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Enhanced A1 Adenosine Receptor-Induced Vascular Contractions In Mesenteric Artery And Aorta Of In L-Name Mouse Model Of Hypertension, Vishal R. Yadav, Bunyen Teng, S. Jamal Mustafa

Clinical and Translational Science Institute

L-NAME-induced hypertension is commonly used to study endothelial dysfunction and related vascular effects. It has been reported that genetic deletion of A1 adenosine receptor (AR) reduces blood pressure (BP) increases in mice and thus, suggesting the involvement of A1AR. Thus, we sought to determine whether A1AR-induced vascular responses were altered in this mouse model of hypertension. L-NAME (1 mg/ml) was given in the drinking water for 28 days to mice. The BP was monitored using non-invasive tail-cuff system. Muscle tension studies were performed using DMT for mesenteric arteries (MAs) and organ bath for aorta. Protein expression was analyzed by western …

Optimization Of The Catalytic Performance Of Pd/Fe3o4 Nanoparticles Prepared Via Microwave-Assisted Synthesis For Pharmaceutical And Catalysis Applications, Hany A. Elazab Dr

Chemical Engineering

Microwave assisted synthesis technique was used to prepare palladium supported on iron oxide nanoparticles. The advantage of using microwave irradiation as a synthetic tool is due to its unique features as a one step, simple, versatile, and rapid process. The reactants are added simply at room temperature without using high-temperature injection. Hydrazine hydrate was added by the following ratios (0.1, 0.2, 0.3, 0.4, 0.6, 0.8, 1, 1.6, and 3) ml to the different prepared samples at room temperature in order to investigate its effect on the catalytic performance of the prepared catalysts. The prepared catalyst could be used as an …

Star-Related Lipid Transfer Protein 10 (Stard10): A Novel Key Player In Alcohol-Induced Breast Cancer Progression, Andrea Floris, Jia Luo, Jacqueline A. Frank, Jennifer Zhou, Sandro Orrù, Michela Biancolella, Sabina Pucci, Augusto Orlandi, Paolo Campagna, Antonella Balzano, Komal Ramani, Maria Lauda Tomasi

Pharmacology and Nutritional Sciences Faculty Publications

Background: Ethanol abuse promotes breast cancer development, metastasis and recurrence stimulating mammary tumorigenesis by mechanisms that remain unclear. Normally, 35% of breast cancer is Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2)-positive that predisposes to poor prognosis and relapse, while ethanol drinking leads to invasion of their ERBB2 positive cells triggering the phosphorylation status of mitogen-activated protein kinase. StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. Interestingly, STARD10 has been described to be highly expressed in 35–40% of ERBB2-positive breast …

Individual-Level Antibody Dynamics Reveal Potential Drivers Of Influenza A Seasonality In Wild Pig Populations, Kim M. Pepin, Kerri Pedersen, Xiu-Feng Wan, Fred L. Cunningham, Colleen T. Webb, Mark Q. Wilber

United States Department of Agriculture Wildlife Services: Staff Publications

Swine are important in the ecology of influenza A virus (IAV) globally. Understanding the ecological role of wild pigs in IAV ecology has been limited because surveillance in wild pigs is often for antibodies (serosurveillance) rather than IAVs, as in humans and domestic swine. As IAV antibodies can persist long after an infection, serosurveillance data are not necessarily indicative of current infection risk. However, antibody responses to IAV infections cause a predictable antibody response, thus time of infection can be inferred from antibody levels in serological samples, enabling identification of risk factors of infection at estimated times of infection. Recent …

Cow-Calf Producers’ Willingness To Pay For Bulls Resistant To Horn Flies (Diptera: Muscidae), Lettie Mckay, Karen L. Delong, Susan Schexnayder, Andrew P. Griffith, David B. Taylor, Pia Olafson, R. T. Trout Fryxell

Department of Entomology: Faculty Publications

Horn flies (Haematobia irritans (L.)) have long posed animal health and welfare concerns. Economic losses to the cattle and dairy industries from their blood-feeding behavior include decreased weight gain, loss in milk productivity, and transmission of bacteria causing mastitis in cattle. Horn fly management strategies are labor intensive and can become ineffective due to the horn fly’s ability to develop insecticide resistance. Research indicates that for some cattle herds, genetically similar animals consistently have fewer flies suggesting those animals are horn fly resistant (HFR) and that the trait is heritable; however, it is currently unknown if cattle producers value this …

