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Interactions Between Earliest Linearbandkeramik Farmers And Central European Hunter Gatherers At The Dawn Of European Neolithization, Alexey G. Nikitin, Peter Stadler, Nadezhda Kotova, Maria Teschler-Nicola, T. Douglas Price, Jessica Hoover, Douglas J. Kennett, Losif Lazaridis, Nadin Rohland, Mark Lipson, David Reich

Open Access Publishing Support Funded Articles

Archaeogenetic research over the last decade has demonstrated that European Neolithic farmers (ENFs) were descended primarily from Anatolian Neolithic farmers (ANFs). ENFs, including early Neolithic central European Linearbandkeramik (LBK) farming communities, also harbored ancestry from European Mesolithic hunter gatherers (WHGs) to varying extents, reflecting admixture between ENFs and WHGs. However, the timing and other details of this process are still imperfectly understood. In this report, we provide a bioarchaeological analysis of three individuals interred at the Brunn 2 site of the Brunn am Gebirge-Wolfholz archeological complex, one of the oldest LBK sites in central Europe. Two of the individuals had …

United States Suicide Analysis: 1999-2016, Malynn Clark

Honors Theses

The purpose of this thesis is to create information visualizations surrounding suicide trends from 1999-2016 in the United States. The original data was obtained from the Centers for Disease Control and Prevention’s Compressed Mortality Database. This database permits users to download several fields of information regarding deaths for the years given. Using this information, many graphs below show trends and patterns for suicide. One notable trend includes the higher proportion of male to female suicides for all categories explored including: age group, race, and metro/nonmetro status. The goal is to bring awareness and understanding surrounding the suicide epidemic in the …

The Effectiveness And Effects Of Alcohol Regulation: Evidence From India, Dara Lee Luca, Emily Owens, Gunjan Sharma

WCBT Faculty Publications

We provide quasi-experimental evidence on the effects of alcohol regulation on alcohol consumption and associated public health outcomes using detailed individual level and aggregate data from India, where state-level laws regulating the minimum legal drinking age generate substantial variation in the availability of commercially produced alcohol across people of different ages. We find that despite significant law evasion, men who are legally allowed to drink are substantially more likely to consume alcohol. Further, men who are legally allowed to drink are significantly more likely to commit violence against their partners, suggesting a causal channel between alcohol consumption and domestic violence. …

The Political Personality Of Former U.S. Vice President Joe Biden, Anne Marie Griebie, Aubrey Immelman

Psychology Faculty Publications

Note: The paper whose abstract appears below, titled "The Political Personality of Former U.S. Vice President Joe Biden" has been replaced on the 'Download' tab with an updated paper containing a more thorough personality assessment and a more detailed leadership style analysis, titled "The Political Personality of 2020 Democratic Presidential Nominee Joe Biden." The earlier paper has been archived and may be uploaded at the bottom of this page from the hyperlink under 'Additional Files.'

This working paper presents the results of an indirect assessment of the personality of former U.S. vice president Joe Biden — a contender for …

Effects Of Temperature And Nitrogen Depletion On Biodiesel Production Under Saline Conditions By A Mixed Algal Community, Sarah J. Kintner

Nanoscience and Microsystems ETDs

The overall objective addressed in this research was to gain a better understanding of how native mixed cultures of phototrophic microorganisms from a saline system may be used for biodiesel production. Laboratory batch reactors were grown under variable temperatures and nitrogen concentrations with original inoculum from a hypersaline pond in central New Mexico. Growth at 40 C° led to lower lipid production, lower nitrate consumption, and less diverse communities than growth at 20° C. All communities were dominated by the cyanobacteria Plectonema except the in second experiment, where they were only 30% of the culture. In a second experiment with …

Persistence And Mitigation Of Antibiotic Resistance In Manure And Manure-Amended Soils, Mara J. Zelt

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

The emergence of antibiotic resistance (AR) is a growing global threat to human and animal health. The work described here asses the AR mitigation potential of management strategies at critical control points in livestock production, and agricultural land management as well as the effectiveness of a communication strategy to convey research-based information to empower behavioral change that could mitigate AR.

