Digital Commons Network^™

Retinoic Acid Receptors In Acute Myeloid Leukemia Therapy, Orsola Di Martino, John S Welch

Open Access Publications

Retinoic acid (RA) signaling pathways regulate fundamental biological processes, such as cell proliferation, development, differentiation, and apoptosis. Retinoid receptors (RARs and RXRs) are ligand-dependent transcription factors. All-trans retinoic acid (ATRA) is the principal endogenous ligand for the retinoic acid receptor alpha (RARA) and is produced by the enzymatic oxidation of dietary vitamin A, whose deficiency is associated with several pathological conditions. Differentiation therapy using ATRA revolutionized the outcome of acute promyelocytic leukemia (APL), although attempts to replicate these results in other cancer types have been met with more modest results. A better knowledge of RA signaling in different leukemia contexts …

Tp53 Mutation Status Divides Myelodysplastic Syndromes With Complex Karyotypes Into Distinct Prognostic Subgroups, Detlef Haase, Matthew J. Walter, Et Al.

Open Access Publications

No abstract provided.

A Single-Nucleus Rna-Sequencing Pipeline To Decipher The Molecular Anatomy And Pathophysiology Of Human Kidneys, Blue B. Lake, Song Chen, Masato Hoshi, Nongluk Plongthongkum, Diane Salamon, Amanda Knoten, Anitha Vijayan, Ramakrishna Venkatesh, Eric H. Kim, Derek Gao, Joseph Gaut, Kun Zhang, Sanjay Jain

Open Access Publications

No abstract provided.

The Single-Cell Transcriptomic Landscape Of Early Human Diabetic Nephropathy, Parker C. Wilson, Haojia Wu, Yuhei Kirita, Kohei Uchimura, Nicolas Ledru, Helmut G. Rennke, Paul A. Welling, Sushrut S. Waikar, Benjamin D. Humphreys

Open Access Publications

No abstract provided.

Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages-Canada) Study: A Pragmatic, Randomized Clinical Trial, Alain Deschamps, Jordan Oberhaus, Angela Mickle, Arbi Ben Abdallah, Michael S Avidan, Et Al.

2020-Current year OA Pubs

No abstract provided.

Viral Mhci Inhibition Evades Tissue-Resident Memory T Cell Formation And Responses, Elvin J. Lauron, Liping Yang, Ian B. Harvey, Dorothy K. Sojka, Graham D. Williams, Michael A. Paley, Michael D. Bern, Eugene Park, Francisco Victorino, Adrianus C.M. Boon, Wayne M. Yokoyama

Open Access Publications

Tissue-resident memory CD8

Regional Gene Repression By Dna Double-Strand Breaks In G1 Phase Cells, Caitlin E. Purman, Patrick L. Collins, Sofia I. Porter, Ankita Saini, Harshath Gupta, Barry P. Sleckman, Eugene M. Oltz

Open Access Publications

DNA damage responses (DDR) to double-strand breaks (DSBs) alter cellular transcription programs at the genome-wide level. Through processes that are less well understood, DSBs also alter transcriptional responses locally, which may be important for efficient DSB repair. Here, we developed an approach to elucidate the

The Children's Respiratory And Environmental Workgroup (Crew) Birth Cohort Consortium: Design, Methods, And Study Population, James E. Gern, Leonard B. Bacharier, Et Al

Open Access Publications

No abstract provided.

Advanced Glycation End Products Are Elevated In Estrogen Receptor-Positive Breast Cancer Patients, Alter Response To Therapy, And Can Be Targeted By Lifestyle Intervention, Katherine R. Walter, Lindsay L. Peterson, Et Al

Open Access Publications

No abstract provided.

Congenital Aortic Valve Stenosis, Gautam K Singh

Open Access Publications

Aortic valve stenosis in children is a congenital heart defect that causes fixed form of hemodynamically significant left ventricular outflow tract obstruction with progressive course. Neonates and young infants who have aortic valve stenosis, usually develop congestive heart failure. Children and adolescents who have aortic valve stenosis, are mostly asymptomatic, although they may carry a small but significant risk of sudden death. Transcatheter or surgical intervention is indicated for symptomatic patients or those with moderate to severe left ventricular outflow tract obstruction. Many may need reintervention.

