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2019

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Mrs Smith - Chapter 2: Vertical And Horizontal Integration And Care Model Implementation In The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk - A Workshop On Leadership And Co-Production, F Gradinger, J Elston, M Fox, C Myers, D Butler Jan 2019

Mrs Smith - Chapter 2: Vertical And Horizontal Integration And Care Model Implementation In The Integrated Care Organisation (Ico) In Torbay And South Devon, Uk - A Workshop On Leadership And Co-Production, F Gradinger, J Elston, M Fox, C Myers, D Butler

Peninsula Medical School

No abstract provided.

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Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang Jan 2019

Dna Methylation Profiling To Predict Recurrence Risk In Meningioma: Development And Validation Of A Nomogram To Optimize Clinical Management, F Nassiri, Y Mamatjan, S Suppiah, Jetan H. Badhiwala, Sheila Mansouri, Shirin Karimi, Olli Saarela, L Poisson, Irina Gepfner-Tuma, Jens Schittenhelm, Ho Keung Ng, H Noushmehr, Patrick Harter, Peter Baumgarten, Michael Weller, Matthias Preusser, C Herold-Mende, M Tatagiba, G Tabatabai, F Sahm, Deimling A Von, Kenneth D. Aldape, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Priscilla K. Brastianos, Nicholas Butowski, Carlos Carlotti, Michael D. Cusimano, Francesco Dimeco, Katharine Drummond, Ian F. Dunn, Evanthia Galanis, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C. Oliver Hanemann, C Herold-Mende, Craig Horbinski, Raymond Y. Huang

Peninsula Medical School

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection of patients who would benefit from adjuvant radiotherapy to delay recurrence. We aimed to develop an individualized prediction model of early recurrence risk combining clinical and molecular factors in meningioma. Methods DNA methylation profiles of clinically annotated tumor samples across multiple institutions were used to develop a methylome model of 5-year recurrence-free survival (RFS). Subsequently, a 5-year meningioma recurrence score was generated using a nomogram that integrated the methylome model with established prognostic clinical factors. Performance of both …

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Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey Jan 2019

Going To Extremes: The Goldilocks/Lagom Principle And Data Distribution, Henry J. Leese, Thozhukat Sathyapalan, Victoria Allgar, Daniel R. Brison, Roger Sturmey

Peninsula Medical School

Numerical data in biology and medicine are commonly presented as mean or median with error or confidence limits, to the exclusion of individual values. Analysis of our own and others’ data indicates that this practice risks excluding ‘Goldilocks’ effects in which a biological variable falls within a range between ‘too much’ and ‘too little’ with a region between where its function is ‘just right’; a concept captured by the Swedish term ‘Lagom’. This was confirmed by a narrative search of the literature using the PubMed database, which revealed numerous relationships of biological and clinical phenomena of the Goldilocks/Lagom form including …

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Evaluation Of The Impact Of The Nice Head Injury Guidelines On Inpatient Mortality From Traumatic Brain Injury: An Interrupted Time Series Analysis, Carl Marincowitz, Fiona Lecky, Victoria Allgar, Trevor Sheldon Jan 2019

Evaluation Of The Impact Of The Nice Head Injury Guidelines On Inpatient Mortality From Traumatic Brain Injury: An Interrupted Time Series Analysis, Carl Marincowitz, Fiona Lecky, Victoria Allgar, Trevor Sheldon

Peninsula Medical School

ObjectiveTo evaluate the impact of National Institute for Health and Care Excellence (NICE) head injury guidelines on deaths and hospital admissions caused by traumatic brain injury (TBI).SettingAll hospitals in England between 1998 and 2017.ParticipantsPatients admitted to hospital or who died up to 30 days following hospital admission with International Classification of Diseases (ICD) coding indicating the reason for admission or death was TBI.InterventionAn interrupted time series analysis was conducted with intervention points when each of the three guidelines was introduced. Analysis was stratified by guideline recommendation specific age groups (0–15, 16–64 and 65+).Outcome measuresThe monthly population mortality and admission rates …

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Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu Jan 2019

