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Articles 23491 - 23520 of 29575
Full-Text Articles in Entire DC Network
Development Of Laser Ablation Direct Analysis In Real Time Imaging-Mass Spectrometry (Ladi-Ms)-Applications To Questions Of Relevance To Forensic Science And Plant Biochemistry, Kristen Leigh Fowble
Development Of Laser Ablation Direct Analysis In Real Time Imaging-Mass Spectrometry (Ladi-Ms)-Applications To Questions Of Relevance To Forensic Science And Plant Biochemistry, Kristen Leigh Fowble
Legacy Theses & Dissertations (2009 - 2024)
Methods for the accomplishment of small molecule imaging by mass spectrometry are challenged by the need for sample pre-treatment steps such as cryo-sectioning, dehydration, chemical fixation, or application of a matrix or solvent, that must be performed to obtain interpretable spatial distribution data. Furthermore, these steps along with requirements of the mass analyzer such as high vacuum, can severely limit the range of sample types that can be analyzed by this powerful method. Here, we report the development of a laser ablation-direct analysis in real time imaging-mass spectrometry (LADI-MS) approach which couples a 213 nm Nd:YAG solid state UV laser …
The Role Of Rock Signaling On Salivary Gland Organoid Formation, Matthew Koslow
The Role Of Rock Signaling On Salivary Gland Organoid Formation, Matthew Koslow
Legacy Theses & Dissertations (2009 - 2024)
Salivary glands are crucial organs that are responsible for secreting saliva which is important for the breakdown of carbohydrates, providing lubrication of the mouth, and maintenance of oral health. Patients diagnosed with Sjögren's Syndrome or receiving treatment for head and neck cancer, can permanently lose salivary gland function, which is referred to as salivary hypofunction. As a result, these patients develop Xerostomia, or the feeling of dry mouth, and suffer from an overall decreased quality of life. To combat the negative effects of salivary hypofunction, stem cell therapy is an attractive option, as implantation of specific cell populations can rescue …
Novel Mass Spectrometric Approaches For Deciphering The Epitranscriptomic Code, William D. Mcintyre
Novel Mass Spectrometric Approaches For Deciphering The Epitranscriptomic Code, William D. Mcintyre
Legacy Theses & Dissertations (2009 - 2024)
According to the results of the Human Genome Project, less than 5% of our genome consists of sequences that code for actual proteins. At the same time, however, ~90% of these non-coding sequences are transcribed into a myriad of classes of ribonucleic acids collectively known as ncRNAs, which have been recognized as essential regulatory factors. It has been recently shown that the activity of ncRNAs can be in turn modulated by post-transcriptional modifications (PTMs), covalent marks that can be established/removed by tightly regulated enzymatic pathways. Now, the race is on to understand the new set of controls of cellular functions …
The Dynamics Of E-Petitioning Behavior In We The People : An Exploration Of Online Mobilized Collective Action, Catherine Dumas
The Dynamics Of E-Petitioning Behavior In We The People : An Exploration Of Online Mobilized Collective Action, Catherine Dumas
Legacy Theses & Dissertations (2009 - 2024)
The purpose of this research is to gain a better understanding of the impact of e-petitioning as a collective mobilized action taken to express policy preferences and the way that signing behavior takes place. Previous studies have analyzed e-petition signature data to track and understand the relationship between signing activity, time, and success of a petition (Hale et al., 2013; Yasseri et al., 2014). By using data mining techniques, namely market basket analysis and social network analysis, this research will explore three case studies that consist of three sets of similar petitions that were initiated on the US e-petitioning platform, …
Examining The Influence Of Technology Affordances Of Fitness Trackers And Health Psychographic Factors On Physical Activity, Xin Zhou
Legacy Theses & Dissertations (2009 - 2024)
Fitness trackers have immense potential to improve individuals’ health behaviors and health outcomes. Studies in disciplines such as public health, communication technology and information systems, have examined factors that can predict use of fitness trackers and their influence on health-related behaviors. However, not much is known about (1) which element(s) of fitness trackers affect individuals’ health behaviors, and (2) the psychological mechanism that guides the relationships between individuals’ health-related beliefs and use of fitness trackers on physical activity behaviors. Guided by the Motivational Technology Model (MTM) and Self-Determination Theory (SDT), this dissertation examined the influence of technology affordances (i.e., customization, …
Significance Of Rna 2'-5' Linkage And Metal-Ion Mediated Base Pairs, Fusheng Shen
Significance Of Rna 2'-5' Linkage And Metal-Ion Mediated Base Pairs, Fusheng Shen
Legacy Theses & Dissertations (2009 - 2024)
