Digital Commons Network^™

High-Quality Genome-Scale Metabolic Modelling Of Pseudomonas Putida Highlights Its Broad Metabolic Capabilities, Juan Nogales, Joshua Mueller, Steinn Gudmundsson, Francisco J. Canalejo, Estrella Duque, Jonathan Monk, Adam M. Feist, Juan Luis Ramos, Wei Niu, Bernhard O. Palsson

Department of Chemical and Biomolecular Engineering: Faculty Publications

Genome-scale reconstructions of metabolism are computational species-specific knowledge bases able to compute systemic metabolic properties. We present a comprehensive and validated reconstruction of the biotechnologically relevant bacterium Pseudomonas putida KT2440 that greatly expands computable predictions of its metabolic states. The reconstruction represents a significant reactome expansion over available reconstructed bacterial metabolic networks. Specifically, iJN1462 (i) incorporates several hundred additional genes and associated reactions resulting in new predictive capabilities, including new nutrients supporting growth; (ii) was validated by in vivo growth screens that included previously untested carbon (48) and nitrogen (41) sources; (iii) yielded gene essentiality predictions showing large accuracy …

Logics Of Accountability: Cross-National Patterns In School-Level Controls, Taeyeon Kim, John T. Yun

Department of Educational Administration: Faculty Publications

This paper explores multiple logics of accountability by examining patterns of control of various school functions under different accountability systems. Research has shown that accountability is a global phenomenon, but how accountability is understood and enacted is locally contextualized, which implies the existence of multiple logics of accountability in practice. By linking theoretical arguments rooted in literature to empirical evidence observed in TALIS 2013, we aim to theorize logics of accountability and then demonstrate the existence of those logics across countries. We first developed a framework of logics of accountability: control-based, professional-based, test-based, and process-based accountability. We then empirically analyzed …

Alcohol Metabolism Potentiates Hiv-Induced Hepatotoxicity: Contribution To End-Stage Liver Disease, Murali Ganesan, Moses New-Aaron, Raghubendra Singh Dagur, Edward Makarov, Weimin Wang, Kusum K. Kharbanda, Srivatsan Kidambi, Larisa Y. Poluektova, Natalia A. Osna

Department of Chemical and Biomolecular Engineering: Faculty Publications

In an era of improved survival due to modern antiretroviral therapy, liver disease has become a major cause of morbidity and mortality, resulting in death in 15–17% of human immunodeficiency virus (HIV)-infected patients. Alcohol enhances HIV-mediated liver damage and promotes the progression to advanced fibrosis and cirrhosis. However, the mechanisms behind these events are uncertain. Here, we hypothesize that ethanol metabolism potentiates accumulation of HIV in hepatocytes, causing oxidative stress and intensive apoptotic cell death. Engulfment of HIV-containing apoptotic hepatocytes by non-parenchymal cells (NPCs) triggers their activation and liver injury progression. This study was performed on primary human hepatocytes and …

The Necessity, Public Interest, And Proportionality In International Investment Law: A Comparative Analysis, Abdulkadir Gülçür

University of Baltimore Journal of International Law

This article deals with relations of the three concepts of international investment law which can be enumerated as “necessity,” “public interest,” and “proportionality.” These three concepts have been reviewed in the light of the relevant investment tribunals’ decisions and judgments of other international judicial bodies. In democratic governments, legal acts and actions must be based on the “public interest.” However, the “public interest” does not constitute by itself a determinative factor for lawfulness. The proportionality principle has a significant role in the investment arbitrations concerning whether the “public interest” aim is met. Albeit those inferences, the “public interest” claim is …

The Perceived Relationship Of Student Engagement: An Analysis Of Underrepresented Student Achievement At A Predominantly White Land Grant Institution, Antomia Farrell

Murray State Theses and Dissertations

Over the course of centuries, agriculture has carried a negative connotation for those who identify as an underrepresented minority. The University of Kentucky College of Agriculture, Food and Environment (CAFE), Office of Diversity (OOD) has worked strategically over the course of the last twenty years, in enhancing recruitment and retention mechanisms to increase the enrollment of underrepresented minority (URM) students and to change the face of agriculture within the Commonwealth of Kentucky.

The purpose of this study is to identify and examine the student engagement and academic achievement of underrepresented students who are juniors and seniors at the University of …

High + Low: A Forty-Five Year Retrospective Of D. Dominick Lombardi, T. Michael Martin

Faculty & Staff Research and Creative Activity

This catalog contains information about the exhibition High + Low, a 45-year retrospective curated by T. Michael Martin, featuring 20 distinct chapters of the art career of D. Dominick Lombardi. The common thread throughout his work is his interest in blending together qualities of highbrow and lowbrow art, and experimentation with various media. His life-long journey began with his exposure to modern art when he first saw a reproduction of Picasso’s Guernica(1939) at the age of 3 or 4, and continued with his introduction to the seductive world of Zapcomix in 1968.

