Digital Commons Network^™

Comparative Analysis Of The Quality Of Life Of Schizophrenic Patients On Antipsychotic Treatment Between Aripiprazole Monotherapy And Combination Of Risperidone-Clozapine At Mental Hospital In West Java, Taufiqurahman Taufiqurahman, Sani Asmi Ramdani Lestari, Ardilla Kemala Dewi

Pharmacology and Clinical Pharmacy Research

Quality of life (QoL) is a critical outcome measure in schizophrenia management, yet antipsychotic side effects may negatively impact patients' well-being. Objective: This study aimed to compare the QoL of schizophrenia patients receiving aripiprazole monotherapy versus a risperidone-clozapine combination at West Java Mental Hospital. An analytical observational study with a cross-sectional design was conducted at the outpatient clinic of West Java Mental Hospital from March to May 2025. The Indonesian version of the WHOQOL-BREF questionnaire was used to assess QoL. A total of 58 outpatients with schizophrenia who met the inclusion criteria were enrolled, comprising 28 patients in the aripiprazole …

An Improved Logarithmic Ratio-Product Type Estimator For Mean Modeling And Estimation Under Neutrosophic Uncertainty, Anchal Yadav, Mukesh Kumar

Neutrosophic Systems with Applications

In classical statistics, population mean estimation generally assumes precise and determinate data along with known auxiliary information. However, in real-world situations where observations are imprecise or expressed in interval form, such as temperature variations or financial market data, classical approaches become less effective. To address this limitation, neutrosophic statistics provide a more flexible framework for handling uncertainty and indeterminacy. This study proposes a neutrosophic logarithmic ratio-product type estimator for estimating the finite population mean using auxiliary information. The bias and mean squared error (MSE) of the proposed estimator are derived using a first-order approximation. Furthermore, performance evaluation is carried out …

Exploring Protein-Protein Interactions: A Promising Avenue For Biomarker And Anti-Tb Drug Development, Rajwa Dwifauza Suryanto, Maritsa Widati Aqila Rumawan, Imam Adi Wicaksono

Pharmacology and Clinical Pharmacy Research

In 2023, tuberculosis (TB) reached its highest incidence with 8.2 million new cases reported by the World Health Organization (WHO). The virulence of Mycobacterium tuberculosis (MTB) is strongly governed by protein-protein interactions (PPIs) that regulate essential processes such as cell wall biosynthesis, immune evasion, and persistence. This study aims to map and analyze the mechanisms of key PPIs in MTB using a scoping review approach. Data was retrieved from PubChem and related literature with the keyword ``PPIs Network TB''. Our findings highlight crucial PPI-driven mechanisms, including the role of DprE1/DprE2 in arabinogalactan synthesis, VapB4/VapC4 in stress response and self-toxicity, ESX-1 …

Low To Moderate Intensity Home-Based And Online Exercise For Cognitive Health In Older Adults: A Narrative Review, Novita Salim, Melisa Intan Barliana, Anna Meiliana

Pharmacology and Clinical Pharmacy Research

Cognitive decline represents one of the most pressing public health challenges associated with global population ageing, prompting growing interest in accessible and scalable exercise-based interventions. This narrative review synthesizes evidence from 15 randomized controlled trials to compare the cognitive effects of 3 exercise modalities in older adults across varying cognitive and functional profiles: conventional aerobic and resistance training, exergame-based interventions, and dual-task or multicomponent training. Interventions were evaluated on their capacity to improve global cognition, executive function, working memory, and attention, with additional consideration of adherence, supervision format, and implementation feasibility. The evidence consistently demonstrates that dual-task and multicomponent training …

The Grizzly, April 30, 2026, Renee Washart, Alex Zelaya, Erik Groff, Cassidy Denning, Andrew Mihniak, Adam Denn, Erin Ewing, Dylan Mchugh

Ursinus College Grizzly Newspaper, 1978 to Present

Meet the Language Fellows • The Rocky Horror Picture Show: A BSP Classic • The Fitness Court • What is Greek Week? • In Case You Missed the URSPYs • Pick a Straw: Sustainable or Gluten-Free • Ursinus Track Gears Up for Champs • Ursinus Women's Golf Faces Uncertain Future

Mapping Mgmt Methylation Sites That May Predict Chemotherapy Success In Glioblastoma, Kennedy Bueno

Celebrating Scholarship and Creativity Day (2018-)

