Digital Commons Network^™

An Integrative Systems Approach Identifies Novel Candidates In Marfan Syndrome-Related Pathophysiology., Raghu Bhushan, Lukas Altinbas, Marten Jäger, Marcin Zaradzki, Daniel Lehmann, Bernd Timmermann, Nicholas P Clayton, Yunxiang Zhu, Klaus Kallenbach, Georgios Kararigas, Peter N Robinson

Faculty Research 2019

Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by mutations in the FBN1 gene. Although many peripheral tissues are affected, aortic complications, such as dilation, dissection and rupture, are the leading causes of MFS-related mortality. Aberrant TGF-beta signalling plays a major role in the pathophysiology of MFS. However, the contributing mechanisms are still poorly understood. Here, we aimed at identifying novel aorta-specific pathways involved in the pathophysiology of MFS. For this purpose, we employed the Fbn1 under-expressing mgR/mgR mouse model of MFS. We performed RNA-sequencing of aortic tissues of 9-week-old mgR/mgR mice compared with wild-type (WT) mice. With …

Representing Glycophenotypes: Semantic Unification Of Glycobiology Resources For Disease Discovery., Jean-Philippe F Gourdine, Matthew H Brush, Nicole A Vasilevsky, Kent Shefchek, Sebastian Köhler, Nicolas Matentzoglu, Monica C Munoz-Torres, Julie A Mcmurry, Xingmin Aaron Zhang, Peter N Robinson, Melissa A Haendel

Faculty Research 2019

While abnormalities related to carbohydrates (glycans) are frequent for patients with rare and undiagnosed diseases as well as in many common diseases, these glycan-related phenotypes (glycophenotypes) are not well represented in knowledge bases (KBs). If glycan-related diseases were more robustly represented and curated with glycophenotypes, these could be used for molecular phenotyping to help to realize the goals of precision medicine. Diagnosis of rare diseases by computational cross-species comparison of genotype-phenotype data has been facilitated by leveraging ontological representations of clinical phenotypes, using Human Phenotype Ontology (HPO), and model organism ontologies such as Mammalian Phenotype Ontology (MP) in the context …

Mini-Implant Supported Canine Retraction With Micro-Osteoperforation: A Split-Mouth Randomized Clinical Trial, Saritha Sivarajan, Jennifer Geraldine Doss, Spyridon N. Papageorgiou, Martyn T. Cobourne, Mang Chek Wey

Research Publications (2016 to 2020)

Objectives: To investigate, using a split-mouth randomized clinical design, the effect of micro-osteoperforation (MOP) on mini-implant supported canine retraction using fixed appliances. Materials and Methods: Thirty subjects (seven males and 23 females) with a mean age of 22.2 (3.72) years were randomized into three canine retraction groups: Group 1 (MOP 4-weekly maxilla/ 8-weekly mandible; n = 10); Group 2 (MOP 8-weekly maxilla/12-weekly mandible; n = 10) and Group 3 (MOP 12-weekly maxilla/4-weekly mandible; n = 10) measured at 4-week intervals over 16 weeks. Subjects also completed pain (5-point Likert scale) and pain impact (Visual Analogue Scale) questionnaires. The primary outcome …

Electronic Field Trips For Science Engagement: The Streaming Science Model, Jamie Loizzo, Mary J. Harner, Deborah J. Weitzenkamp, Kevin Kent

Southeast Research and Extension Center: Reports and Administration

While institutions of higher education work to engage PK-12 youth in STEM (science, technology, engineering, and mathematics) concepts and careers via in-person programming, PK-12 teachers and students face many logistical and access constraints for physically traveling to sites off of school grounds during the school day. Throughout the years, electronic field trips (EFTs) have offered a digital way for schools to engage in meaningful ways with museums, parks, laboratories, and field research sites. In order for EFTs to be effective, they should be cost effective and created collaboratively with teachers, students, subject matter experts, and instructional design and communication professionals. …

Reduction Of Leukocyte Microvascular Adherence And Preservation Of Blood-Brain Barrier Function By Superoxide-Lowering Therapies In A Piglet Model Of Neonatal Asphyxia, Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday

Open Access Publications

No abstract provided.

Tau Phosphorylation Rates Measured By Mass Spectrometry Differ In The Intracellular Brain Vs. Extracellular Cerebrospinal Fluid Compartments And Are Differentially Affected By Alzheimer’S Disease, Nicolas R. Barthelemy, Nipun Mallipeddi, Paul Moiseyev, Chihiro Sato, Randall J. Bateman

Open Access Publications

No abstract provided.