Non-Invasive Coronary Ct Angiography-Derived Fractional Flow Reserve: A Benchmark Study Comparing The Diagnostic Performance Of Four Different Computational Methodologies, Jason Matthew Carson, Sanjay Pant, Carl Roobottom, Robin Alcock, Blanco P Javier, Bulant C Alberto, Yuri Vassilevski, Sergey Simakov, Timur Gamilov, Roman Pryamonosov, Fuyou Liang, Xinyang Ge, Yue Liu, Perumal Nithiarasu

Peninsula Medical School

Non-invasive coronary computed tomography (CT) angiography-derived fractional flow reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive coronary lesions. Its feasibility and diagnostic performance has been reported in several studies. It is unclear if differences in sensitivity and specificity between these studies are due to study design, population, or "computational methodology." We evaluate the diagnostic performance of four different computational workflows for the prediction of cFFR using a limited data set of 10 patients, three based on reduced-order modelling and one based on a 3D rigid-wall model. The results for three of these methodologies yield similar …

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Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin Jan 2019

Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin

Peninsula Medical School

Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied …

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Social Prescribing: Where Is The Evidence? Commissioned Editorial, Kerryn Husk, Julian Elston, Felix Gradinger, Lynne Callaghan, Sheena Asthana Jan 2019

Social Prescribing: Where Is The Evidence? Commissioned Editorial, Kerryn Husk, Julian Elston, Felix Gradinger, Lynne Callaghan, Sheena Asthana

Peninsula Medical School

Social prescribing is the topic of the moment. Many national organisations and individuals from policy, practice, and academia (such as NHS England, the RCGP, the Mayor of London, and National Institute for Health Research) are rightly advocating social prescriptions as an important way to expand the options available for GPs and other community-based practitioners to provide individualised care for people’s physical and mental health through social interventions. No robust figures exist but it is thought that around 20% of patients consult their GP for primarily social issues, given this and the driving forces of an ageing population, increased complex health …

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Evaluation Of A Countywide Alternative To Qof, Aimed At Improving Person-Centred Coordinated Care, J Close, B Fosh, R Byng, R Blackwell, L Witts, L Hall, H Lloyd Jan 2019

Evaluation Of A Countywide Alternative To Qof, Aimed At Improving Person-Centred Coordinated Care, J Close, B Fosh, R Byng, R Blackwell, L Witts, L Hall, H Lloyd

Peninsula Medical School

No abstract provided.

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Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson Jan 2019

Naxdmutations Cause A Novel Neurodegenerative Disorder Exacerbated By Febrile Illnesses, Bergen Nj Van, Y Guo, J Rankin, N Paczia, J Becker-Kettern, Ls Kremer, A Pyle, J Conrotte, Cj Ellaway, P Procopis, K Prelog, T Homfray, J Baptista, E Baple, M Wakeling, S Massey, Dp Kay, A Shukla, Km Girisha, Les Lewis, Sd Santra, R Power, P Daubeney, J Montoya, E Ruiz-Pesini, R Kovacs-Nagy, M Pritsch, U Ahting, Dr Thorburn, H Prokisch, R Taylor, J Christodoulou, C Linster, S Ellard, H Hakonarson

Peninsula Medical School

Physical stress, including high temperatures, may damage the central metabolic nicotinamide nucleotide cofactors [NAD(P)H], generating toxic derivatives [NAD(P)HX]. The highly conserved enzyme NAD(P)HX dehydratase (NAXD) is essential for intracellular repair of NAD(P)HX. Here we present a series of infants and children who suffered episodes of febrile illness-induced neurodegeneration or cardiac failure and early death. Whole-exome or whole-genome sequencing identified recessive NAXD variants in each case. Variants were predicted to be potentially deleterious through in silico analysis. Reverse-transcription PCR confirmed altered splicing in one case. Subject fibroblasts showed highly elevated concentrations of the damaged cofactors SNADHX, R-NADHX and cyclic NADHX. NADHX …

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Investigating Variation And Strength In Social Networks, Timothy D. Immelman, Richard M. Wielkiewicz Jan 2019