It has been known that the template-directed RNA chemical replication reaction produces mixture of backbones containing both 3’-5’ and 2’-5’ linkages. This backbone heterogeneity has been a significant problem in studying the emergence of RNA World from the prebiotic chemistry. However, very recently, it is reported that FMN binding aptamer and a hammerhead ribozyme are still able to retain considerable functions in the presence of certain 2’-5’ linkages, indicating that RNA backbones may be quite flexible and this backbone heterogeneity problem may not be as severe as originally thought. This finding also brings two related important questions: First, how does …
Modeling Chaperone-Substrate Interactions Of Alpha Crystallin From The Ocular Lens, Lisa Marie S. Ramirez
Modeling Chaperone-Substrate Interactions Of Alpha Crystallin From The Ocular Lens, Lisa Marie S. Ramirez
Legacy Theses & Dissertations (2009 - 2024)
The α-crystallins (αA- and αB-crystallin isoforms) from the ocular lens are small heat shock proteins and molecular chaperones, widely believed to play a significant role in protecting the lens from cataract. Mutations and modifications on human αA- and αB-crystallin (HAA and HAB, respectively) are linked to a variety of diseases, including cataract formation, neuropathological protein folding disorders, and many others. It is believed that HAA and HAB prevent the aggregation of other lens proteins. However, the structural and thermodynamic details of the chaperone-substrate (aka “client”) interaction are sparse. Therefore, the main objective of this dissertation is to reveal structural and …
Empirical Essays On Science And New Technology Adoption, Huifeng Yu
Empirical Essays On Science And New Technology Adoption, Huifeng Yu
Legacy Theses & Dissertations (2009 - 2024)
The first chapter studies how the quantity and quality of research output varies over the career using 5.6 million biomedical science articles published over three decades. We show that controlling for selective attrition reconciles conflicts in a longstanding, interdisciplinary literature. While research quality declines monotonically over the career, this decline is easily overlooked because the highest “ability” authors have the longest publishing careers. Our results have implications for broader questions of human capital accumulation over the career and also for federal research policies that shift funding from late- to early-career researchers – while providing more funding to researchers when they …
The State Of Substance Use Education In Master Of Social Work Programs : A Content Analysis Of Msw Curricula & Survey Of Msw Program Leaders, Dane Minnick
Legacy Theses & Dissertations (2009 - 2024)
Substance use is currently a pervasive problem among a large proportion of populations served by the social work profession. Several studies have indicated that social workers routinely provide services to clients with direct and indirect substance use needs, making knowledge of substance use interventions and public policies a necessity for most social workers to operate effectively in the field. However, despite the regularity of interaction with substance using clients, a large body of research has suggested that social work students are ill-prepared to deliver substance use services upon completing their academic training, and that a significant deficit of substance use …
"Farre Fetched And Deare Bought" : Cosmetics And Englishness 1570-1625, Marta Josie Schoel
"Farre Fetched And Deare Bought" : Cosmetics And Englishness 1570-1625, Marta Josie Schoel
Legacy Theses & Dissertations (2009 - 2024)
This study examines cosmetic practice, discourse, and material to explore the ways in which face paint, often made from a mixture of foreign and domestic ingredients, challenges the emergent notion of a pure English identity. Within a broader discourse found in recipe books, anti-cosmetic treatises, public and private documents, and plays for public spectacle—as well as court masques—I examine how early modern performances use cosmetic mixtures as theatrical devices to stage, represent, and negotiate anxieties about England’s increased engagement with the nascent global economy. Worn on the permeable surface of the skin, cosmetic material, such as alum, mercury, and mummia, …
Harm Reduction Policy : Biopower, Race & Stigma At The Heart Of The 'Opioid Crisis', Cole Charles Melby
Harm Reduction Policy : Biopower, Race & Stigma At The Heart Of The 'Opioid Crisis', Cole Charles Melby
Legacy Theses & Dissertations (2009 - 2024)
Across the U.S., concerns regarding substance abuse, addiction, and treatment are coming to the forefront of public discourse, due to increased media coverage of the popularly dubbed ‘opioid crisis.’ As overdose rates increase, particularly in rural and suburban white communities, so have debates about the ethics and efficacy of harm reduction services. Through a review of existing literature and reflections on interviews from key informants at New York State Department of Health, grassroots harm reduction organizations, and a ‘mainstream’ addiction clinic, this thesis will critically examine the history of drug user stigmatization in the U.S. and how it has influenced …
Getting Serious With Comedy : Power, Stand-Up Comedy, And American Public Life, Andrew Michael Cutrone