The first study evaluates the impact of beef cattle diet management strategies on AMR prevalence in manure. Two treatments – forage concentration and essential oils – in cattle diets were evaluated for their impact on AMR bacteria in feedlot manure. …

Flex-Ro: A Robotic High Throughput Field Phenotyping System, Joshua N. Murman

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Research in agriculture is critical to developing techniques to meet the world’s demand for food, fuel, fiber, and feed. Optimization of crop production per unit of land requires scientists across disciplines to collaborate and investigate new areas of science and tools for data collection. The use of robotics has been adopted in several industries to supplement labor, and accurately perform repetitious tasks. However, the use of autonomous robots in commercial agricultural production is still limited. The Flex-Ro (Flexible structured Robotic platform) was developed for use in large area fields as a multipurpose tool to perform monotonous agricultural tasks.

This work …

Xenobiotic Exposure Requires Mitochondrial Metabolism For Redox Homeostasis And Survival In Astrocytes, Jordan Rose

Department of Biochemistry: Dissertations, Theses, and Student Research

Astrocytes are integral components of glutamatergic neurotransmission, providing essential metabolic processes for neuronal homeostasis and acting as the first line of defense against xenobiotics crossing the blood brain barrier. Arsenic is a xenobiotic with widespread natural and industrial prevalence, and has been linked to impaired neurodevelopment and neuronal death. Given the integrated metabolic nature of astrocytes and neurons, we sought to explore how arsenic impacts astrocyte metabolism in order to better understand the mechanisms of xenobiotic toxicity in the mammalian brain.

We demonstrate that astrocyte viability depends upon de novoglutathione (GSH) synthesis during arsenic exposure, and sub-lethal arsenic exposure …

Motherhood And The Periodical Press: The Myth And The Medium, Susan A. Malcom

Department of English: Dissertations, Theses, and Student Research

In this study, I utilize close readings of the periodically published works of three women writers – Kate Chopin, Frances Ellen Watkins Harper, and Elia Peattie –through the lenses of historical/biographical, affective, and biosocial theories. Examining these works against the backdrop of America’s mythologized mother exposes the social ubiquity of the myth and the realities of motherhood nineteenth-century women experienced.

Chapter one examines the mythological nature of American motherhood as it evolved from a politically and socially nuanced Republican Mother and the role of American periodicals as a medium of perpetuating that myth. Historically, American motherhood was an extended function …

Role Of Arginine And/Or Taurine In Protection Against Gentamicin-Induced Nephrotoxicity In Male And Female Rats, Amal H. Emara, Wafaa M. Ismaeil

Journal of Medicine in Scientific Research

Background As a highly effective antibiotic, gentamicin is used in the treatment of serious and life-threatening gram-negative infections. L-arginine (2-amino-5-guanidino-pentanoic acid) has a protective role on renal failure that induced by gentamicin administration and it may decrease the tubular reabsorption of another cationic substance, gentamicin due to its cationic structure. The aim of this study is to determine the influence of gender on nephroprotective effects of L-arginine (Arg) and/or taurine (Tau) on gentamicin (G) induced nephrotoxicity. Methods Adult Sprague-Dawley albino rats of both sexes (150-200 g, 48 male and 48 female), were bred from the animal unit of National Nutrition …

One-Year Angiographic Results Of Left Anterior Descending Bypass Using Internal Mammary Artery: A Series Of 48 Consecutive Patients, Ahmed S. Mahlab

Journal of Medicine in Scientific Research

The left internal mammary artery (LIMA) has been used as a conduit for coronary artery revascularization since 1968. Here we are reporting A total of 48 consecutive patients were operated upon using double mammary arteries. All of them received a mammary graft to the left anterior descending artery (LAD). All 48 of them were controlled angiographically at 1 year postoperative to ensure satisfactory well-functioning grafts.

Comparing Functions, Costs And Rewards Of Quality Engineers And Six Sigma Black Belts, C. Grant Short

All-Inclusive List of Electronic Theses and Dissertations

The respective Bodies of Knowledge (BoKs) as described by the American Society for Quality (ASQ) for Certified Quality Engineers (ASQ, 2015a) and Certified Six Sigma Black Belts (ASQ, 2015b) are quite similar, yet anecdotally, six sigma black belts are recognized and consequently rewarded more highly than are quality engineers. While Quality Engineering work is typically regarded as preventive in nature, work performed by six sigma black belts is in the realm of improvement, hence is reactive in nature. Consequently, a dichotomy exists in that preventive actions, which are less costly by their nature, are not rewarded as well as costlier …

Ecological Feedbacks Stabilize A Turf-Dominated Ecosystem At The Southern Extent Of Kelp Forests In The Northwest Atlantic, Colette Feehan, Sean P. Grace, Carla A. Narvaez