Glioblastoma is the most common malignant primary brain tumor in adults, with a median survival of 15 months post-diagnosis. Resistance to standard temozolomide (TMZ) chemotherapy is common and is strongly influenced by O6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme that reverses TMZ induced DNA damage. Reduced MGMT expression is associated with greater TMZ sensitivity and improved survival. Although MGMT promoter cytosine-phosphate-guanine dinucleotide (CpG) methylation is linked to treatment response, the individual CpG sites responsible for MGMT silencing remain unclear. This research aims to identify which sites are necessary to suppress MGMT expression and increase TMZ sensitivity. This project will map …

Second April 2026 General Education Council Minutes, University Of Nebraska At Kearney General Education Council

General Education Council

No abstract provided.

Peer Cultural Socialization As A Moderator Of Perceived Discrimination And Ethnic-Racial Identity Exploration Among Korean Adoptees, Josie Braun, Majel Baker, Jae-In Kim, Richard Lee, Elisheva Perelman

Celebrating Scholarship and Creativity Day (2018-)

As peers become increasingly salient sources of affirmation and cultural learning across adolescence and emerging adulthood, peer cultural socialization may play a distinct and critical role in moderating Korean adoptees' exploration of their ethnic-racial identity. This study hypothesized that 1) ethnic-racial discrimination experienced in the past year in adulthood (T3) will be unrelated to exploration of Korean ethnic-racial identity in adulthood (T3). However, peer racial socialization in adulthood (T3) will moderate the relationship between ethnic-racial discrimination experienced in adulthood (T3) and exploration of Korean ethnic-racial identity in adulthood (T3), and 2) ethnic-racial discrimination experienced in the past year in adulthood …

Quantitative Fluorescence Imaging Using A Paired Agent Approach For Improving Surgical Decision Making, Sanjana Pannem

Dartmouth College Ph.D Dissertations

Surgical resection remains to be the cornerstone of treatment for most solid tumors, where the primary objective is to remove all visible and microscopic disease. However, the extent of tumor resection is inherently limited by the surgeon’s ability to distinguish tumor from normal tissue, intraoperatively. As a result, positive surgical margins (PSM), where residual tumor remains after surgery, are a common occurrence and are associated with increased recurrence, need for adjuvant therapies, dismal patient outcomes, and high healthcare costs.

Fluorescence guided surgery (FGS) has emerged as a promising technique to enhance intraoperative visualization of tumors and may help reduce the …

Kenyon Collegian - April 30, 2026

The Kenyon Collegian

No abstract provided.

Morphology And Bioactive Compounds Of Gurmar (Gymnema Sylvestre) With Potential As Antidiabetics, Neny Novita Yuliany, Abdillah Maulana Farhan, Putry Lazimatu Ziyaroh, Edia Fitri Dwinianti, Husnatun Nihayah, Mukhamad Su'udi

Jurnal Kultivasi

The medicinal plant Gymnema sylvestre is widely known for its ability to lower blood sugar levels. This study reviewed the physical characteristics and bioactive compounds of G. sylvestre sourced from different regions, emphasizing its potential as an antidiabetic agent. Morphological analysis includes leaf structure, trichome presence, and other anatomical features, which can influence the plant's chemical profile. Phytochemical analysis, performed using techniques like GC-MS, identifies key bioactive compounds such as saponins, flavonoids, and gymnemic acids, which contribute to its hypoglycemic effect. The findings indicate that regional variations can affect the concentration and presence of these compounds, suggesting that environmental factors …

Optimization Of Physalis Angulata L. Callus Induction And Salinity-Induced Antioxidant Production, Firstian Naufal Sistyananda, Erni Suminar, Anne Nuraini, Muhamad Kadapi, Murgayanti, Syariful Mubarok, Rahmat Budiarto, Eddy Renaldi, Kusumiyati

Jurnal Kultivasi

Groundcherry (Physalis angulata L.) is a plant with many medicinal potentials due to its rich secondary metabolites such as phenolic and flavonoid. However, conventional agriculture practices are still limited, especially in Indonesia. This study was divided into two stages. The first stage was conducted to determine optimal 6-BAP and 2,4-D combination for callus induction, while the second stage was conducted to determine callus phenolic, flavonoid, and antioxidant response to salinity stress. The first stage was arranged in factorial completely randomized design with two factors: 6-BAP (0, 2, and 4 mg/L) and 2,4-D (0, 0.5, 1, and 1.5 mg/L). The second …

