Digital Commons Network^™

Investigation Of The Cell-Cycle Dependent Activity Of The Brca1-Rbbp8 Complex For Homologous Recombination, Jil Shah

Honors Undergraduate Theses

When cells undergo mitosis, they must replicate all six billion base pairs of DNA within the nucleus. With the sheer volume of information, it is impossible to replicate with 100% accuracy each time. Homologous recombination (HR) is one of many mechanisms the body has developed to correct and repair replication errors to DNA. HR is specific to double-stranded breaks to DNA, and it requires a sister chromatid to preserve the genetic code. BRCA1 and Rbbp8 interact to form a complex that is heavily involved in this process. Although there is a strong consensus about the involvement of these proteins in …

Proposed Biomedical Applications Of Zirconium-Based Metal-Organic Frameworks As Drug Delivery Systems, Ariel Margaret Perry-Mills

Honors Undergraduate Theses

Metal-organic frameworks (MOFs) are a class of highly crystalline nanoporous materials that self-assemble from inorganic metal oxide clusters and multitopic organic linkers. MOFs can be altered in terms of the types of metals and structures of organic linkers used, allowing for a high degree of customization and manipulation of the synergistic chemical or physical properties that arise from the precise coordination of their molecular components, including exceptionally large surface area and pore size. Zirconium-based MOFs, called UiOs in honor of their conception at the University of Oslo, also show remarkable chemical stability in both acidic and basic environments, making them …

Split Probe Detection Of The Influenza A Virus For Improved Diagnostics In A Point Of Care System, Tamar Yishay

Honors Undergraduate Theses

A group of Influenza viruses, RNA containing viruses of the Orthomyxoviridae family, consists of Influenza virus types A-D and has been known to cause the Flu, a respiratory illness associated with numerous detrimental symptoms that can lead to death. Influenza A virus (IAV) is constantly changing and is capable of causing pandemics. Currently used diagnostic methods include virus culturing, immunoassays including rapid influenza detection tests (RIDTs), and molecular assays including those based on RT-PCR. Most of the methods can be only performed in the certified diagnostic laboratories equipped with sophisticated instrumentation and/or special biosafety facilities. The results using these methods …

Urinalysis Screening Of Drugs In Adulterated Samples Via Direct Analysis In Real Time -- High Resolution/ Mass Spectrometry (Dart-Hr/Ms), Bianca E. Olivieri

Honors Undergraduate Theses

Current screening methods for drug analysis with urine samples includes examination of the sample with an immunoassay. These methods are used to determine the concentration of drug metabolites contained within the sample prior to further confirmatory testing. Drug testing plays a crucial role in maintaining safe workplace environments and safety of individuals. However, a positive result can lead to heavy consequences for the employee including suspension or removal from the workplace. Therefore, a majority of individuals add commonly known products into the sample to evade detection by developing a false negative result. Although specimen integrity examinations are performed to identify …

Academic Competence, Self-Efficacy, And Achievement Expectations Among International Students At The University Of Central Florida, Emily Hynson

Honors Undergraduate Theses

With the vast and continued growth of international students in the U.S., it is important to focus on this expanding group and identify factors that aid or hinder academic performance, achievement, expectations, and competence. Factors known to affect academics among international students, such as language barriers, acculturation to American society, university support and structure, social integration at the university, family support, and motivating factors to study in the U.S were examined. It was hypothesized that these known factors would negatively correlate with the academic outcomes of international students examined in the current study. It was also hypothesized that these factors …

Effects Of A Plant-Based Vegan Diet On The Risk Of Cancer: An Integrative Review Of The Literature, Chelsie M. Silavent

Honors Undergraduate Theses

Cancer, an aggressive chronic disease, impacts the lives of millions of people every day. There are numerous proposed triggers related to the diagnosis and much remains to be learned about the causes. Associated with this disease's variability is the challenge to identify a single causative agent that lead to its prevention. Specific topics that need additional evidence relate to environmental factors and lifestyle behaviors in the development, treatment and, in some instances, even suppression of disease progression. Specifically, a diet that excludes animal-based products but consists of a variety of fruits and vegetables (i.e., plant-based vegan diet) is reported to …