Department of Biology Faculty Scholarship and Creative Works

Temperate marine ecosystems globally are undergoing regime shifts from dominance by habitat-forming kelps to dominance by opportunistic algal turfs. While the environmental drivers of shifts to turf are generally well-documented, the feedback mechanisms that stabilize novel turf-dominated ecosystems remain poorly resolved. Here, we document a decline of kelp Saccharina latissima between 1980 and 2018 at sites at the southernmost extent of kelp forests in the Northwest Atlantic and their replacement by algal turf. We examined the drivers of a shift to turf and feedback mechanisms that stabilize turf reefs. Kelp replacement by turf was linked to a significant multi-decadal increase …

Developing Approaches That Leverage Next Generation Sequencing To Study Broad Biological Problems, Nicole Hales

Biology Dissertations - Archive

The advent of Next Generation Sequencing has been an extremely powerful tool in transforming the way we answer biological questions today. With the price per base pair continuously decreasing, and throughput, sequencing speed and quality of sequence reads increasing, NGS has allowed scientists to develop novel biological applications that have led to significant findings. During my dissertation, I leveraged several non-model organisms across various projects to develop new approaches of NGS to study a broad range of biological questions, including (1) understanding the genetic processes underlying transgenerational plasticity in Daphnia, (2) using Hi-C sequencing to study vertebrate genome structure and …

Leveraging The Dynamic Repeat Element Landscape Of Squamate Reptile Genomes To Understand Broad Patterns Of Vertebrate Genome Evolution And Transposable Element Biology, Giulia Im Pasquesi

Biology Dissertations - Archive

Vertebrate genomes are mostly composed of transposable elements (TE), mobile DNA sequences that have shaped genome structure and evolution by promoting positive (e.g., regulatory network rewiring, embryo development) and negative (e.g., ectopic recombination, disease) genomic processes. Leveraging genomic and transcriptomic data from diverse vertebrate species, I present novel lines of evidence that underscore the unique value of squamate reptile genomes for investigating properties of TE landscape evolution. This dissertation demonstrates that squamate genomes defy paradigms of amniote repeat element evolution set by mammals and birds, in particular: that greater variability in TE content is found between major lineages, that genome …

Family Conflict Observations And Outcomes Among Adopted School-Age Children With Lesbian, Gay, And Heterosexual Parents, Rachel H. Farr, Samuel T. Bruun, Kyle A. Simon

Psychology Faculty Publications

Children’s externalizing problems are associated with family conflict among children and their biological parents, yet these linkages have remained unexamined among adoptive or lesbian and gay parent families. Investigating family processes facilitative of adjustment among adoptees, who face unique developmental challenges, is warranted. This multimethod study of 96 (26 lesbian, 29 gay, 41 heterosexual parent) adoptive families examined observations of adoptive family conflict and associations with child adjustment and feelings about adoption (children’s M_age = 8 years). The sample was recruited from 5 private, domestic infant adoption agencies across the United States. Parents and children reported about children’s externalizing …

A Multi-Year Survey Of Helminths From Wild Saddleback (Leontocebus Weddelli) And Emperor (Saguinus Imperator) Tamarins, Gideon A. Erkenswick, Mrinalini Watsaa, Alfonso S. Gozalo, Shay Dudaie, Lindsey Bailey, Kudakwashe S. Muranda, Alaa Kuziez, Patricia G. Parker

Biology Department Faculty Works

The establishment of baseline data on parasites from wild primates is essential to understand how changes in habitat or climatic disturbances will impact parasite-host relationships. In nature, multiparasitic infections of primates usually fluctuate temporally and seasonally, implying that the acquisition of reliable data must occur over time. Individual parasite infection data from two wild populations of New World primates, the saddleback (Leontocebusweddelli) and emperor (Saguinusimperator) tamarin, were collected over three years to establish baseline levels of helminth prevalence and parasite species richness (PSR). Secondarily, we explore variation in parasite prevalence across age and sex classes, test non-random associations of parasite …

The Manipulation Of Host Transcription By The Ankh Effector Of Legionella., Juanita E. Von Dwingelo

Electronic Theses and Dissertations

Legionella pneumophila is a Gram-negative facultative intracellular bacterium that can be found dispersed throughout freshwater environments, where it primarily parasitizes amoebae and other protozoan species. Humans are an accidental host for L. pneumophila, and infection occurs upon inhalation of aerosolized water droplets that contain the bacteria. L. pneumophila is the causative agent of Legionnaires’ Disease, which is the result of intracellular proliferation within alveolar macrophages. Pathogenesis of L. pneumophila is dependent on the Dot/Icm type 4 secretion system (T4SS) apparatus, which is comprised of 27 proteins and is responsible for translocating over 330 effector proteins into the host cell. Many …

