Digital Commons Network^™

Molecular Determinants Of Ubqln2 Liquid-Liquid Phase Separation Modulated By Ubiquitin, Christine Habjan

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Investigation Of The Role Of Mecp2 In The Precise Laminar And Areal Development Of Neocortical Neurons In A Rett Syndrome Mouse Model, Camerin Ortiz

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Determining Theraputic Efficacy Of Low-Frequency Ultrasound In Targeting In-Vitro Human Attached Cell Lines With Adjuvaant Chemotherapy, Charles Schauer

Renée Crown University Honors Thesis Projects - All

No abstract provided.

An Exploration Of Ruthenium Catalyzed Alder-Ene Reactions, Emily Bonner

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Dom Control Of Mercury Mthylation In The Water Column Of A Meromictic Lake, Madalyn Bozinski

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Frood Culture And National Idenity: Japan And The International Whalling Commission, Emma Fahey

Renée Crown University Honors Thesis Projects - All

No abstract provided.

In Search Of Solidarity: The Politics Of Queer Activism In New York City, Nathan Shearn

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Historical Ecology And Longitudinal Research Strategies Around Lake Mývatn Iceland, Thomas Mcgovern, George Hambrecht, Megan Hicks

Publications and Research

Historical Ecology has proven to be a very influential tool kit for thinking about complex human interactions with changing landscapes, climate, and other humans. It has also provided concrete and practical frameworks for carrying out sustained long- term place-based research projects that break through traditional periodization to look at the dialectical interaction of human economies and local and regional ecosystems through time. The “longitudinal perspective” pioneered by Carole Crumley’s work in Burgundy has proved to be a very effective tool for carrying out sustained multi-year, multi-investigator, and multi- generational investigations in landscapes around the globe. This paper presents an overview …

Placebo Marks, Jake Linford

Scholarly Publications

Scholars often complain that sellers use trademarks to manipulate consumer perception. This manipulation ostensibly harms consumers by limiting their ability to make informed choices. For example, holding other things constant, consumers spend more money on goods with a high-performance reputation. Critics characterize that result as wasteful, if not anticompetitive. But recent marketing research shows that trademarks with a high-performance reputation may sometimes influence perception to the benefit of the consumer.

A trademark with a high-performance reputation can deliver a performance-enhancing placebo effect. Research subjects perform better at physical and mental tasks when they prepare or play with a product bearing …

Preliminary Study On The Effects Of Akkermensia Muciniphilia On Akt Phosphorylation In Diabetic Pig Models, Brian Ko

Honors Theses

The onset of type 2 diabetes has been shown to affect the Akt signaling pathway, responsible for modulating cellular metabolism. The pro biotic Akkermensia muciniphilia has been recently shown to have an anti-inflammatory, anti-diabetic effect on animals inoculated with it, particularly within the Akt signaling pathway. This preliminary study utilized a twofactor experimental design with streptozotocin-induced diabetes and the presence of Akkermensia muciniphila in pig models in order to elucidate the probiotic's mechanism of action on the disease. Following analysis of insulin-sensitive tissues of muscle, pancreas, and liver, there was observed a mixed response to the presence of the probiotic …

About A Revolution: Toward Integrated Treatment In Drug And Mental Health Courts, Sara Gordon

North Carolina Law Review

No abstract provided.

Hemp On The Horizon: The 2018 Farm Bill And The Future Of Cbd*, Shannon Smith

North Carolina Law Review

No abstract provided.

The Religious Exemption Loophole: A Building Public Health Crisis In North Carolina, Brian Champion

North Carolina Law Review

No abstract provided.

Cultivating A Pedagogy Of Empathy: Teaching Science Fiction In A Changing Biotechnological World, Kathy L. Avery

College of Graduate Studies: Theses & Dissertations

CULTIVATING A PEDAGOGY OF EMPATHY: Teaching Science Fiction in a Changing Biotechnological World

By

KATHY L. AVERY

(Under the Direction of John Weaver)

Abstract

I argue that science fiction affords us the ability to think past our anthropocentrism, opening up a space for us to consider our relationship to burgeoning biotechnologies and the other. I provide critical interpretations of science fiction film and literature, which I believe stimulate the power of the narrative imagination to envision the “netherworld experience of the other”. I believe science fiction provides a site of speculation, a means to better understand and consider the role …

Chasing Nutrients And Algal Blooms In Gulf And Caribbean Waters: A Personal Story, Brian E. Lapointe

Gulf and Caribbean Research

Over the past 5 decades, coastal waters have experienced unprecedented global change, including widespread eutrophication, harmful algal blooms (HAB), dead zones, and loss of biodiversity. During this period, I have studied the effects of nutrients (N, P) on HAB dynamics in tropical seagrass and coral reef ecosystems. Important findings that emerged from my research include: 1) a primary role of anthropogenic nitrogen (N) relative to phosphorus (P) as a driving factor in algal blooms and coastal eutrophication; 2) altered N:P stoichiometry that results in greater P—limitation and metabolic stress in reef corals; 3) recognition that macroalgal blooms be considered as …