Estimating Leaf Area In Velvetleaf (Limnocharis Flava) And Kangkong (Ipomea Aquatica): A Precise And Non-Destructive Approach For Wetland Vegetables, Anggrika Riyanti, Benyamin Lakitan, Momon Sodik Imanudin, Muhammad Yazid

Jurnal Kultivasi

Developing a leaf-area estimation model for vegetable cultivars in wetlands is essential to optimizing agricultural cultivation practices. This study aims to develop a non-destructive model for leaf area estimation in wetland vegetable cultivars (velvetleaf (Limnocharis flava) and kangkong (Ipomoea aquatica)) using regression-based models. The plants were cultivated in a wetland system. Measurements of leaf length and width were taken on all leaves of each plant, using the product of length and width (L×W) as predictor. The regression models for estimating leaf area were adjusted from linear, zero-intercept linear, quadratic, and power. The optimal model was evaluated using the determination coefficient …

Growth And Yield Response Of Shallots To Npk, Nk, And Humic Acid Under Different Mycorrhiza Application, Alfu Laila, Endang Sulistyorini

Jurnal Kultivasi

One strategy to increase shallot production is the utilization of microorganisms in the soil, such as arbuscular mycorrhizal fungi (AMF), which is applied together with fertilizer. This research aimed to investigate the effects of different nutrient inputs and mycorrhizal association on the growth and yield of shallots. This study used a split-plot design with three replications as blocks. The main plot included four treatments: no nutrient inputs, NPK fertilizer, NK fertilizer, and humic acid, while the subplot involved the mycorrhiza application (with or without). The measured variables included growth (plant height and number of leaves) and yield (fresh weight and …

Response Of Chlorophyll, Morphology, And Yield Of Several East Java Superior Soybean (Glycine Max L.) Varieties To Levels Of Salinity, Puji Lestari Tarigan, Ida Retno Moeljani, Fadila Suryandika, Hadi Munarko

Jurnal Kultivasi

Soybean production has been extended to saline areas. This development is a strategy to expand planting areas to suboptimal land to increase worldwide production. To support cultivation in these locations, it is necessary to develop superior varieties that are resistant to salinity and provide supporting technological inputs. In saline conditions, soybeans may face stress that leads to morphological, physiological, and yield disturbances. Consequently, the response of several soybeans in East Java should be observed. This study is a pot experiment and arranged in a Factorial Completely Randomized Design (CRD) consisting of two factors, soybean varieties and NaCl concentrations. The treatments …

Growth Response And Yield Performance Of Upland Rice Intercropped With Legumes, Sevirasari, Wilujeng Hidayati, Zulfa Az Zahroh, Bayu Febriansyah, Marifatul Apri Fiana, Nabilla Najwa Rochmaniah, Khavid Faozi, Lafi Na'imatul Bayyinah, Joko Maryanto, Ahmad Fauzi

Jurnal Kultivasi

Intercropping patterns in upland rice must be carefully managed to prevent excessive competition among crops. This research aimed to determine the ideal proportion of upland rice–legume intercropped and legume types for rice growth and yield. The research was conducted in Mersi, East Purwokerto, Banyumas, Central Java, from April–August 2025. The study was arranged in a split-plot design consisting of a main factor in form of the proportion of upland rice to legumes (1:1, 2:1, and 3:1), and a sub-factor, i.e., legume types (peanuts, mung beans, and soybeans). The data were analyzed using Analysis of Variance and Tukey's HSD test at …

Growth Of Vanilla Cuttings Under Modified Acid Soil Media And Application Of Several Plant Growth Regulators, Rifqi Raditya Kurniawan, Yugi Rahayu Ahadiyat, Etik Wukir Tini

Jurnal Kultivasi

This research aimed to optimize the growth of vanilla (Vanilla planifolia) cuttings in acid soils by modifying the growing media and applying several types of plant growth regulators (PGRs). Several types of PGRs, including synthetic compounds such as indole-3-acetic acid (IAA) and 6-benzylaminopurine (BAP), as well as natural extracts from shallot (Allium ascalonicum L.) and moringa leaves (Moringa oleifera), were tested to enhance plant performance in acid-growing conditions. The primary objectives were to determine the optimal soil amendment formula and the most effective PGR type for promoting vanilla growth, and to develop a measurable, easy-to-use PGR formulation accessible to farmers. …