Sex Determination Using Discriminant Function Analysis Of Carpals From Maya Sites In Belize From Pre-Classic To Spanish Colonial Period, Michelle D. Labbe

Honors Undergraduate Theses

The sexing of human skeletal remains is important for identification and demographic purposes. It is made more difficult when elements such as the skull and pelvis are not recovered or are in too poor of a condition to assess. Previous studies have used carpal (wrist) bones of contemporary populations to assess the viability of these skeletal elements exhibiting sexual dimorphism, as these bones are small, compact elements that are usually recovered in good condition. This study evaluates the use of carpal bones recovered from an ancient Maya population from Belize to determine the biological sex of individuals. The study sample …

The Effects Of Medical Cannabis Use Among Adults With Chronic Pain: An Integrative Review Of The Literature, Bridget A. Asevedo

Honors Undergraduate Theses

The purpose of this integrative literature review was to understand the effects of medical cannabis for chronic pain management in adults. Anecdotal reports suggest the use of medical marijuana as a pain management therapy could be an alternative to opioids and other medications which have long term consequences. Potential uses span the health care continuum, from prescribed outpatient symptom management, to acute care, extended care, home care, and hospice treatment settings. The methodology included a review and synthesis of relevant research articles from 2012 to 2018, written in the English language. The findings suggest medical cannabis has the potential of …

Autologous Skin Cell Spray-Transplantation As An Innovative Alternative To Autologous Split- Thickness Skin Grafts For Deep Partial Thickness Burn Wounds: An Integrative Literature Review, Alexandria M. Beaudet

Honors Undergraduate Theses

Burn wounds tend to be a critical problem with a complicated healing process. Although advancements have been made and the treatment of burn wounds has improved significantly, the healing process for deep-partial thickness burn wounds remains problematic. The purpose of this thesis is to review the available literature on an innovate biotechnology, autologous skin cell-spray transplantation, to more effectively treat burn wounds and potentially other injuries in the future. This study was conducted by critically researching and comparing (N=7) peer-reviewed research articles focusing not only on burn wounds using traditional treatments, but also the treatment of burn wounds using revolutionary …

Effect Of Propionic Acid-Derivative Ibuprofen On Neural Stem Call Differentiation; A Potential Link To Autism Spectrum Disorder, Aseelia Samsam

Honors Undergraduate Theses

Propionic acid (PPA) is a short chain fatty acid that is produced by the human gut microbiome. Propionate, butyrate and acetates are the end products of the fermentation of the complex carbohydrates by human gut friendly microbiome and are being used as sources of energy in our body. PPA is used as a food preservative against molds in various daily products and has been implicated in the pathogenesis of autism. In a recent study we showed that PPA in human neuronal stem cell (NSC) culture increases the astrocyte population and decreases the neuronal number and increases the inflammatory cytokines. In …

Barriers To Healthcare For The Transgender Population: A Focus On The Trans Persons' Experience Accessing Healthcare Services, Bryce E. Harrison

Honors Undergraduate Theses

Background: Transgender people face several barriers to healthcare when accessing services. Purpose: The purpose of this study was to explore the lived-experience of the transgender person accessing healthcare. Methods: Colaizzi phenomenological method was used to delve into the experience. The guiding question was: What is the lived experience (challenges, barriers, and/or difficulties) that the transgender person experiences when accessing healthcare? Results: Initial themes were collapsed to create relevant meanings. Five themes emerged from the protocols and were validated by participants. Overall, the transgender person is vulnerable in the healthcare system due to the lack of representation of their identity, which …

Role Of Amyloid Precursor Protein In Neuroregeneration On An In Vitro Model In Alzheimer's Patient-Specific Cell Lines, Lina S. Bedoya Martinez

Honors Undergraduate Theses

Alzheimer's disease (AD) leads to neurodegeneration resulting in cognitive and physical impairments. AD is denoted by accumulation of intracellular neurofibrillary tangles, known as tau, and extracellular plaques of the amyloid beta protein (Aβ). Aβ results from the proteolytic cleavage of the amyloid precursor protein (APP) by β- and gamma-secretases in the amyloidogenic pathway. Although, Aβ has been widely studied for neurodegeneration, the role of APP in both, the healthy and diseased conditions, has not yet been entirely understood. The function that APP has in neural stem cell (NSC) proliferation, differentiation, and migration during adult neurogenesis has been previously studied. Additionally, …

