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Krill Motion In The Southern Ocean: Quantifying In Situ Krill Movement Behaviors And Energetics, Mary Kathryn Kane

Open Access Dissertations

Krill are a major link in the transfer of carbon between primary production and upper trophic level organisms, like whales and penguins, in the Southern Ocean. However, not much is known about in situ individual krill behaviors, and there have been no seasonal comparisons of individual krill motility in the Southern Ocean. To address how individual krill movement behaviors and energetic requirements shift between seasons, we used a novel stereo-camera and environmental sensor system to observe krill in three bays in the Western Antarctic Peninsula in May-June 2013 (i.e., the late austral autumn) and December 2014 (i.e., the late austral …

Overcoming Contemporary Obstacles In Drug Delivery Via Acetalated Dextran Particle Formulations, Nishan K. Shah

Open Access Dissertations

Particle-based delivery systems have been investigated for their potential to increase the efficacy of patient diagnoses and treatments. In many cases, these systems increase the bioavailability and/or decrease the toxicity of clinically relevant drugs. These developments have led to improvements in patient compliance, morbidity, mortality, and quality of life. To date, particle-based delivery systems have been evaluated in hundreds of clinical trials around the world. Unlike conventional delivery systems, particle-based delivery systems offer increased surface area, colloidal stability, and system tunability, all of which can be tailored to target the disease state of interest and specific patient population.

Although there …

Use Of Hyphenated Mass Spectrometry To Uncover True Nafld Effect On Human Drug Disposition Proteins, Benjamin Joseph Barlock

Open Access Dissertations

Nonalcoholic fatty liver disease (NAFLD) is growing in prevalence across the world and is associated with a significant economic cost. In addition to life style modification, no pharmacotherapy method is available to treat NAFLD. As the histology of the liver changes over the course of the disease, it can be expected that the liver proteome will change too. Included in the liver proteome are drug disposition proteins comprised of drug metabolizing enzymes and transporters. These proteins are responsible for the removal of drugs and endogenous compounds from the body. The goals of this dissertation were: (1) Develop methodology to accurately …

How Birds Respond To Antioxidant Capacity, Oxidative Damage, And Fuel Stores During Migration, Clara Cooper-Mullin

Open Access Dissertations

During migration, birds have an elevated metabolic rate and rely heavily on fat for fuel, creating a state where oxidative stress may be high if not counterbalanced by antioxidants. However, no previous studies have examined how birds utilize different aspects of the antioxidant system to combat oxidative damage during flight training, whether dietary antioxidants are absorbed and transported to the site of reactive species generation, the mitochondria, or how oxidative status interacts with fuel stores to shape decisions birds make during migratory stopovers. In this dissertation, I first introduce the physiological challenges of increased production of reactive species confronted by …

The Chirp Function Revisited: A Uniqueness Conjecture For Chirplet Modulation, Jonathan Blackledge, Paul Tobin

Conference papers

The chirp function (a unit amplitude quadratic phase-only function with linear frequency modulation) is well known and is used in a wide range of applications including radar, digital communications, information coding and hiding and many other forms of signal and image processing. This is because the chirp provides an optimal solution to the problem of retrieving information from low energy signals with a low Signal-to-Noise Ratio (SNR). The chirp function also occurs in the solution to many mathematical models used to describe the propagation and scattering of waves (in the Fresnel zone), in quantum mechanics (the quantum shutter problem) and …

Evaluating The Relationship Between Depression, Perceived Stress, Sleep Quality, And Lure Discrimination, Jessica Rothberg

Theses, Dissertations and Culminating Projects

Depression, Stress and disordered sleep have been found to negatively affect cognition. However, the specific mechanisms affected are still unclear. These clinical symptoms are all independently associated with the hippocampus, where a memory process called pattern separation is assumed to occur. The current study aimed to further investigate the association between depression and pattern separation by further examining the role that sleep and stress play in this relationship. This study is an expansion from Shelton and Kirwan (2013) where they used the Mnemonic Similarities Task to evaluate lure discrimination and depression. I expanded on this by also evaluating sleep quality …

Inhibition Of Hsv-1 Binding By Egcg-Stearate, Valerie Paschalis

Theses, Dissertations and Culminating Projects

Herpes simplex virus type 1 (HSV-1) is the causative agent of oral herpes, and is able to establish lifelong latent infection along with painful, recurring symptoms. Epigallocatechin-3- gallate (EGCG) is the most abundant polyphenol derived from green tea (Camellia sinensis), whose anti-inflammatory, antioxidant, anti-cancer, and antiviral properties have been widely studied. Although EGCG is not chemically stable and has poor hydrophobicity, lipophilic derivatives of EGCG have shown increased stability as well as increased antiviral efficacy against HSV. Previous studies have demonstrated that EGCG stearate (EGCG-S), a derivative of EGCG esterified at the 4’ position with stearic acid, is able to …

