Digital Commons Network^™

Guggulsterone Activates Adipocyte Beiging Through Direct Effects On 3t3-L1 Adipocytes And Indirect Effects Mediated Through Raw264.7 Macrophages., Colette N Miller, Janaiya S Samuels, Yusra Azhar, Ashish Parmar, Rangaiah Shashidharamurthy, Srujana Rayalam

PCOM Scholarly Works

Background: Plant-derived phytochemicals have been of emerging interest as anti-obesity compounds due to their apparent effects on promoting reduced lipid accumulation in adipocytes. Despite such promising evidence, little is known about the potential mechanisms behind their anti-obesity effects. The aim of this study is to establish potential anti-obesity effects of the phytochemical guggulsterone (GS). Methods: Mature 3T3-L1 adipocytes were treated with GS, derived from the guggul plant native in northern India, to investigate its effects on mitochondrial biogenesis and adipocyte "beiging." Further, to explore the relationship between macrophages and adipocytes, 3T3-L1s were treated with conditioned media from GS-treated RAW264.7 macrophages. …

The Influence Of Unpredictable, Fragmented Parental Signals On The Developing Brain, Laura M. Glynn, Tallie Z. Baram

Psychology Faculty Articles and Research

Mental illnesses originate early in life, governed by environmental and genetic factors. Because parents are a dominant source of signals to the developing child, parental signals - beginning with maternal signals in utero - are primary contributors to children’s mental health. Existing literature on maternal signals has focused almost exclusively on their quality and valence (e.g. maternal depression, sensitivity). Here we identify a novel dimension of maternal signals: their patterns and especially their predictability/unpredictability, as an important determinant of children’s neurodevelopment. We find that unpredictable maternal mood and behavior presage risk for child and adolescent psychopathology. In experimental models, fragmented/unpredictable …

Using Archival Dna To Elucidate Anole Phylogeny, Gregory C. Mayer, Tony Gamble

Biological Sciences Faculty Research and Publications

No abstract provided.

A Qualitative Study Of The Possible Link Between Masculinity And Aggression Among College Football Players, Leanna Brown

Honors Theses

No abstract provided.

Urban Colonization Through Multiple Genetic Lenses: The City‐Fox Phenomenon Revisited, Alexandra L. Decandia, Kristin Brzeski, Elizabeth Heppenheimer, Catherine V. Caro, Glauco Camenisch, Peter Wandeler, Carlos Driscoll

Michigan Tech Publications, Part 1

Urbanization is driving environmental change on a global scale, creating novel environments for wildlife to colonize. Through a combination of stochastic and selective processes, urbanization is also driving evolutionary change. For instance, difficulty in traversing human‐modified landscapes may isolate newly established populations from rural sources, while novel selective pressures, such as altered disease risk, toxicant exposure, and light pollution, may further diverge populations through local adaptation. Assessing the evolutionary consequences of urban colonization and the processes underlying them is a principle aim of urban evolutionary ecology. In the present study, we revisited the genetic effects of urbanization on red foxes …

The East Texan, 2019-01-31, Texas A&M University-Commerce

All Issues

A color copy of The East Texan, a student newspaper published at Texas A&M University-Commerce.

Buku Ajar Tematik Berbasis Muatan Lokal Untuk Kelas Iv Sekolah Dasar, Bayu Segoro, Ari Sapto, Yuniastuti Yuniastuti

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this development research is to produce textbooks based on local content in Kabupaten Tulungagung for grade IV Primary School. Textbooks based on local content can be used as one learning resource in learning. The textbook product is developed based on the steps of the 4-D development model. Validation and test results that have been done, obtained data that is (a) the validation of the student's book reached a percentage of 85.34% with criteria is very valid; (b) the result of the attractiveness test on the student's book reaches 89.44% percentage with very interesting criteria; (c) the results …

Pembelajaran Lingkungan Bagi Siswa: Hubungan Kemampuan Berpikir Kreatif Dengan Kemampuan Pemecahan Masalah, Diana Vivanti Sigit, Erna Heryanti, Dyah Ayu Widya Pangestika, Ilmi Zajuli Ichsan

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The ability to think creatively and problem solving is the ability that students must have in 21st century. The purpose of this research was to determine the relationship between creative thinking skills and students' problem solving abilities in environmental change material. The research method used is descriptive correlational method. The research was conducted at High School 4 Bekasi in semester of the 2018/2019 academic year. The sample was taken through simple random sampling technique as many as 138 students. The results showed a correlation coefficient between the ability to think creatively with students' problem solving abilities of 0.825. The conclusion …