The exhibition begins with the …

Evidence On Fire, Valena Beety, Jennifer Oliva

Articles by Maurer Faculty

Fire science, a field largely developed by lay “arson investigators,” police officers, or similar first responders untrained in chemistry and physics, has been historically dominated by unreliable methodology, demonstrably false conclusions, and concomitant miscarriages of justice. Fire investigators are neither subject to proficiency testing nor required to obtain more than a high school education. Perhaps surprisingly, courts have largely spared many of the now debunked tenets of fire investigation any serious scientific scrutiny in criminal arson cases. This Article contrasts the courts’ ongoing lax admissibility of unreliable fire-science evidence in criminal cases with their strict exclusion of the same flimsy …

A Potential New Tool For The Toolbox: Assessing Gene Drives For Eradicating Invasive Rodent Populations, K. J. Campbell, J.R. Saah, P.R. Brown, J. Godwin, G.R. Howald, A. Piaggio, P. Thomas, D.M. Tompkins, D. Threadgill, J. Delborne, D.M. Kanavy, T. Kuiken, H. Packard, M. Serr, A. Shiels

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive rodents have significant negative impacts on island biodiversity. All but the smallest of rodent eradications currently rely on island-wide rodenticide applications. Although significant advances have been made in mitigating unintended impacts, rodent eradication on inhabited islands remains extremely challenging. Current tools restrict eradication eff orts to fewer than 15% of islands with critically endangered or endangered species threatened by invasive rodents. The Genetic Biocontrol of Invasive Rodents partnership is an interdisciplinary collaboration to develop and evaluate gene drive technology for eradicating invasive rodent populations on islands. Technological approaches currently being investigated include the production of multiple strains of Mus …

A Bioeconomic Model For The Optimization Of Local Canine Rabies Control, Aaron Anderson, Johann Kotze, Stephanie A. Shwiff, Brody Hatch, Chris Slootmaker, Anne Conan, Darryn Knobel, Louis H. Nel

United States Department of Agriculture Wildlife Services: Staff Publications

We present a new modeling tool that can be used to maximize the impact of canine rabies management resources that are available at the local level. The model is accessible through a web-based interface that allows for flexibility in the management strategies that can be investigated. Rabies vaccination, sterilization, chemo-contraception, and euthanasia can be specified and limited to specific demographic groups. Additionally, we allowed for considerable complexity in the specification of management costs. In many areas, the costs of contacting additional dogs increases as management effort increases, and this can have important strategic implications. We illustrated the application of the …

Taking Greater Responsibility: Austria's Art Restitution Act And The Need For Further Reform, Victoria Bonadies

American University International Law Review

No abstract provided.

Greater Uniformity And Centralization: The Regulatory Development Of Chinese Food And Product Safety Under The Wto, Nga Kit (Christy) Tang

Washington International Law Journal

The WTO Agreements emphasize free trade, which links with diversity, deregulation, and decentralization. China, on the other hand, emphasizes uniformity and centralization, especially regarding the political control and the one-party system of “democratic dictatorship.” China’s joining the WTO, therefore, may be considered as a development that changes the regulatory structure to become more diverse, deregulated, and decentralized. This paper, however, finds the opposite. Under the WTO law, China is encouraged to move towards greater uniformity and centralization with its decentralized and non-uniform settings under the market policy. Moreover, the WTO’s uniform and centralized encouragements can be integrated into the rule-by-man …

Fire Legacies In Eastern Ponderosa Pine Forests, Caleb P. Roberts, Victoria M. Donovan, Carissa L. Wonkka, Larkin A. Powell, Craig R. Allen, David G. Angeler, David A. Wedin, Dirac L. Twidwell Jr

Department of Agronomy and Horticulture: Faculty Publications

Disturbance legacies structure communities and ecological memory, but due to increasing changes in disturbance regimes, it is becoming more difficult to characterize disturbance legacies or determine how long they persist. We sought to quantify the characteristics and persistence of material legacies (e.g., biotic residuals of disturbance) that arise from variation in fire severity in an eastern ponderosa pine forest in North America. We compared forest stand structure and understory woody plant and bird community composition and species richness across unburned, low‐, moderate‐, and high‐severity burn patches in a 27‐year‐old mixed‐severity wildfire that had received minimal post‐fire management. We identified distinct …

