Digital Commons Network^™

A Variant In The Mica Gene Is Associated With Liver Fibrosis Progression In Chronic Hepatitis C Through Tgf-Β1 Dependent Mechanisms., Rasha El Sharkawy, Ali Bayoumi, Mayada Metwally, Alessandra Mangia, Thomas Berg, Manuel Romero-Gomez, Maria Lorena Abate, William L. Irving, David Sheridan, Gregory J. Dore, Ulrich Spengler, Pietro Lampertico, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Rosanna Santoro, Rocío Gallego-Durán, Janett Fischer, Jacob Nattermann, R D'Ambrosio, Duncan Mcleod, Elizabeth Powell, Olivier Latchoumanin, Khaled Thabet, Mustafa A.M. Najim, Mark W. Douglas, Christopher Liddle, Christopher Liddle, Jacob George, Mohammed Eslam, Liver Disease Genetics Consortium (Ildgc) International

Peninsula Medical School

Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage …

American Journal Of Biochemistry And Biotechnology: A Bibliometric Study, Shamili N, Silambarasan D

Library Philosophy and Practice (e-journal)

The present study reveals the bibliometric study of the “American journal of biochemistry and biotechnology” the study covers the growth of literature and authorship pattern of the journal. Further, it analyzed various other bibliometrics aspects such as subject wise distribution of article, intuition wise distribution article, country wise distribution of article, bibliographical wise distribution of citation and self citation.

2019 Sdsu Data Science Symposium Abstracts, South Dakota State University

SDSU Data Science Symposium

No abstract provided.

Development Of A Novel Loop-Mediated Isothermal Amplification Method To Detect Guiana Extended-Spectrum (Ges) Β-Lactamase Genes In Pseudomonas Aeruginosa, Chika Takano, Mitsuko Seki, Dong Wook Kim, Humphrey Gardner, Robert E. Mclaughlin, Paul E. Kilgore, Kazunari Kumasaka, Satoshi Hayakawa

Department of Pharmacy Practice

Infections caused by multidrug-resistant Pseudomonas aeruginosa in hospitalized patients are often fatal, and nosocomial infections caused by Guiana extended-spectrum (GES) β-lactamase-producing strains are of growing concern. Several genotypes of the GES β-lactamase gene (bla_GES) include a single missense mutation, a change from G to A at nucleotide position 493 (G_493A) that changes glycine to serine; the mutant enzyme exhibits carbapenemase activity. Rapid and reliable identification of drug-resistance is important in clinical settings; however, culture methods remain the gold standard. Conventional and real-time PCR cannot identify carbapenemase-producing genotypes, and direct DNA sequencing is essential. We established …

Reinterpretation Of The Substrate Specificity Of The Voltage-Sensing Phosphatase During Dimerization., Martin Kruse, Susy C Kohout, Bertil Hille

Cooper Medical School of Rowan University Departmental Research

Voltage-sensing phosphatases (VSPs) cleave both 3- and 5-phosphates from inositol phospholipids in response to membrane depolarization. When low concentrations of Ciona intestinalis VSP are expressed in Xenopus laevis oocytes, the 5-phosphatase reaction can be observed during large membrane depolarizations. When higher concentrations are expressed, the 5-phosphatase activity is observed with smaller depolarizations, and the 3-phosphatase activity is revealed with strong depolarization. Here we ask whether this apparent induction of 3-phosphatase activity is attributable to the dimerization that has been reported when VSP is expressed at higher concentrations. Using a simple kinetic model, we show that these enzymatic phenomena can be …

Fort Hays State University Faculty Senate Minutes, February 4, 2019, Fhsu Faculty Senate

Faculty Senate

No abstract provided.

Faculty Senate Monthly Packet February 2019, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The February 2019 Monthly packet includes the February agenda and appendices and the Faculty Senate minutes and attachments from the meeting held January 2019.

Lanthorn, Vol. 53, No. 22, February 4, 2019, Grand Valley State University

Volume 53, July 9, 2018 - June 10, 2019

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Faculty Senate Agenda, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 10, 2019
• Academic Freedom and Tenure Annual Report
• Council on Teacher Education Annual Report
• 405.7.2 – External Reviewers
• Greenhouse Gas Resolution
• 403.3.1 – Standards of Conduct – Faculty Responsibilities to Students
• 403.3.2 – Standards of Conduct – Professional Obligations
• 405.2.1 – 405.3.2 – 405.5.1 – 405.10.1 Community Engagement Inclusion
• 407.1.1 – Non Punitive Measure
• 407.8.5(3) – Sexual Harassment
• 407.11.2(2) - Notification of Faculty Member
• 407.11.3(2) – Protection of Complainant and Others

Muddy Waters: Navigating Potential Changes To Clean Water Act, Lori Taylor Gula

UNH Today Archive

No abstract provided.