An Electrochemical Instrument For The Analysis Of Heavy Metals In Water Via Anodic Stripping Coulometry For Applications In Remote Sensing., Kelsey Lynn Kaht

Electronic Theses and Dissertations

From the high levels of arsenic in groundwater in Bangladesh to the lead contamination of drinking water in Flint, Michigan, there are incidents across the globe that highlight the need for a reliable instrument capable of monitoring heavy metals remotely and continuously in a variety of geographical locations. Typical instrumentation for water analysis, such as ICP and AAS, must be housed in a central lab and relies on an operator traveling to the collection site, obtaining a sample, and transporting it back to the lab. This analysis provides a snapshot of the water quality that is limited to the specific …

Electrochemical Determination Of Surface Area-To-Volume Ratio For Metal Nanoparticle Analysis., Jay Narayan Sharma

Electronic Theses and Dissertations

This dissertation describes an electrochemical approach for measuring the surface area-to-volume ratio (SA/V) of electrode-attached metal nanoparticles (NPs), which was used to analyze their size, aggregation state, and porosity. This dissertation further describes the effect of the metal NP electrode assembly method on the SA/V, which is related to metal NP catalytic activity and stability. Cyclic voltammetry (CV) in acid electrolyte followed by anodic stripping voltammetry (ASV) in KBr electrolyte allows the electrochemical measurement of the SA/V of electrode-attached Au nanospheres (NSs). In CV, the forward scan produces a thin surface Au₂O₃ layer on the Au NSs. …

The Effects Of Nicotine And Cigarette Smoking On Cardiac Electrophysiology., Affan B. Irfan

Electronic Theses and Dissertations

Cigarette smoking is a leading cause of preventable disease and premature death worldwide. The adverse effects of cigarette smoking, including proarrhythmia, are related to the mixture of chemicals, including nicotine (which sustains tobacco addiction). However, it remains unclear which individual tobacco smoke constituents and biological pathways mediate this increased risk. The purpose of this research was to explore the chronic effects of cigarette smoking, as well as compare the acute effects of nicotine and cigarette smoking, and the possible role of β-adrenoreceptors, on human cardiac electrophysiology. Chapter 1 is a comprehensive literature review of (a) the ex vivo and in …

Therapeutic Potential Of Withaferin A Against Non-Small Cell Lung Cancer., Al Hassan Kyakulaga

Electronic Theses and Dissertations

Lung cancer is the leading cause of cancer-related deaths worldwide and in the United States. Despite recent advancements in treatment approaches, chemoresistance and metastasis remain a major therapeutic challenge. Withaferin A (WFA), a plant-derived compound has recently emerged as a promising antitumor agent. In the present study, we explored the therapeutic potential of WFA against advanced NSCLC. Briefly, WFA was evaluated for its efficacy, toxicity and pharmacokinetic properties against advanced NSCLC using in vitro and in vivo models. Two human NSCLC cell lines, H1299 and A549 were used in cell culture to determine the anticancer properties of WFA. Repeat dose …

Laser Spectroscopy Investigations Of Jet-Cooled Metal-Containing Free Radicals., Anam Chandra Paul

Electronic Theses and Dissertations

Metal-containing free radicals are important intermediates in metal-surface reactions and the interactions between metals and organic molecules. Among metal-containing free radicals, monovalent derivatives of alkaline earth metals have been extensively investigated by using spectroscopic techniques in a gas phase, mainly in Broida ovens or under supersonic-jet-cooled conditions. In the present study, the results of performed spectroscopic investigations of both metal-containing monoalkoxides (CaOR) and metal oxides (MO) radicals have been reported. Laser-induced fluorescence (LIF) and dispersed fluorescence (DF) spectra of the electronic transition of the calcium CaOR radicals have been obtained under jet-cooled conditions. Complete active space self-consistent field (CASSCF) and …

A Recombinant Cholera Toxin B Subunit Variant (Ctb-Kdel) Exhibits Unique Colon Mucosal Healing Effects That Have Therapeutic Implications For Inflammatory Bowel Disease., Joshua Mark Royal