Implementasi Scaffolding Dalam Pembelajaran Bipa Di Kelas Pemula, Gamal Kusuma Zamahsari, A. H. Roffi’Uddin, Widodo Hs

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This article aims to describe the forms and functions of scaffolding in BIPA learning interactions at the beginner class. The method used is qualitative. The results of this study indicate that teachers in the learning interaction use some variation forms and functions of scaffolding. The visible forms are modeling, bridging, schema building, metacognition development, contextualisation, ilustration, exhibition, and correction. The visible functions are demonstration, recruitment, giving information, direction, explanatory, and direction maintenance. BIPA instructors use these forms and functions to help understand learning material to learners.

Kenyon Collegian - January 31, 2019

The Kenyon Collegian

No abstract provided.

Recommended Reading, The U.S. Naval War College

Naval War College Review

No abstract provided.

Vital U.S. Commercial And Economic Problems, William Y. Elliott

Naval War College Review

The commercial and economic policy of this country is the center from which the goal of war production must be nourished. War strategy, for that matter, depends today, more than ever, on logistics. Therefore, the health of the American economy is a primary concern to you who are vitally, entrusted with the security of this country.

Rwu Alumni Launch A New Way To Wage The Fight Against Malaria, Jill Rodrigues

Featured News Story

For two Roger Williams University alumni, seeing the first thriving crops of the sweet wormwood plant in the fields of Kentucky represent seeds of hope that their company’s new method of producing antimalarial medicine will revolutionize the fight against malaria.

Snc Opens The Addams Family

St. Norbert Times

• News
  • SNC Opens the Addams Family
  • New Policy: A Tobacco-Free Campus
  • SNC Holds MLK Day Activities
• Opinion
  • The Serial Comma: A Killer Debate
  • In Defense of The American working Class
  • Immigration
  • It’s Different
  • Democratic Ransom
  • The Covington Kids Incident and the Media’s Failures
• Features
  • Organization Spotlight: Canadian Cornishams
• Entertainment
  • Junk Drawer: What are you excited for this spring?
  • Sudoku
  • Trivia
  • “The Selection”
  • Book Review: “This Mortal Coil” by Emily Suvada
  • “Mortal Engines”
  • Restaurant Recommendation: The English Inn in Green Bay,
  • Upcoming Events
  • 5 Musical Wishes for 2019
• Sports
  • Men’s Tennis: Hungry For More
  • Name Change Nothing New
  • SNC Baseball Gets …

Risk Factors For Boating Incidents In Inuvik, Northwest Territories, Canada, Catherine Tr Glass, Audrey R. Giles

International Journal of Aquatic Research and Education

Injury prevention programs that focus on boating and water safety in the Northwest Territories (NWT) have existed for decades; however, rates of boating incidents are much higher in the NWT than southern Canada. To better understand this health disparity, we engaged in community-based participatory research informed by postcolonial feminist theory to examine Aboriginal men’s understandings of the risk factors that contribute to boating incidents in Inuvik, NWT. Participants identified four main risk factors for boating incidents in Inuvik: 1) Gender, 2) age, 3) place, and 4) lack of boating safety education. As a result of these findings and the ways …

Astronomy For Educators, Daniel E. Barth

Open Educational Resources

Astronomy for Educators provides new and accomplished K-12 instructors with concepts and projects for low-cost, high-impact STEM classroom instruction that is built around the National Academies National Research Council's K-12 Framework for Science Education.

Commonwealth Times 2019-01-30

Commonwealth Times, 1969-

No abstract provided.

Bentham And The “Famous Footnote”, Randall Otto

Between the Species

It is the contention of this paper that animal liberationists have misconstrued and misused Bentham’s “famous footnote” as an advocacy of species equivalency of interests, as though he were an incipient opponent of what has come to be known as “speciesism.” The context of Bentham’s footnote was of mistreatment of others that are capable of feeling pain. He was advocating in the footnote for laws that would end what he viewed as instances of cruelty toward animals. He was not advocating for vegetarianism or an end to killing animals where they can be of benefit to human beings, where “we …

Cognitive, Behavioral, And Situational Influences On Relapse To Smoking After Group Treatment For Tobacco Dependence, Sara E. Lunden, Jami C. Pittman, Neelam Prashad, Ria Malhotra, Christine Sheffer