Spatial Variability Of Soil Properties Under Different Land Use In The Dang District Of Nepal, Dinesh Panday, Roshan Babu Ojha, Devraj Chalise, Saurav Das, Bikesh Twanabasu

Department of Agronomy and Horticulture: Faculty Publications

Increased nutrient mining, soil erosion, and limited nutrient management has led to declines in soil quality and reduced productivity in many parts of Nepal. A study was conducted in the eastern part of the Dang district of Nepal in 2015 to assess the variability of selected soil properties of three different land use types (agricultural, agroforestry, and grassland) and to map their spatial distribution. A total of 120 soil samples were collected from 0–15 cm depth and analyzed for soil fertility parameters: pH, organic matter (OM), nitrogen (N), phosphorus (P), potassium (K), boron (B), and zinc (Zn). Results revealed that …

Response Surface Analysis Of Genomic Prediction Accuracy Values Using Quality Control Covariates In Soybean, Diego Jarquin, Reka Howard, George L. Graef, Aaron Lorenz

Department of Agronomy and Horticulture: Faculty Publications

An important and broadly used tool for selection purposes and to increase yield and genetic gain in plant breeding programs is genomic prediction (GP). Genomic prediction is a technique where molecular marker information and phenotypic data are used to predict the phenotype (eg, yield) of individuals for which only marker data are available. Higher prediction accuracy can be achieved not only by using efficient models but also by using quality molecular marker and phenotypic data. The steps of a typical quality control (QC) of marker data include the elimination of markers with certain level of minor allele frequency (MAF) and …

Ponderosa Pine Regeneration,Wildland Fuels Management, And Habitat Conservation: Identifying Trade-Offs Following Wildfire, Victoria M. Donovan, Caleb P. Roberts, Carissa L. Wonkka, David A. Wedin, Dirac L. Twidwell

Department of Agronomy and Horticulture: Faculty Publications

Increasing wildfires in western North American conifer forests have led to debates surrounding the application of post-fire management practices. There is a lack of consensus on whether (and to what extent) post-fire management assists or hinders managers in achieving goals, particularly in under-studied regions like eastern ponderosa pine forests. This makes it difficult for forest managers to balance among competing interests. We contrast structural and community characteristics across unburned ponderosa pine forest, severely burned ponderosa pine forest, and severely burned ponderosa pine forest treated with post-fire management with respect to three management objectives: ponderosa pine regeneration, wildland fuels control, and …

Developments In Agricultural Soil Quality And Health: Reflections By The Research Committee On Soil Organic Matter Management, Michelle M. Wander, Larry J. Cihacek, Mark Coyne, Rhae A. Drijber, Julie M. Grossman, Jessica L. M. Gutknecht, William R. Horwath, Sindhu Jagadamma, Daniel C. Olk, Matt Ruark, Sieglinde S. Snapp, Lisa K. Tiemann, Ray Well, Ronald F. Turco

Department of Agronomy and Horticulture: Faculty Publications

The North Central Education and Research Activity Committee (NCERA-59) was formed in 1952 to address how soil organic matter formation and management practices affect soil structure and productivity. It is in this capacity that we comment on the science supporting soil quality and associated soil health assessment for agricultural lands with the goal of hastening progress in this important field. Even though the suite of soil quality indicators being applied by U.S. soil health efforts closely mirrors the “minimum data set” we developed and recommended in the mid-1990s, we question whether the methods or means for their selection and development …

Selection Of Bread Wheat For Low Grain Cadmium Concentration At The Seedling Stage Using Hydroponics Versus Molecular Markers, Caixia Liu, Mary J. Guttieri, Brian M. Waters, Kent M. Eskridge, P. Stephen Baenziger

Department of Agronomy and Horticulture: Faculty Publications

The excessive accumulation of Cd in harvested crops grown on high-Cd soils has increased public concerns for food safety. Due to the high consumption of bread wheat (Triticum aestivum L.) per capita, high concentrations of Cd in wheat grain can significantly affect human health. Breeding is a promising way to reduce grain Cd concentration. However, a lack of efficient selection methods impedes breeding for low grain Cd concentration in bread wheat. In this study, a recombinant inbred population segregating for grain Cd concentration was used to assess the efficacy of two selection methods for decreasing grain Cd concentration in …

Cover Crops And Corn Residue Removal: Impacts On Soil Hydraulic Properties And Their Relationships With Carbon, Michael Sindelar, Humberto Blanco-Canqui, Virginia L. Jin, Richard B. Ferguson