Electronic Theses and Dissertations

This dissertation uncovers the mechanism and explores the utility of a recombinant cholera toxin B subunit (CTB) variant containing a KDEL endoplasmic reticulum (ER) retention motif (CTB-KDEL) as a drug candidate for the treatment of inflammatory bowel disease (IBD). CTB is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Here, we reveal …

The Identification Of Long Non-Coding Rna Zfas1 Through An Exploratory Rna-Sequencing Analysis And Its Association With Epithelial-To-Mesenchymal Transition In Colon Cancer Adenocarcinoma., Stephen J. O'Brien

Electronic Theses and Dissertations

Colorectal adenocarcinoma is the fourth most common cancer diagnosed worldwide and is a significant cause of morbidity and mortality. This dissertation performed an exploratory RNA-sequencing analysis comparing gene expression between colon adenocarcinoma tissue and paired normal colon epithelium. After identification of a number of lncRNAs that were increased in expression in colon adenocarcinoma compared to normal colon epithelium, we aimed to validate the expression and investigate their function in vitro. Specifically, we focused on the lncRNA ZFAS1 and its association with epithelial-to-mesenchymal transition. These studies found the following: 1. Seven candidate lncRNAs were identified from the exploratory RNA-sequencing analysis to …

The Relationship Between Employee Engagement And Work Performance For Individuals Working In Active Asset Management: Examining The Moderate Effect Of Age, Gender, And Job Function., Elizabeth Aubrey Brenner

Electronic Theses and Dissertations

The construct of employee engagement and its relationship to desirable organizational outcomes has received a great deal of attention within Human Resource Development (HRD) literature. However, little research has examined the influence of employee engagement on work performance in the active asset management industry, and no academic study has explored employee engagement in the active asset management industry using the lens of HRD. This study examined the relationship between employee engagement and work performance, and the moderating effect of age, gender, and job function on the relationship between employee engagement and work performance, for individuals employed within active asset management. …

Gc×Gc-Ms And Parallel 2dlc-Ms Based Untargeted Metabolomics., Md Aminul Islam Prodhan

Electronic Theses and Dissertations

Untargeted metabolomics aims to analyze as many metabolites as possible in a biological system. Due to the vast complexity of the metabolome, bioanalytical platforms have been developed for untargeted metabolomics. While comprehensive two-dimensional gas chromatography mass spectrometry (GC×GC-MS) has been used in different scientific fields, its use in untargeted metabolomics is limited due to several challenges, such as complicated data analysis and limited accuracy of metabolite identification. Two-dimensional liquid chromatography mass spectrometry (2DLC-MS) has also been employed in untargeted metabolomics, but with limited metabolite coverage. This dissertation describes the efforts in developing new data analysis algorithms to improve the accuracy …

Police Stress, Depression, And Substance Use Among Police Officers: A General Strain Perspective., Kyra Nicole Fritz

Electronic Theses and Dissertations

This dissertation examines the utility of general strain theory in explaining substance use as a form of coping among a sample of police officers in a Midwestern, metropolitan city. The dissertation is comprised of five chapters, including the introduction, literature review, method, results, and discussion. Chapter one describes the stressful nature of a career in law enforcement, concentrating on the adverse consequences of prolonged stress, including depression and substance use. Chapter one also examines strain, depression, and substance use among police officers using a general strain perspective, highlighting the limitations of existing empirical studies. Chapter two details the theoretical premise …

Understanding Object Motion Encoding In The Mammalian Retina., Victor Julian Depiero

Electronic Theses and Dissertations

Phototransduction, transmission of visual information down the optic nerve incurs delays on the order of 50 – 100ms. This implies that the neuronal representation of a moving object should lag behind the object’s actual position. However, studies have demonstrated that the visual system compensates for neuronal delays using a predictive mechanism called phase advancing, which shifts the population response toward the leading edge of a moving object’s retinal image. To understand how this compensation is achieved in the retina, I investigated cellular and synaptic mechanisms that drive phase advancing. I used three approaches, each testing phase advancing at a …

Influence Of Competitive Sports On Disordered Eating Behaviors In Young Female Athletes, Jill Bernstorf

Electronic Theses and Dissertations

The field of treating and learning about eating disorders in athletes is a growing field that continues to flourish as more knowledge is acquired. The purpose of this study is to examine the influence that length of time in the sport, age at which an individual starts a competitive sport, level of competitiveness, and type of sport (leanness vs. non-leanness focused) has on disordered eating behaviors. The participants were college students who were involved in at least one competitive sport in their life. They completed the EAT-26 questionnaire as well as a basic questionnaire. There was not enough data collected …