Effects Of Phosphate-Solubilizing Fungi On Phosphorus Availability, Retention, And Soil Chemical Properties In Shallot Cultivated On Andisols Of North Sumatra, Agustina Erlinda Marpaung, Tengku Sabrina, Abdul Rauf, Dwi Ningsih Susilowati

Jurnal Kultivasi

The availability of phosphorus (P) is one of the main limiting factors for plant productivity in Andisol soils due to the strong fixation of P by allophane clay minerals, aluminum and iron oxides. Giving the phosphate solubilizing fungi (PSF) is an alternative to increase available P which plants can use to increase the yield. This study aimed to evaluate the effectiveness of phosphate-solubilizing fungi (PSF) in improving P availability on Andisol. The experiment used a block randomized design (BRD) with three replications. The first factor is Andisol soil origin (Soil 1 and Soil 2) and the second is isolate of …

Assessment Of Morphological Differences And Genetic Variation In Head Shape Of Florida Pompano Trachinotus Carolinus, Neriah Nicholas

Electronic Theses and Dissertations 2020 - Present

Genomics research can inform selective breeding programs to improve broodstock and seedstock quality for the U.S. warmwater marine finfish aquaculture industry. Florida pompano Trachinotus carolinus serves as a model species for the industry due to its commercial value and ability to spawn in captivity. This study examined a growth abnormality observed in commercially produced juveniles in partnership with Aquaco Farms LLC. Twenty fish were collected, culled, and euthanized by Aquaco staff, then classified into two head types: “normal” and “concaved”. Eleven morphological measurements were recorded before and after freezing to assess head variation and storage effects. DNA from pectoral fin …

Hyperdynamic Microtubule-Based Structural Changes In Monocyte-Derived-Neuronal-Like Cells From Patients With Schizophrenia, Alfredo Bellon, Alonso Cortez-Resendiz, Lauren N Forrest, Omar Elmarasi, Janani Iyer, Anjali Iyer, Chachrit Khunsriraksakul, Dajiang Liu, L Elliot Hong, Therese M Jay, Marie-Odile Krebs, Anne Hosmalin

Faculty, Staff and Student Publications

A consistent postmortem finding in schizophrenia (SCZ) is reduction in dendrites' size. However, neurons with larger dendritic trees have also been encountered. In vitro experiments with neurons and neuronal-like cells coming directly from patients with SCZ showed similar results, evidencing at times more extensions and at others less arborizations. The process of extending and retracting neuronal outgrowths depends on microtubules polymerization and depolymerization. The possibility that microtubule polymerization/depolymerization is related to defects in the neuronal structure comes from several microtubular anomalies reported in SCZ such as its abnormal distribution in the cytoplasm, irregular shape of microtubules and even absence of …

"Commoning" The Artist-Led Archive; Sharing Heri Dono’S Private Archive With A Public Audience, Eliza O’Donnell, Agni Saraswati

Wacana, Journal of the Humanities of Indonesia

Built from the ground-up and with no formal government support, artist-led archives in Indonesia engage in commoning practices by creating community-centred platforms for knowledge sharing, in both physical and digital spaces. This article examines “acts of commoning” through the lens of artist Heri Dono at Studio Kalahan in Yogyakarta, an artist-led archive that challenges institutional approaches by treating Dono’s practice-based knowledge as shared creative resources, rather than private intellectual property. Three “acts of commoning” are explored through an iterative process of 1) building, 2) reproduction and digitization, and 3) sharing through exhibition and Instagram. It is argued that commoning of …

Michael Dove (2024), "Hearsay Is Not Excluded; A History Of Natural History", Gilang Mahadika

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

Toward An Integrative Anthropological Ecology; Pluralism, Power, And Socioecological Futures, Komang Ariyanto

Wacana, Journal of the Humanities of Indonesia

No abstract provided.