Cyclin D1 Integrates G9a-Mediated Histone Methylation., Zhiping Li, Xuanmao Jiao, Gabriele Di Sante, Adam Ertel, Mathew C. Casimiro, Min Wang, Sanjay Katiyar, Xiaoming Ju, D. V. Klopfenstein, Aydin Tozeren, William Dampier, Iouri Chepelev, Albert Jeltsch, Richard G. Pestell

Department of Cancer Biology Faculty Papers

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle …

The Rider (2019-02-04), Victor G. Ramirez

The Rider Archives

Vol.4 No.18

The Developmental Evolution Of The Novel Treehopper Helmet, Cera Fisher

Doctoral Dissertations

Understanding morphological diversity requires understanding the developmental basis for the origin of novelty. In my dissertation, I use the treehopper helmet to investigate the origin of novelty. This 3-dimensional outgrowth of the prothoracic dorsal body wall has been molded by natural selection into myriad elaborate forms and differentiates treehoppers from their closest relatives. The helmet is hypothesized to have originated by modulation of the ancestral body wall patterning network, or alternatively by co-option of the wing or leg patterning network. I tested these hypotheses using a comparative approach in three species from the order Hemiptera: Entylia carinata, an emerging …

St. Norbert College To Host Nicholas Carr For Killeen Chair Lecture Series, St. Norbert College

Press Releases 2019

No abstract provided.

Anaerobic Degradation Of Hexadecane And Phenanthrene Coupled To Sulfate Reduction By Enriched Consortia From Northern Gulf Of Mexico Seafloor Sediment, Boryoung Shin, Minjae Kim, Karsten Zengler, Kuk-Jeong Chin, Will A. Overholt, Lisa M. Gieg, Konstantinos T. Konstantinidis, Joel E. Kostka

C-IMAGE Publications

To advance understanding of the fate of hydrocarbons released from the Deepwater Horizon oil spill and deposited in marine sediments, this study characterized the microbial populations capable of anaerobic hydrocarbon degradation coupled with sulfate reduction in non-seep sediments of the northern Gulf of Mexico. Anaerobic, sediment-free enrichment cultures were obtained with either hexadecane or phenanthrene as sole carbon source and sulfate as a terminal electron acceptor. Phylogenetic analysis revealed that enriched microbial populations differed by hydrocarbon substrate, with abundant SSU rRNA gene amplicon sequences from hexadecane cultures showing high sequence identity (up to 98%) to Desulfatibacillum alkenivorans (family Desulfobacteraceae), …

Daily Eastern News: February 04, 2019, Eastern Illinois University

February

No abstract provided.

The Social Construction Of Life: Critical Thinking About Biology In Society, Peter J. Taylor

Working Papers on Science in a Changing World

This book aims to expand the boundaries of the influences that readers consider when interpreting the practices and products of the life sciences ("biology") and their impact on society. The chapter topics include: Interpreting Ideas of Nature; The structure of origin stories; Multiple layers in influencing an audience: The case of Darwin's On the Origin of Species; Metaphors of coordination and development; What causes a disease?—the consequences of hereditarianism in the case of pellagra; How changeable are IQ test scores?; Social negotiations around genetic screening; Intersecting processes involving genes and environment.

Each chapter consists of 5 parts:

1. Introduce simple …

Inferring Gene Regulatory Networks From A Population Of Yeast Segregants, Chen Chen, Dabao Zhang, Tony R. Hazbun, Min Zhang

Purdue University Libraries Open Access Publishing Fund

Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by consistent selection of regulatory effects at the second stage. Using this approach, we identified subnetworks that were enriched in gene ontology categories, revealing directional regulatory mechanisms controlling …

Inferring Gene Regulatorynetworks From A Populationof Yeast Segregants, Chen Chen, Tony R. Hazbun, Min Zhang

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Constructing gene regulatory networks is crucial to unraveling the genetic architecture of complex traits and to understanding the mechanisms of diseases. On the basis of gene expression and single nucleotide polymorphism data in the yeast, Saccharomyces cerevisiae, we constructed gene regulatory networks using a two-stage penalized least squares method. A large system of structural equations via optimal prediction of a set of surrogate variables was established at the first stage, followed by consistent selection of regulatory effects at the second stage. Using this approach, we identified subnetworks that were enriched in gene ontology categories, revealing directional regulatory mechanisms controlling these …

Late Summer Glacial Meltwater Contributions To Bull Lake Creek Stream Flow And Water Quality, Wind River Range, Wyoming, Usa, Jeffrey Vanlooy, Gregory S. Vandeberg

Earth System Science and Policy Faculty Publications

The Wind River Range in Wyoming contains more glacial ice than any other location within the USA’s Rocky Mountain states of Colorado, Idaho, Montana, and Wyoming. Bull Lake Creek watershed in the southeast portion of the range contains five major (0.6–1.5 km2) glaciers along with numerous smaller glaciers that contribute to the Wind River. Field measurements were made of discharge from the Knife Point and Bull Lake Glaciers to determine the contribution of glacial meltwater to the river system. Water samples were collected and analyzed for stable isotopes, major ions, nutrients, and selected trace elements. Meltwater from the two glaciers …

