Digital Commons Network^™

The Patentability Of Genetic Therapies: Car-T And Medical Treatment Exclusions Around The World, Luis Gil Abinader, Jorge L. Contreras

Utah Law Faculty Scholarship

More than eighty countries, including the members of the European Patent Convention, the United States, Canada, New Zealand, China, Japan, and India, currently exclude or limit the patentability of methods of medical treatment. CAR-T and other recent gene and cell therapies, which operate based on the extraction of genetic or cellular material from a patient, the alteration of such material, and the reintroduction of such material to the patient’s body, should, under most or all of these legal regimes, be considered medical treatments that are thus excluded from patentability, or as to which patent enforcement is limited. Accordingly, we urge …

Faculty Handbook Section Iii - College Of Liberal Arts Policies And Procedures - Updated 6/1/2019, All Faculty

Faculty Handbooks

No abstract provided.

University Of Dayton Magazine, Summer 2019, University Of Dayton

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD. In the past the magazine was known as UD Alumnus, Focus, Dimensions and UD Quarterly. Articles include "Rebirth of the Arcade," "Darkness Unveiled: Into the Heart of a Black Hole," and "Books of Influence."

Annual Report 2018-2019, Jeffrey Ashley, Amy Patrone

Annual Reports & Administrative Documents

No abstract provided.

Data Acquisition And Processing Report - Summer Hydro 2019, Jennifer A. Dijkstra, Center For Coastal And Ocean Mapping / Joint Hydrographic Center

Center for Coastal and Ocean Mapping

No abstract provided.

Metabolism Underlies Physiological Homeostasis In Drosophila, Omera B. Matoo, Cole R. Julick, Kristi Montooth

School of Biological Sciences: Faculty Publications

Organismal physiology emerges from metabolic pathways and subcellular structures like the mitochondria that can vary across development and among individuals. Here, we tested whether genetic variation at one level of physiology can be buffered at higher levels of biological organization during development by the inherent capacity for homeostasis in physiological systems. We found that the fundamental scaling relationship between mass and metabolic rate, as well as the oxidative capacity per mitochondria, changed significantly across development in the fruit fly Drosophila. However, mitochondrial respiration rate was maintained at similar levels across development. Furthermore, larvae clustered into two types—those that switched to …

Eeg Classification Using Residual Neural Networks, Eren Esener

Electrical Engineering

There is a growing desire to understand the EEG (electroencephalogram) signals related with brain activities. In order to analyze EEG signals, they first must be measured by sensors, which induces a lot of noise; then these signals are classified to understand the intended actions. In many cases a neural network is used as the algorithms for classification. A residual neural network (ResNet) is an artificial neural network (ANN) of a kind that are related with the pyramidal cells in the cerebral cortex. The goal of this work is to investigate the viability of ResNets for classifying EEG signals for hand …

Urban Heat Islands: Causes, Impacts, & Mitigation, Megan Rupard

City and Regional Planning

The purpose of this project is to understand the factors contributing to the urban heat island effect and why it is important to consider when planning a city. This senior project will review the factors that contribute to an urban heat island, what kind of effects urban heat islands have on our city’s and their inhabitants, and how the effects can be mitigated and minimized. This project will review current mitigation strategies that have been developed to combat urban heat islands and analyze the benefits that can be attained from these mitigation strategies. Case studies will be used to understand …

Evaluation Of Insulin-Like Growth Factor-1, Total Ghrelin, And Insulin Resistance In Nutritionally Stunted Egyptian Children, Shimaa M. Abdou, Noha El-Boghdady, Awatif Abd El-Maksoud, Sahar Khairy, Maha El-Sawalhi

Bulletin of Faculty of Pharmacy Cairo University

Stunting represents a worldwide nutritional problem, which has many negative effects on child health and development. This study aimed to investigate the levels of insulin-like growth factor-1(IGF-1), total ghrelin and insulin resistance, as well as certain micronutrients affecting children growth and skeletal maturity in nutritionally stunted Egyptian children. Stunted children were selected to have height for age Z score (HAZ) < -2 standard deviation, whereas, control children were selected to have HAZ > -2. Stunted children were further classified according to weight for age Z score into normal and underweight groups. All stunted children exhibited significantly lower serum levels of IGF-1, Ca, and Mg compared to normal control children. Additionally, both normal weight …

Medication Safety Spontaneous Reporting System: The Lebanese Order Of Pharmacists Initiative, Marwan Akel, Elsy Ramia, Aline Hajj, Souheil Hallit, Nathalie Lahoud, Abeer Zaytoun, Maya Harb, Hind Hajj, Patricia Shuhaiber, Hala Sacre, Pascale Salameh, Rony M. Zeenny