Capillary Electrophoresis Buffer Optimization For Plant Tissue Analysis, Rebekah Davis

Honors Undergraduate Theses

Capillary electrophoresis (CE) is an analytical chemistry approach that allows for the efficient separation by charge of diverse classes of compounds for analysis, including secondary metabolites. The goal of this work was to optimize a buffer system for plant tissue analysis using micellar electrokinetic chromatography (MEKC), and by doing so to understand the role of buffer components in the performance of this form of capillary electrophoresis. In this experiment we implemented a factorial design to optimize buffer composition for separating plant tissue and secondary metabolites. The results of this experiment will be used to optimize a universal buffer for MEKC …

Total Salivary Protein Concentration And Its Correlation To Dental Caries, Emyli Peralta

Honors Undergraduate Theses

Introduction: According to the World Health Organization, dental cavities are the number one chronic disease in children. Saliva coats the teeth all day and can serve many functions to maintain and protect teeth. Saliva has many proteins that can be both detrimental and essential to the preservation of tooth enamel. The purpose of this study is to determine if a correlation exists between the total protein concentration in saliva and the prevalence of cavities in the mouth. We hypothesized that there would be a positive correlation with total salivary protein concentration and the prevalence of cavities in the participant. Methods: …

Exploring Galvanic Replacement As A Method To Engineer Peroxidase-Mimics Nanoparticles, Kuryn T. Magloire

Honors Undergraduate Theses

Peroxidase enzymes are of critical importance within the scientific community for their applications in biosensing assays. In a living system, natural peroxidases function as catalysts in the oxidation of peroxide (e.g., H2O2) - a harmful byproduct of aerobic processes and convert them into harmless compounds. Such an ability allows peroxidases to serve as labels in biosensing assays, where they are conjugated to antibodies and accurately produce a detection signal by catalyzing substrates. However, due to intrinsic limitations, namely instability, Peroxidase made of proteins substantially inhibit broader applications.

Alternatively, nanoparticles produced from noble metals have been found to exhibit peroxidase-like abilities …

The Effect Of Family And Social Support On Suicidal Ideation In Jails, Megan L. Small

Honors Undergraduate Theses

Suicidal ideation and associated behaviors are up to four times more common among jail inmates than the general community (Jenkins et al., 2005; Hayes, 1986). Research finds a variety of social, biological, and psychological factors interact to influence suicidal thoughts of incarcerated individuals (Bonner, 1992; Borrill et al., 2005). Particularly, psychological distress such as, depression and feelings of hopelessness, along with loss of social support and decreased feelings of connectedness have been linked to suicidal ideation and behaviors (Moscicki, 1997; Hawton & van Heeringen, 2009). Recently, the Centers for Disease Control and Prevention (2017) has emphasized the importance of connectedness …

Health Literacy And Health Information Seeking Behaviors Of Student At The University Of Central Florida, Abigail Mcwhorter

Honors Undergraduate Theses

Health literacy is the skill needed to acquire, read, understand, and use health related information to make informed healthcare decisions. It is also the skill needed to follow and maintain a treatment plan. Having a high or adequate health literacy level is important because possessing poor health literacy skill can have a negative impact on one's overall health. This research is important because there are few studies available on the health literacy levels of undergraduate college students. The majority of health literacy studies focus on at risk or underserved populations with low education. Previous studies have shown that education is …

Do Cognitive Metaphors Moderate The Effectiveness Of Protective Behavioral Strategies?, Skyler M. Hoover

Honors Undergraduate Theses

Past research has shown a positive relationship between alcohol consumption and alcohol related consequences. Protective behavioral strategies (PBS) are able to lower the negative effects of drinking alcohol, however, the protective effects of PBS at times is moderated by situational circumstances or individual differences. This study looks at the cognitive metaphor of being a Head or Heart person and the moderating effects it has on PBS and alcohol consumption and alcohol related consequences. Participants completed the AUDIT-C to measure drinking habits, the PBSS to asses strategy usage, the YAAQC to measure drinking problems and a self-report single item measure for …