Clinical Impact Of Revised Cefepime Breakpoint In Patients With Enterobacteriaceae Bacteremia, Kap Sum Foong, Abigail L. Carlson, Munigala Satish, Carey-Ann D. Burnham, David K. Warren

Open Access Publications

No abstract provided.

Calvarial Langerhans Cell Histiocytosis In An Adult: Typical Imaging Findings In An Atypical Age Group, Amjad Samara, Jordan Nepute, Hsiang-Chih Lu, Richard J. Perrin, Rami W. Eldaya

Open Access Publications

No abstract provided.

Me-Class2 Reveals Context Dependent Regulatory Roles For 5-Hydroxymethylcytosine, Christopher E. Schlosberg, Dennis Y. Wu, Harrison W. Gabel, John R. Edwards

Open Access Publications

No abstract provided.

Physician Documentation Of Access To Firearms In Suicidal Patients In The Emergency Department, Sonya Naganathan, Kristen L. Mueller

Open Access Publications

No abstract provided.

Efficient Region-Based Test Strategy Uncovers Genetic Risk Factors For Functional Outcome In Bipolar Disorder, Monika Budde, John Rice, Et Al

Open Access Publications

No abstract provided.

Magnetic Resonance Image Guided Stereotactic Body Radiation Therapy To The Primary Renal Mass In Metastatic Renal Cell Carcinoma, Soumon Rudra, Benjamin Fischer-Valuck, Russell Pachynski, Mackenzie Daly, Olga Green

Open Access Publications

No abstract provided.

International Meta-Analysis Of Ptsd Genome-Wide Association Studies Identifies Sex- And Ancestry-Specific Genetic Risk Loci, Laura J. Bierut, Elliot C. Nelson, John P. Rice, Nancy L. Saccone, Andrew C. Heath, Et Al.

Open Access Publications

No abstract provided.

Behavioral Predictors Of Autism Recurrence Are Genetically Independent And Influence Social Reciprocity: Evidence That Polygenic Asd Risk Is Mediated By Separable Elements Of Developmental Liability, Alexa Pohl, Warren R. Jones, Natasha Marrus, Yi Zhang, Ami Klin, John N. Constantino

Open Access Publications

No abstract provided.

Seasonal Changes In The Prevalence Of Antibiotic-Susceptible Acinetobacter Calcoaceticus-Baumannii Complex Isolates Result In Increased Multidrug Resistance Rates During Winter Months, Jason P. Burnham, Mario F. Feldman, Juan J. Calix

Open Access Publications

No abstract provided.

A Protocol For The Systematic Review And Meta-Analysis Of Studies In Which Cannabinoids Were Tested For Antinociceptive Effects In Animal Models Of Pathological Or Injury-Related Persistent Pain, Nadia Soliman, Andrea G. Hohmann, Simon Haroutounian, Kimberley Wever, Andrew S.C. Rice, David P. Finn

Open Access Publications

No abstract provided.

Variation In The Delivery Of Inpatient Orthopaedic Care To Medicaid Beneficiaries Within A Single Metropolitan Region, Christopher J. Dy, Andrew D. Tipping, Katelin B. Nickel, Winston Jiang, Regis J. O'Keefe, Margaret A. Olsen

Open Access Publications

No abstract provided.

Biomarkers And Preclinical Models For Adult T-Cell Leukemia-Lymphoma Treatment, Lee Ratner

Open Access Publications

No abstract provided.

Step-Up Therapy In Black Children And Adults With Poorly Controlled Asthma, Leonard B. Bacharier, Avraham Beigelman, Mario Castro, Et Al.

Open Access Publications

No abstract provided.