Bulletin of Faculty of Pharmacy Cairo University

Background: The increase in medication use and expansion of the pharmaceutical industry has led to an increase in hazards, errors and adverse events associated with medication use. In Lebanon, medication safety reporting by pharmacists is lacking due to the absence of an official reporting system. Objective: The objective of the Order of Pharmacists of Lebanon (OPL) was to engage pharmacists in reporting the adverse drug reactions by creating an efficient tool for this purpose. Methods: The scientific committee at the OPL worked on designing a reporting tool for adverse drug reactions (ADRs). Results: An electronic platform was created, and several …

Stethoscope As A Vector For Nosocomial Bacterial Infections, Rehana Rehman, Khalid Ahmed, Saifullah Shaikh

Department of Biological & Biomedical Sciences

No abstract provided.

Role Of Ajwa Date (Phoenix Dactyl L) Derived Polyphenols In Male Infertility, Naseer Ahmed, Rehana Rehman, Anwar Gilani

Department of Biological & Biomedical Sciences

Madam, prevalence of male infertility with its associated social and health problems calls for an insight for its elucidation.¹ Over the past few decades, there have been many experimental and clinical studies on the pathophysiology of oxidative stress and its impact on fertility disorders, both in men and women. Oxidative stress impairs sperm function and count, damage to DNA and accelerates the cellular apoptotic functions leading to the inability to achieve conception or lack of development of the embryo. ²34563

Glycine Supplementation Extends Lifespan Of Male And Female Mice., Richard A Miller, David E Harrison, Clinton Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G Ryazanov, Jessica Snyder, Timothy M Stearns, Douglas E Vaughan, Randy Strong

Faculty Research 2019

Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%-6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycine-supplemented females were lighter than controls, but there was no effect on weight in males. End-of-life necropsies suggested that glycine-treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine-supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI-1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late-life diseases.

Effect Of Native Type I Collagen With Polyhexamethylene Biguanide Antimicrobial On Wounds: Interim Registry Results., Michael A Bain, Kerry T Thibodeaux, Marcus S Speyrer, Emily Carlson, George John Koullias

Articles, Abstracts, and Reports

Background: Biofilm can impair wound healing by maintaining an elevated, but ineffective, inflammatory state. This article describes interim results from the prospective RESPOND postmarketing registry evaluating the use of a native type 1, porcine collagen matrix with the embedded antimicrobial polyhexamethylene biguanide (PCMP) in the management of chronic wounds.

Methods: Adults ≥18 years of age with ≥1 appropriate wound were eligible for inclusion. Data that were final on January 26, 2018 were included in this analysis. At week 0, wounds were cleaned, debrided, and prepared as necessary and PCMP was applied, with a dressing to fix it in place. Patients …

Executive Leadership Challenges In Today’S Environment, Herbert J. Degraffe Jr.

Walden Faculty and Staff Publications

Abstract

Individuals in top management positions often have conflicting interpretations concerning the authoritative qualities that align with the intrinsic and external relations of an organization. Although, researchers may still debate about the extent to which athletic development personality factors are important internal components of an individual. The purpose of this correlational study was to determine if athletic development personality factors correlate with decision making at the executive leadership level. The research questions focused on determining if there was a relationship between athletic development personality factors and decision making. Social exchange theory, social representations theory, and leadership theories comprised the theoretical …

Anti-Human Cd9 Antibody Fab Fragment Impairs The Internalization Of Extracellular Vesicles And The Nuclear Transfer Of Their Cargo Proteins., Mark F. Santos, Germana Rappa, Jana Karbanová, Cheryl Vanier, Chikao Morimoto, Denis Corbeil, Aurelio Lorico

College of Osteopathic Medicine (TUN) Publications and Research

The intercellular communication mediated by extracellular vesicles (EVs) has gained international interest during the last decade. Interfering with the mechanisms regulating this cellular process might find application particularly in oncology where cancer cell-derived EVs play a role in tumour microenvironment transformation. Although several mechanisms were ascribed to explain the internalization of EVs, little is our knowledge about the fate of their cargos, which are crucial to mediate their function. We recently demonstrated a new intracellular pathway in which a fraction of endocytosed EV-associated proteins is transported into the nucleoplasm of the host cell via a subpopulation of late endosomes penetrating …