The Envelope Stress Response In Sedimentation-Resistant Escherichia Coli, Neel K. Shah

Honors Undergraduate Theses

Previous research discovered the existence of sedimentation-resistant mutants of E. coli. Genomic studies revealed that these mutants resisted sedimentation due to independent modifications to genes that influenced the Rcs signal transduction pathway, causing increased secretion of an exopolysaccharide capsule comprised primarily of colanic acid. The Rcs system is responsible for detecting envelope stressors; consequently, ampicillin and osmotic stress were used to perturb the cellular envelope and study the response of the mutants compared to wild-type cells. It was found that the overproduction of colanic acid in the mutants confers some resistance to envelope stress; however, the mutants still behaved …

Overview Of Direct Thrombin Inhibitors For Use In Staphylococcus Aereus Infections, Joseph C. Risler

Honors Undergraduate Theses

The pathogenicity and intractable nature of the microorganism Staphylococcus aureus (SA) has been long documented and highlighted by many health care agencies, with emphasis on its ability to exploit the human coagulation system to deadly effect. Two drugs from a class of inhibitors known as Direct Thrombin Inhibitors (DTI) have been shown to have a substantial effect on the enzyme secreted by SA known as Staphylocoagulase (SC), but up until now the application of this potential treatment has been limited. This paper strives to supply an overview of these clinical studies and propose a novel protocol for testing DTI's on …

Eucosma Giganteana (Riley) And Sliphium Perfoliatum L., Morphological Variation In An Insect-Plant Association In Eastern South Dakota, Paul J. Johnson, Arvid Boe, Abigail P. Martens

Native Plant Focused Publications

Silphium perfoliatum L., cup plant, has potential as a new multi-purpose crop. It is pollinator-friendly and has biodiversity enhancement, conservation, economic, and medical potential. In eastern South Dakota, S. perfoliatum can produce more than 20 Mg (million grams) ha-1 of biomass and 0.09 Mg ha-1 of seed in agronomic plantings. The giant eucosma moth, Eucosma giganteana (Riley), is a major pest of agronomic S. perfoliatum in the region. We provide a summary of this insect and its association with its host. Our experimental objectives were to determine if the frequency of rhizome occupation by late instar larvae and if their …

Solvent-Assisted Coordination Driven Assembly Of A Supramolecular Architecture Featuring Two Types Of Connectivity From Discrete Nanocages, Zheng Niu, Lei Wang, Sheng Fang, Pui Ching Lan, Briana Aguila, Jason Perman, Jian-Gong Ma, Peng Cheng, Xiaopeng Li, Shengqian Ma

Chemistry Faculty Publications

The rapid development of supramolecular chemistry provides a powerful bottom-up approach to construct various well-defined nano-architectures with increasing complexity and functionality. Compared to that of small and simple nanometric objects, the self-assembly of larger and more complex nanometric objects, such as nanocages, remains a significant challenge. Herein, we used a discrete nanocage as the monomer to successfully construct a novel three-dimensional (3D) supramolecular architecture, which comprises two types of nanocage building units with different connectivity, using the solvent-assisted coordination-driven assembly approach. The mechanism of this supramolecular assembly process was investigated by electrospray ionization mass spectrometry (ESI-MS) studies, which identified for …

Symmetry Is Not A Universal Law Of Beauty, Helmut Leder, Pablo Tinio, David Brieber, Tonio Kröner, Thomas Jacobsen, Raphael Rosenberg

Department of Educational Foundations Scholarship and Creative Works

Scientific disciplines as diverse as biology, physics, and psychological aesthetics regard symmetry as one of the most important principles in nature and one of the most powerful determinants of beauty. However, symmetry has a low standing in the arts and humanities. This difference in the valuation of symmetry is a remarkable illustration of the gap between the two cultures. To close this gap, we conducted an interdisciplinary, empirical study to directly demonstrate the effects of art expertise on symmetry appreciation. Two groups of art experts—artists and art historians—and a group of non-experts provided spontaneous beauty ratings of visual stimuli that …

Programs And Courses Catalog 2019-2020, University Of Northern Iowa

UNI Programs and Courses Catalogs

This catalog is published for students and other persons who want to know more about the University of Northern Iowa. Its purpose is to communicate as objectively and completely as possible what the university is and what it does. The catalog is presented in sections to give a general view of the university as well as the detailed information required for informed decision making.