Cellular And Molecular Characterization Of Multiplex Autism In Human Induced Pluripotent Stem Cell-Derived Neurons, Emily M A Lewis, Kesavan Meganathan, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni, John N Constantino, Kristen L Kroll

Open Access Publications

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts to model ASD in human cellular systems have principally involved rare de novo mutations associated with ASD phenocopies. However, by definition, these models are not representative of polygenic liability, which accounts for the vast share of population-attributable risk.

Methods: Here, we performed what is, to our knowledge, the first attempt to model multiplex autism using patient-derived induced pluripotent stem cells (iPSCs) in a …

Crispr/Cas9 Mediated Generation Of An Ovine Model For Infantile Neuronal Ceroid Lipofuscinosis (Cln1 Disease), S. L. Eaton, C. Proudfoot, S. G. Lillico, P. Skehel, R. A. Kline, K. Hamer, N. M. Rzechorzek, E. Clutton, R. Gregson, T. King, C. A. O'Neill, J. D. Cooper, G. Thompson, C. B. Whitelaw, T. M. Wishart

Open Access Publications

No abstract provided.

Increased Mtdna Abundance And Improved Function In Human Barth Syndrome Patient Fibroblasts Following Aav-Taz Gene Delivery, Silveli Suzuki-Hatano, Mughil Sriramvenugopal, Manash Ramanathan, Meghan Soustek, Barry J. Byrne, W. T. Cade, Peter B. Kang, Christina A. Pacak

Open Access Publications

No abstract provided.

Forelimbs Of The Theropod Dinosaur Dilophosaurus Wetherilli: Range Of Motion, Influence Of Paleopathology And Soft Tissues, And Description Of A Distal Carpal Bone, Philip J. Senter, Corwin Sullivan

College of Health, Science, and Technology

Forelimb bones of the Early Jurassic theropod Dilophosaurus wetherilli were manually manipulated to determine the range of motion (ROM) of each forelimb joint and to test functional hypotheses of forelimb use. Using bony articular surface margins to delimit ROM, the humerus can be retracted to a position subparallel to the scapular blade, protracted no further than a subvertical position, and elevated only 65°. The elbow cannot be flexed beyond a right angle to the humerus. Supination and pronation are prevented by lack of rolling radio-ulnar joints, and the palms face medially. The distal carpal block of Dilophosaurus, described here for …

The Depravity Of The 1930s And The Modern Administrative State, Steven G. Calabresi, Gary Lawson

Notre Dame Law Review

Gillian Metzger’s 2017 Harvard Law Review foreword, entitled 1930s Redux: The Administrative State Under Siege, is a paean to the modern administrative state, with its massive subdelegations of legislative and judicial power to so-called “expert” bureaucrats, who are layered well out of reach of electoral accountability yet do not have the constitutional status of Article III judges. We disagree with this celebration of technocratic government on just about every level, but this Article focuses on two relatively narrow points.

First, responding more to implicit assumptions that pervade modern discourse than specifically to Professor Metzger’s analysis, we challenge the normally …

Index Of Synodical Decisions 2001-2019, Crcna

Agendas and Acts of Synod

No abstract provided.

The Future Of Recreational Fisheries: Advances In Science, Monitoring, Management, And Practice, Jacob W. Brownscombe, Kieran Hyder, Warren Potts, Kyle L. Wilson, Kevin L. Pope, Andy J. Danylchuk, Steven J. Cooke, Adrian Clarke, Robert Arlinghaus, John R. Post

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Recreational fisheries (RF) are complex social-ecological systems that play an important role in aquatic environments while generating significant social and economic benefits around the world. The nature of RF is diverse and rapidly evolving, including the participants, their priorities and behaviors, and the related ecological impacts and social and economic benefits. RF can lead to negative ecological impacts, particularly through overexploitation of fish populations and spread of non-native species and genotypes through stocking. Hence, careful management and monitoring of RF is essential to sustain these ecologically and socioeconomically important resources. This special issue on recreational fisheries contains diverse research, syntheses, …

Greenwood Library Annual Report 2019, Greenwood Library

Library Annual Reports and Strategic Plans

No abstract provided.

Faculty Senate Annual Report Academic Year 2018-2019, State University Of New York At Cortland

Annual Reports

Faculty Senate Annual Report Academic Year 2018-2019

Healthy Food Labels Tailored To A High-Risk, Minority Population More Effectively Promote Healthy Choices Than Generic Labels, Christopher R. Gustafson, Michael R. Prate

Department of Agricultural Economics: Faculty Publications

The decades-long increase in obesity in the US has led to a number of policies aimed at improving diets, which are thought to play a significant role in obesity. Many of these policies seek to influence individuals’ behaviors. Front-of-package labels providing salient, easily interpretable information to consumers have exhibited promise in helping people identify and choose healthier foods. However, behavioral economics may offer an opportunity to enhance label effectiveness. Tailoring labels to high-risk communities, including minority and rural populations, which have higher rates of diet-related diseases than the overall population, may increase the label’s effectiveness. We conducted a choice experiment …

Elemental Ratios Link Environmental Change And Human Health, R. Paseka, A. Bratt, K. Macneill, A. Burian

School of Natural Resources: Faculty Publications

No abstract provided.