Spring Field Report, March - May 2019, W. Ross Silcock

Nebraska Bird Review

There were many significant reports, including high and low numbers, early and late dates, out-of-range sightings including nesting, and, of course, rarities. High numbers were led by geese; an amazing 1.7 million Snows were estimated by acreage (!) and counts of 10,000 Greater White-fronted and 100,000 Canada Geese were near-record high counts for spring. A bit surprising as record spring counts were 3000 European Starlings and 3000 American White Pelicans. Nightjar surveys by Nebraska Game and Parks Commission and others yielded an amazing 40+ Chuck-will’s-widows in the southeast; Ruddy Turnstones put on a show with 85 in Platte Co; 127 …

Review Of A Field Guide To The Natural World Of The Twin Cities By John J. Moriarty, Photography By Siah L. St. Clair, Douglas H. Johnson, Bonnie Sample

The Prairie Naturalist

A Field Guide to the Natural World of the Twin Cities has two foci: natural areas in the Twin Cities of Minnesota and the species that live in each. The geographical scope is the seven counties that envelop Minneapolis and Saint Paul. The author describes nine major habitat types that can be found there: prairie, savanna, big woods, oak woods, wetlands (marshes and swamps), fens and bogs, lakes, rivers, and urban and suburban. It is useful to know that “big woods” are not just woods that are large in extent, but woodlands that occur in Minnesota and western Wisconsin dominated …

Factors Affecting White Bass Abundance In Two Missouri River Reservoirs, William J. Radigan, Mark J. Fincel

The Prairie Naturalist

Annual angler harvest of white bass (Morone chrysops) increased from 1985–2005 in Lake Oahe and Lake Sharpe, two mainstem Missouri River reservoirs in South Dakota. In 2006, harvest rates dropped appreciably in both reservoirs and remained low through 2015. It is hypothesized that a confirmed 2005 columnaris disease outbreak led to reduced annual angler harvest of white bass from both reservoirs. Mean annual angler harvest prior to the outbreak (1985–2005) in Lake Oahe decreased 65% and in Lake Sharpe decreased 57% post outbreak (2006–2015). To assess potential causes of sustained decreased adult white bass abundance in the reservoirs, …

Identifying And Testing Recursive Vs. Interdependent Links In Simultaneous Equation Models Via The Sire Package, Gianmarco Vacca, Maria Grazia Zoia

The R Journal

Simultaneous equation models (SEMs) are composed of relations which either represent unidirectional links, which entail a causal interpretation, or bidirectional links, due to feedback loops, which lead to the notion of interdependence. The issue is of prominent interest in several respects. Investigating the causal structure of a SEM, on the one hand, brings to light the theoretical assumptions behind the model and, on the other hand, pilots the choice of the befitting estimation method and of which policy to implement. This paper provides an operational method to distinguish causal relations from interdependent ones in SEMs, such as macro-econometric models, models …

Rssampling: A Pioneering Package For Ranked Set Sampling, Busra Sevinc, Bekir Cetintav, Melek Esemen, Selma Gurler

The R Journal

Ranked set sampling (RSS) is an advanced data collection method when the exact measurement of an observation is difficult and/or expensive used in a number of research areas, e.g., environment, bioinformatics, ecology, etc. In this method, random sets are drawn from a population and the units in sets are ranked with a ranking mechanism which is based on a visual inspection or a concomitant variable. Because of the importance of working with a good design and easy analysis, there is a need for a software tool which provides sampling designs and statistical inferences based on RSS and its modifications. This …

Integration Of Networks And Pathways With Starbiotrek Package, Claudia Cava, Isabella Castiglioni

The R Journal

High-throughput genomic technologies bring to light a comprehensive hallmark of molecular changes of a disease. It is increasingly evident that genes are not isolated from each other and the identification of a gene signature can only partially elucidate the de-regulated biological functions in a disease. The comprehension of how groups of genes (pathways) are related to each other (pathway-cross talk) could explain biological mechanisms causing diseases. Biological pathways are important tools to identify gene interactions and decrease the large number of genes to be studied by partitioning them into smaller groups. Furthermore, recent scientific studies have demonstrated that an integration …

Nou Spring Field Days And Annual Meeting, Fairbury, May 17-19, 2019, Janis Paseka

Nebraska Bird Review

The NOU Annual Meeting and Spring Field Days, organized by Jan Johnson, was held in Fairbury on May 17-19, 2019, with 64 in attendance. Our meetings and meals took place in the 4-H building at the Jefferson County Fairgrounds. Despite the forecast for rain, the weather was perfect on Saturday morning, with rain arriving only in the late afternoon. Wind made listening for nightjars difficult on both evenings and it continued to be a problem on Sunday, but the total species list for the meeting was 165. Field trips were led by Shari Schwartz, John Carlini, Bill Flack, and Ross …

The Nebraska Bird Review, Volume 87 June 2019 Number 2

Nebraska Bird Review

Spring Field Report, March - May 2019, by W. Ross Silcock …42-61

Book Review: Sparrows of North America by Rick Wright, reviewed by W. Ross Silcock …62-65

