they interact with Arthur, Helen’s son. Both men display masculine traits as viewed by Victorian Era thought, but these traits vary between manly virtue (dignity and honesty) and manly vice (drinking and swearing). Furthermore, Bronte depicts patterns of abusive masculinity in the character Mr. Huntingdon in his interactions with Arthur as his biological father while …

"Mother Earth, Father God": The Binary Power Of Religion And Gender Codes In The Writing Of Jeanette Winterson And The Music Of Torres, Hannah M. Wilkes

Undergraduate Honors Theses

No abstract provided.

Uridine Promotes Neurite Outgrowth In Neuro2a Cells, Jacquelyn Spathies

Undergraduate Honors Theses

Neurodegenerative diseases such as Alzheimer's and Parkinson's are the main causes of age-related dementia. These diseases can be due to neuronal cell death and/or impairment of neurite outgrowth. Giant oyster mushroom (GOM), Pleurotus giganteus, is used as a nootropic to improve cognitive function. GOM can also be used to prevent the onset of dementia. The underlying mechanism behind the medicinal property of GOM is unclear. Previous studies have shown that GOM has a high concentration of uridine. In this study, I examined the effects of uridine on neurite outgrowth in the Neuro-2a (N2a) neuroblastoma cell line. We also examined …

Genomic Dysregulation By Overexpression Of Transcription Factors, Mackenzie Scroggins

Undergraduate Honors Theses

As one of the major organs, the liver plays vital roles in the homeostasis of an individual. Being able to identify master regulator genes, genes whose product can affect the activation or deactivation of other genes, will enrich our understanding of hepatic function and liver disease. Previously, our lab used genome-wide microarray data to identify several transcription factors that may play a key role in liver expression. Here we ask whether overexpression of these transcription factors in a non-liver cell would result in liver phenotype activation or general disruption of gene regulation. To this end, we stably introduced seven transcription …

Public Health And Personal Choice: The Ethics Of Vaccine Mandates And Parental Refusal In The United States, Rebecca Horan

Undergraduate Honors Theses

No abstract provided.

The Forbidden Water: Politics, Media, And Public Opinion In The Hetch Hetchy Controversy, Gabriel Mansfield

Undergraduate Honors Theses

No abstract provided.

Exploration Of Sonic Hedgehog Gene Expression In Fathead Minnows (Pimephales Promelas), Brooke Renee Greiner

Undergraduate Honors Theses

Pollutants, as a result of wastewater treatments, have been shown to have negative impacts on aquatic ecosystems. To better understand the possible consequences caused by effluents on ecosystems, it is important to examine ecotoxicology data. One of the most commonly used species for water quality testing is the fathead minnow, Pimephales promelas. Ecotoxicology can then be taken one step further to understand the effects of pollutants on a molecular level. Previous research had identified effluents as causes for abnormal minnow fin morphology. In order to collect additional data on development, tanks with fathead minnows were placed at the Charleston …