Divergence In Glucosinolate Profiles Between High- And Low-Elevation Populations Of Arabidopsis Halleri Correspond To Variation In Field Herbivory And Herbivore Behavioral Preferences, James Buckley, Foteini G. Pashalidou, Martin C. Fischer, Alex Widmer, Mark C. Mescher, Moraes Cm De

School of Biological and Marine Sciences

Variation in local herbivore pressure along elevation gradients is predicted to drive variation in plant defense traits. Yet, the extent of intraspecific variation in defense investment along elevation gradients, and its effects on both herbivore preference and performance, remain relatively unexplored. Using populations of Arabidopsis halleri (Brassicaceae) occurring at different elevations in the Alps, we tested for associations between elevation, herbivore damage in the field, and constitutive chemical defense traits (glucosinolates) assayed under common-garden conditions. Additionally, we examined the feeding preferences and performance of a specialist herbivore, the butterfly Pieris brassicae, on plants from different elevations in the Alps. Although …

Spotlighting Innovative Use Cases Of Mobile Learning, Alex Rockey, Samantha Eastman, Mindy Colin, Margaret Merrill

The Emerging Learning Design Journal

Students bring 2-3 devices to class, 100% of 18-29 year olds own a cellphone and 94% own a smartphone (PEW Research Center, 2018), reflecting ubiquitous mobile device ownership among university-aged students across the U.S. Due to the surge of personal devices, campus infrastructure is increasing capacity to rapidly meet demands for wireless access, and instructors are using mobile learning to push classroom boundaries within and beyond the campus environment. This brief showcases innovative uses of mobile learning uncovered through a cross-campus study at four campuses. Our findings have implications for administrative, funding, information technology, and curricular decisions on individual campuses, …

Laws Of Genetics, Sydney N. Sheltz-Kempf

The Hilltop Review

No abstract provided.

Quiet: The Power Of Introverts In A World That Can't Stop Talking: A Book Analysis, Molly Goaley

The Hilltop Review

The topics addressed in Quiet are important to nonscholarly and academic audiences because introversion is a universal personality trait that affects us all in some way. If we are not introverts ourselves, we have colleagues, supervisors, family members, friends or children who are. Studies of extroversion and introversion in organizational teamwork (Zanin & Bisel, 2018), office environments (McElroy & Morrow, 2010), and leadership (Grant et al., 2011) therefore have practical implications regardless of personality type. The purpose of this paper is to compare and contrast Cain’s work with the existing scholarly research in order to gain a deeper understanding of …

Retrospective Study To Evaluate Prescription Pattern And Cost Of Illness In Patients With Rheumatoid Arthritis In A Tertiary Care Hospital Setting, Rajesh V Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: Rheumatoid Arthritis (RA) is a chronic disease associated with poor quality of life of patients, lifelong dependency on medications and long-term disease suffering which leads to both physical and financial disability in terms of cost. RA flare and complications lead to hospitalization and demand in-patient care and these costs impose a significant burden on the patients especially those from a poor socioeconomic background in a developing society like India where the country reserves only 1.4% of the income for healthcare. Objective: The objective of this study is to find the cost of illness associated with hospitalized patients suffering from …

Drug Utilization Review Of Anticancer Drugs With Otherdrugs In Breast Cancer Patients, Mahadev Rao Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background: To study the prescribing pattern of chemotherapeutic drugs in Breast Cancer patients and to survey the prevalence of exigent drug-drug interactions (DDIs) between chemotherapeutic drugs and non-chemotherapeutic drugs and evaluate the risk factors associated with these drug-drug interactions in India. Methods: All discharged patients’ data in the Department of Oncology were collected from September 2019 to March 2020 with the help of Hospital Information System and inpatient file of the breast cancer patients collected from the Medical Records Department. Drugs were screened for interactions by Micromedex solutions database and Epocrates database. Descriptive statistics were generated and was used to …