Department of Agronomy and Horticulture: Faculty Publications

Large-scale crop residue removal may negatively affect soil water dynamics. Integrating cover crop (CC) with crop residue management can be a strategy to offset potential adverse effects of residue removal. We studied: (i) the impact of corn (Zea mays L.) residue removal (56%) with and without the use of winter rye (Secale cereale L.) CC on soil hydraulic properties, (ii) whether CC would ameliorate residue removal effects on hydraulic properties, and (iii) relationships of hydraulic properties with soil organic C (SOC) and other properties under irrigated no-till continuous corn on a silt loam in south central Nebraska after …

Spatial Imaging And Screening For Regime Shifts, Daniel R. Uden, Dirac Twidwell, Craig R. Allen, Matthew O. Jones, David E. Naugle, Jeremy D. Maestas, Brady W. Allred

Department of Agronomy and Horticulture: Faculty Publications

Screening is a strategy for detecting undesirable change prior to manifestation of symptoms or adverse effects. Although the well-recognized utility of screening makes it commonplace in medicine, it has yet to be implemented in ecosystem management. Ecosystem management is in an era of diagnosis and treatment of undesirable change, and as a result, remains more reactive than proactive and unable to effectively deal with today’s plethora of non-stationary conditions. In this paper, we introduce spatial imaging-based screening to ecology. We link advancements in spatial resilience theory, data, and technological and computational capabilities and power to detect regime shifts (i.e., vegetation …

Estimating Percentages Of Fusarium-Damaged Kernels In Hard Wheat By Near-Infrared Hyperspectral Imaging, Stephen R. Delwiche, I. Torres Rodriguez, S. R. Rausch, R. A. Graybosch

Department of Agronomy and Horticulture: Faculty Publications

Fusarium head blight (FHB) is among the most common fungal diseases affecting wheat, resulting in decreased yield, low-density kernels, and production of the mycotoxin deoxynivalenol, a compound toxic to humans and livestock. Human visual analysis of representative wheat samples has been the traditional method for FHB assessment in both official inspection and plant breeding operations. While not requiring specialized equipment, visual analysis is dependent on a trained and consistent workforce, such that in the absence of these aspects, biases may arise among inspectors and evaluation dates. This research was intended to avoid such pitfalls by using longer wavelength radiation than …

Utilizing Trait Networks And Structural Equation Models As Tools To Interpret Multi‑Trait Genome‑Wide Association Studies, Mehdi Momen, Malachy T. Campbell, Harkamal Walia, Gota Morota

Department of Agronomy and Horticulture: Faculty Publications

Background: Plant breeders seek to develop cultivars with maximal agronomic value, which is often assessed using numerous, often genetically correlated traits. As intervention on one trait will affect the value of another, breeding decisions should consider the relationships among traits in the context of putative causal structures (i.e., trait networks). While multi-trait genome-wide association studies (MTM-GWAS) can infer putative genetic signals at the multivariate scale, standard MTM-GWAS does not accommodate the network structure of phenotypes, and therefore does not address how the traits are interrelated. We extended the scope of MTM-GWAS by incorporating trait network structures into GWAS using structural …

"I Don't": A Look At Attitudes Towards Delaying Marriage In A Traditional Community, Abbi Halkola

Master's Theses and Doctoral Dissertations

This sociological research study was designed to explore the attitudes of women in their late twenties and thirties about marriage and how geography (physical and sociological) impacts decisions. This research looks at women in a politically and religiously conservative area in the central Midwest. The research is meant to be exploratory in nature in order to grasp an understanding of how not only educational and career aspirations affect attitudes toward marriage but also at how leisure activities and the sexual revolution play a major role in the desire to delay marriage. Interviews were conducted to expose women’s attitudes, opinions, choices, …

Assessing Student Success: Predictive Validity Of The Act Science Subscore, Meāgan Nichole Treadway

Master's Theses and Doctoral Dissertations

The number of applications to postsecondary institutions continues to increase year over year, and in most cases, the number of applications exceeds the number of students admitted. The use of standardized tests continues to grow to help in these admissions decisions. Due to both high usage rates and the changing demographics of our nation’s student population, the study of test bias is still a relevant conversation today. Aside from larger issues of equity and access, particularly in STEM courses, this has implications for leaders in higher education because universities have a stake in ensuring students are academically fit for the …

A Critical Ethnographical Exploration Of Disability Under Apartheid Conditions: The Promising Potential Of Palestinian Higher Education Institutions, Yasmin Snounu

Master's Theses and Doctoral Dissertations

Utilizing a critical ethnographical methodology, this dissertation explores the experiences and practices of professors and administrators towards accommodating disabled students mainly in Palestine, but also taking into consideration the importance of the both political and disability contexts of the United States, primarily in light of critical disability studies, while also drawing from critical discourse analysis in regard to aspects of language, power hierarchies, and identity. Elements of teacher development theories are used in relation to transformational ways of thinking and the role of educators in combating stigma and promoting/adopting inclusive pedagogical practices towards accommodating disabled students in higher education. My …