Faculty Senate Minutes, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Academic Freedom and Tenure
• Council on Teacher Education
• Greenhouse Gas Resolution

Characterization And Analysis Of Neural Progenitor Cells From Primary Progressive Multiple Sclerosis Patients, Alexandra Nicaise

Doctoral Dissertations

Primary progressive multiple sclerosis (PPMS) is a chronic demyelinating disease of the central nervous system (CNS) currently lacking any effective treatment. Promoting endogenous brain repair offers a potential strategy to halt and possibly restore neurologic function in PPMS. To understand how the microenvironment within white matter lesions plays a role in repair I focused on neural progenitor cells (NPCs) since they have been found within lesions and influence oligodendrocyte progenitor cell (OPC) maturation. To better understand the cellular nature of NPCs in PPMS I developed induced pluripotent stem cells (iPSCs) from blood and skin samples of PPMS patients and age …

Role Of Extracellular Vesicles On Immune Regulation In An Animal Model Of Multiple Sclerosis, Cory Willis

Doctoral Dissertations

Extracellular vesicles play important and crucial roles in orchestrating and modulating cellular responses under both normal and diseased conditions. In my thesis work, I studied extracellular vesicle release from astrocytes during CNS inflammation. Moreover, I studied how extracellular vesicles can modulate and drive the immune response during active CNS disease. Extracellular vesicles encompass a heterogeneous group of cell-derived vesicles that have been found to be important in initiating and directing pathological responses.

In my thesis work, I focused on the characterization and quantification of extracellular vesicles from astrocytes under normal and inflammatory conditions. As described in chapter three of my …

Uneven Terrain Exacerbates The Deficits Of A Passive Prosthesis In The Regulation Of Whole Body Angular Momentum In Individuals With A Unilateral Transtibial Amputation, Jenny A. Kent, Kota Z. Takahashi, Nicholas Stergiou

Journal Articles

Background

Uneven ground is a frequently encountered, yet little-studied challenge for individuals with amputation. The absence of control at the prosthetic ankle to facilitate correction for surface inconsistencies, and diminished sensory input from the extremity, add unpredictability to an already complex control problem, and leave limited means to produce appropriate corrective responses in a timely manner. Whole body angular momentum, L, and its variability across several strides may provide insight into the extent to which an individual can regulate their movement in such a context. The aim of this study was to explore L in individuals with a transtibial amputation, …

February 4, 2019: 2019 Alumni Awards, Celebrating Lunar New Year, "Miss Nelson Is Missing" Scores!, Saint Mary's College Of California

SMC Bulletin 2013-2020

No abstract provided.

Smartphone-Based Calorie Estimation From Food Image Using Distance Information, Nafis Sadeq, Fazle Rabbi Rahat, Ashikur Rahman, Sheikh Iqbal Ahamed, Md Kamrul Hasan

Computer Science Faculty Research and Publications

Personal assistive systems for diet control can play a vital role to combat obesity. As smartphones have become inseparable companions for a large number of people around the world, designing smartphone-based system is perhaps the best choice at the moment. Using this system people can take an image of their food right before eating, know the calorie content based on the food items on the plate. In this paper, we propose a simple method that ensures both user flexibility and high accuracy at the same time. The proposed system employs capturing food images with a fixed posture and estimating the …

The Free Press Vol. 50, Issue No. 12, 02-04-2019, Julie Pike

Free Press, The

Freeing the textbook: Open Education Resources -- ROTC program teaches students leadership -- Online programs make degrees available anywhere -- The nightly routine of a residential assistant -- Professor creates social media activism minor -- Student Senate sees changes in members

Proteomic Study Uncovers Molecular Principles Of Single-Cell-Level Phenotypic Heterogeneity In Lipid Storage Of Nannochloropsis Oceanica, C Chen, A Harst, W You, Et Al

School of Biomedical Sciences

Background Nannochloropsis oceanica belongs to a large group of photoautotrophic eukaryotic organisms that play important roles in fixation and cycling of atmospheric CO2. Its capability of storing solar energy and carbon dioxide in the form of triacylglycerol (TAG) of up to 60% of total weight under nitrogen deprivation stress sparked interest in its use for biofuel production. Phenotypes varying in lipid accumulation among an N. oceanica population can be disclosed by single-cell analysis/sorting using fluorescence-activated cell sorting (FACS); yet the phenomenon of single cell heterogeneity in an algae population remains to be fully understood at the molecular level. In this …

Get To Know: Lydia Odlin, Georgia Southern University

Athletics: News & Publications

• Get To Know: Lydia Odlin

Get To Know: Lydia Odlin, Georgia Southern University

Athletics: News & Publications

• Get To Know: Lydia Odlin