Targeted Resequencing Of Crispr Cas9 Mediated Icer Knockout In Sk-Mel-24 Cells, Justin Wheelan

Theses, Dissertations and Culminating Projects

Inducible cAMP Early Repressor (ICER) is a small transcription factor that originates from an intronic promoter within the cAMP Response Element Modulator (CREM) gene (Molina et al., 1993). ICER acts as a putative tumor suppressor by mediating cAMP antiproliferative activity by competitively binding to cAMP Response Elements (CRE’s) and repressing transcription of genes involved in cell division (Mémin et al., 2002). ICER has been shown to be effectively absent in cancer and suspected to be targeted for proteasomal degradation via ubiquitination (Healey et al., 2013). ICER is most likely regulated via post-translational modifications as a result of mutations on Ras/Raf …

Least Action Principle Applied To A Non-Linear Damped Pendulum, Katherine Rhodes

Theses, Dissertations and Culminating Projects

The principle of least action is a variational principle that states an object will always take the path of least action as compared to any other conceivable path. This principle can be used to derive the equations of motion of many systems, and therefore provides a unifying equation that has been applied in many fields of physics and mathematics. Hamilton’s formulation of the principle of least action typically only accounts for conservative forces, but can be reformulated to include non-conservative forces such as friction. However, it can be shown that with large values of damping, the object will no longer …

The Cultural Politics Of Dan Quayle And Mike Pence, Steve Sanders

Articles by Maurer Faculty

This essay was part of an Indiana Law Review symposium on the five U.S. vice presidents who have hailed from Indiana.

The Gallup polling organization classifies Indiana as a “pink” state, rather than a “red” state, meaning it leans Republican but is not solidly in the GOP column. Yet, if an image of Indiana persists in many people’s minds as a bastion of social conservatism and tradition, that image likely has been shaped in part by the two most recent vice presidents the Hoosier state has sent to Washington: Dan Quayle and Mike Pence.

In selecting their running mates, major …

Sex-Related Differences In Immune Response And Symptomatic Manifestations To Infection With Leishmania Species, Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodriguez

Faculty Work

Worldwide, an estimated 12 million people are infected with Leishmania spp. and an additional 350 million are at risk of infection. Leishmania are intracellular parasites that cause disease by suppressing macrophage microbicidal responses. Infection can remain asymptomatic or lead to a spectrum of diseases including cutaneous, mucocutaneous, and visceral leishmaniasis. Ultimately, the combination of both pathogen and host factors determines the outcome of infection. Leishmaniasis, as well as numerous other infectious diseases, exhibits sex-related differences that cannot be explained solely in terms of environmental exposure or healthcare access. Furthermore, transcriptomic evidence is revealing that biological sex is a variable impacting …

The Persecution Of Stones: War Crimes, Law's Autonomy And The Co-Optation Of Cultural Heritage, Timothy W. Waters

Articles by Maurer Faculty

In 1567, a bridge was built over a river in Bosnia-a bridge widely seen as a work of great beauty. In 1993, it was destroyed in a war. What did its destruction mean? Was it a crime-and which one? An assault on culture-and whose? Between 2004 and 2017, a trial held in The Hague sought to answer these questions. The way it did-the assumptions and categories the prosecutors and judges deployed, the choices they made-tells us something important about how law operates and how it appropriates other bodies of knowledge, whether in a now-obscure Balkan conflict or on the battlefields …

Evidence On Fire, Valena Beety, Jennifer Oliva

Articles by Maurer Faculty

Fire science, a field largely developed by lay “arson investigators,” police officers, or similar first responders untrained in chemistry and physics, has been historically dominated by unreliable methodology, demonstrably false conclusions, and concomitant miscarriages of justice. Fire investigators are neither subject to proficiency testing nor required to obtain more than a high school education. Perhaps surprisingly, courts have largely spared many of the now debunked tenets of fire investigation any serious scientific scrutiny in criminal arson cases. This Article contrasts the courts’ ongoing lax admissibility of unreliable fire-science evidence in criminal cases with their strict exclusion of the same flimsy …

The Effects Of Parental Divorce And Remarriage On Emerging Adult’S Romantic Attachment Styles, Bailey Mortis

Theses and Dissertations--Family Sciences

This study shined light on the gap in literature about the impact of communication and involvement of stepparents has on emerging adult’s romantic attachment styles. A sample of 289 college students between the ages of 18 and 22 at the University of Kentucky was recruited to complete an online survey about their perceived experience with their stepparent and parental figures and the effects on their romantic attachment styles. Parental involvement in children’s lives and having good communication, sets the foundation for individuals to have secure attachment styles. Emerging adults who experience parental figures and stepparents as being uninterested or passive …