Designing A Modified Zeeman Slower For The Paschen-Back Magnetic Regime, Leo Michael Nofs

Master's Theses and Doctoral Dissertations

Controlled study of high-density plasmas, such as those found in fusion reactions and stars, is difficult due to their highly-magnetized environments. A specialized high magnetic field (High-B) trap was developed at the University of Michigan in Georg Raithel's research group to study such highly magnetized, high density plasmas using rubidium atoms. By replacing the atom source with a Zeeman slower, a well-studied device to slow and cool atoms, the atom flux could be increased by a factor more than 1000, leading to higher High-B plasma densities. The goal of this project is to design a Zeeman slower that differs from …

The Lived Experiences Of Black Males Who Earned Doctorates, Boris D. Turner

Master's Theses and Doctoral Dissertations

This dissertation described the lived experiences of Black males who earned doctorates. Using an anti-deficit framework, this study explored the post-college experience and doctoral completion. Past research about Black males utilize a deficit perspective indicating how negative experiences, at times, prevent academic achievement. This study used an interpretive approach with one-on-one face-to-face interviews with seven participants. The interviews were conducted in the geographic area of the Midwest, Southeastern, and Northwest regions of the United States. The narratives, rich and thick in descriptions, provided seven themes. The themes included (a) race, and how participants overcame stereotypes and certain challenges, (b) how …

Assessment Of Mudpuppy (Necturus Maculosus) Presence Along The St. Clair-Detroit River System Using Environmental Dna And Occupancy Modeling, Jenny L. Sutherland

Master's Theses and Doctoral Dissertations

The mudpuppy (Necturus maculosus) is cryptic, fully aquatic salamander within the Great Lakes region. Once abundant throughout its range, evidence now suggests that there have been declines due to habitat loss and lampricide use. Information on the status of mudpuppies along the St. Clair-Detroit River System (SCDRS) is lacking, and since they are important bio-indicators, they could be a gauge for restoration success. Environmental DNA (eDNA) and occupancy modeling were used to determine best detection practices for this cryptic species. Mudpuppy eDNA was detected at all known mudpuppy sites with the addition of one site. Occupancy was highest at shoreline …

Case Study Of Parents’ Experiences As Their Children With Hidden Disabilities Navigate The K-12 System To High School Completion, Tamiko Garrett

Master's Theses and Doctoral Dissertations

The experiences of parents navigating through the K-12 school system as their children with invisible disabilities move toward graduation from secondary education are multifaceted. This qualitative study examined the experiences parents are having or not having at Kalamazoo Central High School (KCHS), a traditional high school within the Kalamazoo Public School (KPS) district. The research questions revealed the experiences of parents navigating their children with invisible disabilities. Conceptually, this study was guided by the ecologies of parental engagement (EPE) framework. The teachings of Pierre Bourdieu and his perspective on social capital were also utilized. Data was collected through semi-structured interviews, …

An Investigation Of How Iep Teams Function In Select Michigan High Schools When Developing A Course Of Study Decision For Students With Disabilities, Patrick Mies

Master's Theses and Doctoral Dissertations

The purpose of this mixed-methods study was to investigate the ways that Individual Education Program (IEP) teams function when developing a course of study decision for students with disabilities in high schools in 19 school districts from four intermediate school districts in Michigan. Topics included teacher professional development for reaching consensus in IEP meetings and personal curriculum (PC) plans for diploma acquisition by students with disabilities. Special education teachers who work with students with disabilities at the secondary level shared survey information, perceptions, and opinions about their experiences in IEP meetings. Special education directors, with oversight for special education programs, …

Debunking The False Dichotomy: Developing And Applying Trans Quantcrit At The Intersection Of Trans/Non-Binary Identities And Religious, Secular, And Spiritual Engagement In College, Kate Curley

Master's Theses and Doctoral Dissertations

Discrimination towards people who identify as trans/non-binary (NB) is still extremely well documented and pervasive across many different demographics. Discussions on religious, secular, or spiritual (RSS) identities and trans/NB identities are often fraught with difficult conflicts between the two. In student affairs published standards, practitioners are expected to serve “regardless” of gender in RSS programs and “regardless” of religion in LGBTQ+ programming. This study sought to explore how RSS campus climate influences students’ attitudes towards trans/NB people and how trans/NB experience their RSS campus climate. Informed by critical theory and using critical consciousness and ally identity development conceptual frameworks, I …