Publications and Research

Socioeconomic disparities in treatment failure rates for evidence-based tobacco dependence treatment are well-established. Adapted cognitive behavioral treatments are extensively tailored to meet the needs of lower socioeconomic status (SES) smokers and dramatically improve early treatment success, but there is little understanding of why treatment failure occurs after a longer period of abstinence than with standard treatment, why early treatment success is not sustained, and why long-term treatment failure rates are no different from standard treatments. We sought to understand the causes of treatment failure from the perspective of diverse participants who relapsed after receiving standard or adapted treatment in a …

Evaluating Management Options To Increase Roadside Carbon Sequestration, Robert Ament, Tony Hartshorn, Scott Powell

CESTiCC Project Reports

We estimated the amount of carbon sequestered along Montana Department of Transportation (MDT) roads and tested 3 different highway right-of-way (ROW) management techniques to increase carbon stocks. Using Geographic Information System techniques, the total ROW acreage owned by MDT was found to sequester 75,292 metric tons of carbon per year and to consist mostly of grasslands (70%). From 2016-2018 we tested 3 ROW management techniques to increase carbon stocks- increase mowing height, plant woody shrubs, or add legumes to reclamation seed mixes of disturbed soils - at 3 sites (Three Forks [3F], Bear Canyon [BC], and Bozeman Pass [BP]) along …

Neurodevelopmental Milestones And Associated Behaviours Are Similar Among Healthy Children Across Diverse Geographical Locations, José Villar, Michelle Fernandes, Manorama Purwar, Eleonora Staines-Urias, Paola Di Nicola, Leila Cheikh Ismail, Roseline Ochieng, Fernando Barros, Maria Carvalho, Elaine Albernaz

Paediatrics and Child Health, East Africa

It is unclear whether early child development is, like skeletal growth, similar across diverse regions with adequate health and nutrition. We prospectively assessed 1307 healthy, well-nourished 2-year-old children of educated mothers, enrolled in early pregnancy from urban areas without major socioeconomic or environmental constraints, in Brazil, India, Italy, Kenya and UK. We used a specially developed psychometric tool, WHO motor milestones and visual tests. Similarities across sites were measured using variance components analysis and standardised site differences (SSD). In 14 of the 16 domains, the percentage of total variance explained by between-site differences ranged from 1.3% (cognitive score) to 9.2% …

The Tenets Of Teneurin: Conserved Mechanisms Regulate Diverse Developmental Processes In The Drosophila Nervous System, Alison T. Depew, Michael A. Aimino, Timothy J. Mosca

Department of Neuroscience Faculty Papers

To successfully integrate a neuron into a circuit, a myriad of developmental events must occur correctly and in the correct order. Neurons must be born and grow out toward a destination, responding to guidance cues to direct their path. Once arrived, each neuron must segregate to the correct sub-region before sorting through a milieu of incorrect partners to identify the correct partner with which they can connect. Finally, the neuron must make a synaptic connection with their correct partner; a connection that needs to be broadly maintained throughout the life of the animal while remaining responsive to modes of plasticity …

The Comparative Genomics And Complex Population History Of Papio Baboons, Jeffrey Rogers, Muthuswamy Raveendran, R. Alan Harris, Thomas Mailund, Kalle Leppälä, Georgios Athanasiadis, Mikkel Heide Schierup, Jade Cheng, Kasper Munch, Jerilyn A. Walker, Miriam K. Konkel, Vallmer E. Jordan, Cody J. Steely, Thomas O. Beckstrom, Christina Bergey, Andrew Burrell, Dominik Schrempf, Angela Noll, Maximillian Kothe, Gisela H. Kopp, Yue Liu, Shwetha Murali, Konstantinos Billis, Fergal J. Martin, Matthieu Muffato, Laura A. Cox, James Else, Todd Disotell, Donna M. Muzny, Jane Phillips-Conroy, Bronwen Aken, Evan E. Eichler, Tomas Marques-Bonet, Carolin Kosiol

Faculty Publications

Copyright © 2019 The Authors, Recent studies suggest that closely related species can accumulate substantial genetic and phenotypic differences despite ongoing gene flow, thus challenging traditional ideas regarding the genetics of speciation. Baboons (genus Papio) are Old World monkeys consisting of six readily distinguishable species. Baboon species hybridize in the wild, and prior data imply a complex history of differentiation and introgression. We produced a reference genome assembly for the olive baboon (Papio anubis) and whole-genome sequence data for all six extant species. We document multiple episodes of admixture and introgression during the radiation of Papio baboons, thus demonstrating their …