Retirement Planning Versus Family Support: What Drives Peoples` Decisions?, Radion Svynarenko

Theses and Dissertations--Family Sciences

A slight majority of American households headed by 55–64-year-olds do not have any savings for retirement, and those who have retirement savings have a median of around $109,000 saved, which is equivalent to an inflation-protected annuity of $405 per month (i.e., well below the official poverty level). Among the main reasons cited for the lack of retirement savings among parents is a desire to provide financial support to their young adult children. Indeed, on the whole, parents spend twice as much on financial support of their adult children as they save for retirement (Merryl Lynch, 2018). Understanding the precursors and …

Lessons From Mexican Folklore: An Essay On U.S. Immigration Policy, Child Separation, And La Llorona, Richard Delgado, Jean Stefancic

Essays, Reviews, and Shorter Works

No abstract provided.

Addiction As Disease, Teneille R. Brown

Utah Law Faculty Scholarship

The opioid addiction epidemic is the most overwhelming public health crisis our country has faced. It is now creating a legal crisis, as the its poisonous fruits spill over into the criminal, tort, and family courts. The epidemic costs the U.S. economy about $500 billion every year, and the pressure is crippling our legal systems. This Article is an attempt to relieve some of that pressure, by advocating for a comprehensive public health campaign based upon a new model of addiction. Research shows that the prevalent “moral choice” model of addiction has facilitated stigma and discouraged treatment, by viewing affected …

Essays On Investments, Michael Farrell

Theses and Dissertations--Finance and Quantitative Methods

The first chapter studies mutual funds. I model intraquarter trading and use a genetic algorithm to estimate the trade pattern that is most consistent with the fund's daily reported returns. I validate the model empirically on a sample of institutional trades from Ancerno and I confirm that the method more accurately predicts daily holdings when compared to existing naive assumptions. Further, my method is substantially more accurate in classifying a fund's tendency to supply liquidity, and this increased precision has important implications for identifying superior performing funds. Specifically, a long-short strategy based on the model's liquidity provision measures earns significant …

Differential Abundance And Clustering Analysis With Empirical Bayes Shrinkage Estimation Of Variance (Dasev) For Proteomics And Metabolomics Data, Zhengyan Huang

Theses and Dissertations--Epidemiology and Biostatistics

Mass spectrometry (MS) is widely used for proteomic and metabolomic profiling of biological samples. Data obtained by MS are often zero-inflated. Those zero values are called point mass values (PMVs). Zero values can be further grouped into biological PMVs and technical PMVs. The former type is caused by the absence of components and the latter type is caused by detection limit. There is no simple solution to separate those two types of PMVs. Mixture models were developed to separate the two types of zeros apart and to perform the differential abundance analysis. However, we notice that the mixture model can …

Rebooting Empathy For The Digital Generation Lawyer, Lauren A. Newell

Scholarly Works

No abstract provided.

2019 Symposium Brochure

Programs

No abstract provided.

Discontinuation And Switching Patterns Of Tumour Necrosis Factor Inhibitors (Tnfis) In Tnfi-Naive And Tnfi-Experienced Patients With Psoriatic Arthritis: An Observational Study From The Us-Based Corrona Registry., Philip Mease, Chitra Karki, Mei Liu, Youfu Li, Bernice Gershenson, Hua Feng, Peter Hur, Jeffrey D Greenberg

Articles, Abstracts, and Reports

Objective: To examine patterns of tumour necrosis factor inhibitor (TNFi) use in TNFi-naive and TNFi-experienced patients with psoriatic arthritis (PsA) in the USA.

Methods: All patients aged ≥18 years with PsA enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry who initiated a TNFi (index therapy) between March 2013 and January 2017 and had ≥1 follow-up visit were included. Times to and rates of discontinuation/switch of the index TNFi were compared between TNFi-naive and TNFi-experienced cohorts. Patient demographics and disease characteristics at the time of TNFi initiation (baseline) were compared between cohorts and between patients who continued versus discontinued their index TNFi …

Focused Transcranial Ultrasound For Treatment Of Neurodegenerative Dementia., Natalie Eleanor Nicodemus, Sergio Becerra, Taylor P Kuhn, Hannah R Packham, John Duncan, Kennedy Mahdavi, Jessica Iovine, Santosh Kesari, Scott Pereles, Mike Whitney, Michael Mamoun, Daniel Franc, Alexander Bystritsky, Sheldon Jordan

Articles, Abstracts, and Reports

Introduction: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).