Getting Serious With Comedy : Power, Stand-Up Comedy, And American Public Life, Andrew Michael Cutrone
Legacy Theses & Dissertations (2009 - 2024)
This master’s thesis theorizes the political and cultural significance of stand-up comedy as an institution in the contemporary US public sphere, against the dominant perception that it is an enterprise severed from social consequence. Via a critical application of Ferguson’s theorization of power in The Reorder of Things (2012), in addition to a reading of stand-up comedy routines and related public discourse that utilizes feminist and queer of color theory, I show how subjective terrains of race, gender, and sexuality produce the discursive and political materials which organize stand-up discourse and performance in moments of “racial comedy,” “gender comedy,” and …
Environmental Influences On Rates Of Osteo- And Rheumatoid Arthritis, Azad Abdulrahman Mohammed
Environmental Influences On Rates Of Osteo- And Rheumatoid Arthritis, Azad Abdulrahman Mohammed
Legacy Theses & Dissertations (2009 - 2024)
Abstract
Development Of A Neutropenic Murine Model For Invasive Candida Auris Infection, Steven Torres
Development Of A Neutropenic Murine Model For Invasive Candida Auris Infection, Steven Torres
Legacy Theses & Dissertations (2009 - 2024)
In less than a decade, the emerging fungal pathogen Candida auris has become a major public health threat due to its multidrug resistant (MDR) phenotype, high transmissibility, and high mortality rates that range between 30%-60%. Unlike other Candida species, C. auris has acquired high levels of resistance to an already limited arsenal of antifungals. As an emerging pathogen, there are currently a limited number of documented murine models of C. auris infection. These animal models using a range of inoculums from 105 –108 cells per mouse, and the environmental and occupational exposure of working with these models has not been …
Epidemiology Of Self-Reported Maternal Depression During Pregnancy And Association With Adverse Birth Outcomes In New York State, 2012-2017, Solita Julianna Jones
Epidemiology Of Self-Reported Maternal Depression During Pregnancy And Association With Adverse Birth Outcomes In New York State, 2012-2017, Solita Julianna Jones
Legacy Theses & Dissertations (2009 - 2024)
Background
Family Instability As A Turning Point In The Life-Course : An Examination Of Whether And How Family Instability And Specific Types Of Family Instability Directly And Indirectly Influence Delinquency, Walter Shelley
Legacy Theses & Dissertations (2009 - 2024)
“A family’s resources and the doors they open cast a long shadow over children’s life trajectories…This view is at odds with the popular ethos that we are makers of our own fortune.” (Alexander, Entwisle, & Olson, 2010, pg. 1). Perhaps no aspect about an individual’s life is not shaped in some way by their family. In fact, it could be surmised that families set the stage for all later outcomes in the life-course. An event in a family such as family instability could play an important role in shaping an individual’s behavior and outcomes in their life course. However, heterogeneity …
The Aids Volcano : Narratives Of Hiv/Aids In The Iranian Public Sphere, Elham Pourtaher
The Aids Volcano : Narratives Of Hiv/Aids In The Iranian Public Sphere, Elham Pourtaher
Legacy Theses & Dissertations (2009 - 2024)
Broadly construed, this thesis will examine the transformations in the socio-cultural construction of HIV/AIDS in Iran from the joint perspectives of media and medical sociology. Until recently, official public narratives in Iran primarily regarded AIDS to be a drug-related disease. However, beginning from the early 2010s, a new narrative frame (often called as “the third wave”) introduces a significant “alarming” collective shift in the transmissions modes of the disease toward sexual pathways. Having observed the rather rapid transformation of the public AIDS framing, this research began with an empirical question: considering the fact that the shift implied the prevalence of …
Characterizing Body Fluids With Raman Spectroscopy : Towards Real World Application, Marisia Ann Fikiet
Characterizing Body Fluids With Raman Spectroscopy : Towards Real World Application, Marisia Ann Fikiet
Legacy Theses & Dissertations (2009 - 2024)
This project continues the research on a new method of body fluid identification and furthers its field capabilities. This method of identification uses Raman spectroscopy and advanced chemometrics to distinguish between body fluids. It is an improvement on current methods because it is confirmatory, non-destructive, and has simple sample preparation. The first objective of this research is to create a model for differentiating body fluids for a new desktop instrument. It was determined that due to resolution differences from a research grade instrument, a new model needed to be made for this the desktop instrument. This model will be able …
Black Trojans : The Free Black Community's Grassroots Abolition Campaign In Troy, New York Before 1861, Jennifer J. Thompson Burns
Black Trojans : The Free Black Community's Grassroots Abolition Campaign In Troy, New York Before 1861, Jennifer J. Thompson Burns
Legacy Theses & Dissertations (2009 - 2024)