Association Of Phlebotomus Guggisbergi With Leishmania Major And Leishmania Tropica In A Complex Transmission Setting For Cutaneous Leishmaniasis In Gilgil, Nakuru County, Kenya, Barrack O. Owino, Damaris Matoke-Muhia, Yasser Alraey, Jackline Milkah Mwangi, Johnstone M. Ingonga, Philip M. Ngumbi, Aitor Casas-Sanchez, Alvaro Acosta-Serrano, Daniel K. Masiga

All Peer-Reviewed Publications

Background Phlebotomus (Larroussius) guggisbergi is among the confirmed vectors for cutaneous leishmaniasis (CL) transmission in Kenya. This scarring and stigmatizing form of leishmaniasis accounts for over one million annual cases worldwide. Most recent CL epidemics in Kenya have been reported in Gilgil, Nakuru County, where the disease has become a public health issue. However, little is known about the factors that drive its transmission. Here, we sought to determine the occurrence, distribution and host blood feeding preference of the vectors, and to identify Leishmania species and infection rates in sandflies using molecular techniques. This information could lead to a better …

Mine Reclamation's Reliance On King Coal: Meeting Legacy Environmental Obligations With A Declining Industry, Claire Jarrell

University of Colorado Law Review

Coal mines throughout Appalachia have left the land scarred and the water damaged. Although mine reclamation programs are the only major system of recourse for addressing environmental degradation caused by mining, the downturn of the coal market has put reclamation programs in a precarious position for achieving that end. Funds for coal mine reclamation are derived from the current coal industry's profits. As coal profits continue to atrophy, so too does the pot of money designated for reclamation efforts. These dwindling financial resources are particularly problematic because there is still significant need for reclamation funding throughout Appalachia.

This Comment explores …

The Quasi-Parent Conundrum, Michael J. Higdon

University of Colorado Law Review

Although family law is very much concerned with legal parentage and its attendant rights, children are much more concerned with maintaining relationships with those who care for them, regardless of whether that person is a legal parent or someone functioning as one. What happens though if the child's legal parent attempts to banish the quasi-parent from the child's life? Doing so can be extremely damaging to the child. Nonetheless, parents do possess a constitutional right to make decisions about how to rear their children, including who may have access to the child.

Trying to strike a balance between protecting the …

Vertical Sleeve Gastrectomy Improves Ventilatory Drive Through A Leptin-Dependent Mechanism, Deanna M. Arble, Alan R. Schwartz, Vsevolod Y. Polotsky, Darleen A. Sandoval, Randy J. Seeley

Biological Sciences Faculty Research and Publications

Obesity hypoventilation syndrome (OHS) is a serious disorder characterized by daytime hypercapnia, disordered breathing, and a reduction in chemosensitivity. Vertical sleeve gastrectomy (VSG), a bariatric surgical procedure resulting in weight loss and weight-independent improvements in glucose metabolism, has been observed to substantially improve sleep-disordered breathing. However, it is unclear if the ventilatory effects of VSG are secondary to weight loss or the marked change in metabolic physiology. Using preclinical mouse models, we found that VSG leads to an improvement in the hypercapnic ventilatory response (HCVR) and reductions in circulating leptin levels independent of reductions in body mass, fat mass, and …

Pharmaceutical Drugs Of Uncertain Value, Lifecycle Regulation At The Us Food And Drug Administration, And Institutional Incumbency, Matthew Herder

Articles, Book Chapters, & Popular Press

Policy Points

• The US Food and Drug Administration (FDA) has in recent years allowed onto the market several drugs with limited evidence of safety and effectiveness, provided that manufacturers agree to carry out additional studies while the drugs are in clinical use.
• Studies suggest that these postmarketing requirements (PMRs) frequently lack transparency, are subject to delays, and fail to answer the questions of greatest clinical importance. Yet, none of the literature speaks directly to the challenges that the FDA—as a regulatory institution—encounters in enforcing PMRs.
• Through a series of interviews with FDA leadership, this article analyzes and situates those challenges …

Accounting For Intermediaries And Transnational Linkages In The Multi-Level Perspective: Mongolia’S Renewable Energy Transition, Madeline Lee

CMC Senior Theses

As the international community takes increasing action to mitigate the effects of climate change, increased focus has been placed on the topic of energy transitions in developing countries. This paper uses the multi-level perspective (MLP) framework to analyze the ongoing energy transition in Mongolia, specifically the integration of large-scale wind and solar energy systems. Attention is paid to the presence of transnational linkages and intermediaries that have substantially contributed to Mongolia’s success in diffusing renewable energy technology, as well as challenges Mongolia has faced as a result of limited technological and institutional capacity. The paper concludes that Mongolia’s transition shares …

Global Consciousness: A Functionalist Neurophilosophical Perspective, Connor C. Bowen

CMC Senior Theses

The purpose of this thesis is to explore a thought-provoking consequence of the functionalist theory of mind. Given the current organizational structure of Earth and field theories of consciousness in neuroscience, Earth is probably conscious. The argument is explored through an examination of the current organizational structure of Earth and field theories of consciousness in neuroscience, which leads to the conclusion that Earth is conscious. Various theories of mind have been proposed by neuroscientists and philosophers alike in an attempt to qualify what consciousness is and what provides the basis for consciousness to occur. Support, in the form of data …