Methods: A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm

Results: Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported.

Discussion: The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.

Fe Limitation Decreases Transcriptional Regulation Over The Diel Cycle In The Model Diatom Thalassiosira Pseudonana., Johanna A L Goldman, Megan J Schatz, Chris T Berthiaume, Sacha N Coesel, Mónica V Orellana, E Virginia Armbrust

Articles, Abstracts, and Reports

Iron (Fe) is an important growth factor for diatoms and its availability is further restricted by changes in the carbonate chemistry of seawater. We investigated the physiological attributes and transcriptional profiles of the diatom Thalassiosira pseudonana grown on a day: night cycle under different CO2/pH and iron concentrations, that in combination generated available iron (Fe') concentrations of 1160, 233, 58 and 12 pM. We found the light-dark conditions to be the main driver of transcriptional patterns, followed by Fe' concentration and CO2 availability, respectively. At the highest Fe' (1160 pM), 55% of the transcribed genes were differentially expressed between day …

Advanced Placement (Ap) Computer Science Principles: Searching For Equity In A Two-Tiered Solution To Underrepresentation, Keith Howard, Douglas D. Havard

Education Faculty Articles and Research

The purpose of this research is to examine the relationship between students’ participation in the two high school AP computer science exam options and their selected fields of study once they enter post-secondary education. Two studies using national public-use datasets of participation and performance were conducted. Study 1 compared score distributions for the traditional Computer Science A exam to those of the newer Computer Science Principles exam during its first two years of implementation. In Study 1, Chi-square analyses revealed large differences in performance between the two exams, with the Computer Science Principles scores clustering more around marginal pass rates. …

Bulletin: General Catalog Issue 2019-2020, Portland State University

Bulletin & Curriculum Change Documents

Volume 1 - Programs is available via the Download option, Volume 2 - Courses is available in the Additional Files below

A Profile Of Freshman Inquiry Students Fall 2019, Portland State University. University Studies Program, Rowanna L. Carpenter

University Studies Assessment Research

In order to better understand the students who enroll in Freshman Inquiry (FRINQ) courses and identify areas where they may need support, University Studies (UNST) began collecting and compiling data on these students. This report presents a profile of FRINQ students from Fall 2019. It presents an overview of all students enrolled in FRINQ during Fall 2019 and then summarizes information from the Prior Learning Survey. It is organized around three areas that contribute to student success: academic preparation and concern; financial and physical wellbeing; and connectedness to campus.

Development Of Laser Ablation Direct Analysis In Real Time Imaging-Mass Spectrometry (Ladi-Ms)-Applications To Questions Of Relevance To Forensic Science And Plant Biochemistry, Kristen Leigh Fowble

Legacy Theses & Dissertations (2009 - 2024)

Methods for the accomplishment of small molecule imaging by mass spectrometry are challenged by the need for sample pre-treatment steps such as cryo-sectioning, dehydration, chemical fixation, or application of a matrix or solvent, that must be performed to obtain interpretable spatial distribution data. Furthermore, these steps along with requirements of the mass analyzer such as high vacuum, can severely limit the range of sample types that can be analyzed by this powerful method. Here, we report the development of a laser ablation-direct analysis in real time imaging-mass spectrometry (LADI-MS) approach which couples a 213 nm Nd:YAG solid state UV laser …

The Role Of Rock Signaling On Salivary Gland Organoid Formation, Matthew Koslow

Legacy Theses & Dissertations (2009 - 2024)

Salivary glands are crucial organs that are responsible for secreting saliva which is important for the breakdown of carbohydrates, providing lubrication of the mouth, and maintenance of oral health. Patients diagnosed with Sjögren's Syndrome or receiving treatment for head and neck cancer, can permanently lose salivary gland function, which is referred to as salivary hypofunction. As a result, these patients develop Xerostomia, or the feeling of dry mouth, and suffer from an overall decreased quality of life. To combat the negative effects of salivary hypofunction, stem cell therapy is an attractive option, as implantation of specific cell populations can rescue …

Novel Mass Spectrometric Approaches For Deciphering The Epitranscriptomic Code, William D. Mcintyre

Legacy Theses & Dissertations (2009 - 2024)

According to the results of the Human Genome Project, less than 5% of our genome consists of sequences that code for actual proteins. At the same time, however, ~90% of these non-coding sequences are transcribed into a myriad of classes of ribonucleic acids collectively known as ncRNAs, which have been recognized as essential regulatory factors. It has been recently shown that the activity of ncRNAs can be in turn modulated by post-transcriptional modifications (PTMs), covalent marks that can be established/removed by tightly regulated enzymatic pathways. Now, the race is on to understand the new set of controls of cellular functions …