Cluster Analysis To Define Distinct Clinical Phenotypes Among Septic Patients With Bloodstream Infections, Maria Cristina Vazquez Guilamet, Michael Bernauer, Scott T. Micek, Marin H. Kollef

Open Access Publications

No abstract provided.

Cell Type-Specific Modulation Of Sensory And Affective Components Of Itch In The Periaqueductal Gray, Vijay K. Samineni, Jose G. Grajales-Reyes, Saranya S. Sundaram, Judy J. Yoo, Robert W. Gereau Iv

Open Access Publications

No abstract provided.

Persistence Of Right Ventricular Dysfunction And Altered Morphometry In Asymptomatic Preterm Infants Through One Year Of Age: Cardiac Phenotype Of Prematurity, Collin T Erickson, Meghna D Patel, Swati Choudhry, Karl Stessy Bisselou, Tim Sekarski, Mary Craft, Ling Li, Afif El Khuffash, Aaron Hamvas, Shelby Kutty, Gautam K Singh, Philip T Levy

Open Access Publications

INTRODUCTION: Prematurity impacts myocardial development and may determine long-term outcomes. The objective of this study was to test the hypothesis that preterm neonates develop right ventricle dysfunction and adaptive remodelling by 32 weeks post-menstrual age that persists through 1 year corrected age.

MATERIALS AND METHODS: A subset of 80 preterm infants (born <29 weeks) was selected retrospectively from a prospectively enrolled cohort and measures of right ventricle systolic function and morphology by two-dimensional echocardiography were assessed at 32 weeks post-menstrual age and at 1 year of corrected age. Comparisons were made to 50 term infants at 1 month and 1 year of age. Sub-analyses were performed in preterm-born infants with bronchopulmonary dysplasia and/or pulmonary hypertension.

RESULT: In both term and preterm infants, right ventricle function and morphology increased over the first year (p < 0.01). The magnitudes of right ventricle function measures were lower in preterm-born infants at each time period (p < 0.01 for all) and right ventricle morphology indices were wider in all preterm infants by 1 year corrected age, irrespective of lung disease. Measures of a) right ventricle function were further decreased and b) morphology increased through 1 year in preterm infants with bronchopulmonary dysplasia and/or pulmonary hypertension (p < 0.01).

CONCLUSION: Preterm infants exhibit abnormal right ventricle performance with remodelling at 32 weeks post-menstrual age that persists through 1 year corrected age, suggesting a less developed intrinsic myocardial function response …

A Promising Bioconjugate Vaccine Against Hypervirulent Klebsiella Pneumoniae, Mario F. Feldman, Anne E. Mayer Bridwell, Nichollas E. Scott, Evgeny Vinogradov, Samuel R. Mckee, Sthefany M. Chavez, Joy Twentyman, Christina L. Stallings, David A. Rosen, Christian M. Harding

Open Access Publications

No abstract provided.

Current State In Scientific Publishing: Aoa Critical Issues Symposium, Jennifer Moriatis Wolf, Linda J Sandell, Seth S Leopold, Karen L Dodson

Open Access Publications

Orthopaedic surgery has a rich history of publication of the science that supports the practice of our specialty, which dates from 1887. Orthopaedic publishing has evolved since that time, expanding from print to online access, with increasing variation in publication models, including open-access journals and article repositories, and methods of information delivery that include video, data archives, and commentary. This symposium provides an overview of the changes and challenges in the publication of orthopaedic science.

Emotional Response Inhibition Is Greater In Older Than Younger Adults, Jill D. Waring, Taylor R. Greif, Eric J. Lenze

Open Access Publications

No abstract provided.

Abcc9-Related Intellectual Disability Myopathy Syndrome Is A Katp Channelopathy With Loss-Of-Function Mutations In Abcc9, Conor Mcclenaghan, Theresa Harter, Monica Sala-Rabanal, Chris H. Emfinger, Yan Huang, Soma S. Singareddy, Colin G. Nichols, Jamie Gunn, David F. Wozniak, Attila Kovacs, Maria S. Remedi, Et Al.

Open Access Publications

No abstract provided.