2019 Schedule Of Events, Seton Hall University

Petersheim Academic Exposition

No abstract provided.

Comprehensiveness Of Product Placement Study In Hollywood And Bollywood Movies, Nikita A. Subba

Merge

This research study is a detailed content analysis focused on finding a relationship between product placements found in Hollywood and Bollywood movies that share similar plotlines with one another from the year 2006 to 2015. The researcher examined twenty movies, ten movies from each movie industry. It was found that both Hollywood and Bollywood movies use a lot of brand integration as well as long durations of brand exposure. However, the detailed log produced through the coding sheet indicated that between the years of 2006 to 2015, Bollywood used a slightly higher number and duration of product placement than the …

The Isolation Of Presumptive Pathogens From The Pellets Of Seven North American Owl Species, Quoc Nguyen

Merge

Most birds, especially raptors such as owls (Strigiformes), egest pellets, which are regurgitated masses of the owl’s prey. The contents of the pellets may contain hair, teeth, and bones which are usually indigestible since an owl’s stomach lacks the necessary ability to break down the ingested material. Furthermore, the formed pellets cannot pass through the digestive tract and are regurgitated since it would either be too dangerous to pass through the digestive system or would block additional ingestion of new food, hence the reason to egest the pellets. Research on the pathogenic bacteria in owl pellets are scant but understanding …

Cropping Systems Research Summary 2019: Soybean And Soygreen Research Reports, Charles Burr

West Central Research and Extension Center, North Platte

Project Titles

Soybean Seeding Rates

Soygreen^® Treatments for Iron Deficiency Chlorosis

Cropping Systems Research Summary 2019: Agroecosystems Entomology Project Research Reports, Samantha R. Daniel, Andrea Rilaković, Katharine A. Swoboda Bhattarai, M. G. Sacilotto, C. A. Deans, S. Behmer, Julie A. Peterson

West Central Research and Extension Center, North Platte

Investigating the role of spiders in integrated pest Management for biological control of Nebraska crop pests, Samantha R. Daniel. Advisors: Julie A. Peterson and Robert Wright

Simulating larval movement of Western bean cutworm in blended refuges by laboratory feeding on non-Bt, Cry1F and Vip3A maize, Andrea Rilaković and Katharine Swoboda Bhattrai

Determining western bean cutworm Striacosta albicosta (Lepidoptera: Noctuidae) optimal nutritional intake via choice studies, M. G. Sacilotto, Katharine Swosoda Battharai, C. A. Deans, S. Behmer, and Julie A. Peterson

Weed Science Research Summary 2019: Weed Control And Spray Drift

West Central Research and Extension Center, North Platte

Weed Science

Large-scale off-target movement assessment of dicamba in Nebraska, Guilherme S. Alves, Kasey Schroeder, Jeff Golus, Greg R. Kruger

Spray drift from aerial application in South Dakota, Guilherme S. Alves, Kasey Schroeder, Arthur F. T. Duarte, Daniel A. Doretto, Greg R. Kruger

Dicamba spray drift as influenced by wind speed and nozzle type, Guilherme S. Alves, Greg R. Kruger, João Paulo A. R. da Cunha, Denise G. de Santana, Luís André T. Pinto, Frederico Guimarães, and Milos Zaric

Spray drift and droplet spectrum from dicamba sprayed alone or mixed with adjuvants using air-induction nozzles, Guilherme S. Alves, Greg R. …

Assessment Of Cover Crop Management Strategies In Nebraska, Us, Maxwel C. Oliveira, Liberty Butts, Rodrigo Werle

West Central Research and Extension Center, North Platte

Adoption of cover crops has the potential to increase agricultural sustainability in the US and beyond. In 2017, a survey was conducted with Nebraska stakeholders in an attempt to evaluate current cover crop management strategies adopted in soybean (Glycine max [L.] Merr.), field corn (Zea mays L.), and seed corn production. Eighty-two Nebraska stakeholders answered the survey, of which 80% identified themselves as growers. Eighty-seven percent of respondents manage cover crops, and the average cover crop ha planted on a per farm basis is 32%. The primary method of establishing cover crops following soybeans and field corn is …

Developmental And Reproductive Characteristics Of Beef Heifers Classified By Number Of Estrous Cycles Experienced By Start Of First Breeding, Andy Roberts, Jaclyn N. Ketchum, Richard N. Funston