This dissertation explores the evolution and trajectory of the abolition movement led by black men and women in Troy, New York, before 1861. At the grassroots level, black Trojan men and women claimed public spaces and founded societies and associations that simultaneously supported local black upliftment and laid the foundation from which a larger abolitionist network, within New York State and across state and national borders, was constructed. Through the operations of an “Aboveground Railroad” system that complimented the Underground Railroad system through Troy but focused on the movement of free people, as well as communications in abolition and black …
Butterflies As Charismatic Indicators : Can Study Of Impact Of On-Farm Habitat Enrichment On Butterfly Populations Provide Insight About Habitat Quality For Other Insects?, Erin Allen
Legacy Theses & Dissertations (2009 - 2024)
Populations of insect pollinators have been declining precipitously across the Northern Hemisphere, due to disease, insecticide application, and habitat degradation and loss. As a result, crop pollination services are at risk, and the ecological insurance provided by biodiversity is in jeopardy. Regional efforts to combat the decline of pollinator diversity and abundance include the New York State Pollinator Protection Plan to assess regional pollinator health, strategies to enhance wild pollinator habitat, as well as on-farm habitat enhancement strategies to augment pollinator populations in and around crops. One such habitat enhancement strategy involves improving native floral resource availability, which is often …
Queering Sexual Development Frameworks : A Dynamic Systems Approach To Conceptualizing Other-Sex Sexuality Among Lesbians, Kolbe Franklin
Queering Sexual Development Frameworks : A Dynamic Systems Approach To Conceptualizing Other-Sex Sexuality Among Lesbians, Kolbe Franklin
Legacy Theses & Dissertations (2009 - 2024)
Essentialist models of sexual identity development have dominated social discourse and public opinion since the 1980s. This perspective posits that sexual orientation is an intrinsic, core identity that has roots in specific biological factors. Based on this perspective it is assumed that a person’s sexuality will manifest in a linear fashion throughout the life course. Notably, this model positions individuals with same-sex sexual attractions and behaviors as specific “types” of people. While this perspective has become largely institutionalized in public opinion, within academic research on sexual orientation, there has been little consensus on the veracity of this model. Specifically, the …
Synthesis Of Cadmium Arsenide Semiconductor Nanoparticles, Superatomic Silver Clusters, And Silver Coordination Polymers, Sarthak Jashubhai Patel
Synthesis Of Cadmium Arsenide Semiconductor Nanoparticles, Superatomic Silver Clusters, And Silver Coordination Polymers, Sarthak Jashubhai Patel
Legacy Theses & Dissertations (2009 - 2024)
Nanomaterials have chemical, electronic, optical, and other properties distinct from their bulk counterparts. However, the atom-precise synthesis of these materials remains a challenge, leaving open many scientific questions regarding the size regime between nanoparticulate (quantum confined) and bulk character. In this work, efforts toward the synthesis of nanoparticulate and atom-precise metal and semimetal materials are described. The synthesis of II-V semiconductor Cd3As2 having a near-zero bandgap is discussed. Analysis by UV-Vis absorption spectroscopy and powder X-ray diffraction indicate the formation of material with unexpected crystallinity and absorption properties The interaction between the molecular source of As and the solvent was …
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
The Role Of Progesterone Receptor In The Developing Medial Preoptic Nucleus, Diana Lalitsasivimol
Legacy Theses & Dissertations (2009 - 2024)
Numerous neurodevelopmental and neuropsychiatric diseases have a distinct sex bias in
Artificial Intelligence And Utility : Deep Problems For A.I. Ethics, Trevor Howard Groves
Artificial Intelligence And Utility : Deep Problems For A.I. Ethics, Trevor Howard Groves
Legacy Theses & Dissertations (2009 - 2024)
As technology advances further, new problems arise for us to contend with philosophically. Indeed, popular media has already begun presenting the possible issues our society must deal with. One of these is A.I., and how they will challenge old notions of subjects like identity, consciousness, and ethics. It is this third category that this paper is concerned with, namely how the existence of A.I. will affect our choice of ethical theory in regards to their treatment. It is my intention to demonstrate that one particular category of ethical theory, hedonistic consequentialist ones, will be ill equipped to handle these considerations. …
Unbecoming : A Collection Of Short Fiction, Angélica Luisa Valentín Schubert
Unbecoming : A Collection Of Short Fiction, Angélica Luisa Valentín Schubert
Legacy Theses & Dissertations (2009 - 2024)
This collection contains nine short stories addressing various concepts and issues relating to contemporary femininity in the United States.