The Study Of Prevalence Of Diabetes Mellitus And Its Complications In Hiv Patients In, Leelavathi D. Acharya Dr

Manipal College of Pharmaceutical Sciences, Manipal Theses and Dissertations

Background –Diabetes is a chronic, metabolic disorder that is characterized by resulting from defects in insulin secretion, insulin action or both which will affect the patient Quality of life. Pharmaceutical Care is the responsible provision of drug therapy for of achieving definite therapeutic outcomes that improve the patient‘s quality of life.It contributes to the resolution of medical conditions and can help avoid undesirable outcomes about patient‘s drug therapy problems, resulting in benefits to patients.Objectives –To study the impact of Pharmaceutical care in type 2 diabetic patients in a tertiarycare hospital.Methodology –A prospective interventional study was conducted for a period of …

Agrotechnology Of Melon Cultivation On Weak And Moderately Saline Soils, M Bektursunova,

Central Asian Problems of Modern Science and Education

In that article, weak and medium in having too much soil and in those agrotexnology of about melon and advices were given about planting melon.

Cortactin Phosphorylation By Casein Kinase 2 Regulates Actin-Related Protein 2/3 Complex Activity, Invadopodia Function And Tumor Cell Invasion, Steven M. Markwell, Amanda G. Ammer, Erik T. Interval, Jessica L. Allen, Brenen W. Papenberg, River A. Hames, Johnathan E. Castaño, Dorothy A. Schafer, Scott A. Weed

Clinical and Translational Science Institute

Malregulation of the actin cytoskeleton enhances tumor cell motility and invasion. The actin-binding protein cortactin facilitates branched actin network formation through activation of the actin-related protein (Arp) 2/3 complex. Increased cortactin expression due to gene amplification is observed in head and neck squamous cell carcinoma (HNSCC) and other cancers, corresponding with elevated tumor progression and poor patient outcome. Arp2/3 complex activation is responsible for driving increased migration and extracellular matrix (ECM) degradation by governing invadopodia formation and activity. Although cortactin-mediated activation of Arp2/3 complex and invadopodia regulation has been well established, signaling pathways responsible for governing cortactin binding to Arp2/3 …

Cyclin C: The Story Of A Non-Cycling Cyclin, Jan Jezek, Daniel G J Smethurst, David C Stieg, Z A C Kiss, Sara E Hanley, Vidyaramanan Ganesan, Kai-Ti Chang, Katrina F Cooper, Randy Strich

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The class I cyclin family is a well-studied group of structurally conserved proteins that interact with their associated cyclin-dependent kinases (Cdks) to regulate different stages of cell cycle progression depending on their oscillating expression levels. However, the role of class II cyclins, which primarily act as transcription factors and whose expression remains constant throughout the cell cycle, is less well understood. As a classic example of a transcriptional cyclin, cyclin C forms a regulatory sub-complex with its partner kinase Cdk8 and two accessory subunits Med12 and Med13 called the Cdk8-dependent kinase module (CKM). The CKM reversibly associates with the multi-subunit …

Pldα1-Knockdown Soybean Seeds Display Higher Unsaturated Glycerolipid Contents And Seed Vigor In High Temperature And Humidity Environments, Xuemin Wang, Gaoyang Zhang, Sung‑Chul Bahn, Geliang Wang, Yanrui Zhang, Beibei Chen, Yuliang Zhang, Jian Zhao

Biology Department Faculty Works

BackgroundSoybean oil constitutes an important source of vegetable oil and biofuel. However, high temperature and humidity adversely impacts soybean seed development, yield, and quality during plant development and after harvest. Genetic improvement of soybean tolerance to stress environments is highly desirable.ResultsTransgenic soybean lines with knockdown of phospholipase Dα1 (PLDα1KD) were generated to study PLDα1′s effects on lipid metabolism and seed vigor under high temperature and humidity conditions. Under such stress, as compared with normal growth conditions, PLDα1KD lines showed an attenuated stress-induced deterioration during soybean seed development, which was associated with elevated expression of reactive oxygen species-scavenging genes when compared …

Peter Pan (2019) | Program, Jacksonville State University

Performance Archive

Performed: 4-9 Jan 2019; Peter Pan was a musical based on the play by Sir J.M. Barrie with lyrics by Carolyn Leighand music by Morris Charlap. Carrie Colton was director, Dr. Jeremy Benson was conductor, Matt Davenport was assistant conductor, Dr. Nathan Wight was technical director, John Longshore was OPAC executive director, Chase Greene was audio designer, Shad Ramsey was flying director, Mike Morin was lighting designer, Chaney Billips was costumer, Wanda Burgess and Lynn Luke were assistants to the costumer, Cheyenne Oliver was stage manager. This file was created from a legacy format and may not include all information.