Investigating Variation And Strength In Social Networks, Timothy D. Immelman, Richard M. Wielkiewicz

Psychology Faculty Publications

Participants were 318 college students from two small, Catholic liberal arts institutions in the Upper Midwest. Variation (i.e., having friends with varied interests and activities) of an individual’s social network was measured by a researcher-developed inventory, the Social Network Variation Scale (SNVS). Social network strength was measured by the researcher-developed Social Network Strength Scale (SNSS). People with more variation or more strength in their social network had higher levels of happiness and lower levels of stress. Autonomy mediated the relationships between variation and stress and strength and stress. Personality moderated the relationships between variation and happiness and variation and stress.

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Country Snapshot Albania, Leonie Vrugtman Jan 2019

Country Snapshot Albania, Leonie Vrugtman

Occasional Papers on Religion in Eastern Europe

A brief summary of the history and current status of religion in Albania.

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Survey Report North Macedonia, Viktorija Borovska Jan 2019

Survey Report North Macedonia, Viktorija Borovska

Occasional Papers on Religion in Eastern Europe

One of the activities of the project ‘Role of Religion in Western Balkan Societies’ was an elite survey that enabled us to gain an insight into views and perceptions on issues related to religiosity, the role and influence of religion, threats and opportunities of religious diversity and suggestions on how religion can contribute to the different social aspects of the various countries of the region.

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Cross Country Comparison And Concluding Remarks, Viktorija Borovska Jan 2019

Cross Country Comparison And Concluding Remarks, Viktorija Borovska

Occasional Papers on Religion in Eastern Europe

Political, economic and cultural elites in the Western Balkans share common views on the role of religion in society, but different perspectives on the challenges and concerns related to interreligious relations.

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De Pilares Y Fundamentos: Siete Tesis Respecto De La Hermenéutica Del Pentateuco, Gerald A. Klingbeil Jan 2019

De Pilares Y Fundamentos: Siete Tesis Respecto De La Hermenéutica Del Pentateuco, Gerald A. Klingbeil

Faculty Publications

No abstract provided.

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An Opportunity To Be Creative, S. Joseph Kidder, Kristy L. Hudson Jan 2019

An Opportunity To Be Creative, S. Joseph Kidder, Kristy L. Hudson

Faculty Publications

No abstract provided.

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Food Choice By A Free-Ranging Antillean Manatee (Trichechus Manatus Manatus) In Tabasco, Mexico, Daniel Gonzalez-Socoloske, David Olivera-Gomez Jan 2019

Food Choice By A Free-Ranging Antillean Manatee (Trichechus Manatus Manatus) In Tabasco, Mexico, Daniel Gonzalez-Socoloske, David Olivera-Gomez

Faculty Publications

Understanding foraging ecology is an important element of effective conservation strategies. While West Indian manatees (Trichechus manatus) have been documented to consume a wide variety of vascular plants and algae, little is known about the diet of the Endangered Antillean subspecies (T. m. manatus) at freshwater sites such as the wetlands of Tabasco, the largest manatee habitat in Mexico. Here we present the results of a study of wild manatee diet in a freshwater site in Mexico. Controlled food choice experiments were conducted on a wild adult manatee during the dry seasons of 2011 and 2012. …

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Connecting To God Through Giving, S. Joseph Kidder Jan 2019

Connecting To God Through Giving, S. Joseph Kidder

Faculty Publications

No abstract provided.

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Called To Lead In Tumultuous Times, Bordes Henry-Saturné Jan 2019

Called To Lead In Tumultuous Times, Bordes Henry-Saturné

Faculty Publications

No abstract provided.

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Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek Jan 2019

Longings And Losses: Working With Grieving Families, David Sedlacek, Beverly Sedlacek

Faculty Publications

No abstract provided.

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Parenting Adolescents In Today’S World, Alina M. Baltazar Jan 2019

Parenting Adolescents In Today’S World, Alina M. Baltazar

Faculty Publications

No abstract provided.