02-05-19 Hsc Committee Meeting Agenda (Revised), Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

A Rational Approach For Creating Peptides Mimicking Antibody Binding, Sameer Sachdeva, Hyun Joo, Jerry Tsai, Bhaskara Jasti, Xiaoling Li

School of Pharmacy Faculty Articles

This study reports a novel method to design peptides that mimic antibody binding. Using the Knob-Socket model for protein-protein interaction, the interaction surface between Cetuximab and EGFR was mapped. EGFR binding peptides were designed based on geometry and the probability of the mapped knob-sockets pairs. Designed peptides were synthesized and then characterized for binding specificity, affinity, cytotoxicity of drug-peptide conjugate and inhibition of phosphorylation. In cell culture studies, designed peptides specifically bind and internalize to EGFR overexpressing cells with three to four-fold higher uptake compared to control cells that do not overexpress EGFR. The designed peptide, Pep11, bound to EGFR …

Good Vibrations: New Research Uncovers How A Species Of Protected Giant Weta Communicates, Sarah Schaier

UNH Today Archive

No abstract provided.

A Close-Up Look At Pcr, Callie J. Donahue, Ashley A. Adair, Leslie Kate Wright, Dina Newman

Articles

The Polymerase Chain Reaction (PCR) is a fundamental laboratory technique that allows for the amplification of many copies of a desired DNA target sequence. Despite its prevalence, undergraduate students often have poor comprehension about the underlying molecular mechanisms of PCR and the components necessary to carry out the reaction. We designed an interactive modeling activity to help students visualize the underlying molecular processes of denaturation, annealing, and extension, and to see how PCR parallels in vivo DNA replication. During the activity, students mimic denaturation, annealing, and extension by synthesizing DNA strands from individual nucleotides and primers in the 5’ to …

Refernment: An R Package For Annotating Rna Editing In Plastid Genomes, Tanner A. Robison, Paul G. Wolf

Biology Faculty Publications

PREMISE OF THE STUDY: In the absence of cDNA, the annotation of RNA editing in plastomes must be done manually, representing a significant time cost to those studying the organellar genomes of ferns and hornworts.

METHODS AND RESULTS: We developed an R package to automatically annotate apparent nonsense mutations in plastid genomes. The software successfully annotates such sites and results in no false positives for data with no sequencing or assembly errors.

CONCLUSIONS: Compared to manual annotation, ReFernment offers greater speed and accuracy for annotating RNA editing sites. This software should be especially useful for researchers generating large numbers of …

Novel Test Fixture For Characterizing Mems Switch Microcontact Reliability And Performance, Protap Mahanta, Farhana Anwar, Ronald A. Coutu Jr.

Electrical and Computer Engineering Faculty Research and Publications

In microelectromechanical systems (MEMS) switches, the microcontact is crucial in determining reliability and performance. In the past, actual MEMS devices and atomic force microscopes (AFM)/scanning probe microscopes (SPM)/nanoindentation-based test fixtures have been used to collect relevant microcontact data. In this work, we designed a unique microcontact support structure for improved post-mortem analysis. The effects of contact closure timing on various switching conditions (e.g., cold-switching and hot-switching) was investigated with respect to the test signal. Mechanical contact closing time was found to be approximately 1 us for the contact force ranging from 10–900 μN. On the other hand, for the 1 …

Habitat Usage Patterns Of Bottlenose Dolphins (Tursiops Truncatus) In Terrebonne And Timbalier Bays, Louisiana, Mary Allison Manning

LSU Master's Theses

I coupled fine-scale environmental data with observed behavior and group composition data to examine overall distribution within the bay system and to characterize the habitat associated with foraging and the presence of calves. Semi-isolated populations of bottlenose dolphins (Tursiops truncatus) along Louisiana’s coast are undergoing increased risks from boat traffic, oil spills, land subsidence, and planned water diversions (CPRA 2017). Characterizing the habitat use of bottlenose dolphins in Terrebonne and Timbalier bays, Louisiana, is important given the likely high site fidelity, small home ranges, and low exchange of individuals with nearby coastal populations (Lane et al. 2015, McDonald …