Overview Of Multi-Agents Modeling And Simulation For Underwater Unmanned Combat Systems, Hongtao Liang, Fengju Kang, Yanfang Fu

Journal of System Simulation

Abstract: Military UUV is developing toward the direction of intellectualization and coordination of multi-UUV system. It is composed of complex underwater unmanned system (UUS) with changeable underwater environment and complex combat mission. Multi-agents (MAS) modeling technology has become the mainstream method to study this kind of complex system. The development and characteristics of UUS are briefly and comprehensively reviewed. The latest developments of MAS theory are systematically summarized, and MAS modeling and simulation technology for multi-UUV cooperative combat system (MUCCS) are analyzed. A novel MAS theory method, that is immune agent interactive network (IAIN), is proposed, which combines the modeling …

Comparisons Of Five Dna Repair Pathways Between Elasmobranch Fishes And Humans, Lucia Llorente

HCNSO Student Theses and Dissertations

Although DNA repair capacity has been correlated with lifespan in terrestrial vertebrate species, it remains unknown how evolutionarily conserved the process is across all vertebrate taxa. In particular, chondrichthyan fishes have lifespans that range from 3-350 years and they are evolutionarily separated from modern humans Homo sapiens by approximately 400 million years. We hypothesized that chondrichthyan fishes would show significant homology in nuclear excision repair (NER) genes with humans, and that the expression of NER genes will correlate with the lifespan of the respective assessed species. For this study, DNA repair gene homology and expression was performed on the nurse …

Submittal Of The Mixed Waste Landfill Five-Year Report, Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, January 2019, Sandia National Laboratories/Nm Snl

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Five-Year Report for the January 2014 through December 2017 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.2 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014 and the first Five-Year Report was due January 8, 2019.

The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective …

Synthetic Glycolate Metabolism Pathways Stimulate Crop Growth And Productivity In The Field, Paul F. South, Amanda P. Cavanagh, Helen W. Liu, Donald R. Ort

Faculty Publications

y © The Authors, some rights reserved Photorespiration is required in C3 plants to metabolize toxic glycolate formed when ribulose-1,5-bisphosphate carboxylase-oxygenase oxygenates rather than carboxylates ribulose-1,5-bisphosphate. Depending on growing temperatures, photorespiration can reduce yields by 20 to 50% in C3 crops. Inspired by earlier work, we installed into tobacco chloroplasts synthetic glycolate metabolic pathways that are thought to be more efficient than the native pathway. Flux through the synthetic pathways was maximized by inhibiting glycolate export from the chloroplast. The synthetic pathways tested improved photosynthetic quantum yield by 20%. Numerous homozygous transgenic lines increased biomass productivity by >40% in replicated …

Mary In The News: Jan. 4, 2019, Michael Duricy

Marian Library Blog Archive

Read recent items about Mary in both Catholic and secular news. Also, see International Marian Research Institute news and updates.

Building Bridges Across Curricular And Status Lines: Gender Inequity Throughout The Legal Academy, Kristen K. Tiscione, Melissa H. Weresh

Journal of Legal Education

No abstract provided.