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Intercambios Promotores De Conocimiento Y Desarrollo. El Caso Del Tecnológico De Monterrey, Gustavo Gregorutti, Ángeles Domínguez Jan 2019

Intercambios Promotores De Conocimiento Y Desarrollo. El Caso Del Tecnológico De Monterrey, Gustavo Gregorutti, Ángeles Domínguez

Faculty Publications

Exchanges that foster knowledge and development. The case of the Tecnológico de Monterrey This chapter describes the growing bilateral exchange between Mexico and the United States. Both economies have taken important steps to integrate regionally with agreements that include, but are not limited to, services and human resources. Some universities have taken advantage of such agreements and have established academic exchanges that promote research and development (R&D), benefiting researchers, students and universities in the region. In particular, the study analyzes how the Tecnológico de Monterrey has been establishing academic relations with universities in the United States. To understand some of …

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Predictors Of Morbidity And Mortality Among Thoracic Trauma Patients, Jeremy Patrick Mcconnell Jan 2019

Predictors Of Morbidity And Mortality Among Thoracic Trauma Patients, Jeremy Patrick Mcconnell

University of the Pacific Theses and Dissertations

Background. There are roughly 300,000 rib fractures treated for in the United States each year. These represent 10-26% of thoracic trauma injuries and have about a 10% mortality rate. There is a common belief that mortality in rib fracture patients can be contributed to the diagnosis of pneumonia, but this study does not support that claim. Purpose. To determine the predictors of morbidity and mortality in rib fracture patients. Methods. Using a level 1 trauma center patient registry, we retrospectively analyzed all patients that were admitted with at least one rib fracture (n=1,344). All predictors were analyzed with linear regressions. …

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Exploring The Attitudes And Beliefs Of Audiology Students About People Who Are Deaf Or Hard Of Hearing, Nancy Grosz Sager Jan 2019

Exploring The Attitudes And Beliefs Of Audiology Students About People Who Are Deaf Or Hard Of Hearing, Nancy Grosz Sager

University of the Pacific Theses and Dissertations

This study was undertaken to explore and understand the attitudes and beliefs of audiology students about Deaf and Hard of Hearing people. The problem of practice was that some audiologists continue to advise parents not to sign with their Deaf or Hard of Hearing children. This problem was studied using the conceptual framework of General Systems Theory, looking at the problem through the lens of Critical Disability Theory, to determine if audiology students view Deaf and Hard of Hearing people from a medical model or from a social/cultural model. Using a qualitative case study methodology, I interviewed six first-year doctor …

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The Evolution Of Sunset Magazine's Cooking Department: The Accommodation Of Men's And Women's Cooking In The 1930s, Jennifer Hoolhorst Pagano Jan 2019

The Evolution Of Sunset Magazine's Cooking Department: The Accommodation Of Men's And Women's Cooking In The 1930s, Jennifer Hoolhorst Pagano

University of the Pacific Theses and Dissertations

The Western regional magazine Sunset has been published under a series of owners and publishers since 1898. In 1928, Sunset was purchased by Lawrence Lane, a Midwestern magazine executive who transformed it from a failing turn-of-the-century, general interest publication about the West, into a successful magazine about living in the West for the Western middle-class. Sunset had always been a magazine for men and women, and one that appealed to both male and female intellectuals at the time Lane purchased it. Lane and his editors attempted to interject more rigid middle-class ideals into a magazine that had espoused ideas that …

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Factors Underlying High School Mathematics Teachers' Perceptions Of Challenging Math Tasks, Mariya Anne Sullivan Jan 2019

Factors Underlying High School Mathematics Teachers' Perceptions Of Challenging Math Tasks, Mariya Anne Sullivan

University of the Pacific Theses and Dissertations

In this confirmatory factor analysis, factors previously identified to explain the variability in Middle School Mathematics Teachers’ perception of the Common Core State Standards of Mathematics were considered as factors hypothesized to effect high school math teachers’ perceptions of challenging math tasks (CMTs). The factor of student characterization (i.e., disposition, academic preparation, and student behavior) was additionally considered as a factor hypothesized to explain teachers’ perceptions of CMTs, as well as site-based variables (i.e., curriculum, assessment and evaluation, professional development, and collaboration). In addition, teachers’ understanding of the importance of the mathematical practice standards and teacher familiarity with enacting CMTs …