‘Clothesure’: The End Of The Narrative Of A Pilgrim’S Clothes; And How Pilgrim’S Clothes Contribute To Narrative Identity, Stephen F. Haller

International Journal of Religious Tourism and Pilgrimage

This paper provides the story, or narrative, which explains how pilgrim’s-identity is created and endures through the clothes they wear. The closure, or preferred ending, of this story of a pilgrim’s clothes, would be a ceremonious disposal, like burning them. Pilgrims are reluctant to simply throw their clothes, boots, and gear away. This paper is a philosophical reflection on how a pilgrim’s clothes construct the identity of a pilgrim; and how inanimate objects, like clothes, might become meaningful, or even ‘sacred’ in a non-religious way. This comes about because of a decision to treat them that way. We make sense …

Monastic Botanical Gardens: Medicinal Plants, Cultural Heritage, And Tourist Routes, Polyxeni G. Moira Dr, Dimitrios Mylonopoulos

International Journal of Religious Tourism and Pilgrimage

in the natural environment. The natural environment, of which humans are an integral part, served as the first laboratory for the production of medicines. Medicinal botany can be traced back to ancient Greece, continued through ancient Rome, was closely linked to Islamic tradition, and persisted through the rise of Christianity in monasteries, enduring to the present day. Monastic botanical gardens serve as living proof of the relationship between humans, nature, healing, and spirituality. These gardens, which for centuries cultivated plants for medicinal, nutritional, and functional uses, can now be leveraged to promote tourism, cultural heritage, and environmental awareness.

This study …

Spectator 2026-04-30, Editors Of The Spectator

The Spectator

No abstract provided.

Neuroinflammation At The Crossroads Of Neurodegeneration: The Roles Of Microglia And Astrocytes In Parkinson's Disease, Alzheimer's Disease, And Multiple Sclerosis, Mohannad A. Almikhlafi

Neurosciences

Neuroinflammation plays a critical role in the pathogenesis of neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. This review explores the underlying mechanisms of neuroinflammation, with a focus on the roles of microglia, astrocytes, peripheral immune cell infiltration, and cytokine release. The complex interplay between oxidative stress and chronic inflammation accelerates neurodegeneration, contributing to disease progression. Microglial activation, initially protective, becomes harmful when sustained over time, driving chronic inflammation. Similarly, astrocytes once considered passive are now recognized for their active involvement in both inflammatory and neuroprotective responses, depending on their activation state. Prolonged activation of microglia and …

Role Of Bevacizumab In Multiple Glioblastomas: A Retrospective Single-Center Analysis, Yongrui Zhao, Yidong Chen, Leiming Wang, Ye Cheng, Feng Yan, Jiankun Xu

Neurosciences

Objective: To explore the prognostic factors of multiple glioblastomas (M-GBMs) and the role of bevacizumab (BEV) in M-GBMs. Methods: 162 patients treated for primary glioblastoma (GBM) from 2020 to 2024 were retrospectively reviewed. Kaplan–Meier analysis was performed to compare progression-free survival (PFS) and overall survival (OS) between the single glioblastoma (S-GBM) group and the M-GBMs group. Independent predictors of OS among M-GBMs patients were evaluated via multivariable Cox regression analysis. Results: 116 patients had S-GBM, and 46 had M-GBMs. Compared with S-GBM patients, M-GBMs patients had poorer PFS (6.5 vs. 11 months, p<0.001) and OS (15.5 vs. 21 months, p=0.005). In the M-GBMs group, based on the RANO resection criteria, both univariable analysis and multivariable Cox models confirmed that the extent of resection, use of radiotherapy and chemotherapy, p53 overexpression, and use of BEV were all factors that significantly influenced OS. Specifically, the use of BEV prolonged OS from 12 months to 19.5 months (p = 0.017). From the initiation of BEV therapy, the median PFS was 5.5 months (95% CI 4.45–6.56 months), and the median survival was significantly longer than in those who did not received BEV (10 vs. 3 months, p = 0.021). Conclusion: The extent of resection, radiotherapy/chemotherapy, p53 …

Umn Morris Faculty And Staff Honored, Communications And Marketing

Campus News Archive

No abstract provided.

Data-Driven Neuro-Fuzzy Modeling And Rule Optimization For Intelligent Prediction Of Bioreactor Dynamics, Kamala Najaf Mammadzada

Chemical Technology, Control and Management

Modeling wastewater bioreactors is a challenging problem in environmental engineering because the processes are constantly changing and the microorganisms do not behave in a linear or predictable way. This makes it difficult to predict and control the system behavior. This research investigates three artificial intelligence approaches for modeling wastewater bioreactors: the Mamdani Fuzzy Inference System (FIS), the Adaptive Neuro-Fuzzy Inference System (ANFIS), and clustering-based fuzzy models. These models help us predict what is happening in the bioreactors. For instance they help us predict how the amount of substances in the water is changing over time like dS₀/dt dSs/dt …