Aging Out: 2018 Legislation Seeking To Address Virginia’S Permanency Problem For Children In Foster Care, Valerie L'Herrou

Richmond Public Interest Law Review

Virginia has one of the highest rates of youth who “age out” of the foster care system and one of the lowest family reunification rates in the country. This is due to several factors, including that the termination of parental rights has an accelerated timeline in Virginia compared to the federal timeline. Children who age out of the system lack a sense of permanency that is critical to healthy psychological development. As a result, many such children tend to experience lower levels of educational attainment and income, and higher levels of substance use, criminal justice system involvement, and homelessness than …

Free To Bleed: Virginia House Bill 83 And The Dignity Of Menstruating Inmates, Holly Seibold, Gianna Fienberg

Richmond Public Interest Law Review

For many individuals, their monthly period is an embarrassing and stigmatizing event, but for those who are homeless or have a low income, are students, or are incarcerated, it is something much more dangerous. A lack of menstrual hygiene can lead to serious health risks including skin infections, urinary tract and bladder infections, and toxic shock syndrome. Because of the cost of menstrual supplies, though, many are prevented from adequately caring for their menstrual health. Students, the homeless and low-income, and the incarcerated are regularly confronted by a lack of access to menstrual supplies and are thus forced to use …

Grey Water: Agricultural Use Of Reclaimed Water In California, Bahman Sheikh, Kara L. Nelson, Brent Haddad, Anne Thebo

Journal of Contemporary Water Research and Education

Potential for use of recycled water is great, especially for agricultural irrigation, which comprises by far the highest percentage of water taken from developed sources in the arid and semi-arid regions of the world. In California, 80% of developed water is used for agriculture, and the same pattern prevails throughout the western United States. The potential for recycled water use in agriculture remains under-realized because of numerous impediments. Understanding how the incentives and impediments to agricultural reuse vary based on local context is critical to understanding the tradeoffs and technology requirements for different end uses of recycled water. Public perceptions …

Depth-Dependent Environmental Drivers Of Microbial Plankton Community Structure In The Northern Gulf Of Mexico, Cole Easson, Jose Lopez

Biology Faculty Articles

The Gulf of Mexico (GoM) is a dynamic marine ecosystem influenced by multiple natural and anthropogenic processes and inputs, such as the intrusion of warm oligotrophic water via the Loop Current, freshwater and nutrient input by the Mississippi River, and hydrocarbon inputs via natural seeps and industrial spills. Microbial plankton communities are important to pelagic food webs including in the GoM but understanding the drivers of the natural dynamics of these passively distributed microorganisms can be challenging in such a large and heterogeneous system. As part of the DEEPEND consortium, we applied high throughput 16S rRNA sequencing to investigate the …

Research On Interaction Model Of Hand Tracking Based On Cognitive Theory, Shaobai Zhang, Zhang Teng

Journal of System Simulation

Abstract: This paper aims to solve the problems in a vector integration to endpoint (VITE) model of human reaching and grasping under perturbations of object size, distance and orientation. We discuss how to reduce the numbers of disturbances of three main kinds of components: hand/wrist transport, grip aperture and hand orientation. Based on the achievements of cognitive psychology, and a tracking and cognitive model for operational 3D gestures, this paper proposes a new divide-and-conquer model that is used for indicating current grasping status and to trigger three main kinds of methods of when to start or stop working. The model …

Predator-Prey Dynamics-Based Optimization, Qiuqin Lu, Guangqiu Huang

Journal of System Simulation

Abstract: To solve the complex function optimization problem, a predator-prey dynamics optimization algorithm is proposed. The algorithm assumes that there are two species of predator and prey in an ecosystem. There is competition among the same species, the higher the population density, the more intense the competition, and then characteristics of populations are more likely to produce changes; strong populations are more likely to defeat weak populations when competition, and thus to obtain significant changes in their own characteristics. When predator populations eat prey populations, their characteristics also change. The competition operator, the predator-prey operator and the growth operator are …

Analysis For Science Librarians Of The 2018 Nobel Prize In Physiology Or Medicine: The Life And Work Of James P. Allison And Tasuku Honjo, Neyda V. Gilman

Library Scholarship

On October 1, 2018, James P. Allison and Tasuku Honjo were awarded the 2018 Physiology or Medicine Nobel for their work leading to Immune Checkpoint Inhibition (ICI). ICI is the fourth pillar of cancer treatment and has been used to treat previously un-treatable cancers. Allison discovered that the protein CTLA-4 acts as a T cell brake while Honjo discovered another T cell brake, PD-1. Releasing these brakes allows the immune system to attack tumors, sometimes leading to complete elimination. While there is still more research to be done, Allison’s and Honjo’s work is a breakthrough in cancer immunotherapy.