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Faculty Adaptation To Emerging Instructional Technologies In Higher Education, Marilyn Murrillo Jan 2019

Faculty Adaptation To Emerging Instructional Technologies In Higher Education, Marilyn Murrillo

University of the Pacific Theses and Dissertations

This study examined how and why faculty adopt podcasting as an instructional technology tool in their teaching. Podcasting is an instructional technology tool being used for teaching and learning in higher education. Faculty may record lectures with audio, video, and/or PowerPoint slides to instruct students on class material. Students may access podcasts at their convenience through various devices, including mobile devices and computers. Research has shown that students who use podcasts to study for tests tend to perform more successfully on tests. This study was a qualitative multiple case study of seven California community college faculty using podcasting as an …

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An Autoethnographic Study: An Identity Lost And A Passage Discovered, Simone Shonte Martinez Jan 2019

An Autoethnographic Study: An Identity Lost And A Passage Discovered, Simone Shonte Martinez

University of the Pacific Theses and Dissertations

The professional careers of teachers with a chronic illness can sometimes be devastating. This study addresses the insufficient understanding of the identity crisis a teacher goes through when one is suddenly diagnosed with a chronic illness. While researching different types of theories, identity theory best fit this topic and my interest. Within identity theory, there are four perspectives to view identity. The four perspectives are Nature, Institution, Discourse, and Affinity identities. In order to understand identity, one must understand how identity is formed. Chronic illness identity is a change from all other identities that have been constructed. This study uses …

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Intrapulmonary Inoculation Of Multicellular Tumor Spheroids To Construct An Orthotopic Lung Cancer Xenograft Model That Mimics Four Clinical Stages Of Non-Small Cell Lung Cancer, Yingbo Huang Jan 2019

Intrapulmonary Inoculation Of Multicellular Tumor Spheroids To Construct An Orthotopic Lung Cancer Xenograft Model That Mimics Four Clinical Stages Of Non-Small Cell Lung Cancer, Yingbo Huang

University of the Pacific Theses and Dissertations

Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development and progression of lung cancer as seen …

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Blubber Transcriptome And Proteome Responses To Repeated Adrenocorticotropic Hormone Administration In A Marine Mammal, Jared Deyarmin Jan 2019

Blubber Transcriptome And Proteome Responses To Repeated Adrenocorticotropic Hormone Administration In A Marine Mammal, Jared Deyarmin

University of the Pacific Theses and Dissertations

Chronic physiological stress impacts animal fitness by catabolizing metabolic stores and suppressing reproduction and immunity. This can be especially deleterious for capital breeding carnivores, such as marine mammals, which rely on lipid stores accrued during intensive foraging to sustain prolonged periods of fasting associated with reproduction. Therefore, chronic stress may cause a decrease in fitness in these animals, leading to population declines and potentially detrimental shifts in food web dynamics as a result. However, the impacts and indicators of chronic stress in animals are currently poorly understood. To identify downstream mediators of repeated stress responses in marine mammals, adrenocorticotropic hormone …

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Improving Teacher Retention By Addressing Teachers' Compassion Fatigue, Jacquelyn Ollison Jan 2019

Improving Teacher Retention By Addressing Teachers' Compassion Fatigue, Jacquelyn Ollison

University of the Pacific Theses and Dissertations

California is experiencing a massive teacher shortage, and urban schools are disproportionately affected by it negatively. Retention efforts to date have not included strategies to address Compassion Fatigue (burnout and secondary trauma) teachers experience when working with traumatized students at urban schools. This dissertation explores whether Compassion Fatigue is an unaddressed reason for teacher attrition at urban schools. A mixed method practical action research approach using the Professional Quality of Life Scale Version Five (ProQOL 5) and qualitative interviews, portions of which were turned into illustrative vignettes drove the exploration. Approximately 114 teachers completed the ProQOL 5. Statistical analysis of …

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