The Characterization Of Alzheimer’S Disease And The Development Of Early Detection Paradigms: Insights From Nosology, Biomarkers And Machine Learning, Isabel Milano

CMC Senior Theses

Alzheimer’s Disease (AD) is the only condition in the top ten leading causes of death for which we do not have an effective treatment that prevents, slows, or stops its progression. Our ability to design useful interventions relies on (a) increasing our understanding of the pathological process of AD and (b) improving our ability for its early detection. These goals are impeded by our current reliance on the clinical symptoms of AD for its diagnosis. This characterizations of AD often falsely assumes a unified, underlying AD-specific pathology for similar presentations of dementia that leads to inconsistent diagnoses. It also hinges …

Deal Or No Deal: The Relationship Between Firm Determinants & Venture-Capital Financing Decisions, Raghav Prasad

CMC Senior Theses

In this paper, I analyze how firm attributes such as their age, industry, nature of industry, spinoff status and debt ratio influence venture-capital financing decision. I look at a sample of 280 firms that went public in the United States between 2015- 2019. This paper finds that firm age and debt are negatively related to the likelihood of being venture-capital backed. It also finds that firms in technology and biotechnology industries are more likely to be backed by a venture-capitalist.

Detection Of Sickle Cell Disease-Associated Single Nucleotide Polymorphism Using A Graphene Field Effect Transistor, Kandace Fung

CMC Senior Theses

Sickle Cell Disease (SCD) is a hereditary monogenic disorder that affects millions of people worldwide and is associated with symptoms such as stroke, lethargy, chronic anemia, and increased mortality. SCD can be quickly detected and diagnosed using a simple blood test as an infant, but as of now, there is currently limited treatment to cure an individual of sickle cell disease. Recently, there have been several promising developments in CRISPR-Cas-associated gene-editing therapeutics; however, there have been limitations in gene-editing efficiency monitoring, which if improved, could be beneficial to advancing CRISPR-based therapy, especially in SCD. The CRISPR-Chip, a three-terminal graphene-based field …

Studying Geometric Optical Illusions Through The Lens Of A Convolutional Neural Network, Nick Laberge

CMC Senior Theses

Geometrical optical illusions such as the Muller Lyer illusion and the Ponzo illusion have been widely researched over the past 100+ years, yet researchers have not reached a consensus on why human perception is deceived by these illusions or which illusions are the results of the same effects. In this paper, I study these illusions through the lens of a convolutional neural network. First, I successfully train the network to correctly classify how a human would perceive a particular class of illusion (such as the Muller Lyer illusion), then I test the network’s ability to generalize to illusions that it …

Giardia Lamblia Growth In Viscoelastic Fluids, Kelly Watanabe

CMC Senior Theses

Giardia lamblia is a single-celled protozoan parasite that when ingested, causes diarrheal disease and infects 33% of people in developing countries. Previous studies observe Giardia in water-like fluids, but Giardia's infectious environment consists of viscoelastic mucus in the small intestine. Therefore, Giardia was cultured in viscoelastic fluids, and its population growth was observed in vitro. To create shear-thinning viscoelastic fluids, 0.2% and 0.4% long-chain polyacrylamide (LCPAM) was added to cell culture media. Giardia was cultured in control media, 0.2% LCPAM, and 0.4% LCPAM, and population growth was quantitatively determined over time. Increasing LCPAM concentration resulted in a solution with …

Mechanisms Driving Digital New Venture Creation & Performance: An Insider Action Research Study Of Pure Digital Entrepreneurship In Edtech, Kisito Futonge Nzembayie

Doctoral

Digitisation has ushered in a new era of value creation where cross border data flows generate more economic value than traditional flows of goods. The powerful new combination of digital and traditional forms of innovation has seen several new industries branded with a ‘tech’ suffix. In the education technology sector (EdTech), which is the industry context of this research, digitisation is driving double-digit growth into a projected $240 billion industry by 2021. Yet, despite its contemporary significance, the field of entrepreneurship has paid little attention to the phenomenon of digital entrepreneurship. As several scholars observe, digitisation challenges core organising axioms …

The Case Of Inter-Expert Creative Collaboration In Science Gallery Dublin: A Discourse Analytical Approach, Diane Tangney [Thesis]

Doctoral

The phenomenon of creativity has been a focus of enquiry by psychologists for many years. Compared with individual creativity, much less is known about creativity in collaborative contexts (Glăveanu, 2010; Sawyer, 2010). Taking a sociocultural view of creativity, this study contributes to an emerging strand of research that focusses centrally on how creativity unfolds in the performance of creative collaboration.

The research design followed an inductive path conducive to theory building and employed a single case study method (Yin, 2009). Science Gallery Dublin, part of Trinity College Dublin (TCD), is presented as a special place for creative collaboration.

In response …

Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek

Faculty Publications

No abstract provided.