West Central Research and Extension Center, North Platte

A retrospective analysis was conducted to evaluate the effect of number of estrous cycles exhibited before breeding on growth and reproductive performance of replacement beef heifers fed ad-libitum or restricted by 20% less than ad-libitum during postweaning development over a 9-yr period. Progesterone concentration in blood samples collected at 9- to 11-d intervals were used to assign heifers into groups by number of estrous cycles exhibited before the start of breeding: 0 (nonpubertal; n = 395), 1 (n = 205), 2 (n = 211), 3 (n = 116), or >3 (n = 249). Heifers (P …

Evaluation Of Foliar Insecticides For The Control Of Western Bean Cutworm In Field Corn, 2018, Katharine A. Swoboda-Bhattarai, Samantha R. Daniel, Julie A. Peterson

West Central Research and Extension Center, North Platte

The objectives of this field trial were to evaluate the efficacy of single applications of foliar insecticides at preventing feeding damage by the western bean cutworm (WBC), an important pest of corn and dry beans that has undergone a rapid range expansion into the eastern Corn Belt during the last 18 yr. This study was conducted within the historic range of WBC, at the University of Nebraska-Lincoln’s Henry J. Stumpf International Wheat Center in Perkins County, NE (40.856851°N, −101.701335°W). An RCB design with a total of 16 treatments (including an untreated check) and four replications was used. Plots measured 20 …

Fungicide Application Technology For Controlling The Sugarcane Orange Rust, Thales Cassemiro Alves, João Arantes Rodrigues Da Cunha, Rafael Marcão Tavares, Guilherme Sousa Alves, Sérgio Macedo Silva

West Central Research and Extension Center, North Platte

With the epidemic onset of the sugarcane orange rust, fungicide applications of the Strobilurins and Triazoles groups have become necessary in susceptible varieties. This study aimed at evaluating the operational conditions of fungicide application in sugarcane (SP81-3250 variety), in relation to the spray deposition on the upper canopy and the effectiveness of the orange rust control. Treatments consisted of two application volumes (30 L ha-1 or 40 L ha-1) and three nozzle deflection angles (0 º, 90 º or 135 º), plus a ground application at the rate of 200 L ha-1, sprayed with a uniform flat spray nozzle of …

Response Of Amaranthus Spp. Following Exposure To Sublethal Herbicide Rates Via Spray Particle Drift, Bruno C. Vieira, Joe D. Luck, Keenan L. Amundsen, Todd A. Gaines, Rodrigo Werle, Greg Kruger

West Central Research and Extension Center, North Platte

The adverse consequences of herbicide drift towards sensitive crops have been extensively reported in the literature. However, little to no information is available on the consequences of herbicide drift onto weed species inhabiting boundaries of agricultural fields. Exposure to herbicide drift could be detrimental to long-term weed management as several weed species have evolved herbicide-resistance after recurrent selection with sublethal herbicide rates This study investigated the deposition of glyphosate, 2,4-D, and dicamba spray particle drift from applications with two different nozzles in a low speed wind tunnel, and their impact on growth and development of Amaranthus spp. Herbicide drift …

Droplet Size And Nozzle Tip Pressure From A Pulse–Width Modulation Sprayer, Thomas R. Butts, Liberty E. Butts, Joe D. Luck, Bradley K. Fritz, Wesley C. Hoffmann, Greg R. Kruger

West Central Research and Extension Center, North Platte

Pulse-width modulation (PWM) sprayers can improve application accuracy through flow control, turn compensation, and high-resolution overlap control by pulsing an electronically-actuated solenoid valve which controls the relative proportion of time each solenoid valve is open (duty cycle). The objective of this experiment was to identify the droplet size distribution and nozzle tip pressure when influenced by PWM duty cycle, nozzle technology, and gauge pressure to provide PWM guidelines. The experiment was conducted in a low-speed wind tunnel at the Pesticide Application Technology Laboratory using a SharpShooter® PWM system. In general, for non-venturi nozzles, as duty cycle decreased, droplet size slightly …

Approaches To Evaluating Grower Irrigation And Fertilizer Nitrogen Amount And Timing, Tsz Him Lo, Daran Rudnick, Charles Burr, Matt Stockton, Rodrigo Werle

West Central Research and Extension Center, North Platte

Diversity in the knowledge, mindset, strategies, and tools that growers use to manage irrigation and fertilizer nitrogen culminates in diversity in profitability and environmental impact among farms. As growers, academia, and industry strive together to tackle the technological and non-technological challenges impeding better irrigation and fertilizer nitrogen management, a science-based evaluation of grower input amount and timing becomes an important initial step in the process. Providing such valuable feedback to growers is a high-priority objective for the University of Nebraska-Lincoln Testing Ag Performance Solutions (UNL-TAPS) farm management competition. In this competition, each team of mostly growers made management decisions for …