Climate Change And Salmonella, New York State, Kevin Taylor Welch
Climate Change And Salmonella, New York State, Kevin Taylor Welch
Legacy Theses & Dissertations (2009 - 2024)
A study of climate change and Salmonella was conducted, serving as the evidence-based results for action to mitigate adverse Salmonella outcomes for the population of New York State (NYS), and to facilitate dissemination of findings in regard to validated approaches for broader use to mitigate climate change and adverse communicable disease outcomes in a variety of other settings. This study bolsters understanding of dynamic exposures and outcomes for improved and targeted public health approaches to localized climate change and communicable disease outcomes. The approach was developed and refined through continuously validated and calibrated methodology for the enhancement of disease control …
Of Donuts And Promo : In Silico Approaches To Identification Of Transcriptional Regulators Of Salivary Acinar Differentiation, Connor Cillian Duffy
Of Donuts And Promo : In Silico Approaches To Identification Of Transcriptional Regulators Of Salivary Acinar Differentiation, Connor Cillian Duffy
Legacy Theses & Dissertations (2009 - 2024)
The salivary gland is an organ often taken for granted by most people. However, its proper function is essential for several everyday activities, such as speaking, swallowing, and tasting. As such, impaired salivary gland function, such as that caused by Sjögren’s Syndrome or radiotherapy for head and neck cancers, can lead to a significantly reduced quality of life. The cells that produce saliva in salivary glands are known as acinar cells, which arise from proacinar cells generated during embryonic development. As such, in studying the promoter regions of proacinar and acinar genes, it may be possible to identify common transcription …
Efficient Algorithms For Mining Healthcare Data :, Yan Hu
Efficient Algorithms For Mining Healthcare Data :, Yan Hu
Legacy Theses & Dissertations (2009 - 2024)
Data-Driven Healthcare (DDH) is defined as the usage of available medical big data to provide the best and most personalized care, which is believed to be one of the most promising directions for transforming healthcare. The healthcare data includes claims and cost data, clinical data, pharmaceutical R&D data, patient behavior and sentiment data, and health data on the web. There has been a remarkable upsurge in the adoption of healthcare data over the past several years. In particular, it has been used for medical concept extraction, patient trajectory modeling, disease inference, etc.
Protein Ligation : Selenocysteine, Komal Shah
Protein Ligation : Selenocysteine, Komal Shah
Legacy Theses & Dissertations (2009 - 2024)
Selenium is present in human and animal body in the form of selenocysteine and
Assessing Novel Expectancies About Ayahuasca : A Preliminary Report, Brianna Rose Altman
Assessing Novel Expectancies About Ayahuasca : A Preliminary Report, Brianna Rose Altman
Legacy Theses & Dissertations (2009 - 2024)
Given the growing popularity of Ayahuasca, we sought to identify why people might use this psychoactive brew rather than classic hallucinogens like LSD or psilocybin. Experienced users (N=139) completed an online survey about their use of hallucinogens, including ayahuasca, how their ayahuasca experiences differed from those with other hallucinogens, and their willingness to use ayahuasca over other hallucinogens in the future. Participants reported meaningful differences between ayahuasca and other hallucinogens, which apparently related to positive connections to nature and other people, dramatic or terrifying negative thoughts, and aversive physical reactions. Multiple measures of self-reported likelihood of using ayahuasca again increased …