Conservation Database For The Gulf Coast Region Of The United States, Andrew Shamaskin, Sathishkumar Samiappan, Jiangdong Liu, Kristine Evans, Anna Linhoss

CFR Publications

Strategic, data-driven conservation approaches are gaining popularity. A high-resolution geospatial database indicating the ecosystem functions and socioeconomic activity can be very useful for any conservation expert or funding agency. This database presents the developed measures that are derived from openly available geospatial and non-geospatial data sources, and is intended to provide ecological and socioeconomic evidence to support conservation planning efforts along the Gulf Coast Region of the United States. This database was developed by the Strategic Conservation Assessment of Gulf Coast Landscapes (SCA) Project, which is building a series of online tools that can aid in conservation planning efforts along …

Gender And Ethnic Differences In Sound Tolerance, Nicole Concepcion, Rachel Wallace Ms, Scott Vrana Phd, Lcp

IRBEH/Spit for Science Publications and Presentations

No abstract provided.

The Effect Of Food And Sleep Tracking On Quality Of Life, Souad Aboufadel, Sara Piecukonis

Loma Linda University Research Reports

Abstract Background: Various factors such as sleep quality and amount and food intake can have an impact on quality of life in terms of the amount of stress or fatigue that an individual experiences as an outcome. Food tracking has been commonly used as a tool for weight loss. Yet, current research has been looking at other possible advantages related to food tracking.

Objective: To examine the effects of food and sleep tracking on health-related quality of life with respects to sleep quality and quantity, stress, and fatigue, in adults aged 18 years or older.

Methods: Participants …

The Use Of Mobility Devices And Personal Assistance: A Joint Modeling Approach, Hongdao Meng, Lindsay J. Peterson, Lijuan Feng, Debra Dobbs, Kathryn Hyer

Aging Studies Faculty Publications

Objective: To examine whether mobility device use substitutes for personal assistance among U.S. older adults.

Method: Using the National Health and Aging Trends Study, we identified 3,211 community-living older adults (aged 65 and older) who reported mobility difficulties at baseline. We used recursive bivariate probit models to simultaneously estimate the effect of covariates on the likelihood of using (a) mobility devices and (b) personal assistance to accommodate mobility difficulty. Independent variables included age, gender, race, physical/mental health status, cognition, and comorbidities.

Results: Predictors of the use of personal assistance and mobility devices exhibit important similarities and differences. Device use reduced …

The Effects Of Prototypicality And Gender Salience On Liking And Friendship Potential Of A Female Interlocutor, Rong Ma, Anita Atwell Seate Atwell Seate, Nick Joyce

Scholarship and Professional Work - Communication

Drawing on self-categorization theory, this article examines the indirect effects of gender salience and prototypicality on friendship potential through increasing liking of a female interlocutor. We manipulated biographies of the fictitious interlocutor to change perceptions of prototypicality. For women, gender salience interacted with prototypicality to directly predict liking and the desire to become friends with the interlocutor indirectly through liking. Specifically, there was an interaction between prototypicality and gender salience, such that as gender salience increased, the prototypical interlocutor was liked significantly more and had higher friendship potential. For men, the same relationships did not appear. We discuss the implications …

Ethnographic Narrative Project, Kimberly Goodwin

CGU Theses & Dissertations

This paper details the journey of a first-year teacher. It is a highly reflective exploration of their inner landscape – one that documents the development of the teaching self in relation to students and society at large. Separated into four distinct sections, this work serves as an account of personal motivation to teach, getting to know students beyond the classroom walls, immersion in the community to situate educational work, and a comprehensive reflection upon teaching effectiveness and the evolution of the educating self. Development as a professional educator as stated in Teacher Performance Expectation (TPE) 6 demands continual introspection and …