NOU Spring Field Days and Annual Meeting in Fairbury, May 17-19, 2019, by Janis Paseka … 65

Subscription and Organization Information …71

Review Of Gulls Simplified: A Comparative Approach To Identification By Pete Dunne And Kevin T. Karlson, Garrett J. Macdonald

The Prairie Naturalist

The title of Pete Dunne and Kevin Karlson’s new book, Gulls Simplified, may seem like an oxymoron to many birders. Gulls are, after all, one of the most vexing groups of North American birds due to their myriad identification challenges, and many seasoned birders simply “don’t do gulls.” Indeed, Dunne, in the first line of the Introduction (page 13), writes, “Ask any bird-watcher to name the bird group that is most intimidating, and to a man, woman, and tour leader they often shout: GULLS!” The genesis of the book, and the authors’ approach to identification within, arises from the notion …

Incidental Captures Of Plains Spotted Skunks In Central South Dakota, Samantha Fino, Joshua D. Stafford, Aaron T. Pearse, Jonathan A. Jenks

The Prairie Naturalist

The plains spotted skunk (Spilogale putorius interrupta) had a historically broad distribution in the central United States, extending from the Mississippi River west to the Rocky Mountains. This subspecies of the eastern spotted skunk (S. putorius) has experienced population declines in recent decades possibly due to habitat loss and reduction of prey through conversion of grasslands and forests to croplands, as well as reductions in abandoned buildings, fence rows, creek bottoms, and wood piles throughout the region (Crabb 1948, Kaplan and Mead 1991, Gompper and Hackett 2005, Sasse 2017). Woody debris provides access to prey, and …

Thalamic Morphology In Non-Semantic Primary Progressive Aphasia, Holly Rochelle Paxton

Theses and Dissertations

Background: Primary progressive aphasia (PPA) is a clinical dementia syndrome characterized by impairments in language. The presence of Alzheimer disease (AD) neuropathology has been observed in approximately 40% of PPA cases. Cross-sectional and longitudinal features of cortical atrophy in PPA are emerging but less is known about the integrity of subcortical structures, particularly the thalamus. As a major relay station in the brain, the thalamus is implicated in language functioning given its reciprocal connections with perisylvian regions in the cortex. High-dimensional brain mapping was used to characterize thalamic morphology in individuals with and without non-semantic PPA. Further, shape differences were …

The Power Of Motherhood: Leah Widtsoe's Writings On Women's Roles, Influence, And The Priesthood, Ashley Marie Laneri

Theses and Dissertations

The Power of Motherhood: Leah Widtsoe's Writings on Women's Roles, Influence, and the Priesthood Ashley Marie Laneri Department of Religious Education, BYU Master of ArtsThis thesis analyzes Leah Widtsoe's writings in the 1930s. Her primary emphasis was on motherhood. Widtsoe encouraged women to realize the importance of their role as mothers and the positive results a good mother can have on generations to come. Each chapter examines how Widtsoe used motherhood to help women understand their role in the Church and their role in society. The first chapter outlines Widtsoe's personal life and analyzes why motherhood was a central part …

Mismatch Negativity Event Related Potential Elicited By Speech Stimuli In Geriatric Patients, Dana Lynn Pierce

Theses and Dissertations

Hearing loss, as a result of old age, has been linked to a decline in speech perception despite the use of additional listening devices. Even though the relationship between hearing loss and decreased speech perception has been well established, research in this area has often focused on the behavioral aspects of language and not on the functionality of the brain itself. In the present study, the mismatch negativity, an event related potential, was examined in order to determine the differences in speech perception between young adult participants, geriatric normal hearing participants, and geriatric hearing-impaired participants. It was hypothesized that a …

Downregulation Of Cenpf Remodels Prostate Cancer Cells And Alters Cellular Metabolism., Muhammad Shahid, Minhyung Kim, Min Young Lee, Austin Yeon, Sungyong You, Hyung L Kim, Jayoung Kim

Articles, Abstracts, and Reports

Metabolic alterations in prostate cancer (PC) are associated with progression and aggressiveness. However, the underlying mechanisms behind PC metabolic functions are unknown. The authors' group recently reported on the important role of centromere protein F (CENPF), a protein associated with the centromere-kinetochore complex and chromosomal segregation during mitosis, in PC MRI visibility. This study focuses on discerning the role of CENPF in metabolic perturbation in human PC3 cells. A series of bioinformatics analyses shows that CENPF is one gene that is strongly associated with aggressive PC and that its expression is positively correlated with metastasis. By identifying and reconstructing the …